9022671

4-[2-[(5-ethyl-8-methoxy-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]ethyl]morpholine

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2983
Screen concentration 13.0 μM
Source Chembridge (Drug-like library)
PubChem CID 6405161
SMILES CCN1C2=C(C=C(C=C2)OC)C3=C1N=C(N=N3)SCCN4CCOCC4
Standardized SMILES CCn1c2ccc(OC)cc2c3nnc(SCCN4CCOCC4)nc13
Molecular weight 373.4725
ALogP 3.13
H-bond donor count 0
H-bond acceptor count 7
Response signature 60S ribosome export

Pool Growth Kinetics
% growth inhibition (Het. pool) 3.46
% growth inhibition (Hom. pool) 2.44


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 6405161
Download HIP data (tab-delimited text)  (excel)
Gene:CCT7(YJL111W)|FD-Score:5.09|P-value:1.76E-7|Clearance:0.35||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance Gene:CDC15(YAR019C)|FD-Score:6.88|P-value:2.95E-12|Clearance:1.79||SGD DESC:Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress Gene:DYS1(YHR068W)|FD-Score:4.32|P-value:7.84E-6|Clearance:0.81||SGD DESC:Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric Gene:GCD7(YLR291C)|FD-Score:-3.51|P-value:2.22E-4|Clearance:0||SGD DESC:Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression Gene:GWT1(YJL091C)|FD-Score:4.75|P-value:1.04E-6|Clearance:0.04||SGD DESC:Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors Gene:LSG1(YGL099W)|FD-Score:10.8|P-value:1.52E-27|Clearance:3.93||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:MCM2(YBL023C)|FD-Score:4.68|P-value:1.44E-6|Clearance:0.36||SGD DESC:Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress Gene:NMD3(YHR170W)|FD-Score:11|P-value:1.65E-28|Clearance:3.93||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:PRP43(YGL120C)|FD-Score:-7.16|P-value:4.06E-13|Clearance:0||SGD DESC:RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome Gene:RRP7(YCL031C)|FD-Score:4.7|P-value:1.28E-6|Clearance:0.02||SGD DESC:Essential protein involved in rRNA processing and ribosome biogenesis; protein abundance increases in response to DNA replication stress Gene:TIF6(YPR016C)|FD-Score:3.51|P-value:2.24E-4|Clearance:0.26||SGD DESC:Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits Gene:UTP8(YGR128C)|FD-Score:-3.1|P-value:9.58E-4|Clearance:0||SGD DESC:Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA Gene:YOR146W(YOR146W_d)|FD-Score:3.19|P-value:7.12E-4|Clearance:0.16||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C Gene:YPT1(YFL038C)|FD-Score:-3.33|P-value:4.29E-4|Clearance:0||SGD DESC:Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p) Gene:YRB1(YDR002W)|FD-Score:3.25|P-value:5.69E-4|Clearance:0.06||SGD DESC:Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1 Gene:CCT7(YJL111W)|FD-Score:5.09|P-value:1.76E-7|Clearance:0.35||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance Gene:CDC15(YAR019C)|FD-Score:6.88|P-value:2.95E-12|Clearance:1.79||SGD DESC:Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress Gene:DYS1(YHR068W)|FD-Score:4.32|P-value:7.84E-6|Clearance:0.81||SGD DESC:Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric Gene:GCD7(YLR291C)|FD-Score:-3.51|P-value:2.22E-4|Clearance:0||SGD DESC:Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression Gene:GWT1(YJL091C)|FD-Score:4.75|P-value:1.04E-6|Clearance:0.04||SGD DESC:Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors Gene:LSG1(YGL099W)|FD-Score:10.8|P-value:1.52E-27|Clearance:3.93||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:MCM2(YBL023C)|FD-Score:4.68|P-value:1.44E-6|Clearance:0.36||SGD DESC:Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress Gene:NMD3(YHR170W)|FD-Score:11|P-value:1.65E-28|Clearance:3.93||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:PRP43(YGL120C)|FD-Score:-7.16|P-value:4.06E-13|Clearance:0||SGD DESC:RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome Gene:RRP7(YCL031C)|FD-Score:4.7|P-value:1.28E-6|Clearance:0.02||SGD DESC:Essential protein involved in rRNA processing and ribosome biogenesis; protein abundance increases in response to DNA replication stress Gene:TIF6(YPR016C)|FD-Score:3.51|P-value:2.24E-4|Clearance:0.26||SGD DESC:Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits Gene:UTP8(YGR128C)|FD-Score:-3.1|P-value:9.58E-4|Clearance:0||SGD DESC:Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA Gene:YOR146W(YOR146W_d)|FD-Score:3.19|P-value:7.12E-4|Clearance:0.16||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C Gene:YPT1(YFL038C)|FD-Score:-3.33|P-value:4.29E-4|Clearance:0||SGD DESC:Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p) Gene:YRB1(YDR002W)|FD-Score:3.25|P-value:5.69E-4|Clearance:0.06||SGD DESC:Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 6405161
Download HOP data (tab-delimited text)  (excel)
Gene:AFI1(YOR129C)|FD-Score:3.92|P-value:4.36E-5||SGD DESC:Arf3p polarization-specific docking factor, required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p Gene:AIM32(YML050W)|FD-Score:-3.39|P-value:3.52E-4||SGD DESC:Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss Gene:AKL1(YBR059C)|FD-Score:-3.32|P-value:4.44E-4||SGD DESC:Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization Gene:ALP1(YNL270C)|FD-Score:3.77|P-value:8.08E-5||SGD DESC:Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication Gene:APP1(YNL094W)|FD-Score:-3.19|P-value:7.20E-4||SGD DESC:Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway Gene:ARR2(YPR200C)|FD-Score:3.1|P-value:9.80E-4||SGD DESC:Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p Gene:ATG1(YGL180W)|FD-Score:-3.11|P-value:9.51E-4||SGD DESC:Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p Gene:BNA1(YJR025C)|FD-Score:3.12|P-value:8.98E-4||SGD DESC:3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p Gene:BST1(YFL025C)|FD-Score:5.04|P-value:2.36E-7||SGD DESC:GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules Gene:CCC1(YLR220W)|FD-Score:-3.44|P-value:2.91E-4||SGD DESC:Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress Gene:CIT1(YNR001C)|FD-Score:3.34|P-value:4.19E-4||SGD DESC:Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication Gene:CRC1(YOR100C)|FD-Score:3.89|P-value:5.04E-5||SGD DESC:Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation Gene:EMI2(YDR516C)|FD-Score:-3.95|P-value:3.92E-5||SGD DESC:Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:EOS1(YNL080C)|FD-Score:-5.16|P-value:1.26E-7||SGD DESC:Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene Gene:FMP52(YER004W)|FD-Score:-3.28|P-value:5.11E-4||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation Gene:FRE4(YNR060W)|FD-Score:6.16|P-value:3.70E-10||SGD DESC:Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels Gene:GCN4(YEL009C)|FD-Score:3.86|P-value:5.67E-5||SGD DESC:Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels Gene:GLC3(YEL011W)|FD-Score:3.09|P-value:9.90E-4||SGD DESC:Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:HER2(YMR293C)|FD-Score:4.27|P-value:9.68E-6||SGD DESC:Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase Gene:HIT1(YJR055W)|FD-Score:3.5|P-value:2.30E-4||SGD DESC:Protein of unknown function, required for growth at high temperature Gene:ILV6(YCL009C)|FD-Score:3.31|P-value:4.73E-4||SGD DESC:Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria Gene:ITR2(YOL103W)|FD-Score:-5.15|P-value:1.28E-7||SGD DESC:Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively Gene:MAK3(YPR051W)|FD-Score:-5.45|P-value:2.53E-8||SGD DESC:Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus Gene:MDG1(YNL173C)|FD-Score:-3.64|P-value:1.35E-4||SGD DESC:Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations Gene:MRPL25(YGR076C)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit; mutation confers increased replicative lifespan Gene:MSS11(YMR164C)|FD-Score:3.63|P-value:1.43E-4||SGD DESC:Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals Gene:NEW1(YPL226W)|FD-Score:-5.22|P-value:9.03E-8||SGD DESC:ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction Gene:NHP6B(YBR089C-A)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication Gene:NVJ1(YHR195W)|FD-Score:-3.26|P-value:5.53E-4||SGD DESC:Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) Gene:PAF1(YBR279W)|FD-Score:3.12|P-value:9.07E-4||SGD DESC:Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1 Gene:PMT7(YDR307W_p)|FD-Score:-4.97|P-value:3.42E-7||SGD DESC:Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation Gene:PPT2(YPL148C)|FD-Score:-3.27|P-value:5.34E-4||SGD DESC:Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation Gene:REI1(YBR267W)|FD-Score:4.29|P-value:8.86E-6||SGD DESC:Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network Gene:RPL35B(YDL136W)|FD-Score:3.42|P-value:3.12E-4||SGD DESC:Ribosomal 60S subunit protein L35B; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35B has a paralog, RPL35A, that arose from the whole genome duplication Gene:RSM23(YGL129C)|FD-Score:3.43|P-value:2.97E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p Gene:SLY41(YOR307C)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Protein involved in ER-to-Golgi transport Gene:SNF1(YDR477W)|FD-Score:-3.32|P-value:4.58E-4||SGD DESC:AMP-activated serine/threonine protein kinase; found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth in response to starvation Gene:TAT1(YBR069C)|FD-Score:-5.69|P-value:6.44E-9||SGD DESC:Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress Gene:TRM3(YDL112W)|FD-Score:-9.24|P-value:1.28E-20||SGD DESC:2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs Gene:TRP4(YDR354W)|FD-Score:3.99|P-value:3.35E-5||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:UTR1(YJR049C)|FD-Score:3.69|P-value:1.13E-4||SGD DESC:ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication Gene:VAN1(YML115C)|FD-Score:5.37|P-value:3.83E-8||SGD DESC:Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant Gene:VMA13(YPR036W)|FD-Score:-3.14|P-value:8.59E-4||SGD DESC:Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase Gene:VPS13(YLL040C)|FD-Score:-3.15|P-value:8.05E-4||SGD DESC:Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively Gene:VPS30(YPL120W)|FD-Score:3.71|P-value:1.05E-4||SGD DESC:Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; ortholog of the higher eukaryotic gene Beclin 1 Gene:VPS72(YDR485C)|FD-Score:3.82|P-value:6.64E-5||SGD DESC:Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting Gene:XDJ1(YLR090W)|FD-Score:-3.37|P-value:3.71E-4||SGD DESC:Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YBR196C-A(YBR196C-A_p)|FD-Score:-4.64|P-value:1.75E-6||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YCL021W-A(YCL021W-A_p)|FD-Score:4.19|P-value:1.40E-5||SGD DESC:Putative protein of unknown function Gene:YGL188C-A(YGL188C-A_p)|FD-Score:3.23|P-value:6.21E-4||SGD DESC:Putative protein of unknown function Gene:YGR015C(YGR015C_p)|FD-Score:-4.93|P-value:4.09E-7||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion Gene:YIR044C(YIR044C)|FD-Score:3.38|P-value:3.59E-4||SGD DESC:Possible pseudogene in strain S288C; YIR044C and the adjacent ORF, YIR043C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family Gene:YKR070W(YKR070W_p)|FD-Score:8.22|P-value:9.91E-17||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YLR224W(YLR224W_p)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene Gene:YML009W-B(YML009W-B_d)|FD-Score:3.56|P-value:1.82E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition Gene:YOL029C(YOL029C_p)|FD-Score:5.13|P-value:1.47E-7||SGD DESC:Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens Gene:YOL163W(YOL163W_p)|FD-Score:3.1|P-value:9.66E-4||SGD DESC:Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family Gene:YOR050C(YOR050C_d)|FD-Score:3.2|P-value:6.94E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable Gene:YPR196W(YPR196W_p)|FD-Score:3.64|P-value:1.35E-4||SGD DESC:Putative maltose-responsive transcription factor Gene:AFI1(YOR129C)|FD-Score:3.92|P-value:4.36E-5||SGD DESC:Arf3p polarization-specific docking factor, required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p Gene:AIM32(YML050W)|FD-Score:-3.39|P-value:3.52E-4||SGD DESC:Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss Gene:AKL1(YBR059C)|FD-Score:-3.32|P-value:4.44E-4||SGD DESC:Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization Gene:ALP1(YNL270C)|FD-Score:3.77|P-value:8.08E-5||SGD DESC:Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication Gene:APP1(YNL094W)|FD-Score:-3.19|P-value:7.20E-4||SGD DESC:Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway Gene:ARR2(YPR200C)|FD-Score:3.1|P-value:9.80E-4||SGD DESC:Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p Gene:ATG1(YGL180W)|FD-Score:-3.11|P-value:9.51E-4||SGD DESC:Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p Gene:BNA1(YJR025C)|FD-Score:3.12|P-value:8.98E-4||SGD DESC:3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p Gene:BST1(YFL025C)|FD-Score:5.04|P-value:2.36E-7||SGD DESC:GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules Gene:CCC1(YLR220W)|FD-Score:-3.44|P-value:2.91E-4||SGD DESC:Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress Gene:CIT1(YNR001C)|FD-Score:3.34|P-value:4.19E-4||SGD DESC:Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein; CIT1 has a paralog, CIT2, that arose from the whole genome duplication Gene:CRC1(YOR100C)|FD-Score:3.89|P-value:5.04E-5||SGD DESC:Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation Gene:EMI2(YDR516C)|FD-Score:-3.95|P-value:3.92E-5||SGD DESC:Non-essential protein of unknown function; required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression regulated by glucose-repression transcription factors Mig1/2p; EMI2 has a paralog, GLK1, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:EOS1(YNL080C)|FD-Score:-5.16|P-value:1.26E-7||SGD DESC:Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene Gene:FMP52(YER004W)|FD-Score:-3.28|P-value:5.11E-4||SGD DESC:Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation Gene:FRE4(YNR060W)|FD-Score:6.16|P-value:3.70E-10||SGD DESC:Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels Gene:GCN4(YEL009C)|FD-Score:3.86|P-value:5.67E-5||SGD DESC:Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels Gene:GLC3(YEL011W)|FD-Score:3.09|P-value:9.90E-4||SGD DESC:Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:HER2(YMR293C)|FD-Score:4.27|P-value:9.68E-6||SGD DESC:Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase Gene:HIT1(YJR055W)|FD-Score:3.5|P-value:2.30E-4||SGD DESC:Protein of unknown function, required for growth at high temperature Gene:ILV6(YCL009C)|FD-Score:3.31|P-value:4.73E-4||SGD DESC:Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria Gene:ITR2(YOL103W)|FD-Score:-5.15|P-value:1.28E-7||SGD DESC:Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively Gene:MAK3(YPR051W)|FD-Score:-5.45|P-value:2.53E-8||SGD DESC:Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus Gene:MDG1(YNL173C)|FD-Score:-3.64|P-value:1.35E-4||SGD DESC:Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations Gene:MRPL25(YGR076C)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit; mutation confers increased replicative lifespan Gene:MSS11(YMR164C)|FD-Score:3.63|P-value:1.43E-4||SGD DESC:Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals Gene:NEW1(YPL226W)|FD-Score:-5.22|P-value:9.03E-8||SGD DESC:ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction Gene:NHP6B(YBR089C-A)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication Gene:NVJ1(YHR195W)|FD-Score:-3.26|P-value:5.53E-4||SGD DESC:Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) Gene:PAF1(YBR279W)|FD-Score:3.12|P-value:9.07E-4||SGD DESC:Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1 Gene:PMT7(YDR307W_p)|FD-Score:-4.97|P-value:3.42E-7||SGD DESC:Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation Gene:PPT2(YPL148C)|FD-Score:-3.27|P-value:5.34E-4||SGD DESC:Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation Gene:REI1(YBR267W)|FD-Score:4.29|P-value:8.86E-6||SGD DESC:Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network Gene:RPL35B(YDL136W)|FD-Score:3.42|P-value:3.12E-4||SGD DESC:Ribosomal 60S subunit protein L35B; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35B has a paralog, RPL35A, that arose from the whole genome duplication Gene:RSM23(YGL129C)|FD-Score:3.43|P-value:2.97E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p Gene:SLY41(YOR307C)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Protein involved in ER-to-Golgi transport Gene:SNF1(YDR477W)|FD-Score:-3.32|P-value:4.58E-4||SGD DESC:AMP-activated serine/threonine protein kinase; found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; regulates filamentous growth in response to starvation Gene:TAT1(YBR069C)|FD-Score:-5.69|P-value:6.44E-9||SGD DESC:Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress Gene:TRM3(YDL112W)|FD-Score:-9.24|P-value:1.28E-20||SGD DESC:2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs Gene:TRP4(YDR354W)|FD-Score:3.99|P-value:3.35E-5||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:UTR1(YJR049C)|FD-Score:3.69|P-value:1.13E-4||SGD DESC:ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p); UTR1 has a paralog, YEF1, that arose from the whole genome duplication Gene:VAN1(YML115C)|FD-Score:5.37|P-value:3.83E-8||SGD DESC:Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant Gene:VMA13(YPR036W)|FD-Score:-3.14|P-value:8.59E-4||SGD DESC:Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase Gene:VPS13(YLL040C)|FD-Score:-3.15|P-value:8.05E-4||SGD DESC:Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively Gene:VPS30(YPL120W)|FD-Score:3.71|P-value:1.05E-4||SGD DESC:Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; ortholog of the higher eukaryotic gene Beclin 1 Gene:VPS72(YDR485C)|FD-Score:3.82|P-value:6.64E-5||SGD DESC:Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting Gene:XDJ1(YLR090W)|FD-Score:-3.37|P-value:3.71E-4||SGD DESC:Chaperone with a role in facilitating mitochondrial protein import; ascomycete-specific member of the DnaJ-like family, closely related to Ydj1p; predicted to be C-terminally prenylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YBR196C-A(YBR196C-A_p)|FD-Score:-4.64|P-value:1.75E-6||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YCL021W-A(YCL021W-A_p)|FD-Score:4.19|P-value:1.40E-5||SGD DESC:Putative protein of unknown function Gene:YGL188C-A(YGL188C-A_p)|FD-Score:3.23|P-value:6.21E-4||SGD DESC:Putative protein of unknown function Gene:YGR015C(YGR015C_p)|FD-Score:-4.93|P-value:4.09E-7||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion Gene:YIR044C(YIR044C)|FD-Score:3.38|P-value:3.59E-4||SGD DESC:Possible pseudogene in strain S288C; YIR044C and the adjacent ORF, YIR043C, together may encode a non-functional member of the conserved, often subtelomerically-encoded Cos protein family Gene:YKR070W(YKR070W_p)|FD-Score:8.22|P-value:9.91E-17||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YLR224W(YLR224W_p)|FD-Score:3.71|P-value:1.02E-4||SGD DESC:F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene Gene:YML009W-B(YML009W-B_d)|FD-Score:3.56|P-value:1.82E-4||SGD DESC:Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition Gene:YOL029C(YOL029C_p)|FD-Score:5.13|P-value:1.47E-7||SGD DESC:Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens Gene:YOL163W(YOL163W_p)|FD-Score:3.1|P-value:9.66E-4||SGD DESC:Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family Gene:YOR050C(YOR050C_d)|FD-Score:3.2|P-value:6.94E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable Gene:YPR196W(YPR196W_p)|FD-Score:3.64|P-value:1.35E-4||SGD DESC:Putative maltose-responsive transcription factor

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YHR170W11.001.65E-283.93NMD3Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
YGL099W10.801.52E-273.93LSG1Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
YAR019C6.882.95E-121.79CDC15Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress
YJL111W5.091.76E-70.35CCT7Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance
YJL091C4.751.04E-60.04GWT1Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors
YCL031C4.701.28E-60.02RRP7Essential protein involved in rRNA processing and ribosome biogenesis; protein abundance increases in response to DNA replication stress
YBL023C4.681.44E-60.36MCM2Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress
YHR068W4.327.84E-60.81DYS1Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric
YPR016C3.512.24E-40.26TIF6Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits
YDR002W3.255.69E-40.06YRB1Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1
YOR146W_d3.197.12E-40.16YOR146W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C
YDR208W3.030.001210.09MSS4Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation
YDR160W2.950.001600.12SSY1Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
YOR102W_d2.830.002330.00YOR102W_dDubious open reading frame, unlikely to encode a functional protein; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex
YGR172C2.830.002340.04YIP1Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF4

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YKR070W_p8.229.91E-17YKR070W_pPutative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YNR060W6.163.70E-10FRE4Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels
YML115C5.373.83E-8VAN1Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant
YOL029C_p5.131.47E-7YOL029C_pPutative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens
YFL025C5.042.36E-7BST1GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules
YBR267W4.298.86E-6REI1Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network
YMR293C4.279.68E-6HER2Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase
YCL021W-A_p4.191.40E-5YCL021W-A_pPutative protein of unknown function
YDR354W3.993.35E-5TRP4Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
YOR129C3.924.36E-5AFI1Arf3p polarization-specific docking factor, required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p
YOR100C3.895.04E-5CRC1Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YEL009C3.865.67E-5GCN4Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels
YDR485C3.826.64E-5VPS72Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting
YNL270C3.778.08E-5ALP1Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication
YBR089C-A3.711.02E-4NHP6BHigh-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication

GO enrichment analysis for SGTC_2983
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.2282.44E-70SGTC_7651319-0117 244.0 μMChemDiv (Drug-like library)34877460.097087460S ribosome export
0.2132.45E-61SGTC_618k072-0232 33.2 μMChemDiv (Drug-like library)58727560.068965560S ribosome export
0.2057.93E-57SGTC_1913914-0123 66.5 μMChemDiv (Drug-like library)31444120.090909160S ribosome export
0.2042.65E-56SGTC_970535-0701 19.1 μMChemDiv (Drug-like library)28320130.16867560S ribosome export
0.1831.84E-45SGTC_1958st076513 41.9 μMTimTec (Natural product derivative library)7321220.070588260S ribosome export
0.1681.46E-38SGTC_1070indatraline 8.8 μMNIH Clinical Collection103144720.073170760S ribosome export
0.1661.64E-37SGTC_32769139060 49.5 μMChembridge (Drug-like library)48706190.11578960S ribosome export
0.1652.21E-37SGTC_8103825-7150 143.0 μMChemDiv (Drug-like library)223304110.12222260S ribosome export
0.1632.66E-36SGTC_1775st081588 35.2 μMTimTec (Natural product derivative library)14264430.2560S ribosome export
0.1591.24E-34SGTC_5700987-0065 62.6 μMChemDiv (Drug-like library)31044280.045454560S ribosome export
0.1505.38E-31SGTC_1833914-0051 30.6 μMChemDiv (Drug-like library)15962320.086956560S ribosome export
0.1476.33E-30SGTC_5794491-1009 110.0 μMChemDiv (Drug-like library)12710410.112560S ribosome export
0.1461.41E-29SGTC_1983454-2873 16.2 μMChemDiv (Drug-like library)7109570.084337360S ribosome export
0.1461.51E-29SGTC_490717-0965 32.1 μMChemDiv (Drug-like library)58893490.077777860S ribosome export
0.1454.25E-29SGTC_31709103054 49.5 μMChembridge (Drug-like library)164329700.076923160S ribosome export

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3185910826749.47 μM0.3754910486Chembridge (Drug-like library)415.548963.1650760S ribosome export
SGTC_14801070-004441.2 μM0.3181823124987ChemDiv (Drug-like library)294.390783.41702
SGTC_12610712-001012.7 μM0.3108112840123ChemDiv (Drug-like library)292.338443.43504RNA processing & uracil transport
SGTC_3081911724349.47 μM0.30985945595589Chembridge (Drug-like library)299.793082.47314fatty acid desaturase (OLE1)
SGTC_3258913847749.47 μM0.2941184970355Chembridge (Drug-like library)367.44482.06116
SGTC_3183910821449.47 μM0.2926834974831Chembridge (Drug-like library)385.522983.18106RPP1 & pyrimidine depletion
SGTC_6403381-096037.1 μM0.2820511745025ChemDiv (Drug-like library)473.60655.44305
SGTC_3249913518349.47 μM0.2705884902779Chembridge (Drug-like library)365.471983.0271560S ribosome export
SGTC_9342950-0684338 μM0.2682931121253ChemDiv (Drug-like library)360.452164.09703
SGTC_12021988-006829.6 μM0.265062850480ChemDiv (Drug-like library)426.555.45913RNA processing & uracil transport