Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YKL154W | 7.78 | 3.62E-15 | 2.98 | SRP102 | Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane |
YML064C | 4.80 | 7.90E-7 | 0.50 | TEM1 | GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis |
YKR022C | 4.30 | 8.42E-6 | 0.17 | NTR2 | Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly |
YFR002W | 4.13 | 1.80E-5 | 0.49 | NIC96 | Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p) |
YIL031W | 3.64 | 1.36E-4 | 0.15 | ULP2 | Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate |
YPL190C | 3.49 | 2.42E-4 | 0.17 | NAB3 | RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing |
YDR267C | 3.31 | 4.59E-4 | 0.01 | CIA1 | Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein |
YMR185W_p | 3.30 | 4.83E-4 | 0.19 | RTP1_p | Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene |
YOR176W | 3.11 | 9.35E-4 | 0.01 | HEM15 | Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway |
YKR062W | 3.10 | 9.66E-4 | 0.05 | TFA2 | TFIIE small subunit, involved in RNA polymerase II transcription initiation |
YGR024C | 3.05 | 0.00116 | 0.11 | THG1 | tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes |
YPR048W | 2.94 | 0.00167 | 0.10 | TAH18 | Conserved NAPDH-dependent diflavin reductase; component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress; Tah18p-dependent nitric oxide synthesis confers high-temperature stress tolerance |
YBR256C | 2.84 | 0.00227 | 0.06 | RIB5 | Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway |
YOR103C | 2.78 | 0.00271 | 0.03 | OST2 | Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins |
YPL228W | 2.75 | 0.00298 | 0.20 | CET1 | Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide |