Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YOR176W | 3.76 | 8.64E-5 | 0.36 | HEM15 | Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway |
YPR085C | 3.49 | 2.43E-4 | 0.36 | ASA1 | Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1 |
YPL228W | 3.45 | 2.76E-4 | 0.36 | CET1 | Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide |
YJR093C | 3.09 | 9.99E-4 | 0.08 | FIP1 | Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p |
YKL172W | 3.01 | 0.00129 | 0.02 | EBP2 | Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering |
YLR033W | 2.99 | 0.00138 | 0.04 | RSC58 | Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance |
YDL043C | 2.95 | 0.00159 | 0.05 | PRP11 | Subunit of the SF3a splicing factor complex, required for spliceosome assembly |
YIL031W | 2.90 | 0.00184 | 0.04 | ULP2 | Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate |
YDR189W | 2.86 | 0.00209 | 0.03 | SLY1 | Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex |
YFR037C | 2.84 | 0.00228 | 0.06 | RSC8 | Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters |
YKL045W | 2.78 | 0.00274 | 0.02 | PRI2 | Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair |
YLR076C_d | 2.76 | 0.00292 | 0.11 | YLR076C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10 |
YLR153C | 2.64 | 0.00410 | 0.05 | ACS2 | Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions |
YLR175W | 2.60 | 0.00472 | 0.00 | CBF5 | Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita |
YNL062C | 2.59 | 0.00474 | 0.03 | GCD10 | Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression |