9091303

(4-butylphenyl)-(2,6-dimethylmorpholin-4-yl)methanone

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3035
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 25237002
SMILES CCCCC1=CC=C(C=C1)C(=O)N2CC(OC(C2)C)C
Standardized SMILES CCCCc1ccc(cc1)C(=O)N2CC(C)OC(C)C2
Molecular weight 275.3859
ALogP 3.54
H-bond donor count 0
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 4.57
% growth inhibition (Hom. pool) 4.71


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 25237002
Download HIP data (tab-delimited text)  (excel)
Gene:LCB2(YDR062W)|FD-Score:3.12|P-value:8.96E-4|Clearance:0.2||SGD DESC:Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine Gene:PRP19(YLL036C)|FD-Score:-3.18|P-value:7.25E-4|Clearance:0||SGD DESC:Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain Gene:RLI1(YDR091C)|FD-Score:3.19|P-value:7.06E-4|Clearance:0.2||SGD DESC:Essential iron-sulfur protein required for ribosome biogenesis and translation initiation and termination; facilitates binding of a multifactor complex (MFC) of initiation factors to the small ribosomal subunit; predicted ABC family ATPase; forms a complex with Lto1p and Yae1p that may be involved in protection of the ribosome from damage due to reactive oxygen species Gene:RPP1(YHR062C)|FD-Score:3.4|P-value:3.36E-4|Clearance:0.2||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:SEC5(YDR166C)|FD-Score:3.22|P-value:6.48E-4|Clearance:0.2||SGD DESC:Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in assembly of the exocyst complex; required with Sec3p for ER inheritance where it promotes anchoring of the cortical ER at the bud tip Gene:LCB2(YDR062W)|FD-Score:3.12|P-value:8.96E-4|Clearance:0.2||SGD DESC:Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine Gene:PRP19(YLL036C)|FD-Score:-3.18|P-value:7.25E-4|Clearance:0||SGD DESC:Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain Gene:RLI1(YDR091C)|FD-Score:3.19|P-value:7.06E-4|Clearance:0.2||SGD DESC:Essential iron-sulfur protein required for ribosome biogenesis and translation initiation and termination; facilitates binding of a multifactor complex (MFC) of initiation factors to the small ribosomal subunit; predicted ABC family ATPase; forms a complex with Lto1p and Yae1p that may be involved in protection of the ribosome from damage due to reactive oxygen species Gene:RPP1(YHR062C)|FD-Score:3.4|P-value:3.36E-4|Clearance:0.2||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:SEC5(YDR166C)|FD-Score:3.22|P-value:6.48E-4|Clearance:0.2||SGD DESC:Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in assembly of the exocyst complex; required with Sec3p for ER inheritance where it promotes anchoring of the cortical ER at the bud tip

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 25237002
Download HOP data (tab-delimited text)  (excel)
Gene:APL2(YKL135C)|FD-Score:3.3|P-value:4.85E-4||SGD DESC:Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress Gene:CHS7(YHR142W)|FD-Score:4.47|P-value:3.92E-6||SGD DESC:Protein of unknown function; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress Gene:CIN4(YMR138W)|FD-Score:3.24|P-value:5.94E-4||SGD DESC:GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog Gene:CLB2(YPR119W)|FD-Score:3.11|P-value:9.49E-4||SGD DESC:B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome Gene:DAL81(YIR023W)|FD-Score:-3.49|P-value:2.44E-4||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:DSE2(YHR143W)|FD-Score:3.44|P-value:2.91E-4||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP Gene:GTR2(YGR163W)|FD-Score:4.72|P-value:1.18E-6||SGD DESC:Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD Gene:HSL1(YKL101W)|FD-Score:4.88|P-value:5.27E-7||SGD DESC:Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p Gene:HSL7(YBR133C)|FD-Score:3.24|P-value:5.97E-4||SGD DESC:Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress Gene:MAC1(YMR021C)|FD-Score:3.94|P-value:4.00E-5||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MDM31(YHR194W)|FD-Score:3.43|P-value:3.04E-4||SGD DESC:Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34 Gene:MFB1(YDR219C)|FD-Score:-3.47|P-value:2.62E-4||SGD DESC:Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding Gene:MOH1(YBL049W)|FD-Score:3.38|P-value:3.57E-4||SGD DESC:Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for survival in stationary phase Gene:NGL3(YML118W)|FD-Score:-3.19|P-value:7.04E-4||SGD DESC:3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication Gene:NIT2(YJL126W)|FD-Score:3.35|P-value:3.97E-4||SGD DESC:Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member Gene:PAC2(YER007W)|FD-Score:3.11|P-value:9.41E-4||SGD DESC:Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl Gene:PRY2(YKR013W)|FD-Score:3.92|P-value:4.41E-5||SGD DESC:Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication Gene:PSY3(YLR376C)|FD-Score:3.26|P-value:5.56E-4||SGD DESC:Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C Gene:PUT4(YOR348C)|FD-Score:-3.13|P-value:8.63E-4||SGD DESC:Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells Gene:TRK2(YKR050W)|FD-Score:4.15|P-value:1.65E-5||SGD DESC:Component of the Trk1p-Trk2p potassium transport system; TRK2 has a paralog, TRK1, that arose from the whole genome duplication Gene:YBT1(YLL048C)|FD-Score:3.1|P-value:9.75E-4||SGD DESC:Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters Gene:YGR273C(YGR273C_p)|FD-Score:-3.49|P-value:2.41E-4||SGD DESC:Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene Gene:YHL026C(YHL026C_p)|FD-Score:3.79|P-value:7.58E-5||SGD DESC:Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History) Gene:YIL025C(YIL025C_d)|FD-Score:4.68|P-value:1.41E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR294C(YLR294C_d)|FD-Score:3.24|P-value:5.87E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14 Gene:YPR114W(YPR114W_p)|FD-Score:3.28|P-value:5.15E-4||SGD DESC:Putative protein of unknown function Gene:APL2(YKL135C)|FD-Score:3.3|P-value:4.85E-4||SGD DESC:Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress Gene:CHS7(YHR142W)|FD-Score:4.47|P-value:3.92E-6||SGD DESC:Protein of unknown function; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress Gene:CIN4(YMR138W)|FD-Score:3.24|P-value:5.94E-4||SGD DESC:GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog Gene:CLB2(YPR119W)|FD-Score:3.11|P-value:9.49E-4||SGD DESC:B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome Gene:DAL81(YIR023W)|FD-Score:-3.49|P-value:2.44E-4||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:DSE2(YHR143W)|FD-Score:3.44|P-value:2.91E-4||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP Gene:GTR2(YGR163W)|FD-Score:4.72|P-value:1.18E-6||SGD DESC:Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD Gene:HSL1(YKL101W)|FD-Score:4.88|P-value:5.27E-7||SGD DESC:Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p Gene:HSL7(YBR133C)|FD-Score:3.24|P-value:5.97E-4||SGD DESC:Protein arginine N-methyltransferase; exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p; relocalizes away from bud neck upon DNA replication stress Gene:MAC1(YMR021C)|FD-Score:3.94|P-value:4.00E-5||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MDM31(YHR194W)|FD-Score:3.43|P-value:3.04E-4||SGD DESC:Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34 Gene:MFB1(YDR219C)|FD-Score:-3.47|P-value:2.62E-4||SGD DESC:Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding Gene:MOH1(YBL049W)|FD-Score:3.38|P-value:3.57E-4||SGD DESC:Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for survival in stationary phase Gene:NGL3(YML118W)|FD-Score:-3.19|P-value:7.04E-4||SGD DESC:3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication Gene:NIT2(YJL126W)|FD-Score:3.35|P-value:3.97E-4||SGD DESC:Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member Gene:PAC2(YER007W)|FD-Score:3.11|P-value:9.41E-4||SGD DESC:Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl Gene:PRY2(YKR013W)|FD-Score:3.92|P-value:4.41E-5||SGD DESC:Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication Gene:PSY3(YLR376C)|FD-Score:3.26|P-value:5.56E-4||SGD DESC:Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C Gene:PUT4(YOR348C)|FD-Score:-3.13|P-value:8.63E-4||SGD DESC:Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells Gene:TRK2(YKR050W)|FD-Score:4.15|P-value:1.65E-5||SGD DESC:Component of the Trk1p-Trk2p potassium transport system; TRK2 has a paralog, TRK1, that arose from the whole genome duplication Gene:YBT1(YLL048C)|FD-Score:3.1|P-value:9.75E-4||SGD DESC:Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters Gene:YGR273C(YGR273C_p)|FD-Score:-3.49|P-value:2.41E-4||SGD DESC:Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene Gene:YHL026C(YHL026C_p)|FD-Score:3.79|P-value:7.58E-5||SGD DESC:Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History) Gene:YIL025C(YIL025C_d)|FD-Score:4.68|P-value:1.41E-6||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR294C(YLR294C_d)|FD-Score:3.24|P-value:5.87E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14 Gene:YPR114W(YPR114W_p)|FD-Score:3.28|P-value:5.15E-4||SGD DESC:Putative protein of unknown function

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YHR062C3.403.36E-40.20RPP1Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YDR166C3.226.48E-40.20SEC5Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in assembly of the exocyst complex; required with Sec3p for ER inheritance where it promotes anchoring of the cortical ER at the bud tip
YDR091C3.197.06E-40.20RLI1Essential iron-sulfur protein required for ribosome biogenesis and translation initiation and termination; facilitates binding of a multifactor complex (MFC) of initiation factors to the small ribosomal subunit; predicted ABC family ATPase; forms a complex with Lto1p and Yae1p that may be involved in protection of the ribosome from damage due to reactive oxygen species
YDR062W3.128.96E-40.20LCB2Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
YHR019C3.060.001120.20DED81Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
YPR181C2.900.001880.20SEC23GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p
YPL190C2.830.002310.20NAB3RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; required for termination of non-poly(A) transcripts and efficient splicing
YKL152C2.790.002650.20GPM1Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
YLR378C2.760.002870.20SEC61Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER
YFR002W2.750.003000.20NIC96Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p)
YBL084C2.710.003350.20CDC27Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
YDL195W2.600.004720.20SEC31Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance
YLR197W2.570.005100.20NOP56Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects
YML091C2.370.008840.09RPM2Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus
YGR060W2.280.011400.01ERG25C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YKL101W4.885.27E-7HSL1Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p
YGR163W4.721.18E-6GTR2Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD
YIL025C_d4.681.41E-6YIL025C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YHR142W4.473.92E-6CHS7Protein of unknown function; may be involved in chitin biosynthesis by regulation of Chs3p export from the ER; relocalizes from bud neck to ER upon DNA replication stress
YKR050W4.151.65E-5TRK2Component of the Trk1p-Trk2p potassium transport system; TRK2 has a paralog, TRK1, that arose from the whole genome duplication
YMR021C3.944.00E-5MAC1Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport
YKR013W3.924.41E-5PRY2Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication
YHL026C_p3.797.58E-5YHL026C_pPutative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History)
YHR143W3.442.91E-4DSE2Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP
YHR194W3.433.04E-4MDM31Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34
YBL049W3.383.57E-4MOH1Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for survival in stationary phase
YJL126W3.353.97E-4NIT2Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
YKL135C3.304.85E-4APL2Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
YPR114W_p3.285.15E-4YPR114W_pPutative protein of unknown function
YLR376C3.265.56E-4PSY3Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; structural analysis reveals a similar DNA-binding region in both Psy3p and Csm2p and that both regions work together to form a single DNA binding site; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but not mitomycin C

GO enrichment analysis for SGTC_3035
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1171.87E-19SGTC_31129123419 49.5 μMChembridge (Drug-like library)170158540.16129RPP1 & pyrimidine depletion
0.1127.89E-18SGTC_229benomyl 22.9 μMMiscellaneous287800.176471tubulin folding & SWR complex
0.1023.86E-15SGTC_2103551-0445 56.8 μMChemDiv (Drug-like library)28651800.164384
0.1017.86E-15SGTC_21745790901 200.0 μMChembridge (Fragment library)7860200.126984tubulin folding & SWR complex
0.0984.45E-14SGTC_13611608-0041 5.6 μMChemDiv (Drug-like library)X13610.09375RPP1 & pyrimidine depletion
0.0857.88E-11SGTC_13923455-1037 33.9 μMChemDiv (Drug-like library)9811320.131579
0.0831.85E-10SGTC_32619137475 49.5 μMChembridge (Drug-like library)170276900.0945946RPP1 & pyrimidine depletion
0.0832.17E-10SGTC_166k072-0058 166.4 μMChemDiv (Drug-like library)58462290.117647DNA intercalators
0.0806.26E-10SGTC_1493970-0822 46.1 μMChemDiv (Drug-like library)31142500.157143tubulin folding & SWR complex
0.0764.64E-9SGTC_2350330-0087 5.0 mMChemDiv (Drug-like library)464948180.134328TSC3-RPN4
0.0758.92E-9SGTC_9751335-0046 28.5 μMChemDiv (Drug-like library)164867400.109589RPP1 & pyrimidine depletion
0.0732.06E-8SGTC_23196033012 152.6 μMChembridge (Fragment library)8472460.0952381tubulin folding & SWR complex
0.0722.78E-8SGTC_228caffeine 993.1 μMMiscellaneous25190.0862069
0.0714.53E-8SGTC_120849-0099 9.3 μMChemDiv (Drug-like library)60713880.1
0.0715.83E-8SGTC_276colchicine 750.0 μMMiscellaneous28330.101266

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3030908761949.47 μM0.84210525236973Chembridge (Drug-like library)261.359323.08502
SGTC_3027908954149.47 μM0.5777789943819Chembridge (Drug-like library)288.427723.92802fatty acid desaturase (OLE1)
SGTC_2961222-003974.9 μM0.4255325984176ChemDiv (Drug-like library)218.291524.22812
SGTC_810411-00469.97 μM0.41304312925265ChemDiv (Drug-like library)297.230645.4701
SGTC_790052-000794.09 μM0.3877552801472ChemDiv (Drug-like library)276.370664.63813
SGTC_9591222-0044107 μM0.3877556083612ChemDiv (Drug-like library)232.31814.68512
SGTC_3153910025849.47 μM0.38181825236848Chembridge (Drug-like library)315.429843.93603
SGTC_9581222-000733 μM0.387312461ChemDiv (Drug-like library)246.344685.14112
SGTC_5331222-02226.71 μM0.3773583982874ChemDiv (Drug-like library)324.37045.58204PDR1
SGTC_2969909140828.7 μM0.370374286311Chembridge (Drug-like library)254.326923.31812