9022109

N-(3-methoxyphenyl)-3-(4-methylphenyl)propanamide

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2984
Screen concentration 39.0 μM
Source Chembridge (Drug-like library)
PubChem CID 6459207
SMILES CC1=CC=C(C=C1)CCC(=O)NC2=CC(=CC=C2)OC
Standardized SMILES COc1cccc(NC(=O)CCc2ccc(C)cc2)c1
Molecular weight 269.3383
ALogP 3.58
H-bond donor count 1
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 11.42
% growth inhibition (Hom. pool) 5.53


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 6459207
Download HIP data (tab-delimited text)  (excel)
Gene:AUR1(YKL004W)|FD-Score:4.79|P-value:8.21E-7|Clearance:1.09||SGD DESC:Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance Gene:NOC4(YPR144C)|FD-Score:3.1|P-value:9.54E-4|Clearance:0.07||SGD DESC:Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits Gene:NSE3(YDR288W)|FD-Score:3.7|P-value:1.07E-4|Clearance:0.06||SGD DESC:Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress Gene:NTR2(YKR022C)|FD-Score:3.33|P-value:4.33E-4|Clearance:0.11||SGD DESC:Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly Gene:PRE2(YPR103W)|FD-Score:3.57|P-value:1.78E-4|Clearance:0.16||SGD DESC:Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome Gene:RPS2(YGL123W)|FD-Score:3.34|P-value:4.23E-4|Clearance:0.01||SGD DESC:Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5 Gene:SDA1(YGR245C)|FD-Score:3.64|P-value:1.36E-4|Clearance:0.07||SGD DESC:Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis Gene:SPP382(YLR424W)|FD-Score:3.23|P-value:6.29E-4|Clearance:0.12||SGD DESC:Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation Gene:SRP72(YPL210C)|FD-Score:3.42|P-value:3.18E-4|Clearance:0.08||SGD DESC:Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane Gene:TRR1(YDR353W)|FD-Score:4.95|P-value:3.76E-7|Clearance:1.09||SGD DESC:Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication Gene:AUR1(YKL004W)|FD-Score:4.79|P-value:8.21E-7|Clearance:1.09||SGD DESC:Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance Gene:NOC4(YPR144C)|FD-Score:3.1|P-value:9.54E-4|Clearance:0.07||SGD DESC:Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits Gene:NSE3(YDR288W)|FD-Score:3.7|P-value:1.07E-4|Clearance:0.06||SGD DESC:Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress Gene:NTR2(YKR022C)|FD-Score:3.33|P-value:4.33E-4|Clearance:0.11||SGD DESC:Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly Gene:PRE2(YPR103W)|FD-Score:3.57|P-value:1.78E-4|Clearance:0.16||SGD DESC:Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome Gene:RPS2(YGL123W)|FD-Score:3.34|P-value:4.23E-4|Clearance:0.01||SGD DESC:Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5 Gene:SDA1(YGR245C)|FD-Score:3.64|P-value:1.36E-4|Clearance:0.07||SGD DESC:Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis Gene:SPP382(YLR424W)|FD-Score:3.23|P-value:6.29E-4|Clearance:0.12||SGD DESC:Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation Gene:SRP72(YPL210C)|FD-Score:3.42|P-value:3.18E-4|Clearance:0.08||SGD DESC:Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane Gene:TRR1(YDR353W)|FD-Score:4.95|P-value:3.76E-7|Clearance:1.09||SGD DESC:Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 6459207
Download HOP data (tab-delimited text)  (excel)
Gene:AQY2(YLL052C)|FD-Score:3.4|P-value:3.35E-4||SGD DESC:Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains Gene:ATP10(YLR393W)|FD-Score:-4.57|P-value:2.38E-6||SGD DESC:Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6 Gene:CKB1(YGL019W)|FD-Score:3.65|P-value:1.32E-4||SGD DESC:Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases Gene:COX14(YML129C)|FD-Score:-3.23|P-value:6.22E-4||SGD DESC:Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes Gene:COX23(YHR116W)|FD-Score:-3.19|P-value:7.06E-4||SGD DESC:Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs Gene:COX5B(YIL111W)|FD-Score:-3.36|P-value:3.91E-4||SGD DESC:Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication Gene:DCI1(YOR180C)|FD-Score:3.69|P-value:1.14E-4||SGD DESC:Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed Gene:DOT5(YIL010W)|FD-Score:-3.29|P-value:4.94E-4||SGD DESC:Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth Gene:DSE2(YHR143W)|FD-Score:3.42|P-value:3.07E-4||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP Gene:ECM13(YBL043W)|FD-Score:-4.28|P-value:9.27E-6||SGD DESC:Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication Gene:ECM15(YBL001C)|FD-Score:-3.36|P-value:3.89E-4||SGD DESC:Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis Gene:EMC6(YLL014W)|FD-Score:3.36|P-value:3.83E-4||SGD DESC:Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93 Gene:GLN3(YER040W)|FD-Score:-3.25|P-value:5.82E-4||SGD DESC:Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source Gene:HDA2(YDR295C)|FD-Score:-3.18|P-value:7.37E-4||SGD DESC:Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance Gene:HSM3(YBR272C)|FD-Score:-4.54|P-value:2.76E-6||SGD DESC:Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation Gene:ICS2(YBR157C)|FD-Score:3.86|P-value:5.62E-5||SGD DESC:Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization Gene:IFM1(YOL023W)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:Mitochondrial translation initiation factor 2 Gene:MAL31(YBR298C)|FD-Score:3.37|P-value:3.73E-4||SGD DESC:Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C Gene:MRP8(YKL142W)|FD-Score:3.25|P-value:5.87E-4||SGD DESC:Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis Gene:MSS11(YMR164C)|FD-Score:-7.52|P-value:2.81E-14||SGD DESC:Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals Gene:NUP188(YML103C)|FD-Score:-4.24|P-value:1.10E-5||SGD DESC:Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188 Gene:OMA1(YKR087C)|FD-Score:3.61|P-value:1.55E-4||SGD DESC:Metalloendopeptidase of the mitochondrial inner membrane; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes Gene:OPI9(YLR338W_d)|FD-Score:4.02|P-value:2.87E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C Gene:OST6(YML019W)|FD-Score:3.74|P-value:9.05E-5||SGD DESC:Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p Gene:PDR16(YNL231C)|FD-Score:3.47|P-value:2.57E-4||SGD DESC:Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress Gene:PIN4(YBL051C)|FD-Score:-3.52|P-value:2.14E-4||SGD DESC:Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage Gene:PNG1(YPL096W)|FD-Score:3.32|P-value:4.43E-4||SGD DESC:Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p Gene:PSK1(YAL017W)|FD-Score:-3.23|P-value:6.13E-4||SGD DESC:PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication Gene:RPL15B(YMR121C)|FD-Score:3.16|P-value:7.85E-4||SGD DESC:Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress Gene:SAC6(YDR129C)|FD-Score:3.39|P-value:3.48E-4||SGD DESC:Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:SLM2(YNL047C)|FD-Score:3.93|P-value:4.17E-5||SGD DESC:Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication Gene:SLY41(YOR307C)|FD-Score:3.56|P-value:1.87E-4||SGD DESC:Protein involved in ER-to-Golgi transport Gene:SPE2(YOL052C)|FD-Score:3.19|P-value:7.07E-4||SGD DESC:S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically Gene:SWI5(YDR146C)|FD-Score:-3.66|P-value:1.26E-4||SGD DESC:Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog, ACE2, that arose from the whole genome duplication Gene:TRP2(YER090W)|FD-Score:5.23|P-value:8.56E-8||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:TRP3(YKL211C)|FD-Score:3.1|P-value:9.84E-4||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:VPS35(YJL154C)|FD-Score:-4.77|P-value:9.22E-7||SGD DESC:Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p Gene:VTC2(YFL004W)|FD-Score:-3.16|P-value:7.96E-4||SGD DESC:Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion Gene:WHI5(YOR083W)|FD-Score:-3.59|P-value:1.62E-4||SGD DESC:Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1 Gene:YCT1(YLL055W)|FD-Score:-3.5|P-value:2.34E-4||SGD DESC:High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene Gene:YDR193W(YDR193W_d)|FD-Score:-5.13|P-value:1.46E-7||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YER091C-A(YER091C-A_d)|FD-Score:3.81|P-value:7.02E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YGR161W-C(YGR161W-C_p)|FD-Score:-3.44|P-value:2.91E-4||SGD DESC:Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species Gene:YIL163C(YIL163C_p)|FD-Score:3.23|P-value:6.26E-4||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data Gene:YJR115W(YJR115W_p)|FD-Score:4.15|P-value:1.67E-5||SGD DESC:Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication Gene:YKL071W(YKL071W_p)|FD-Score:3.2|P-value:6.97E-4||SGD DESC:Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YLR126C(YLR126C_p)|FD-Score:4.26|P-value:1.05E-5||SGD DESC:Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:YLR412C-A(YLR412C-A_p)|FD-Score:3.33|P-value:4.37E-4||SGD DESC:Putative protein of unknown function Gene:YMD8(YML038C)|FD-Score:3.99|P-value:3.27E-5||SGD DESC:Putative nucleotide sugar transporter, has similarity to Vrg4p Gene:YNL034W(YNL034W_p)|FD-Score:3.15|P-value:8.29E-4||SGD DESC:Putative protein of unknown function; YNL034W is not an essential gene Gene:YOL163W(YOL163W_p)|FD-Score:-3.53|P-value:2.06E-4||SGD DESC:Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family Gene:YOR214C(YOR214C_p)|FD-Score:3.69|P-value:1.12E-4||SGD DESC:Putative protein of unknown function; YOR214C is not an essential gene Gene:YPL039W(YPL039W_p)|FD-Score:-3.93|P-value:4.25E-5||SGD DESC:Putative protein of unknown function; YPL039W is not an essential gene Gene:AQY2(YLL052C)|FD-Score:3.4|P-value:3.35E-4||SGD DESC:Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains Gene:ATP10(YLR393W)|FD-Score:-4.57|P-value:2.38E-6||SGD DESC:Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6 Gene:CKB1(YGL019W)|FD-Score:3.65|P-value:1.32E-4||SGD DESC:Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases Gene:COX14(YML129C)|FD-Score:-3.23|P-value:6.22E-4||SGD DESC:Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes Gene:COX23(YHR116W)|FD-Score:-3.19|P-value:7.06E-4||SGD DESC:Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs Gene:COX5B(YIL111W)|FD-Score:-3.36|P-value:3.91E-4||SGD DESC:Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication Gene:DCI1(YOR180C)|FD-Score:3.69|P-value:1.14E-4||SGD DESC:Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed Gene:DOT5(YIL010W)|FD-Score:-3.29|P-value:4.94E-4||SGD DESC:Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth Gene:DSE2(YHR143W)|FD-Score:3.42|P-value:3.07E-4||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP Gene:ECM13(YBL043W)|FD-Score:-4.28|P-value:9.27E-6||SGD DESC:Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication Gene:ECM15(YBL001C)|FD-Score:-3.36|P-value:3.89E-4||SGD DESC:Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis Gene:EMC6(YLL014W)|FD-Score:3.36|P-value:3.83E-4||SGD DESC:Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; homologous to worm F33D4.7/EMC-6, fly CG11781, human TMEM93 Gene:GLN3(YER040W)|FD-Score:-3.25|P-value:5.82E-4||SGD DESC:Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source Gene:HDA2(YDR295C)|FD-Score:-3.18|P-value:7.37E-4||SGD DESC:Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance Gene:HSM3(YBR272C)|FD-Score:-4.54|P-value:2.76E-6||SGD DESC:Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b; structural study suggests Hsm3p is a scaffold protein for Rpt1p-Rpt2p complex formation Gene:ICS2(YBR157C)|FD-Score:3.86|P-value:5.62E-5||SGD DESC:Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization Gene:IFM1(YOL023W)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:Mitochondrial translation initiation factor 2 Gene:MAL31(YBR298C)|FD-Score:3.37|P-value:3.73E-4||SGD DESC:Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C Gene:MRP8(YKL142W)|FD-Score:3.25|P-value:5.87E-4||SGD DESC:Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis Gene:MSS11(YMR164C)|FD-Score:-7.52|P-value:2.81E-14||SGD DESC:Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals Gene:NUP188(YML103C)|FD-Score:-4.24|P-value:1.10E-5||SGD DESC:Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188 Gene:OMA1(YKR087C)|FD-Score:3.61|P-value:1.55E-4||SGD DESC:Metalloendopeptidase of the mitochondrial inner membrane; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes Gene:OPI9(YLR338W_d)|FD-Score:4.02|P-value:2.87E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C Gene:OST6(YML019W)|FD-Score:3.74|P-value:9.05E-5||SGD DESC:Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p Gene:PDR16(YNL231C)|FD-Score:3.47|P-value:2.57E-4||SGD DESC:Phosphatidylinositol transfer protein (PITP); controlled by the multiple drug resistance regulator Pdr1p; localizes to lipid particles and microsomes; controls levels of various lipids, may regulate lipid synthesis; homologous to Pdr17p; protein abundance increases in response to DNA replication stress Gene:PIN4(YBL051C)|FD-Score:-3.52|P-value:2.14E-4||SGD DESC:Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage Gene:PNG1(YPL096W)|FD-Score:3.32|P-value:4.43E-4||SGD DESC:Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p Gene:PSK1(YAL017W)|FD-Score:-3.23|P-value:6.13E-4||SGD DESC:PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication Gene:RPL15B(YMR121C)|FD-Score:3.16|P-value:7.85E-4||SGD DESC:Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress Gene:SAC6(YDR129C)|FD-Score:3.39|P-value:3.48E-4||SGD DESC:Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:SLM2(YNL047C)|FD-Score:3.93|P-value:4.17E-5||SGD DESC:Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication Gene:SLY41(YOR307C)|FD-Score:3.56|P-value:1.87E-4||SGD DESC:Protein involved in ER-to-Golgi transport Gene:SPE2(YOL052C)|FD-Score:3.19|P-value:7.07E-4||SGD DESC:S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically Gene:SWI5(YDR146C)|FD-Score:-3.66|P-value:1.26E-4||SGD DESC:Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog, ACE2, that arose from the whole genome duplication Gene:TRP2(YER090W)|FD-Score:5.23|P-value:8.56E-8||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:TRP3(YKL211C)|FD-Score:3.1|P-value:9.84E-4||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:VPS35(YJL154C)|FD-Score:-4.77|P-value:9.22E-7||SGD DESC:Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p Gene:VTC2(YFL004W)|FD-Score:-3.16|P-value:7.96E-4||SGD DESC:Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion Gene:WHI5(YOR083W)|FD-Score:-3.59|P-value:1.62E-4||SGD DESC:Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1 Gene:YCT1(YLL055W)|FD-Score:-3.5|P-value:2.34E-4||SGD DESC:High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene Gene:YDR193W(YDR193W_d)|FD-Score:-5.13|P-value:1.46E-7||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YER091C-A(YER091C-A_d)|FD-Score:3.81|P-value:7.02E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YGR161W-C(YGR161W-C_p)|FD-Score:-3.44|P-value:2.91E-4||SGD DESC:Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species Gene:YIL163C(YIL163C_p)|FD-Score:3.23|P-value:6.26E-4||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data Gene:YJR115W(YJR115W_p)|FD-Score:4.15|P-value:1.67E-5||SGD DESC:Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication Gene:YKL071W(YKL071W_p)|FD-Score:3.2|P-value:6.97E-4||SGD DESC:Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YLR126C(YLR126C_p)|FD-Score:4.26|P-value:1.05E-5||SGD DESC:Putative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:YLR412C-A(YLR412C-A_p)|FD-Score:3.33|P-value:4.37E-4||SGD DESC:Putative protein of unknown function Gene:YMD8(YML038C)|FD-Score:3.99|P-value:3.27E-5||SGD DESC:Putative nucleotide sugar transporter, has similarity to Vrg4p Gene:YNL034W(YNL034W_p)|FD-Score:3.15|P-value:8.29E-4||SGD DESC:Putative protein of unknown function; YNL034W is not an essential gene Gene:YOL163W(YOL163W_p)|FD-Score:-3.53|P-value:2.06E-4||SGD DESC:Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family Gene:YOR214C(YOR214C_p)|FD-Score:3.69|P-value:1.12E-4||SGD DESC:Putative protein of unknown function; YOR214C is not an essential gene Gene:YPL039W(YPL039W_p)|FD-Score:-3.93|P-value:4.25E-5||SGD DESC:Putative protein of unknown function; YPL039W is not an essential gene

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YDR353W4.953.76E-71.09TRR1Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication
YKL004W4.798.21E-71.09AUR1Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
YDR288W3.701.07E-40.06NSE3Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress
YGR245C3.641.36E-40.07SDA1Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
YPR103W3.571.78E-40.16PRE2Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome
YPL210C3.423.18E-40.08SRP72Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
YGL123W3.344.23E-40.01RPS2Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
YKR022C3.334.33E-40.10NTR2Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly
YLR424W3.236.29E-40.12SPP382Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation
YPR144C3.109.54E-40.07NOC4Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits
YDR064W3.030.001220.05RPS13Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15
YOR151C2.980.001420.02RPB2RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit
YDR390C2.960.001530.00UBA2Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
YCL054W2.960.001550.03SPB1AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YHR024C2.930.001710.01MAS2Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YER090W5.238.56E-8TRP2Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
YLR126C_p4.261.05E-5YLR126C_pPutative glutamine amidotransferase; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
YJR115W_p4.151.67E-5YJR115W_pPutative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication
YLR338W_d4.022.87E-5OPI9_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C
YML038C3.993.27E-5YMD8Putative nucleotide sugar transporter, has similarity to Vrg4p
YNL047C3.934.17E-5SLM2Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication
YBR157C3.865.62E-5ICS2Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization
YER091C-A_d3.817.02E-5YER091C-A_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YML019W3.749.05E-5OST6Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p
YOR214C_p3.691.12E-4YOR214C_pPutative protein of unknown function; YOR214C is not an essential gene
YOR180C3.691.14E-4DCI1Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed
YGL019W3.651.32E-4CKB1Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
YOL023W3.631.44E-4IFM1Mitochondrial translation initiation factor 2
YKR087C3.611.55E-4OMA1Metalloendopeptidase of the mitochondrial inner membrane; involved in turnover of membrane-embedded proteins; mediates degradation of Cox1p in coa2 mutant cells; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes
YOR307C3.561.87E-4SLY41Protein involved in ER-to-Golgi transport

GO enrichment analysis for SGTC_2984
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.3202.44E-140SGTC_29799012552 45.5 μMChembridge (Drug-like library)171009050.193548
0.1181.25E-19SGTC_22547938975 95.2 μMChembridge (Fragment library)29692770.123077
0.1171.94E-19SGTC_21976588183 93.1 μMChembridge (Fragment library)8841360.215385
0.1103.30E-17SGTC_1617st002906 78.0 μMTimTec (Natural product derivative library)51508590.111111
0.1062.65E-16SGTC_22246650123 117.6 μMChembridge (Fragment library)29083700.112676
0.0992.40E-14SGTC_1710st031758 61.5 μMTimTec (Natural product derivative library)53943410.25
0.0993.25E-14SGTC_1975st070967 30.8 μMTimTec (Natural product derivative library)2613910.0793651
0.0984.59E-14SGTC_22557941087 197.4 μMChembridge (Fragment library)9355610.117647
0.0977.44E-14SGTC_2409alverine citrate 64.0 μMMiscellaneous217180.173077
0.0936.78E-13SGTC_2684capsaicin 100.0 μMMiscellaneous15489430.25
0.0937.08E-13SGTC_11941488-0194 225.0 μMChemDiv (Drug-like library)13914520.0857143
0.0931.02E-12SGTC_21375261020 140.0 μMChembridge (Fragment library)7636550.15625
0.0921.65E-12SGTC_15412',3',6-trimethoxyflavone 64.0 μMTimTec (Pure natural product library)6888010.21875
0.0921.76E-12SGTC_1603st002045 67.8 μMTimTec (Natural product derivative library)58879850.109375TSC3-RPN4
0.0911.97E-12SGTC_2683piperine 63.0 μMTimTec (Pure natural product library)6380240.1

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_3207911416349.47 μM0.617021849233Chembridge (Drug-like library)269.338263.43812
SGTC_2839900395125.97 μM0.6041672990634Chembridge (Drug-like library)283.364843.81512
SGTC_3082911700849.47 μM0.57446841448529Chembridge (Drug-like library)240.300342.44112
SGTC_3171910319249.47 μM0.49019613018434Chembridge (Drug-like library)269.338263.50512
SGTC_3091911637249.47 μM0.48076917169793Chembridge (Drug-like library)285.337662.95313
SGTC_3109912285349.47 μM0.4807691234709Chembridge (Drug-like library)287.376683.17413
SGTC_3205911348349.47 μM0.47058817018033Chembridge (Drug-like library)271.311083.06813
SGTC_2900532852885.29 μM0.46795359Chembridge (Drug-like library)261.703583.26212Golgi
SGTC_3204911418349.47 μM0.4509817027248Chembridge (Drug-like library)329.2463533.40317
SGTC_2986902244571.43 μM0.4423086459286Chembridge (Drug-like library)285.337663.30813