Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YML127W | 6.14 | 4.24E-10 | 0.71 | RSC9 | Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway |
YPR107C | 5.43 | 2.89E-8 | 0.44 | YTH1 | Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation |
YDL150W | 4.99 | 3.09E-7 | 0.37 | RPC53 | RNA polymerase III subunit C53 |
YOR210W | 4.62 | 1.95E-6 | 0.39 | RPB10 | RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III |
YDL193W | 4.23 | 1.19E-5 | 0.29 | NUS1 | Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY |
YKR008W | 3.93 | 4.17E-5 | 0.32 | RSC4 | Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tandem bromodomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p |
YNL282W | 3.61 | 1.51E-4 | 0.10 | POP3 | Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs |
YDR141C | 3.52 | 2.19E-4 | 0.06 | DOP1 | Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies |
YGL098W | 3.45 | 2.79E-4 | 0.01 | USE1 | Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p |
YDR167W | 3.45 | 2.84E-4 | 0.03 | TAF10 | Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification |
YJR007W | 3.41 | 3.21E-4 | 0.02 | SUI2 | Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress |
YOL144W | 3.39 | 3.48E-4 | 0.01 | NOP8 | Nucleolar protein required for 60S ribosomal subunit biogenesis |
YPR181C | 3.38 | 3.62E-4 | 0.02 | SEC23 | GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p |
YPR187W | 3.36 | 3.91E-4 | 0.10 | RPO26 | RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit |
YDR188W | 3.26 | 5.52E-4 | 0.03 | CCT6 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif |