Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YDR353W | 4.95 | 3.76E-7 | 1.09 | TRR1 | Cytoplasmic thioredoxin reductase; key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress; protein abundance increases in response to DNA replication stress; TRR1 has a paralog, TRR2, that arose from the whole genome duplication |
YKL004W | 4.79 | 8.21E-7 | 1.09 | AUR1 | Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance |
YDR288W | 3.70 | 1.07E-4 | 0.06 | NSE3 | Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress |
YGR245C | 3.64 | 1.36E-4 | 0.07 | SDA1 | Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis |
YPR103W | 3.57 | 1.78E-4 | 0.16 | PRE2 | Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome |
YPL210C | 3.42 | 3.18E-4 | 0.08 | SRP72 | Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane |
YGL123W | 3.34 | 4.23E-4 | 0.01 | RPS2 | Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5 |
YKR022C | 3.33 | 4.33E-4 | 0.10 | NTR2 | Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly |
YLR424W | 3.23 | 6.29E-4 | 0.12 | SPP382 | Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation |
YPR144C | 3.10 | 9.54E-4 | 0.07 | NOC4 | Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits |
YDR064W | 3.03 | 0.00122 | 0.05 | RPS13 | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15 |
YOR151C | 2.98 | 0.00142 | 0.02 | RPB2 | RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit |
YDR390C | 2.96 | 0.00153 | 0.00 | UBA2 | Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability |
YCL054W | 2.96 | 0.00155 | 0.03 | SPB1 | AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants |
YHR024C | 2.93 | 0.00171 | 0.01 | MAS2 | Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins |