Deletion Strain | FD score | P-value | Gene | Gene Description |
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YDR017C | 9.26 | 1.01E-20 | KCS1 | Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance |
YER164W | 9.18 | 2.17E-20 | CHD1 | Chromatin remodeler that regulates various aspects of transcription; acts in in conjunction with Isw1b to regulate chromatin structure and maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes |
YHR067W | 8.09 | 3.02E-16 | HTD2 | Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology |
YGR081C | 7.66 | 9.61E-15 | SLX9 | Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant |
YKR097W | 7.29 | 1.50E-13 | PCK1 | Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol |
YBR033W_p | 6.18 | 3.26E-10 | EDS1_p | Putative zinc cluster protein, predicted to be a transcription factor; not an essential gene; EDS1 has a paralog, RGT1, that arose from the whole genome duplication |
YBR133C | 5.40 | 3.42E-8 | HSL7 | Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress |
YEL050C | 5.38 | 3.76E-8 | RML2 | Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor |
YPR196W_p | 5.09 | 1.78E-7 | YPR196W_p | Putative maltose-responsive transcription factor |
YJL092W | 4.94 | 4.01E-7 | SRS2 | DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability |
YOR307C | 4.77 | 9.08E-7 | SLY41 | Protein involved in ER-to-Golgi transport |
YOL101C | 4.72 | 1.21E-6 | IZH4 | Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family; expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism; protein increases in abundance and relocalizes from nucleus to ER upon DNA replication stress |
YPL056C_p | 4.69 | 1.33E-6 | LCL1_p | Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan |
YDL083C | 4.64 | 1.74E-6 | RPS16B | Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S16 and bacterial S9; RPS16B has a paralog, RPS16A, that arose from the whole genome duplication |
YOL049W | 4.63 | 1.83E-6 | GSH2 | Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock |