9091578

5-ethyl-N-(1-pyridin-4-ylethyl)-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3042
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 25236497
SMILES CCC1CCC2=C(C1)C=C(S2)C(=O)NC(C)C3=CC=NC=C3
Standardized SMILES CCC1CCc2sc(cc2C1)C(=O)NC(C)c3ccncc3
Molecular weight 314.4451
ALogP 3.89
H-bond donor count 1
H-bond acceptor count 3
Response signature ERG2

Pool Growth Kinetics
% growth inhibition (Het. pool) 14.15
% growth inhibition (Hom. pool) 10.74


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 25236497
Download HIP data (tab-delimited text)  (excel)
Gene:CDC33(YOL139C)|FD-Score:3.28|P-value:5.18E-4|Clearance:0.2||SGD DESC:mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth Gene:NCP1(YHR042W)|FD-Score:3.2|P-value:6.94E-4|Clearance:0.2||SGD DESC:NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p Gene:NUS1(YDL193W)|FD-Score:-3.44|P-value:2.91E-4|Clearance:0||SGD DESC:Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY Gene:PAP1(YKR002W)|FD-Score:-4.36|P-value:6.48E-6|Clearance:0||SGD DESC:Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping Gene:RPB10(YOR210W)|FD-Score:-3.35|P-value:3.99E-4|Clearance:0||SGD DESC:RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III Gene:SRP54(YPR088C)|FD-Score:-3.59|P-value:1.63E-4|Clearance:0||SGD DESC:Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain Gene:STH1(YIL126W)|FD-Score:-4.05|P-value:2.56E-5|Clearance:0||SGD DESC:ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p Gene:TSR1(YDL060W)|FD-Score:3.42|P-value:3.09E-4|Clearance:0.2||SGD DESC:Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:YGR114C(YGR114C_d)|FD-Score:-3.25|P-value:5.69E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6 Gene:CDC33(YOL139C)|FD-Score:3.28|P-value:5.18E-4|Clearance:0.2||SGD DESC:mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth Gene:NCP1(YHR042W)|FD-Score:3.2|P-value:6.94E-4|Clearance:0.2||SGD DESC:NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p Gene:NUS1(YDL193W)|FD-Score:-3.44|P-value:2.91E-4|Clearance:0||SGD DESC:Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY Gene:PAP1(YKR002W)|FD-Score:-4.36|P-value:6.48E-6|Clearance:0||SGD DESC:Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping Gene:RPB10(YOR210W)|FD-Score:-3.35|P-value:3.99E-4|Clearance:0||SGD DESC:RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III Gene:SRP54(YPR088C)|FD-Score:-3.59|P-value:1.63E-4|Clearance:0||SGD DESC:Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain Gene:STH1(YIL126W)|FD-Score:-4.05|P-value:2.56E-5|Clearance:0||SGD DESC:ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p Gene:TSR1(YDL060W)|FD-Score:3.42|P-value:3.09E-4|Clearance:0.2||SGD DESC:Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:YGR114C(YGR114C_d)|FD-Score:-3.25|P-value:5.69E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 25236497
Download HOP data (tab-delimited text)  (excel)
Gene:ADE4(YMR300C)|FD-Score:4.15|P-value:1.63E-5||SGD DESC:Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway Gene:ATG12(YBR217W)|FD-Score:-5.32|P-value:5.17E-8||SGD DESC:Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation Gene:BCK1(YJL095W)|FD-Score:3.22|P-value:6.41E-4||SGD DESC:Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p Gene:ECM2(YBR065C)|FD-Score:3.33|P-value:4.30E-4||SGD DESC:Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p Gene:ERG2(YMR202W)|FD-Score:3.88|P-value:5.31E-5||SGD DESC:C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis Gene:GOR1(YNL274C)|FD-Score:3.18|P-value:7.48E-4||SGD DESC:Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress Gene:HMX1(YLR205C)|FD-Score:3.11|P-value:9.23E-4||SGD DESC:ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants Gene:LTV1(YKL143W)|FD-Score:-3.23|P-value:6.14E-4||SGD DESC:Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature Gene:OST3(YOR085W)|FD-Score:3.18|P-value:7.40E-4||SGD DESC:Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins Gene:PCK1(YKR097W)|FD-Score:3.2|P-value:6.89E-4||SGD DESC:Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol Gene:PEX10(YDR265W)|FD-Score:3.44|P-value:2.88E-4||SGD DESC:Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders Gene:RPS7B(YNL096C)|FD-Score:-4.72|P-value:1.17E-6||SGD DESC:Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7B has a paralog, RPS7A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:RTA1(YGR213C)|FD-Score:3.51|P-value:2.21E-4||SGD DESC:Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein Gene:SNF2(YOR290C)|FD-Score:-3.87|P-value:5.47E-5||SGD DESC:Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p Gene:SNO4(YMR322C_p)|FD-Score:3.51|P-value:2.22E-4||SGD DESC:Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation Gene:STB5(YHR178W)|FD-Score:-4.25|P-value:1.05E-5||SGD DESC:Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro Gene:STP1(YDR463W)|FD-Score:-4.37|P-value:6.12E-6||SGD DESC:Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication Gene:TDA5(YLR426W_p)|FD-Score:3.43|P-value:3.01E-4||SGD DESC:Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele Gene:TPN1(YGL186C)|FD-Score:3.75|P-value:8.83E-5||SGD DESC:Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p Gene:TRP1(YDR007W)|FD-Score:-3.4|P-value:3.38E-4||SGD DESC:Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) Gene:UGA1(YGR019W)|FD-Score:3.18|P-value:7.27E-4||SGD DESC:Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress Gene:VAM10(YOR068C)|FD-Score:3.33|P-value:4.28E-4||SGD DESC:Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering Gene:VAM6(YDL077C)|FD-Score:3.14|P-value:8.47E-4||SGD DESC:Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p Gene:VTC2(YFL004W)|FD-Score:3.18|P-value:7.44E-4||SGD DESC:Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion Gene:YCR050C(YCR050C_p)|FD-Score:-4.11|P-value:2.01E-5||SGD DESC:Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein Gene:YDL121C(YDL121C_p)|FD-Score:3.13|P-value:8.68E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein Gene:YDL180W(YDL180W_p)|FD-Score:3.55|P-value:1.95E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole Gene:YEL057C(YEL057C_p)|FD-Score:4.38|P-value:6.05E-6||SGD DESC:Protein of unknown function involved in telomere maintenance; target of UME6 regulation Gene:YGR069W(YGR069W_d)|FD-Score:3.28|P-value:5.15E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YJL175W(YJL175W_d)|FD-Score:-3.94|P-value:4.14E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor Gene:YPT7(YML001W)|FD-Score:3.2|P-value:6.83E-4||SGD DESC:Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7 Gene:ADE4(YMR300C)|FD-Score:4.15|P-value:1.63E-5||SGD DESC:Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway Gene:ATG12(YBR217W)|FD-Score:-5.32|P-value:5.17E-8||SGD DESC:Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation Gene:BCK1(YJL095W)|FD-Score:3.22|P-value:6.41E-4||SGD DESC:Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p Gene:ECM2(YBR065C)|FD-Score:3.33|P-value:4.30E-4||SGD DESC:Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p Gene:ERG2(YMR202W)|FD-Score:3.88|P-value:5.31E-5||SGD DESC:C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis Gene:GOR1(YNL274C)|FD-Score:3.18|P-value:7.48E-4||SGD DESC:Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress Gene:HMX1(YLR205C)|FD-Score:3.11|P-value:9.23E-4||SGD DESC:ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants Gene:LTV1(YKL143W)|FD-Score:-3.23|P-value:6.14E-4||SGD DESC:Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature Gene:OST3(YOR085W)|FD-Score:3.18|P-value:7.40E-4||SGD DESC:Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins Gene:PCK1(YKR097W)|FD-Score:3.2|P-value:6.89E-4||SGD DESC:Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol Gene:PEX10(YDR265W)|FD-Score:3.44|P-value:2.88E-4||SGD DESC:Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders Gene:RPS7B(YNL096C)|FD-Score:-4.72|P-value:1.17E-6||SGD DESC:Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7B has a paralog, RPS7A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:RTA1(YGR213C)|FD-Score:3.51|P-value:2.21E-4||SGD DESC:Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein Gene:SNF2(YOR290C)|FD-Score:-3.87|P-value:5.47E-5||SGD DESC:Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p Gene:SNO4(YMR322C_p)|FD-Score:3.51|P-value:2.22E-4||SGD DESC:Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation Gene:STB5(YHR178W)|FD-Score:-4.25|P-value:1.05E-5||SGD DESC:Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro Gene:STP1(YDR463W)|FD-Score:-4.37|P-value:6.12E-6||SGD DESC:Transcription factor; undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing; STP1 has a paralog, STP2, that arose from the whole genome duplication Gene:TDA5(YLR426W_p)|FD-Score:3.43|P-value:3.01E-4||SGD DESC:Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele Gene:TPN1(YGL186C)|FD-Score:3.75|P-value:8.83E-5||SGD DESC:Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p Gene:TRP1(YDR007W)|FD-Score:-3.4|P-value:3.38E-4||SGD DESC:Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) Gene:UGA1(YGR019W)|FD-Score:3.18|P-value:7.27E-4||SGD DESC:Gamma-aminobutyrate (GABA) transaminase; also known as 4-aminobutyrate aminotransferase; involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization; protein abundance increases in response to DNA replication stress Gene:VAM10(YOR068C)|FD-Score:3.33|P-value:4.28E-4||SGD DESC:Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering Gene:VAM6(YDL077C)|FD-Score:3.14|P-value:8.47E-4||SGD DESC:Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p Gene:VTC2(YFL004W)|FD-Score:3.18|P-value:7.44E-4||SGD DESC:Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion Gene:YCR050C(YCR050C_p)|FD-Score:-4.11|P-value:2.01E-5||SGD DESC:Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein Gene:YDL121C(YDL121C_p)|FD-Score:3.13|P-value:8.68E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein Gene:YDL180W(YDL180W_p)|FD-Score:3.55|P-value:1.95E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole Gene:YEL057C(YEL057C_p)|FD-Score:4.38|P-value:6.05E-6||SGD DESC:Protein of unknown function involved in telomere maintenance; target of UME6 regulation Gene:YGR069W(YGR069W_d)|FD-Score:3.28|P-value:5.15E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YJL175W(YJL175W_d)|FD-Score:-3.94|P-value:4.14E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor Gene:YPT7(YML001W)|FD-Score:3.2|P-value:6.83E-4||SGD DESC:Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YDL060W3.423.09E-40.20TSR1Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
YOL139C3.285.18E-40.20CDC33mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p); protein abundance increases in response to DNA replication stress; mutants are defective for adhesion and pseudohyphal growth
YHR042W3.206.94E-40.20NCP1NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p
YMR134W_p3.020.001260.20ERG29_pProtein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes
YPR010C3.000.001350.20RPA135RNA polymerase I second largest subunit A135
YEL058W2.910.001820.20PCM1Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors
YOR020C2.890.001950.20HSP10Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES
YGR013W2.880.002020.20SNU71Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart
YOR287C2.670.003770.03RRP36Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit
YKL165C2.640.004160.03MCD4Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes
YLR305C2.610.004590.06STT4Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization
YIL109C2.550.005460.00SEC24Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p
YKL089W2.540.005490.10MIF2Protein required for structural integrity of elongating spindles; localizes to the kinetochore; interacts with histones H2A, H2B, and H4; phosphorylated by Ipl1p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-C and fission yeast cnp3
YLR127C2.440.007310.02APC2Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of the APC/C; has similarity to cullin Cdc53p
YOR236W2.420.007760.03DFR1Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YEL057C_p4.386.05E-6YEL057C_pProtein of unknown function involved in telomere maintenance; target of UME6 regulation
YMR300C4.151.63E-5ADE4Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway
YMR202W3.885.31E-5ERG2C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis
YGL186C3.758.83E-5TPN1Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p
YDL180W_p3.551.95E-4YDL180W_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YGR213C3.512.21E-4RTA1Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein
YMR322C_p3.512.22E-4SNO4_pPossible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation
YDR265W3.442.88E-4PEX10Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders
YLR426W_p3.433.01E-4TDA5_pPutative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele
YOR068C3.334.28E-4VAM10Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering
YBR065C3.334.30E-4ECM2Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p
YGR069W_d3.285.15E-4YGR069W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL095W3.226.41E-4BCK1Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
YML001W3.206.83E-4YPT7Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion; interacts with the cargo selection/retromer complex for retrograde sorting; similar to mammalian Rab7
YKR097W3.206.89E-4PCK1Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol

GO enrichment analysis for SGTC_3042
biological processes

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1382.16E-26SGTC_1874staurosporine 7.6 μMICCB bioactive library468641930.0776699cell wall signaling
0.1258.41E-22SGTC_12440416-0015 52.5 μMChemDiv (Drug-like library)962010.0625ERG2
0.1181.09E-19SGTC_21445628481 200.0 μMChembridge (Fragment library)28183990.125ERG2
0.1165.23E-19SGTC_22727805186 180.0 μMChembridge (Fragment library)29560620.103896cell wall signaling
0.1159.55E-19SGTC_20555235184 200.0 μMChembridge (Fragment library)28360340.0869565ERG2
0.1041.72E-15SGTC_28207989630 71.4 μMChembridge (Drug-like library)29840980.117647ERG2
0.0992.85E-14SGTC_12063978-0017 132.0 μMChemDiv (Drug-like library)38736770.111111ERG2
0.0993.57E-14SGTC_23007976697 71.6 μMChembridge (Fragment library)22361090.111111ERG2
0.0993.92E-14SGTC_24635473429 200.0 μMMiscellaneous53994050.180556ERG2
0.0962.25E-13SGTC_8410251-0215 91.2 μMChemDiv (Drug-like library)38886140.0793651
0.0952.38E-13SGTC_234nsc-17383 10.7 μMMiscellaneous4089740.0681818ERG2
0.0939.76E-13SGTC_500h-89 112.0 μMICCB bioactive library4492410.11236cell wall signaling
0.0863.88E-11SGTC_1826st055655 41.6 μMTimTec (Natural product derivative library)6761680.120482ERG2
0.0864.87E-11SGTC_9052-aminofluorene 215.0 μMChemDiv (Drug-like library)15390.0909091cell wall signaling
0.0841.32E-10SGTC_2514salinomycin 42.7 μMMicrosource (Natural product library)236822280.0991736

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3142908649849.47 μM0.68421125236367Chembridge (Drug-like library)300.41853.51513iron homeostasis
SGTC_2972909361959.92 μM0.58730225236256Chembridge (Drug-like library)300.41853.51513
SGTC_23639053361176 μM0.3965526469797Chembridge (Fragment library)260.718822.51212Golgi
SGTC_3155909926549.47 μM0.3880625236499Chembridge (Drug-like library)330.83184.15213
SGTC_3145908551649.47 μM0.27941225236195Chembridge (Drug-like library)306.466143.79903fatty acid desaturase (OLE1)
SGTC_3115912367149.47 μM0.2769233286988Chembridge (Drug-like library)297.2475533.82115
SGTC_23899091542195.52 μM0.2615383626624Chembridge (Fragment library)252.719961.88313iron homeostasis
SGTC_2968909066333.37 μM0.26027425236811Chembridge (Drug-like library)325.224123.43413
SGTC_2808794646845.46 μM0.2531652970879Chembridge (Drug-like library)404.546163.75115
SGTC_3181910827749.47 μM0.24657517097298Chembridge (Drug-like library)284.35293.02813iron homeostasis