Deletion Strain | FD score | P-value | Gene | Gene Description |
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YJR050W | 7.01 | 1.23E-12 | ISY1 | Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles |
YNL285W_d | 5.49 | 2.03E-8 | YNL285W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YIL043C | 5.43 | 2.81E-8 | CBR1 | Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia |
YDR129C | 5.36 | 4.13E-8 | SAC6 | Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress |
YNL176C_p | 4.84 | 6.59E-7 | TDA7_p | Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele |
YHR048W_p | 4.66 | 1.58E-6 | YHK8_p | Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles |
YDR079C-A | 4.60 | 2.15E-6 | TFB5 | Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair |
YLR358C_p | 4.54 | 2.81E-6 | YLR358C_p | Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps ORF RSC2/YLR357W |
YCR037C | 4.51 | 3.18E-6 | PHO87 | Low-affinity inorganic phosphate (Pi) transporter; involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments; PHO87 has a paralog, PHO90, that arose from the whole genome duplication |
YCR024C-A | 4.31 | 8.08E-6 | PMP1 | Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p; small single-membrane span proteolipid; forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines; PMP1 has a paralog, PMP2, that arose from the whole genome duplication |
YJR126C | 4.18 | 1.46E-5 | VPS70 | Protein of unknown function involved in vacuolar protein sorting |
YDR297W | 4.16 | 1.57E-5 | SUR2 | Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis |
YCR101C_p | 4.14 | 1.73E-5 | YCR101C_p | Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene |
YGL012W | 4.13 | 1.82E-5 | ERG4 | C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol |
YNR013C | 4.12 | 1.92E-5 | PHO91 | Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth |