9092212

2-(2-fluorophenoxy)-1-[4-(2-methylphenyl)piperazin-1-yl]ethanone

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3046
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 25236637
SMILES CC1=CC=CC=C1N2CCN(CC2)C(=O)COC3=CC=CC=C3F
Standardized SMILES Cc1ccccc1N2CCN(CC2)C(=O)COc3ccccc3F
Molecular weight 328.3806
ALogP 3.4
H-bond donor count 0
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 12.4
% growth inhibition (Hom. pool) 8.88


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 25236637
Download HIP data (tab-delimited text)  (excel)
Gene:ALG2(YGL065C)|FD-Score:3.57|P-value:1.77E-4|Clearance:0.19||SGD DESC:Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol Gene:CDC123(YLR215C)|FD-Score:3.12|P-value:9.15E-4|Clearance:0.06||SGD DESC:Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein Gene:IPP1(YBR011C)|FD-Score:3.51|P-value:2.25E-4|Clearance:0.19||SGD DESC:Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase Gene:RRP1(YDR087C)|FD-Score:3.21|P-value:6.53E-4|Clearance:0.1||SGD DESC:Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles Gene:SEC26(YDR238C)|FD-Score:3.31|P-value:4.60E-4|Clearance:0.1||SGD DESC:Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP) Gene:ALG2(YGL065C)|FD-Score:3.57|P-value:1.77E-4|Clearance:0.19||SGD DESC:Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol Gene:CDC123(YLR215C)|FD-Score:3.12|P-value:9.15E-4|Clearance:0.06||SGD DESC:Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein Gene:IPP1(YBR011C)|FD-Score:3.51|P-value:2.25E-4|Clearance:0.19||SGD DESC:Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase Gene:RRP1(YDR087C)|FD-Score:3.21|P-value:6.53E-4|Clearance:0.1||SGD DESC:Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles Gene:SEC26(YDR238C)|FD-Score:3.31|P-value:4.60E-4|Clearance:0.1||SGD DESC:Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 25236637
Download HOP data (tab-delimited text)  (excel)
Gene:ARO7(YPR060C)|FD-Score:12.5|P-value:5.09E-36||SGD DESC:Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis Gene:ATP23(YNR020C)|FD-Score:3.14|P-value:8.34E-4||SGD DESC:Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p Gene:BRP1(YGL007W_d)|FD-Score:3.22|P-value:6.41E-4||SGD DESC:Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1 Gene:BUL1(YMR275C)|FD-Score:3.47|P-value:2.55E-4||SGD DESC:Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication Gene:BXI1(YNL305C)|FD-Score:3.43|P-value:2.97E-4||SGD DESC:Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p Gene:CDC50(YCR094W)|FD-Score:-3.63|P-value:1.42E-4||SGD DESC:Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication Gene:DAL81(YIR023W)|FD-Score:4.98|P-value:3.13E-7||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:GSM1(YJL103C)|FD-Score:3.88|P-value:5.25E-5||SGD DESC:Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis Gene:HEK2(YBL032W)|FD-Score:3.17|P-value:7.53E-4||SGD DESC:RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K Gene:HOP1(YIL072W)|FD-Score:-4.98|P-value:3.12E-7||SGD DESC:Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein?DNA filaments Gene:HSV2(YGR223C)|FD-Score:3.32|P-value:4.46E-4||SGD DESC:Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization Gene:IDP1(YDL066W)|FD-Score:5.57|P-value:1.26E-8||SGD DESC:Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes Gene:IRS4(YKR019C)|FD-Score:-3.1|P-value:9.65E-4||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:KEL3(YPL263C)|FD-Score:-4.52|P-value:3.14E-6||SGD DESC:Cytoplasmic protein of unknown function Gene:LTP1(YPR073C)|FD-Score:3.89|P-value:5.03E-5||SGD DESC:Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine Gene:MSB1(YOR188W)|FD-Score:3.86|P-value:5.64E-5||SGD DESC:Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:OCA5(YHL029C_p)|FD-Score:3.53|P-value:2.08E-4||SGD DESC:Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts Gene:PAF1(YBR279W)|FD-Score:3.49|P-value:2.44E-4||SGD DESC:Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1 Gene:PAT1(YCR077C)|FD-Score:3.75|P-value:8.98E-5||SGD DESC:Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress Gene:PCI8(YIL071C)|FD-Score:3.27|P-value:5.47E-4||SGD DESC:Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain Gene:PEX13(YLR191W)|FD-Score:3.16|P-value:7.82E-4||SGD DESC:Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p Gene:PPH22(YDL188C)|FD-Score:3.82|P-value:6.59E-5||SGD DESC:Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication Gene:RPL14A(YKL006W)|FD-Score:-3.32|P-value:4.51E-4||SGD DESC:Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication Gene:SNO2(YNL334C)|FD-Score:3.32|P-value:4.43E-4||SGD DESC:Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin Gene:SPO74(YGL170C)|FD-Score:3.55|P-value:1.95E-4||SGD DESC:Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation Gene:SPT3(YDR392W)|FD-Score:3.73|P-value:9.40E-5||SGD DESC:Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters Gene:YDR250C(YDR250C_d)|FD-Score:-3.12|P-value:9.15E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Gene:YER134C(YER134C)|FD-Score:3.62|P-value:1.50E-4||SGD DESC:Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene Gene:YFR016C(YFR016C)|FD-Score:-3.25|P-value:5.72E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene Gene:YLR171W(YLR171W_d)|FD-Score:4.03|P-value:2.79E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNL120C(YNL120C_d)|FD-Score:3.82|P-value:6.75E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene Gene:YPL107W(YPL107W_p)|FD-Score:3.18|P-value:7.34E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene Gene:ARO7(YPR060C)|FD-Score:12.5|P-value:5.09E-36||SGD DESC:Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis Gene:ATP23(YNR020C)|FD-Score:3.14|P-value:8.34E-4||SGD DESC:Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p Gene:BRP1(YGL007W_d)|FD-Score:3.22|P-value:6.41E-4||SGD DESC:Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1 Gene:BUL1(YMR275C)|FD-Score:3.47|P-value:2.55E-4||SGD DESC:Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex; disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases; BUL1 has a paralog, BUL2, that arose from the whole genome duplication Gene:BXI1(YNL305C)|FD-Score:3.43|P-value:2.97E-4||SGD DESC:Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p Gene:CDC50(YCR094W)|FD-Score:-3.63|P-value:1.42E-4||SGD DESC:Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication Gene:DAL81(YIR023W)|FD-Score:4.98|P-value:3.13E-7||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:GSM1(YJL103C)|FD-Score:3.88|P-value:5.25E-5||SGD DESC:Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis Gene:HEK2(YBL032W)|FD-Score:3.17|P-value:7.53E-4||SGD DESC:RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K Gene:HOP1(YIL072W)|FD-Score:-4.98|P-value:3.12E-7||SGD DESC:Meiosis-specific protein required for chromosome synapsis; displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for chiasma formation; in vitro, displays the ability to promote intra- and intermolecular synapsis between double-stranded DNA molecules and to fold DNA into rigid protein?DNA filaments Gene:HSV2(YGR223C)|FD-Score:3.32|P-value:4.46E-4||SGD DESC:Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization Gene:IDP1(YDL066W)|FD-Score:5.57|P-value:1.26E-8||SGD DESC:Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes Gene:IRS4(YKR019C)|FD-Score:-3.1|P-value:9.65E-4||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:KEL3(YPL263C)|FD-Score:-4.52|P-value:3.14E-6||SGD DESC:Cytoplasmic protein of unknown function Gene:LTP1(YPR073C)|FD-Score:3.89|P-value:5.03E-5||SGD DESC:Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine Gene:MSB1(YOR188W)|FD-Score:3.86|P-value:5.64E-5||SGD DESC:Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:OCA5(YHL029C_p)|FD-Score:3.53|P-value:2.08E-4||SGD DESC:Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts Gene:PAF1(YBR279W)|FD-Score:3.49|P-value:2.44E-4||SGD DESC:Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1 Gene:PAT1(YCR077C)|FD-Score:3.75|P-value:8.98E-5||SGD DESC:Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress Gene:PCI8(YIL071C)|FD-Score:3.27|P-value:5.47E-4||SGD DESC:Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain Gene:PEX13(YLR191W)|FD-Score:3.16|P-value:7.82E-4||SGD DESC:Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p Gene:PPH22(YDL188C)|FD-Score:3.82|P-value:6.59E-5||SGD DESC:Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication Gene:RPL14A(YKL006W)|FD-Score:-3.32|P-value:4.51E-4||SGD DESC:Ribosomal 60S subunit protein L14A; N-terminally acetylated; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14A has a paralog, RPL14B, that arose from the whole genome duplication Gene:SNO2(YNL334C)|FD-Score:3.32|P-value:4.43E-4||SGD DESC:Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin Gene:SPO74(YGL170C)|FD-Score:3.55|P-value:1.95E-4||SGD DESC:Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation Gene:SPT3(YDR392W)|FD-Score:3.73|P-value:9.40E-5||SGD DESC:Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters Gene:YDR250C(YDR250C_d)|FD-Score:-3.12|P-value:9.15E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data Gene:YER134C(YER134C)|FD-Score:3.62|P-value:1.50E-4||SGD DESC:Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene Gene:YFR016C(YFR016C)|FD-Score:-3.25|P-value:5.72E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene Gene:YLR171W(YLR171W_d)|FD-Score:4.03|P-value:2.79E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNL120C(YNL120C_d)|FD-Score:3.82|P-value:6.75E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene Gene:YPL107W(YPL107W_p)|FD-Score:3.18|P-value:7.34E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YGL065C3.571.77E-40.20ALG2Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol
YBR011C3.512.25E-40.20IPP1Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
YDR238C3.314.60E-40.10SEC26Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)
YDR087C3.216.53E-40.10RRP1Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles
YLR215C3.129.15E-40.06CDC123Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein
YGL011C3.060.001120.00SCL1Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria
YMR239C3.050.001130.13RNT1Nuclear dsRNA-specific ribonuclease (RNase III); involved in rDNA transcription, rRNA processing and U2 snRNA 3' end formation by cleavage of a stem-loop structure at the 3' end of U2 snRNA; involved in polyadenylation-independent transcription termination; involved in the cell wall stress response, regulating the degradation of cell wall integrity and morphogenesis checkpoint genes
YDL196W_d2.920.001750.02YDL196W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
YOR272W2.900.001850.13YTM1Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats
YBR256C2.780.002754.58E-4RIB5Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway
YBR109C2.780.002750.10CMD1Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin
YLR145W2.680.003670.04RMP1Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P
YPL020C2.640.004130.11ULP1Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; sequestered to the nucleolus under stress conditions
YLR430W2.530.005630.06SEN1Presumed helicase and subunit of the Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3' end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; has a separate role in coordinating DNA replication with transcription, by associating with moving replication forks and preventing errors that occur when forks encounter transcribed regions; homolog of Senataxin, which is implicated in Ataxia-Oculomotor Apraxia 2 and a dominant form of ALS
YDL043C2.470.006680.09PRP11Subunit of the SF3a splicing factor complex, required for spliceosome assembly

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YPR060C12.505.09E-36ARO7Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis
YDL066W5.571.26E-8IDP1Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
YIR023W4.983.13E-7DAL81Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
YLR171W_d4.032.79E-5YLR171W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YPR073C3.895.03E-5LTP1Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine
YJL103C3.885.25E-5GSM1Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis
YOR188W3.865.64E-5MSB1Protein of unknown function; may be involved in positive regulation of 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4; potential Cdc28p substrate; relocalizes from bud neck to cytoplasm upon DNA replication stress
YDL188C3.826.59E-5PPH22Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication
YNL120C_d3.826.75E-5YNL120C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene
YCR077C3.758.98E-5PAT1Deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; associated with topoisomerase II; functionally linked to Pab1p; forms cytoplasmic foci upon DNA replication stress
YDR392W3.739.40E-5SPT3Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
YER134C3.621.50E-4YER134CMagnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene
YGL170C3.551.95E-4SPO74Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation
YHL029C_p3.532.08E-4OCA5_pCytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YBR279W3.492.44E-4PAF1Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1

GO enrichment analysis for SGTC_3046
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1985.47E-53SGTC_29329016711 44.5 μMChembridge (Drug-like library)71173280.185714
0.1899.28E-49SGTC_29769009005 19.5 μMChembridge (Drug-like library)29931480.123288
0.1845.52E-46SGTC_33039125618 40.6 μMChembridge (Drug-like library)226954670.108108
0.1819.33E-45SGTC_486niguldipine 82.0 μMMiscellaneous12360.163043amide catabolism
0.1485.51E-30SGTC_22137173844 200.0 μMChembridge (Fragment library)8927280.212121
0.1369.21E-26SGTC_5810958-0271 211.0 μMChemDiv (Drug-like library)45911450.12987
0.1351.57E-25SGTC_840443-0269 128.8 μMChemDiv (Drug-like library)61500580.0972222
0.1218.55E-21SGTC_1656st012921 11.0 μMTimTec (Natural product derivative library)67328210.166667
0.1194.20E-20SGTC_31019120531 49.5 μMChembridge (Drug-like library)248249040.0897436
0.1187.29E-20SGTC_2580diallyl disulphide 81.4 μMMicrosource (Natural product library)165900.0196078
0.1172.56E-19SGTC_8350312-0010 67.2 μMChemDiv (Drug-like library)16261960.138462
0.1165.68E-19SGTC_21325317594 122.7 μMChembridge (Fragment library)7945770.0547945SWF1 & branched chain AA biosynthesis
0.1142.32E-18SGTC_28459003024 43.0 μMChembridge (Drug-like library)29901730.142857amide catabolism
0.1124.82E-18SGTC_32289131799 49.5 μMChembridge (Drug-like library)170158180.164384amide catabolism
0.1056.91E-16SGTC_9903985-0011 41.3 μMChemDiv (Drug-like library)53995650.0972222amide catabolism

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3156909993149.47 μM0.74468118111053Chembridge (Drug-like library)344.835243.85903
SGTC_3029908868349.47 μM0.50943425236615Chembridge (Drug-like library)300.41853.34703
SGTC_3056909490049.47 μM0.48214325236784Chembridge (Drug-like library)342.4072233.88404
SGTC_3214534-389065.3 μM0.459016699746ChemDiv (Drug-like library)345.82333.24704RPP1 & pyrimidine depletion
SGTC_3157909927449.47 μM0.45762717217662Chembridge (Drug-like library)339.43143.29104
SGTC_3143908665849.47 μM0.4528325236626Chembridge (Drug-like library)300.41853.45803
SGTC_3036909018149.47 μM0.43636425236586Chembridge (Drug-like library)314.445083.65303
SGTC_3149909785549.47 μM0.43636425236625Chembridge (Drug-like library)365.287983.88103Golgi
SGTC_3020908914049.47 μM0.43333317217859Chembridge (Drug-like library)366.241783.42604
SGTC_22016605497169.86 μM0.42670741Chembridge (Fragment library)232.32142.18102ergosterol biosynthesis