9089636

2-(4-ethylphenoxy)-2-methyl-1-(4-pyridin-2-ylpiperazin-1-yl)propan-1-one

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3023
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 17249241
SMILES CCC1=CC=C(C=C1)OC(C)(C)C(=O)N2CCN(CC2)C3=CC=CC=N3
Standardized SMILES CCc1ccc(OC(C)(C)C(=O)N2CCN(CC2)c3ccccn3)cc1
Molecular weight 353.458
ALogP 3.84
H-bond donor count 0
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 6.76
% growth inhibition (Hom. pool) 4.28


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 17249241
Download HIP data (tab-delimited text)  (excel)
Gene:CDC27(YBL084C)|FD-Score:3.22|P-value:6.41E-4|Clearance:0.05||SGD DESC:Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition Gene:FAD1(YDL045C)|FD-Score:3.17|P-value:7.50E-4|Clearance:0.07||SGD DESC:Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin Gene:OST1(YJL002C)|FD-Score:3.76|P-value:8.61E-5|Clearance:0.35||SGD DESC:Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins Gene:RPR2(YIR015W)|FD-Score:3.36|P-value:3.90E-4|Clearance:0.14||SGD DESC:Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress Gene:RRP1(YDR087C)|FD-Score:3.11|P-value:9.47E-4|Clearance:0.1||SGD DESC:Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles Gene:SPB1(YCL054W)|FD-Score:3.41|P-value:3.28E-4|Clearance:0.05||SGD DESC:AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants Gene:CDC27(YBL084C)|FD-Score:3.22|P-value:6.41E-4|Clearance:0.05||SGD DESC:Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition Gene:FAD1(YDL045C)|FD-Score:3.17|P-value:7.50E-4|Clearance:0.07||SGD DESC:Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin Gene:OST1(YJL002C)|FD-Score:3.76|P-value:8.61E-5|Clearance:0.35||SGD DESC:Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins Gene:RPR2(YIR015W)|FD-Score:3.36|P-value:3.90E-4|Clearance:0.14||SGD DESC:Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress Gene:RRP1(YDR087C)|FD-Score:3.11|P-value:9.47E-4|Clearance:0.1||SGD DESC:Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles Gene:SPB1(YCL054W)|FD-Score:3.41|P-value:3.28E-4|Clearance:0.05||SGD DESC:AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 17249241
Download HOP data (tab-delimited text)  (excel)
Gene:ADH5(YBR145W)|FD-Score:-3.68|P-value:1.17E-4||SGD DESC:Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication Gene:ARG7(YMR062C)|FD-Score:4.45|P-value:4.28E-6||SGD DESC:Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine Gene:ECM2(YBR065C)|FD-Score:-3.1|P-value:9.53E-4||SGD DESC:Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p Gene:ERP3(YDL018C)|FD-Score:3.77|P-value:8.22E-5||SGD DESC:Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport Gene:EST3(YIL009C-A)|FD-Score:3.23|P-value:6.18E-4||SGD DESC:Component of the telomerase holoenzyme, involved in telomere replication Gene:FRE5(YOR384W)|FD-Score:3.19|P-value:7.23E-4||SGD DESC:Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:HOC1(YJR075W)|FD-Score:3.13|P-value:8.79E-4||SGD DESC:Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele Gene:HUG1(YML058W-A)|FD-Score:-3.1|P-value:9.52E-4||SGD DESC:Protein involved in the Mec1p-mediated checkpoint pathway; transcription is induced by DNA damage; protein abundance increases in response to DNA replication stress Gene:IRC13(YOR235W_d)|FD-Score:3.62|P-value:1.47E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci Gene:LHP1(YDL051W)|FD-Score:-3.3|P-value:4.87E-4||SGD DESC:RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen Gene:MDR1(YGR100W)|FD-Score:3.21|P-value:6.71E-4||SGD DESC:Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function Gene:OSW2(YLR054C)|FD-Score:3.15|P-value:8.13E-4||SGD DESC:Protein of unknown function proposed to be involved in the assembly of the spore wall Gene:PEX15(YOL044W)|FD-Score:-3.96|P-value:3.73E-5||SGD DESC:Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly Gene:RPE1(YJL121C)|FD-Score:3.35|P-value:4.04E-4||SGD DESC:D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress Gene:SLX1(YBR228W)|FD-Score:3.23|P-value:6.18E-4||SGD DESC:Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p Gene:SLX8(YER116C)|FD-Score:3.35|P-value:4.09E-4||SGD DESC:Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress Gene:SPG5(YMR191W)|FD-Score:3.39|P-value:3.45E-4||SGD DESC:Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources Gene:STP1(YDR463W)|FD-Score:4.29|P-value:9.05E-6||SGD DESC:Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication Gene:TAH1(YCR060W)|FD-Score:-3.71|P-value:1.02E-4||SGD DESC:Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); contains a single TPR domain with at least two TPR motifs; R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II Gene:UBA3(YPR066W)|FD-Score:4.32|P-value:7.73E-6||SGD DESC:Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern Gene:YCR050C(YCR050C_p)|FD-Score:7.79|P-value:3.47E-15||SGD DESC:Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein Gene:YDL068W(YDL068W_d)|FD-Score:3.11|P-value:9.48E-4||SGD DESC:Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YKL023W(YKL023W_p)|FD-Score:3.16|P-value:7.77E-4||SGD DESC:Putative protein of unknown function, predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YKR104W(YKR104W)|FD-Score:3.52|P-value:2.14E-4||SGD DESC:Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds Gene:YLR252W(YLR252W_d)|FD-Score:3.09|P-value:9.94E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism Gene:YMR082C(YMR082C_d)|FD-Score:3.3|P-value:4.77E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPR071W(YPR071W_p)|FD-Score:3.13|P-value:8.61E-4||SGD DESC:Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C Gene:YSC83(YHR017W)|FD-Score:3.29|P-value:4.96E-4||SGD DESC:Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83 Gene:ADH5(YBR145W)|FD-Score:-3.68|P-value:1.17E-4||SGD DESC:Alcohol dehydrogenase isoenzyme V; involved in ethanol production; ADH5 has a paralog, ADH1, that arose from the whole genome duplication Gene:ARG7(YMR062C)|FD-Score:4.45|P-value:4.28E-6||SGD DESC:Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine Gene:ECM2(YBR065C)|FD-Score:-3.1|P-value:9.53E-4||SGD DESC:Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p Gene:ERP3(YDL018C)|FD-Score:3.77|P-value:8.22E-5||SGD DESC:Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport Gene:EST3(YIL009C-A)|FD-Score:3.23|P-value:6.18E-4||SGD DESC:Component of the telomerase holoenzyme, involved in telomere replication Gene:FRE5(YOR384W)|FD-Score:3.19|P-value:7.23E-4||SGD DESC:Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:HOC1(YJR075W)|FD-Score:3.13|P-value:8.79E-4||SGD DESC:Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele Gene:HUG1(YML058W-A)|FD-Score:-3.1|P-value:9.52E-4||SGD DESC:Protein involved in the Mec1p-mediated checkpoint pathway; transcription is induced by DNA damage; protein abundance increases in response to DNA replication stress Gene:IRC13(YOR235W_d)|FD-Score:3.62|P-value:1.47E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci Gene:LHP1(YDL051W)|FD-Score:-3.3|P-value:4.87E-4||SGD DESC:RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen Gene:MDR1(YGR100W)|FD-Score:3.21|P-value:6.71E-4||SGD DESC:Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function Gene:OSW2(YLR054C)|FD-Score:3.15|P-value:8.13E-4||SGD DESC:Protein of unknown function proposed to be involved in the assembly of the spore wall Gene:PEX15(YOL044W)|FD-Score:-3.96|P-value:3.73E-5||SGD DESC:Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly Gene:RPE1(YJL121C)|FD-Score:3.35|P-value:4.04E-4||SGD DESC:D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress Gene:SLX1(YBR228W)|FD-Score:3.23|P-value:6.18E-4||SGD DESC:Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p Gene:SLX8(YER116C)|FD-Score:3.35|P-value:4.09E-4||SGD DESC:Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress Gene:SPG5(YMR191W)|FD-Score:3.39|P-value:3.45E-4||SGD DESC:Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources Gene:STP1(YDR463W)|FD-Score:4.29|P-value:9.05E-6||SGD DESC:Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication Gene:TAH1(YCR060W)|FD-Score:-3.71|P-value:1.02E-4||SGD DESC:Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); contains a single TPR domain with at least two TPR motifs; R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly large protein complexes such as box C/D snoRNPs and RNA polymerase II Gene:UBA3(YPR066W)|FD-Score:4.32|P-value:7.73E-6||SGD DESC:Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern Gene:YCR050C(YCR050C_p)|FD-Score:7.79|P-value:3.47E-15||SGD DESC:Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein Gene:YDL068W(YDL068W_d)|FD-Score:3.11|P-value:9.48E-4||SGD DESC:Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YKL023W(YKL023W_p)|FD-Score:3.16|P-value:7.77E-4||SGD DESC:Putative protein of unknown function, predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm Gene:YKR104W(YKR104W)|FD-Score:3.52|P-value:2.14E-4||SGD DESC:Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds Gene:YLR252W(YLR252W_d)|FD-Score:3.09|P-value:9.94E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism Gene:YMR082C(YMR082C_d)|FD-Score:3.3|P-value:4.77E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPR071W(YPR071W_p)|FD-Score:3.13|P-value:8.61E-4||SGD DESC:Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C Gene:YSC83(YHR017W)|FD-Score:3.29|P-value:4.96E-4||SGD DESC:Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YJL002C3.768.61E-50.35OST1Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
YCL054W3.413.28E-40.05SPB1AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YIR015W3.363.90E-40.14RPR2Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress
YBL084C3.226.41E-40.05CDC27Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
YDL045C3.177.50E-40.07FAD1Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin
YDR087C3.119.47E-40.10RRP1Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles
YBR004C3.010.001320.09GPI18Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria
YDL060W2.920.001770.04TSR1Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
YOR260W2.880.002000.05GCD1Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
YMR185W_p2.830.002330.10RTP1_pProtein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene
YPR108W2.730.003200.07RPN7Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits
YIL126W2.660.003920.09STH1ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p
YDR113C2.570.005030.06PDS1Securin, inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation
YML093W2.520.005900.09UTP14Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
YKR004C2.430.007550.00ECM9Non-essential protein of unknown function

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YCR050C_p7.793.47E-15YCR050C_pNon-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein
YMR062C4.454.28E-6ARG7Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine
YPR066W4.327.73E-6UBA3Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
YDR463W4.299.05E-6STP1Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication
YDL018C3.778.22E-5ERP3Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
YOR235W_d3.621.47E-4IRC13_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci
YKR104W3.522.14E-4YKR104WPutative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds
YMR191W3.393.45E-4SPG5Protein required for proteasome assembly during quiescence; binds to base of the proteasome regulartory particle; required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YJL121C3.354.04E-4RPE1D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress
YER116C3.354.09E-4SLX8Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress
YMR082C_d3.304.77E-4YMR082C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR017W3.294.96E-4YSC83Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83
YIL009C-A3.236.18E-4EST3Component of the telomerase holoenzyme, involved in telomere replication
YBR228W3.236.18E-4SLX1Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p
YGR100W3.216.71E-4MDR1Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function

GO enrichment analysis for SGTC_3023
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.0831.77E-10SGTC_1842st055362 61.2 μMTimTec (Natural product derivative library)6760320.0759494
0.0731.59E-8SGTC_30369090181 49.5 μMChembridge (Drug-like library)252365860.235294
0.0723.43E-8SGTC_30139080133 71.4 μMChembridge (Drug-like library)170501930.177215
0.0681.72E-7SGTC_1166k206-0078 225.0 μMChemDiv (Drug-like library)54045950.125
0.0664.23E-7SGTC_30519093778 49.5 μMChembridge (Drug-like library)172173780.25
0.0655.39E-7SGTC_2151287-0124 461.5 μMChemDiv (Drug-like library)55608630.0666667
0.0612.30E-6SGTC_30229087993 49.5 μMChembridge (Drug-like library)171736440.121951
0.0594.81E-6SGTC_31729105863 49.5 μMChembridge (Drug-like library)23487850.192308ERG2
0.0588.18E-6SGTC_880180-0332 8.7 μMChemDiv (Drug-like library)31017450.0833333
0.0589.43E-6SGTC_698k064-0052 127.0 μMChemDiv (Drug-like library)50887510.0963855DNA damage response
0.0561.40E-5SGTC_1608st001473 40.5 μMTimTec (Natural product derivative library)72922670.123077
0.0561.61E-5SGTC_9631269-2853 151.0 μMChemDiv (Drug-like library)36682230.215385
0.0561.76E-5SGTC_5382922-0838 53.3 μMChemDiv (Drug-like library)7770390.0821918Golgi
0.0542.83E-5SGTC_32689137683 49.5 μMChembridge (Drug-like library)19532280.106667
0.0543.82E-5SGTC_21545570129 200.0 μMChembridge (Fragment library)6733660.223881

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_3028908777849.47 μM0.66666717217395Chembridge (Drug-like library)373.876464.04304
SGTC_3150909757449.47 μM0.64285717217476Chembridge (Drug-like library)339.43143.52304
SGTC_3058909386149.47 μM0.46268717217477Chembridge (Drug-like library)373.876464.25504
SGTC_3157909927449.47 μM0.44444417217662Chembridge (Drug-like library)339.43143.29104
SGTC_22887946289167.31 μM0.4406781246052Chembridge (Fragment library)271.314381.80204
SGTC_22267298446200 μM0.4333333283010Chembridge (Fragment library)287.379982.70104
SGTC_21645685496200 μM0.431034759046Chembridge (Fragment library)257.28781.65704
SGTC_3136909567249.47 μM0.43076917217380Chembridge (Drug-like library)373.876464.21804
SGTC_22867945697125 μM0.426231245733Chembridge (Fragment library)287.379982.06904
SGTC_3214534-389065.3 μM0.424242699746ChemDiv (Drug-like library)345.82333.24704RPP1 & pyrimidine depletion