Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YDR047W | 7.44 | 5.13E-14 | 1.81 | HEM12 | Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda |
YNL178W | 5.62 | 9.37E-9 | 0.45 | RPS3 | Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3 |
YGL171W | 5.18 | 1.12E-7 | 0.14 | ROK1 | RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation |
YDR427W | 5.04 | 2.33E-7 | 0.90 | RPN9 | Non-ATPase regulatory subunit of the 26S proteasome; has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress |
YGL040C | 4.14 | 1.74E-5 | 0.06 | HEM2 | Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus |
YKL195W | 4.08 | 2.22E-5 | 0.06 | MIA40 | Oxidoreductase that mediates mitochondrial intermembrane space import; substrates include small proteins containing twin cysteine motifs; acts in concert with Erv1p, which oxidizes the cysteine residues of Mia40p to comprise a disulfide relay system that catalyzes import; also mediates folding of Atp23p |
YGL225W | 4.03 | 2.83E-5 | 0.05 | VRG4 | Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi |
YKL210W | 3.98 | 3.42E-5 | 0.23 | UBA1 | Ubiquitin activating enzyme (E1); involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress |
YPL016W | 3.75 | 8.71E-5 | 0.04 | SWI1 | Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer |
YBL004W | 3.71 | 1.03E-4 | 0.05 | UTP20 | Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA |
YDL147W | 3.66 | 1.24E-4 | 0.05 | RPN5 | Subunit of the COP9 signalosome (CSN) and non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein |
YNR053C | 3.61 | 1.51E-4 | 0.21 | NOG2 | Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation |
YPR113W | 3.40 | 3.38E-4 | 0.01 | PIS1 | Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins |
YLR141W | 3.39 | 3.51E-4 | 0.08 | RRN5 | Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p |
YFL034C-B | 3.30 | 4.76E-4 | 0.06 | MOB2 | Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p |