Deletion Strain | FD score | P-value | Gene | Gene Description |
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YEL013W | 8.75 | 1.11E-18 | VAC8 | Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions |
YDR516C | 6.81 | 4.73E-12 | EMI2 | Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress |
YBL061C | 6.37 | 9.21E-11 | SKT5 | Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication |
YAR002C-A | 6.25 | 2.05E-10 | ERP1 | Member of the p24 family involved in ER to Golgi transport; forms heterotrimeric complex with Erp2p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP1 has a paralog, ERP6, that arose from the whole genome duplication |
YDR214W | 6.24 | 2.20E-10 | AHA1 | Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress |
YDR158W | 6.24 | 2.21E-10 | HOM2 | Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis |
YNL022C_p | 6.18 | 3.18E-10 | YNL022C_p | Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; predicted to be involved in ribosome biogenesis |
YOR323C | 5.77 | 4.04E-9 | PRO2 | Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis |
YKL115C_d | 5.38 | 3.65E-8 | YKL115C_d | Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1 |
YGL234W | 4.88 | 5.22E-7 | ADE5,7 | Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities |
YLR111W_d | 4.70 | 1.30E-6 | YLR111W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YDR144C | 4.60 | 2.14E-6 | MKC7 | GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p |
YGR249W | 4.59 | 2.25E-6 | MGA1 | Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants |
YIL025C_d | 4.57 | 2.43E-6 | YIL025C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YNL327W | 4.57 | 2.45E-6 | EGT2 | Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner |