Deletion Strain | FD score | P-value | Gene | Gene Description |
---|
YEL028W_d | 7.99 | 6.64E-16 | YEL028W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YOR008C | 7.74 | 5.11E-15 | SLG1 | Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response |
YGL202W | 6.30 | 1.48E-10 | ARO8 | Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis |
YIL014C-A_p | 6.29 | 1.63E-10 | YIL014C-A_p | Putative protein of unknown function |
YIL072W | 5.91 | 1.69E-9 | HOP1 | Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein?DNA filaments |
YLR240W | 5.76 | 4.26E-9 | VPS34 | Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p; a fraction is localized, with Vps15p, to nuclear pores at nucleus-vacuole junctions and may facilitate transcription elongation for genes positioned at the nuclear periphery |
YDR129C | 5.73 | 4.93E-9 | SAC6 | Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress |
YDR354W | 5.59 | 1.16E-8 | TRP4 | Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis |
YKL011C | 5.49 | 1.97E-8 | CCE1 | Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA |
YKL032C | 4.98 | 3.23E-7 | IXR1 | Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b |
YPL097W | 4.88 | 5.31E-7 | MSY1 | Mitochondrial tyrosyl-tRNA synthetase |
YKL212W | 4.79 | 8.21E-7 | SAC1 | Phosphatidylinositol phosphate (PtdInsP) phosphatase; involved in hydrolysis of PtdIns[4]P in the early and medial Golgi; regulated by interaction with Vps74p; ER localized transmembrane protein which cycles through the Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance; regulates sphingolipid biosynthesis through the modulation of PtdIns(4)P metabolism |
YAL048C | 4.69 | 1.40E-6 | GEM1 | Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases |
YCR075C | 4.59 | 2.20E-6 | ERS1 | Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains |
YMR044W | 4.42 | 4.85E-6 | IOC4 | Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing |