Deletion Strain | FD score | P-value | Gene | Gene Description |
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YEL009C | 8.08 | 3.15E-16 | GCN4 | Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels |
YIL056W | 8.04 | 4.54E-16 | VHR1 | Transcriptional activator; required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations; VHR1 has a paralog, VHR2, that arose from the whole genome duplication |
YML034W | 7.74 | 4.99E-15 | SRC1 | Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance |
YOR187W | 6.87 | 3.10E-12 | TUF1 | Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans |
YHL008C_p | 6.75 | 7.15E-12 | YHL008C_p | Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole |
YGL160W | 6.62 | 1.86E-11 | AIM14 | NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p |
YDR389W | 6.50 | 4.00E-11 | SAC7 | GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate |
YGL177W_d | 6.37 | 9.43E-11 | YGL177W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YJL103C | 6.29 | 1.56E-10 | GSM1 | Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis |
YGL026C | 6.13 | 4.34E-10 | TRP5 | Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis |
YJR049C | 6.11 | 5.03E-10 | UTR1 | ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication |
YLL006W | 6.10 | 5.26E-10 | MMM1 | ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth |
YCR073W-A | 6.07 | 6.20E-10 | SOL2 | Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication |
YLR296W_d | 5.93 | 1.52E-9 | YLR296W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YER038W-A_d | 5.82 | 3.00E-9 | YER038W-A_d | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria |