9012552

5-chloro-N-pyridin-3-ylnaphthalene-1-carboxamide

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2979
Screen concentration 45.5 μM
Source Chembridge (Drug-like library)
PubChem CID 17100905
SMILES C1=CC2=C(C=CC=C2Cl)C(=C1)C(=O)NC3=CN=CC=C3
Standardized SMILES Clc1cccc2c(cccc12)C(=O)Nc3cccnc3
Molecular weight 282.7243
ALogP 3.04
H-bond donor count 1
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 11.16
% growth inhibition (Hom. pool) 6.49


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 17100905
Download HIP data (tab-delimited text)  (excel)
Gene:CKS1(YBR135W)|FD-Score:-4.05|P-value:2.60E-5|Clearance:0||SGD DESC:Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters Gene:INN1(YNL152W)|FD-Score:3.35|P-value:4.00E-4|Clearance:0.03||SGD DESC:Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis Gene:PRE2(YPR103W)|FD-Score:3.32|P-value:4.48E-4|Clearance:0.02||SGD DESC:Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome Gene:SDA1(YGR245C)|FD-Score:4.04|P-value:2.63E-5|Clearance:0.69||SGD DESC:Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis Gene:SRM1(YGL097W)|FD-Score:3.3|P-value:4.82E-4|Clearance:0.25||SGD DESC:Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p Gene:CKS1(YBR135W)|FD-Score:-4.05|P-value:2.60E-5|Clearance:0||SGD DESC:Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters Gene:INN1(YNL152W)|FD-Score:3.35|P-value:4.00E-4|Clearance:0.03||SGD DESC:Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis Gene:PRE2(YPR103W)|FD-Score:3.32|P-value:4.48E-4|Clearance:0.02||SGD DESC:Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome Gene:SDA1(YGR245C)|FD-Score:4.04|P-value:2.63E-5|Clearance:0.69||SGD DESC:Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis Gene:SRM1(YGL097W)|FD-Score:3.3|P-value:4.82E-4|Clearance:0.25||SGD DESC:Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 17100905
Download HOP data (tab-delimited text)  (excel)
Gene:ACK1(YDL203C)|FD-Score:-4.08|P-value:2.29E-5||SGD DESC:Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria Gene:APS3(YJL024C)|FD-Score:4.69|P-value:1.34E-6||SGD DESC:Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress Gene:AQY2(YLL052C)|FD-Score:3.81|P-value:7.00E-5||SGD DESC:Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains Gene:ATG27(YJL178C)|FD-Score:-4.31|P-value:8.10E-6||SGD DESC:Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site Gene:AXL2(YIL140W)|FD-Score:3.35|P-value:4.08E-4||SGD DESC:Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate Gene:BRP1(YGL007W_d)|FD-Score:3.22|P-value:6.41E-4||SGD DESC:Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1 Gene:CAF16(YFL028C)|FD-Score:4.07|P-value:2.40E-5||SGD DESC:Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator Gene:COQ9(YLR201C)|FD-Score:-3.27|P-value:5.43E-4||SGD DESC:Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes Gene:COX23(YHR116W)|FD-Score:-3.47|P-value:2.59E-4||SGD DESC:Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs Gene:COX5B(YIL111W)|FD-Score:-3.31|P-value:4.59E-4||SGD DESC:Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication Gene:DCS2(YOR173W)|FD-Score:3.64|P-value:1.34E-4||SGD DESC:Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance Gene:DOT5(YIL010W)|FD-Score:-4.46|P-value:4.11E-6||SGD DESC:Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth Gene:HDA2(YDR295C)|FD-Score:-3.46|P-value:2.72E-4||SGD DESC:Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance Gene:HOG1(YLR113W)|FD-Score:3.44|P-value:2.87E-4||SGD DESC:Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress Gene:HSM3(YBR272C)|FD-Score:-3.54|P-value:1.99E-4||SGD DESC:Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation Gene:LDB7(YBL006C)|FD-Score:3.26|P-value:5.58E-4||SGD DESC:Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions Gene:MSS11(YMR164C)|FD-Score:-6.07|P-value:6.42E-10||SGD DESC:Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals Gene:NRG2(YBR066C)|FD-Score:-3.42|P-value:3.12E-4||SGD DESC:Transcriptional repressor; mediates glucose repression and negatively regulates filamentous growth; NRG2 has a paralog, NRG1, that arose from the whole genome duplication Gene:NUP188(YML103C)|FD-Score:-3.88|P-value:5.27E-5||SGD DESC:Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188 Gene:OPY1(YBR129C)|FD-Score:-3.81|P-value:6.99E-5||SGD DESC:Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:OST6(YML019W)|FD-Score:4.64|P-value:1.72E-6||SGD DESC:Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p Gene:OTU1(YFL044C)|FD-Score:-4.57|P-value:2.43E-6||SGD DESC:Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress Gene:PDE1(YGL248W)|FD-Score:-3.2|P-value:6.94E-4||SGD DESC:Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation Gene:PDR1(YGL013C)|FD-Score:3.91|P-value:4.63E-5||SGD DESC:Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication Gene:PEX14(YGL153W)|FD-Score:-3.15|P-value:8.14E-4||SGD DESC:Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p Gene:PRM10(YJL108C)|FD-Score:3.77|P-value:8.08E-5||SGD DESC:Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation Gene:PRY2(YKR013W)|FD-Score:3.29|P-value:4.94E-4||SGD DESC:Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication Gene:PSK1(YAL017W)|FD-Score:-3.15|P-value:8.29E-4||SGD DESC:PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication Gene:RBK1(YCR036W)|FD-Score:3.91|P-value:4.59E-5||SGD DESC:Putative ribokinase Gene:RPP2A(YOL039W)|FD-Score:-4.29|P-value:9.12E-6||SGD DESC:Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm Gene:SDH4(YDR178W)|FD-Score:4.86|P-value:5.79E-7||SGD DESC:Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain Gene:THI7(YLR237W)|FD-Score:3.61|P-value:1.53E-4||SGD DESC:Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia Gene:URA1(YKL216W)|FD-Score:3.25|P-value:5.83E-4||SGD DESC:Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid Gene:VTC2(YFL004W)|FD-Score:-3.77|P-value:8.03E-5||SGD DESC:Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion Gene:YBL044W(YBL044W_p)|FD-Score:3.16|P-value:7.78E-4||SGD DESC:Putative protein of unknown function; YBL044W is not an essential protein Gene:YDR193W(YDR193W_d)|FD-Score:-5.58|P-value:1.18E-8||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YER038W-A(YER038W-A_d)|FD-Score:4.08|P-value:2.21E-5||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria Gene:YGR161W-C(YGR161W-C_p)|FD-Score:-3.59|P-value:1.65E-4||SGD DESC:Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species Gene:YMD8(YML038C)|FD-Score:5.67|P-value:7.33E-9||SGD DESC:Putative nucleotide sugar transporter, has similarity to Vrg4p Gene:YMR001C-A(YMR001C-A_p)|FD-Score:-4.84|P-value:6.43E-7||SGD DESC:Putative protein of unknown function Gene:YMR034C(YMR034C_p)|FD-Score:3.15|P-value:8.25E-4||SGD DESC:Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene Gene:YNL277W-A(YNL277W-A_p)|FD-Score:-4.02|P-value:2.89E-5||SGD DESC:Putative protein of unknown function Gene:YNR065C(YNR065C_p)|FD-Score:3.91|P-value:4.63E-5||SGD DESC:Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene Gene:YOR186W(YOR186W_p)|FD-Score:3.75|P-value:8.86E-5||SGD DESC:Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication Gene:YPL113C(YPL113C_p)|FD-Score:-3.23|P-value:6.20E-4||SGD DESC:Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene Gene:ZDS2(YML109W)|FD-Score:-3.56|P-value:1.86E-4||SGD DESC:Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication Gene:ACK1(YDL203C)|FD-Score:-4.08|P-value:2.29E-5||SGD DESC:Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria Gene:APS3(YJL024C)|FD-Score:4.69|P-value:1.34E-6||SGD DESC:Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress Gene:AQY2(YLL052C)|FD-Score:3.81|P-value:7.00E-5||SGD DESC:Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains Gene:ATG27(YJL178C)|FD-Score:-4.31|P-value:8.10E-6||SGD DESC:Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site Gene:AXL2(YIL140W)|FD-Score:3.35|P-value:4.08E-4||SGD DESC:Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate Gene:BRP1(YGL007W_d)|FD-Score:3.22|P-value:6.41E-4||SGD DESC:Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1 Gene:CAF16(YFL028C)|FD-Score:4.07|P-value:2.40E-5||SGD DESC:Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator Gene:COQ9(YLR201C)|FD-Score:-3.27|P-value:5.43E-4||SGD DESC:Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes Gene:COX23(YHR116W)|FD-Score:-3.47|P-value:2.59E-4||SGD DESC:Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs Gene:COX5B(YIL111W)|FD-Score:-3.31|P-value:4.59E-4||SGD DESC:Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication Gene:DCS2(YOR173W)|FD-Score:3.64|P-value:1.34E-4||SGD DESC:Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance Gene:DOT5(YIL010W)|FD-Score:-4.46|P-value:4.11E-6||SGD DESC:Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth Gene:HDA2(YDR295C)|FD-Score:-3.46|P-value:2.72E-4||SGD DESC:Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance Gene:HOG1(YLR113W)|FD-Score:3.44|P-value:2.87E-4||SGD DESC:Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress Gene:HSM3(YBR272C)|FD-Score:-3.54|P-value:1.99E-4||SGD DESC:Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation Gene:LDB7(YBL006C)|FD-Score:3.26|P-value:5.58E-4||SGD DESC:Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions Gene:MSS11(YMR164C)|FD-Score:-6.07|P-value:6.42E-10||SGD DESC:Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals Gene:NRG2(YBR066C)|FD-Score:-3.42|P-value:3.12E-4||SGD DESC:Transcriptional repressor; mediates glucose repression and negatively regulates filamentous growth; NRG2 has a paralog, NRG1, that arose from the whole genome duplication Gene:NUP188(YML103C)|FD-Score:-3.88|P-value:5.27E-5||SGD DESC:Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188 Gene:OPY1(YBR129C)|FD-Score:-3.81|P-value:6.99E-5||SGD DESC:Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:OST6(YML019W)|FD-Score:4.64|P-value:1.72E-6||SGD DESC:Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p Gene:OTU1(YFL044C)|FD-Score:-4.57|P-value:2.43E-6||SGD DESC:Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family; protein abundance increases in response to DNA replication stress Gene:PDE1(YGL248W)|FD-Score:-3.2|P-value:6.94E-4||SGD DESC:Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation Gene:PDR1(YGL013C)|FD-Score:3.91|P-value:4.63E-5||SGD DESC:Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication Gene:PEX14(YGL153W)|FD-Score:-3.15|P-value:8.14E-4||SGD DESC:Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p Gene:PRM10(YJL108C)|FD-Score:3.77|P-value:8.08E-5||SGD DESC:Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation Gene:PRY2(YKR013W)|FD-Score:3.29|P-value:4.94E-4||SGD DESC:Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication Gene:PSK1(YAL017W)|FD-Score:-3.15|P-value:8.29E-4||SGD DESC:PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication Gene:RBK1(YCR036W)|FD-Score:3.91|P-value:4.59E-5||SGD DESC:Putative ribokinase Gene:RPP2A(YOL039W)|FD-Score:-4.29|P-value:9.12E-6||SGD DESC:Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm Gene:SDH4(YDR178W)|FD-Score:4.86|P-value:5.79E-7||SGD DESC:Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain Gene:THI7(YLR237W)|FD-Score:3.61|P-value:1.53E-4||SGD DESC:Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia Gene:URA1(YKL216W)|FD-Score:3.25|P-value:5.83E-4||SGD DESC:Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid Gene:VTC2(YFL004W)|FD-Score:-3.77|P-value:8.03E-5||SGD DESC:Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion Gene:YBL044W(YBL044W_p)|FD-Score:3.16|P-value:7.78E-4||SGD DESC:Putative protein of unknown function; YBL044W is not an essential protein Gene:YDR193W(YDR193W_d)|FD-Score:-5.58|P-value:1.18E-8||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YER038W-A(YER038W-A_d)|FD-Score:4.08|P-value:2.21E-5||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria Gene:YGR161W-C(YGR161W-C_p)|FD-Score:-3.59|P-value:1.65E-4||SGD DESC:Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species Gene:YMD8(YML038C)|FD-Score:5.67|P-value:7.33E-9||SGD DESC:Putative nucleotide sugar transporter, has similarity to Vrg4p Gene:YMR001C-A(YMR001C-A_p)|FD-Score:-4.84|P-value:6.43E-7||SGD DESC:Putative protein of unknown function Gene:YMR034C(YMR034C_p)|FD-Score:3.15|P-value:8.25E-4||SGD DESC:Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene Gene:YNL277W-A(YNL277W-A_p)|FD-Score:-4.02|P-value:2.89E-5||SGD DESC:Putative protein of unknown function Gene:YNR065C(YNR065C_p)|FD-Score:3.91|P-value:4.63E-5||SGD DESC:Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene Gene:YOR186W(YOR186W_p)|FD-Score:3.75|P-value:8.86E-5||SGD DESC:Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication Gene:YPL113C(YPL113C_p)|FD-Score:-3.23|P-value:6.20E-4||SGD DESC:Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene Gene:ZDS2(YML109W)|FD-Score:-3.56|P-value:1.86E-4||SGD DESC:Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintenance of Cdc55p in the cytoplasm where it promotes mitotic entry; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; ZDS2 has a paralog, ZDS1, that arose from the whole genome duplication

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YGR245C4.042.63E-50.69SDA1Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
YNL152W3.354.00E-40.03INN1Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis
YPR103W3.324.48E-40.02PRE2Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome
YGL097W3.304.82E-40.25SRM1Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
YOR151C3.050.001150.09RPB2RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit
YPL228W2.960.001530.04CET1Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide
YHR024C2.920.001770.03MAS2Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
YDL045C2.890.001950.01FAD1Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin
YPL210C2.870.002040.04SRP72Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
YKL182W2.830.002340.06FAS1Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YHR068W2.760.002850.04DYS1Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric
YJR007W2.720.003250.01SUI2Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress
YOR157C2.710.003380.01PUP1Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z
YKL145W2.700.003490.16RPT1One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance
YER168C2.530.005648.84E-4CCA1ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YML038C5.677.33E-9YMD8Putative nucleotide sugar transporter, has similarity to Vrg4p
YDR178W4.865.79E-7SDH4Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain
YJL024C4.691.34E-6APS3Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress
YML019W4.641.72E-6OST6Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p
YER038W-A_d4.082.21E-5YER038W-A_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria
YFL028C4.072.40E-5CAF16Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator
YCR036W3.914.59E-5RBK1Putative ribokinase
YGL013C3.914.63E-5PDR1Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication
YNR065C_p3.914.63E-5YNR065C_pProtein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene
YLL052C3.817.00E-5AQY2Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YJL108C3.778.08E-5PRM10Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation
YOR186W_p3.758.86E-5YOR186W_pPutative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent; YOR186W has a paralog, YLR297W, that arose from the whole genome duplication
YOR173W3.641.34E-4DCS2Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance
YLR237W3.611.53E-4THI7Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
YLR113W3.442.87E-4HOG1Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNA Pol II in response to osmotic shock; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p and Ptp3p; protein abundance increases in response to DNA replication stress

GO enrichment analysis for SGTC_2979
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.3202.44E-140SGTC_29849022109 39.0 μMChembridge (Drug-like library)64592070.193548
0.0961.32E-13SGTC_30799117512 49.5 μMChembridge (Drug-like library)71850440.19403
0.0938.13E-13SGTC_2234tolnaftate 200.0 μMMiscellaneous55100.0895522
0.0872.16E-11SGTC_12430416-0003 5.7 μMChemDiv (Drug-like library)21419770.0892857PDR1
0.0822.43E-10SGTC_29879018338 71.4 μMChembridge (Drug-like library)50556820.126761RPP1 & pyrimidine depletion
0.0815.11E-10SGTC_2656pseudo-anisatin 100.0 μMMicrosource (Natural product library)67088090.0277778
0.0806.35E-10SGTC_295k015-0027 31.0 μMChemDiv (Drug-like library)38874240.056338PDR1
0.0799.84E-10SGTC_1700st030840 7.9 μMTimTec (Natural product derivative library)54993070.0813954PDR1
0.0764.51E-9SGTC_5274476-4215 268.0 μMChemDiv (Drug-like library)44187540.116279PDR1
0.0758.19E-9SGTC_2762leflunomide 42.1 μMMiscellaneous38990.263158
0.0713.89E-8SGTC_29929074591 71.4 μMChembridge (Drug-like library)177413210.140845
0.0714.44E-8SGTC_12770873-0036 22.0 μMChemDiv (Drug-like library)59657350.0714286PDR1
0.0708.75E-8SGTC_6641222-0054 14.9 μMChemDiv (Drug-like library)68139910.0714286sphingolipid biosynthesis & PDR1
0.0691.03E-7SGTC_2416tofa 880.0 nMMiscellaneous1151750.0952381sphingolipid biosynthesis & PDR1
0.0691.25E-7SGTC_8410251-0215 91.2 μMChemDiv (Drug-like library)38886140.0576923

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_20485246248200 μM0.581395677046Chembridge (Fragment library)216.2110631.66913
SGTC_8480368-008985.6 μM0.555556762535ChemDiv (Drug-like library)267.110722.79212iron homeostasis
SGTC_22757947463200 μM0.51225414Chembridge (Fragment library)216.235880.85813iron homeostasis
SGTC_2969909140828.7 μM0.4230774286311Chembridge (Drug-like library)254.326923.31812
SGTC_1010490-5701117.49 μM0.4081634661669ChemDiv (Drug-like library)358.562192.91512
SGTC_2967908953849.85 μM0.407407728216Chembridge (Drug-like library)300.663633.0715
SGTC_23246149169200 μM0.3962262888231Chembridge (Fragment library)247.273062.0124
SGTC_2968909066333.37 μM0.38596525236811Chembridge (Drug-like library)325.224123.43413
SGTC_3082911700849.47 μM0.38461541448529Chembridge (Drug-like library)240.300342.44112
SGTC_21245246320200 μM0.382979579342Chembridge (Fragment library)216.2110631.66913heme biosynthesis & mitochondrial translocase