9074105

N-[[5-(3-chloro-4-methylphenyl)furan-2-yl]methyl]-1H-1,2,4-triazol-5-amine

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_2990
Screen concentration 71.4 μM
Source Chembridge (Drug-like library)
PubChem CID 6502001
SMILES CC1=C(C=C(C=C1)C2=CC=C(O2)CNC3=NC=NN3)Cl
Standardized SMILES Cc1ccc(cc1Cl)c2oc(CNc3nc[nH]n3)cc2
Molecular weight 288.7322
ALogP 3.67
H-bond donor count 2
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 13.33
% growth inhibition (Hom. pool) 6.97


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 6502001
Download HIP data (tab-delimited text)  (excel)
Gene:CDC123(YLR215C)|FD-Score:3.28|P-value:5.18E-4|Clearance:0.19||SGD DESC:Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein Gene:COG2(YGR120C)|FD-Score:-3.81|P-value:6.95E-5|Clearance:0||SGD DESC:Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:DIB1(YPR082C)|FD-Score:3.48|P-value:2.50E-4|Clearance:0.2||SGD DESC:17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein Gene:FIP1(YJR093C)|FD-Score:6.73|P-value:8.25E-12|Clearance:1.58||SGD DESC:Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p Gene:GNA1(YFL017C)|FD-Score:-3.95|P-value:3.91E-5|Clearance:0||SGD DESC:Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA Gene:HRP1(YOL123W)|FD-Score:-3.77|P-value:8.06E-5|Clearance:0||SGD DESC:Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences Gene:NAB3(YPL190C)|FD-Score:3.87|P-value:5.53E-5|Clearance:0.3||SGD DESC:RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing Gene:NIC96(YFR002W)|FD-Score:5.44|P-value:2.64E-8|Clearance:1.58||SGD DESC:Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p) Gene:NTR2(YKR022C)|FD-Score:3.09|P-value:9.85E-4|Clearance:0.15||SGD DESC:Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly Gene:OST2(YOR103C)|FD-Score:3.57|P-value:1.79E-4|Clearance:0.09||SGD DESC:Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins Gene:SEC13(YLR208W)|FD-Score:-6.21|P-value:2.67E-10|Clearance:0||SGD DESC:Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress Gene:SRP102(YKL154W)|FD-Score:7|P-value:1.26E-12|Clearance:1.58||SGD DESC:Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane Gene:STU1(YBL034C)|FD-Score:-3.74|P-value:9.20E-5|Clearance:0||SGD DESC:Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles Gene:TEM1(YML064C)|FD-Score:6.9|P-value:2.61E-12|Clearance:1.58||SGD DESC:GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis Gene:UTP10(YJL109C)|FD-Score:-3.79|P-value:7.65E-5|Clearance:0||SGD DESC:Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance Gene:CDC123(YLR215C)|FD-Score:3.28|P-value:5.18E-4|Clearance:0.19||SGD DESC:Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein Gene:COG2(YGR120C)|FD-Score:-3.81|P-value:6.95E-5|Clearance:0||SGD DESC:Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:DIB1(YPR082C)|FD-Score:3.48|P-value:2.50E-4|Clearance:0.2||SGD DESC:17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein Gene:FIP1(YJR093C)|FD-Score:6.73|P-value:8.25E-12|Clearance:1.58||SGD DESC:Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p Gene:GNA1(YFL017C)|FD-Score:-3.95|P-value:3.91E-5|Clearance:0||SGD DESC:Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA Gene:HRP1(YOL123W)|FD-Score:-3.77|P-value:8.06E-5|Clearance:0||SGD DESC:Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences Gene:NAB3(YPL190C)|FD-Score:3.87|P-value:5.53E-5|Clearance:0.3||SGD DESC:RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing Gene:NIC96(YFR002W)|FD-Score:5.44|P-value:2.64E-8|Clearance:1.58||SGD DESC:Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p) Gene:NTR2(YKR022C)|FD-Score:3.09|P-value:9.85E-4|Clearance:0.15||SGD DESC:Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly Gene:OST2(YOR103C)|FD-Score:3.57|P-value:1.79E-4|Clearance:0.09||SGD DESC:Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins Gene:SEC13(YLR208W)|FD-Score:-6.21|P-value:2.67E-10|Clearance:0||SGD DESC:Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress Gene:SRP102(YKL154W)|FD-Score:7|P-value:1.26E-12|Clearance:1.58||SGD DESC:Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane Gene:STU1(YBL034C)|FD-Score:-3.74|P-value:9.20E-5|Clearance:0||SGD DESC:Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles Gene:TEM1(YML064C)|FD-Score:6.9|P-value:2.61E-12|Clearance:1.58||SGD DESC:GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis Gene:UTP10(YJL109C)|FD-Score:-3.79|P-value:7.65E-5|Clearance:0||SGD DESC:Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 6502001
Download HOP data (tab-delimited text)  (excel)
Gene:ACF4(YJR083C)|FD-Score:-3.27|P-value:5.39E-4||SGD DESC:Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate Gene:APL3(YBL037W)|FD-Score:-3.63|P-value:1.44E-4||SGD DESC:Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport Gene:ATG13(YPR185W)|FD-Score:-3.38|P-value:3.68E-4||SGD DESC:Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling Gene:BSC2(YDR275W)|FD-Score:-3.13|P-value:8.75E-4||SGD DESC:Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; BSC2 has a paralog, IRC23, that arose from the whole genome duplication Gene:BUD28(YLR062C_d)|FD-Score:4.54|P-value:2.82E-6||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:COX8(YLR395C)|FD-Score:3.29|P-value:5.01E-4||SGD DESC:Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain Gene:CPR7(YJR032W)|FD-Score:-3.38|P-value:3.69E-4||SGD DESC:Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity Gene:CRR1(YLR213C)|FD-Score:-3.83|P-value:6.47E-5||SGD DESC:Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation Gene:DAS1(YJL149W)|FD-Score:-3.25|P-value:5.73E-4||SGD DESC:Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C Gene:DDI3(YNL335W_p)|FD-Score:3.22|P-value:6.34E-4||SGD DESC:Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants Gene:DSS4(YPR017C)|FD-Score:3.4|P-value:3.33E-4||SGD DESC:Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol Gene:DUN1(YDL101C)|FD-Score:3.21|P-value:6.72E-4||SGD DESC:Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair Gene:ECM29(YHL030W)|FD-Score:-3.64|P-value:1.37E-4||SGD DESC:Scaffold protein; assists in association of the proteasome core particle with the regulatory particle; degraded by the mature proteasome after assembly; contains HEAT-like repeats; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:ECM7(YLR443W)|FD-Score:3.36|P-value:3.91E-4||SGD DESC:Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency Gene:ECM8(YBR076W)|FD-Score:3.35|P-value:4.01E-4||SGD DESC:Non-essential protein of unknown function Gene:EDS1(YBR033W_p)|FD-Score:-3.24|P-value:5.90E-4||SGD DESC:Putative zinc cluster protein, predicted to be a transcription factor; not an essential gene; EDS1 has a paralog, RGT1, that arose from the whole genome duplication Gene:ENO1(YGR254W)|FD-Score:-3.1|P-value:9.74E-4||SGD DESC:Enolase I, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose; protein abundance increases in response to DNA replication stress Gene:GLG2(YJL137C)|FD-Score:-10|P-value:6.06E-24||SGD DESC:Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication Gene:GPD2(YOL059W)|FD-Score:3.35|P-value:4.10E-4||SGD DESC:NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1 Gene:HDA2(YDR295C)|FD-Score:-3.39|P-value:3.50E-4||SGD DESC:Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance Gene:ICE2(YIL090W)|FD-Score:3.27|P-value:5.40E-4||SGD DESC:Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells Gene:INP1(YMR204C)|FD-Score:-3.32|P-value:4.56E-4||SGD DESC:Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane Gene:IRC21(YMR073C)|FD-Score:-3.52|P-value:2.16E-4||SGD DESC:Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study Gene:LCB4(YOR171C)|FD-Score:-3.19|P-value:7.01E-4||SGD DESC:Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes Gene:LEU9(YOR108W)|FD-Score:3.27|P-value:5.34E-4||SGD DESC:Alpha-isopropylmalate synthase II (2-isopropylmalate synthase); catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; LEU9 has a paralog, LEU4, that arose from the whole genome duplication Gene:MDY2(YOL111C)|FD-Score:6.59|P-value:2.20E-11||SGD DESC:Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes Gene:MMR1(YLR190W)|FD-Score:-3.81|P-value:6.82E-5||SGD DESC:Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p Gene:MRH4(YGL064C)|FD-Score:-3.73|P-value:9.42E-5||SGD DESC:Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function Gene:MRN1(YPL184C)|FD-Score:-3.83|P-value:6.29E-5||SGD DESC:RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation Gene:MRP7(YNL005C)|FD-Score:4.19|P-value:1.39E-5||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:PBS2(YJL128C)|FD-Score:3.37|P-value:3.70E-4||SGD DESC:MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition Gene:PDR3(YBL005W)|FD-Score:3.57|P-value:1.78E-4||SGD DESC:Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:PET494(YNR045W)|FD-Score:-4.05|P-value:2.58E-5||SGD DESC:Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane Gene:PEX31(YGR004W)|FD-Score:-3.73|P-value:9.49E-5||SGD DESC:Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p Gene:PIB1(YDR313C)|FD-Score:-3.6|P-value:1.61E-4||SGD DESC:RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain Gene:PLB2(YMR006C)|FD-Score:-6.76|P-value:6.73E-12||SGD DESC:Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine Gene:POT1(YIL160C)|FD-Score:-3.14|P-value:8.45E-4||SGD DESC:3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids Gene:PRY2(YKR013W)|FD-Score:3.76|P-value:8.48E-5||SGD DESC:Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication Gene:PTK1(YKL198C)|FD-Score:3.31|P-value:4.59E-4||SGD DESC:Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein Gene:REG2(YBR050C)|FD-Score:-3.85|P-value:5.88E-5||SGD DESC:Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease Gene:SCS3(YGL126W)|FD-Score:3.58|P-value:1.72E-4||SGD DESC:Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol Gene:SLX1(YBR228W)|FD-Score:3.32|P-value:4.54E-4||SGD DESC:Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p Gene:SMA2(YML066C)|FD-Score:-3.7|P-value:1.09E-4||SGD DESC:Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation Gene:SSB2(YNL209W)|FD-Score:-3.13|P-value:8.77E-4||SGD DESC:Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication Gene:SWT21(YNL187W)|FD-Score:-9.12|P-value:3.70E-20||SGD DESC:Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats Gene:TMS1(YDR105C)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance Gene:TRM8(YDL201W)|FD-Score:-3.13|P-value:8.67E-4||SGD DESC:Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p Gene:UBI4(YLL039C)|FD-Score:-4.48|P-value:3.69E-6||SGD DESC:Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress Gene:VOA1(YGR106C)|FD-Score:4.21|P-value:1.28E-5||SGD DESC:Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval Gene:VPS21(YOR089C)|FD-Score:3.51|P-value:2.27E-4||SGD DESC:Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication Gene:YBL044W(YBL044W_p)|FD-Score:3.97|P-value:3.62E-5||SGD DESC:Putative protein of unknown function; YBL044W is not an essential protein Gene:YCR087C-A(YCR087C-A_p)|FD-Score:3.57|P-value:1.82E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene Gene:YDR157W(YDR157W_d)|FD-Score:3.47|P-value:2.63E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YEL010W(YEL010W_d)|FD-Score:-3.26|P-value:5.66E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YER066C-A(YER066C-A_d)|FD-Score:-5.69|P-value:6.29E-9||SGD DESC:Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W Gene:YGL082W(YGL082W_p)|FD-Score:-3.47|P-value:2.64E-4||SGD DESC:Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene Gene:YGR161W-C(YGR161W-C_p)|FD-Score:-4.29|P-value:8.95E-6||SGD DESC:Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species Gene:YHR078W(YHR078W_p)|FD-Score:-4.35|P-value:6.79E-6||SGD DESC:High osmolarity-regulated gene of unknown function Gene:YJR038C(YJR038C_d)|FD-Score:-7.25|P-value:2.11E-13||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YJR120W(YJR120W)|FD-Score:3.59|P-value:1.64E-4||SGD DESC:Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p Gene:YLR290C(YLR290C_p)|FD-Score:-3.13|P-value:8.61E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene Gene:YML020W(YML020W_p)|FD-Score:3.54|P-value:1.99E-4||SGD DESC:Putative protein of unknown function Gene:YOR012W(YOR012W_p)|FD-Score:3.28|P-value:5.12E-4||SGD DESC:Putative protein of unknown function Gene:YOX1(YML027W)|FD-Score:-3.42|P-value:3.12E-4||SGD DESC:Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication Gene:YPL185W(YPL185W_d)|FD-Score:3.23|P-value:6.30E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C Gene:YPL199C(YPL199C_p)|FD-Score:3.24|P-value:5.98E-4||SGD DESC:Putative protein of unknown function, predicted to be palmitoylated Gene:YPL216W(YPL216W_p)|FD-Score:3.1|P-value:9.63E-4||SGD DESC:Putative protein of unknown function; YPL216W is not an essential gene Gene:YPS5(YGL259W_p)|FD-Score:-3.15|P-value:8.20E-4||SGD DESC:Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p Gene:ACF4(YJR083C)|FD-Score:-3.27|P-value:5.39E-4||SGD DESC:Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate Gene:APL3(YBL037W)|FD-Score:-3.63|P-value:1.44E-4||SGD DESC:Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport Gene:ATG13(YPR185W)|FD-Score:-3.38|P-value:3.68E-4||SGD DESC:Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling Gene:BSC2(YDR275W)|FD-Score:-3.13|P-value:8.75E-4||SGD DESC:Protein of unknown function; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; BSC2 has a paralog, IRC23, that arose from the whole genome duplication Gene:BUD28(YLR062C_d)|FD-Score:4.54|P-value:2.82E-6||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:COX8(YLR395C)|FD-Score:3.29|P-value:5.01E-4||SGD DESC:Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain Gene:CPR7(YJR032W)|FD-Score:-3.38|P-value:3.69E-4||SGD DESC:Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity Gene:CRR1(YLR213C)|FD-Score:-3.83|P-value:6.47E-5||SGD DESC:Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation Gene:DAS1(YJL149W)|FD-Score:-3.25|P-value:5.73E-4||SGD DESC:Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C Gene:DDI3(YNL335W_p)|FD-Score:3.22|P-value:6.34E-4||SGD DESC:Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants Gene:DSS4(YPR017C)|FD-Score:3.4|P-value:3.33E-4||SGD DESC:Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol Gene:DUN1(YDL101C)|FD-Score:3.21|P-value:6.72E-4||SGD DESC:Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair Gene:ECM29(YHL030W)|FD-Score:-3.64|P-value:1.37E-4||SGD DESC:Scaffold protein; assists in association of the proteasome core particle with the regulatory particle; degraded by the mature proteasome after assembly; contains HEAT-like repeats; protein increases in abundance and relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:ECM7(YLR443W)|FD-Score:3.36|P-value:3.91E-4||SGD DESC:Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency Gene:ECM8(YBR076W)|FD-Score:3.35|P-value:4.01E-4||SGD DESC:Non-essential protein of unknown function Gene:EDS1(YBR033W_p)|FD-Score:-3.24|P-value:5.90E-4||SGD DESC:Putative zinc cluster protein, predicted to be a transcription factor; not an essential gene; EDS1 has a paralog, RGT1, that arose from the whole genome duplication Gene:ENO1(YGR254W)|FD-Score:-3.1|P-value:9.74E-4||SGD DESC:Enolase I, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose; protein abundance increases in response to DNA replication stress Gene:GLG2(YJL137C)|FD-Score:-10|P-value:6.06E-24||SGD DESC:Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG2 has a paralog, GLG1, that arose from the whole genome duplication Gene:GPD2(YOL059W)|FD-Score:3.35|P-value:4.10E-4||SGD DESC:NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1 Gene:HDA2(YDR295C)|FD-Score:-3.39|P-value:3.50E-4||SGD DESC:Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance Gene:ICE2(YIL090W)|FD-Score:3.27|P-value:5.40E-4||SGD DESC:Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells Gene:INP1(YMR204C)|FD-Score:-3.32|P-value:4.56E-4||SGD DESC:Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane Gene:IRC21(YMR073C)|FD-Score:-3.52|P-value:2.16E-4||SGD DESC:Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study Gene:LCB4(YOR171C)|FD-Score:-3.19|P-value:7.01E-4||SGD DESC:Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes Gene:LEU9(YOR108W)|FD-Score:3.27|P-value:5.34E-4||SGD DESC:Alpha-isopropylmalate synthase II (2-isopropylmalate synthase); catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; LEU9 has a paralog, LEU4, that arose from the whole genome duplication Gene:MDY2(YOL111C)|FD-Score:6.59|P-value:2.20E-11||SGD DESC:Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes Gene:MMR1(YLR190W)|FD-Score:-3.81|P-value:6.82E-5||SGD DESC:Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p Gene:MRH4(YGL064C)|FD-Score:-3.73|P-value:9.42E-5||SGD DESC:Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function Gene:MRN1(YPL184C)|FD-Score:-3.83|P-value:6.29E-5||SGD DESC:RNA-binding protein that may be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES); interacts genetically with chromatin remodelers and splicing factors, linking chromatin state, splicing and as a result mRNA maturation Gene:MRP7(YNL005C)|FD-Score:4.19|P-value:1.39E-5||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:PBS2(YJL128C)|FD-Score:3.37|P-value:3.70E-4||SGD DESC:MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition Gene:PDR3(YBL005W)|FD-Score:3.57|P-value:1.78E-4||SGD DESC:Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:PET494(YNR045W)|FD-Score:-4.05|P-value:2.58E-5||SGD DESC:Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane Gene:PEX31(YGR004W)|FD-Score:-3.73|P-value:9.49E-5||SGD DESC:Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p Gene:PIB1(YDR313C)|FD-Score:-3.6|P-value:1.61E-4||SGD DESC:RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain Gene:PLB2(YMR006C)|FD-Score:-6.76|P-value:6.73E-12||SGD DESC:Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine Gene:POT1(YIL160C)|FD-Score:-3.14|P-value:8.45E-4||SGD DESC:3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids Gene:PRY2(YKR013W)|FD-Score:3.76|P-value:8.48E-5||SGD DESC:Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication Gene:PTK1(YKL198C)|FD-Score:3.31|P-value:4.59E-4||SGD DESC:Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein Gene:REG2(YBR050C)|FD-Score:-3.85|P-value:5.88E-5||SGD DESC:Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease Gene:SCS3(YGL126W)|FD-Score:3.58|P-value:1.72E-4||SGD DESC:Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol Gene:SLX1(YBR228W)|FD-Score:3.32|P-value:4.54E-4||SGD DESC:Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p Gene:SMA2(YML066C)|FD-Score:-3.7|P-value:1.09E-4||SGD DESC:Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation Gene:SSB2(YNL209W)|FD-Score:-3.13|P-value:8.77E-4||SGD DESC:Cytoplasmic ATPase that is a ribosome-associated molecular chaperone; functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; SSB2 has a paralog, SSB1, that arose from the whole genome duplication Gene:SWT21(YNL187W)|FD-Score:-9.12|P-value:3.70E-20||SGD DESC:Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats Gene:TMS1(YDR105C)|FD-Score:3.21|P-value:6.60E-4||SGD DESC:Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance Gene:TRM8(YDL201W)|FD-Score:-3.13|P-value:8.67E-4||SGD DESC:Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p Gene:UBI4(YLL039C)|FD-Score:-4.48|P-value:3.69E-6||SGD DESC:Ubiquitin; becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats; protein abundance increases in response to DNA replication stress Gene:VOA1(YGR106C)|FD-Score:4.21|P-value:1.28E-5||SGD DESC:Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval Gene:VPS21(YOR089C)|FD-Score:3.51|P-value:2.27E-4||SGD DESC:Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication Gene:YBL044W(YBL044W_p)|FD-Score:3.97|P-value:3.62E-5||SGD DESC:Putative protein of unknown function; YBL044W is not an essential protein Gene:YCR087C-A(YCR087C-A_p)|FD-Score:3.57|P-value:1.82E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene Gene:YDR157W(YDR157W_d)|FD-Score:3.47|P-value:2.63E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YEL010W(YEL010W_d)|FD-Score:-3.26|P-value:5.66E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YER066C-A(YER066C-A_d)|FD-Score:-5.69|P-value:6.29E-9||SGD DESC:Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W Gene:YGL082W(YGL082W_p)|FD-Score:-3.47|P-value:2.64E-4||SGD DESC:Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene Gene:YGR161W-C(YGR161W-C_p)|FD-Score:-4.29|P-value:8.95E-6||SGD DESC:Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species Gene:YHR078W(YHR078W_p)|FD-Score:-4.35|P-value:6.79E-6||SGD DESC:High osmolarity-regulated gene of unknown function Gene:YJR038C(YJR038C_d)|FD-Score:-7.25|P-value:2.11E-13||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YJR120W(YJR120W)|FD-Score:3.59|P-value:1.64E-4||SGD DESC:Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p Gene:YLR290C(YLR290C_p)|FD-Score:-3.13|P-value:8.61E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene Gene:YML020W(YML020W_p)|FD-Score:3.54|P-value:1.99E-4||SGD DESC:Putative protein of unknown function Gene:YOR012W(YOR012W_p)|FD-Score:3.28|P-value:5.12E-4||SGD DESC:Putative protein of unknown function Gene:YOX1(YML027W)|FD-Score:-3.42|P-value:3.12E-4||SGD DESC:Homeobox transcriptional repressor; binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress; YOX1 has a paralog, YHP1, that arose from the whole genome duplication Gene:YPL185W(YPL185W_d)|FD-Score:3.23|P-value:6.30E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C Gene:YPL199C(YPL199C_p)|FD-Score:3.24|P-value:5.98E-4||SGD DESC:Putative protein of unknown function, predicted to be palmitoylated Gene:YPL216W(YPL216W_p)|FD-Score:3.1|P-value:9.63E-4||SGD DESC:Putative protein of unknown function; YPL216W is not an essential gene Gene:YPS5(YGL259W_p)|FD-Score:-3.15|P-value:8.20E-4||SGD DESC:Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YKL154W7.001.26E-121.58SRP102Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane
YML064C6.902.61E-121.58TEM1GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
YJR093C6.738.25E-121.58FIP1Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p
YFR002W5.442.64E-81.58NIC96Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p)
YPL190C3.875.53E-50.30NAB3RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing
YOR103C3.571.79E-40.09OST2Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
YPR082C3.482.50E-40.20DIB117-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein
YLR215C3.285.18E-40.19CDC123Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein
YKR022C3.099.85E-40.15NTR2Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly
YPL075W2.950.001610.04GCR1Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
YLR457C2.910.001810.04NBP1Spindle pole body (SPB) component; required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex; NBP1 has a paralog, YPR174C, that arose from the whole genome duplication
YOR176W2.870.002060.02HEM15Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway
YBL041W2.850.002180.01PRE7Beta 6 subunit of the 20S proteasome
YGL112C2.840.002220.08TAF6Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
YKR002W2.770.002840.07PAP1Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YOL111C6.592.20E-11MDY2Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes
YLR062C_d4.542.82E-6BUD28_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YGR106C4.211.28E-5VOA1Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval
YNL005C4.191.39E-5MRP7Mitochondrial ribosomal protein of the large subunit
YBL044W_p3.973.62E-5YBL044W_pPutative protein of unknown function; YBL044W is not an essential protein
YKR013W3.768.48E-5PRY2Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication
YJR120W3.591.64E-4YJR120WProtein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
YGL126W3.581.72E-4SCS3Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol
YBL005W3.571.78E-4PDR3Transcriptional activator of the pleiotropic drug resistance network; regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in cells lacking a functional mitochondrial genome; PDR3 has a paralog, PDR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
YCR087C-A_p3.571.82E-4YCR087C-A_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene
YML020W_p3.541.99E-4YML020W_pPutative protein of unknown function
YOR089C3.512.27E-4VPS21Rab family GTPase; required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress; VPS21 has a paralog, YPT53, that arose from the whole genome duplication
YDR157W_d3.472.63E-4YDR157W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR017C3.403.33E-4DSS4Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol
YJL128C3.373.70E-4PBS2MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition

GO enrichment analysis for SGTC_2990
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.3016.12E-124SGTC_29929074591 71.4 μMChembridge (Drug-like library)177413210.1125
0.1171.76E-19SGTC_30059076496 71.4 μMChembridge (Drug-like library)213684100.0657895
0.0732.25E-8SGTC_30799117512 49.5 μMChembridge (Drug-like library)71850440.1
0.0723.54E-8SGTC_32239129970 49.5 μMChembridge (Drug-like library)172483860.102564
0.0691.05E-7SGTC_2714st079313 56.9 μMTimTec (Natural product derivative library)29397990.0625
0.0672.18E-7SGTC_2762leflunomide 42.1 μMMiscellaneous38990.111111
0.0641.03E-6SGTC_494Boc-Gly-Val-Val-CHO 140.0 μMMiscellaneous66103240.0375
0.0631.28E-6SGTC_24845809818 12.0 μMMiscellaneous28705480.0833333
0.0596.21E-6SGTC_29569076196 2.5 μMChembridge (Drug-like library)164238680.115385
0.0571.14E-5SGTC_32069114350 49.5 μMChembridge (Drug-like library)170872430.111111
0.0571.19E-5SGTC_3364111-0029 111.0 μMChemDiv (Drug-like library)31311750.0731707
0.0561.54E-5SGTC_23399000433 200.0 μMChembridge (Fragment library)29889540.209677
0.0534.06E-5SGTC_29227999257 32.5 μMChembridge (Drug-like library)29883770.0833333
0.0534.69E-5SGTC_1864st057645 30.4 μMTimTec (Natural product derivative library)6886660.0985916amide catabolism
0.0525.54E-5SGTC_31309127414 49.5 μMChembridge (Drug-like library)14946460.116279

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3001907604171.43 μM0.69230816004211Chembridge (Drug-like library)289.720283.73425
SGTC_3000907506271.43 μM0.61538517057871Chembridge (Drug-like library)274.705643.17924
SGTC_3218913128549.47 μM0.42105317156417Chembridge (Drug-like library)304.1873434.33723endomembrane recycling
SGTC_2991907466971.43 μM0.39682517333109Chembridge (Drug-like library)353.2182034.25924azole & statin
SGTC_3018908260249.47 μM0.33898317332089Chembridge (Drug-like library)335.227743.83823
SGTC_3352915155945.59 μM0.33823517159339Chembridge (Drug-like library)407.7374834.52934
SGTC_3003907561271.43 μM0.3088246501993Chembridge (Drug-like library)348.197863.315
SGTC_3332914106911.2 μM0.3030317332883Chembridge (Drug-like library)369.67284.71823
SGTC_2950907289521.46 μM0.29508217332245Chembridge (Drug-like library)379.678743.92223
SGTC_3308912833217.57 μM0.27941217332805Chembridge (Drug-like library)369.67284.50223plasma membrane duress