9093778

1-(4-benzylpiperazin-1-yl)-2-(3-methylphenoxy)propan-1-one

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3051
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 17217378
SMILES CC1=CC(=CC=C1)OC(C)C(=O)N2CCN(CC2)CC3=CC=CC=C3
Standardized SMILES CC(Oc1cccc(C)c1)C(=O)N2CCN(Cc3ccccc3)CC2
Molecular weight 338.4433
ALogP 3.59
H-bond donor count 0
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 3.86
% growth inhibition (Hom. pool) 4.97


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 17217378
Download HIP data (tab-delimited text)  (excel)
Gene:ARC40(YBR234C)|FD-Score:-3.26|P-value:5.48E-4|Clearance:0||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches Gene:FRS2(YFL022C)|FD-Score:3.6|P-value:1.56E-4|Clearance:0.22||SGD DESC:Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar Gene:MCD1(YDL003W)|FD-Score:3.18|P-value:7.35E-4|Clearance:0.05||SGD DESC:Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase Gene:RPC11(YDR045C)|FD-Score:3.4|P-value:3.37E-4|Clearance:0.22||SGD DESC:RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS Gene:RPF1(YHR088W)|FD-Score:-3.18|P-value:7.28E-4|Clearance:0||SGD DESC:Nucleolar protein involved in the assembly and export of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA Gene:RPP0(YLR340W)|FD-Score:3.13|P-value:8.83E-4|Clearance:0.07||SGD DESC:Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10 Gene:RSC3(YDR303C)|FD-Score:3.51|P-value:2.27E-4|Clearance:0.22||SGD DESC:Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p Gene:ARC40(YBR234C)|FD-Score:-3.26|P-value:5.48E-4|Clearance:0||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches Gene:FRS2(YFL022C)|FD-Score:3.6|P-value:1.56E-4|Clearance:0.22||SGD DESC:Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar Gene:MCD1(YDL003W)|FD-Score:3.18|P-value:7.35E-4|Clearance:0.05||SGD DESC:Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase Gene:RPC11(YDR045C)|FD-Score:3.4|P-value:3.37E-4|Clearance:0.22||SGD DESC:RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS Gene:RPF1(YHR088W)|FD-Score:-3.18|P-value:7.28E-4|Clearance:0||SGD DESC:Nucleolar protein involved in the assembly and export of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA Gene:RPP0(YLR340W)|FD-Score:3.13|P-value:8.83E-4|Clearance:0.07||SGD DESC:Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10 Gene:RSC3(YDR303C)|FD-Score:3.51|P-value:2.27E-4|Clearance:0.22||SGD DESC:Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 17217378
Download HOP data (tab-delimited text)  (excel)
Gene:ATC1(YDR184C)|FD-Score:4.4|P-value:5.52E-6||SGD DESC:Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress Gene:BFA1(YJR053W)|FD-Score:-3.15|P-value:8.30E-4||SGD DESC:Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis Gene:CSN9(YDR179C)|FD-Score:3.59|P-value:1.66E-4||SGD DESC:Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling Gene:DAL80(YKR034W)|FD-Score:3.63|P-value:1.43E-4||SGD DESC:Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication Gene:ICT1(YLR099C)|FD-Score:3.52|P-value:2.18E-4||SGD DESC:Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication Gene:KEL3(YPL263C)|FD-Score:-3.62|P-value:1.49E-4||SGD DESC:Cytoplasmic protein of unknown function Gene:MRPL11(YDL202W)|FD-Score:3.12|P-value:9.04E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MSB2(YGR014W)|FD-Score:4.05|P-value:2.58E-5||SGD DESC:Mucin family member involved in signaling; functions in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; is processed into secreted and cell-associated forms by the aspartyl protease, Yps1p; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate Gene:NRG1(YDR043C)|FD-Score:-3.52|P-value:2.19E-4||SGD DESC:Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; NRG1 has a paralog, NRG2, that arose from the whole genome duplication Gene:PKH3(YDR466W)|FD-Score:3.67|P-value:1.21E-4||SGD DESC:Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant Gene:PRS1(YKL181W)|FD-Score:3.35|P-value:4.10E-4||SGD DESC:5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes Gene:TRP4(YDR354W)|FD-Score:-3.57|P-value:1.81E-4||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:YBR051W(YBR051W_d)|FD-Score:-3.54|P-value:2.03E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase Gene:YBR242W(YBR242W_p)|FD-Score:3.24|P-value:5.93E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene Gene:YCR050C(YCR050C_p)|FD-Score:3.2|P-value:6.83E-4||SGD DESC:Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein Gene:YFR016C(YFR016C)|FD-Score:-3.81|P-value:6.99E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene Gene:YGL101W(YGL101W_p)|FD-Score:3.39|P-value:3.45E-4||SGD DESC:Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p Gene:YPR084W(YPR084W_p)|FD-Score:3.68|P-value:1.15E-4||SGD DESC:Putative protein of unknown function Gene:ATC1(YDR184C)|FD-Score:4.4|P-value:5.52E-6||SGD DESC:Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress Gene:BFA1(YJR053W)|FD-Score:-3.15|P-value:8.30E-4||SGD DESC:Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis Gene:CSN9(YDR179C)|FD-Score:3.59|P-value:1.66E-4||SGD DESC:Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling Gene:DAL80(YKR034W)|FD-Score:3.63|P-value:1.43E-4||SGD DESC:Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication Gene:ICT1(YLR099C)|FD-Score:3.52|P-value:2.18E-4||SGD DESC:Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication Gene:KEL3(YPL263C)|FD-Score:-3.62|P-value:1.49E-4||SGD DESC:Cytoplasmic protein of unknown function Gene:MRPL11(YDL202W)|FD-Score:3.12|P-value:9.04E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:MSB2(YGR014W)|FD-Score:4.05|P-value:2.58E-5||SGD DESC:Mucin family member involved in signaling; functions in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; is processed into secreted and cell-associated forms by the aspartyl protease, Yps1p; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate Gene:NRG1(YDR043C)|FD-Score:-3.52|P-value:2.19E-4||SGD DESC:Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; NRG1 has a paralog, NRG2, that arose from the whole genome duplication Gene:PKH3(YDR466W)|FD-Score:3.67|P-value:1.21E-4||SGD DESC:Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant Gene:PRS1(YKL181W)|FD-Score:3.35|P-value:4.10E-4||SGD DESC:5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes Gene:TRP4(YDR354W)|FD-Score:-3.57|P-value:1.81E-4||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:YBR051W(YBR051W_d)|FD-Score:-3.54|P-value:2.03E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase Gene:YBR242W(YBR242W_p)|FD-Score:3.24|P-value:5.93E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene Gene:YCR050C(YCR050C_p)|FD-Score:3.2|P-value:6.83E-4||SGD DESC:Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein Gene:YFR016C(YFR016C)|FD-Score:-3.81|P-value:6.99E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene Gene:YGL101W(YGL101W_p)|FD-Score:3.39|P-value:3.45E-4||SGD DESC:Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p Gene:YPR084W(YPR084W_p)|FD-Score:3.68|P-value:1.15E-4||SGD DESC:Putative protein of unknown function

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YFL022C3.601.56E-40.22FRS2Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
YDR303C3.512.27E-40.22RSC3Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p
YDR045C3.403.37E-40.22RPC11RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS
YDL003W3.187.35E-40.05MCD1Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase
YLR340W3.138.83E-40.07RPP0Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10
YFL008W3.060.001100.22SMC1Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure
YDR052C2.840.002240.08DBF4Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress
YGL068W2.770.002840.04MNP1Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth
YDL166C2.720.003260.04FAP7Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D
YBR011C2.680.003730.05IPP1Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
YHR186C2.620.004360.05KOG1Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
YPL204W2.570.005040.01HRR25Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta)
YGL123W2.570.005150.01RPS2Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
YGL011C2.550.005350.07SCL1Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria
YPR108W2.490.006460.00RPN7Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YDR184C4.405.52E-6ATC1Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress
YGR014W4.052.58E-5MSB2Mucin family member involved in signaling; functions in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; is processed into secreted and cell-associated forms by the aspartyl protease, Yps1p; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate
YPR084W_p3.681.15E-4YPR084W_pPutative protein of unknown function
YDR466W3.671.21E-4PKH3Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
YKR034W3.631.43E-4DAL80Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication
YDR179C3.591.66E-4CSN9Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling
YLR099C3.522.18E-4ICT1Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication
YGL101W_p3.393.45E-4YGL101W_pPutative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p
YKL181W3.354.10E-4PRS15-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
YBR242W_p3.245.93E-4YBR242W_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene
YCR050C_p3.206.83E-4YCR050C_pNon-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein
YDL202W3.129.04E-4MRPL11Mitochondrial ribosomal protein of the large subunit
YER121W_p3.050.00113YER121W_pPutative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
YLR371W3.040.00117ROM2GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p
YHR075C3.030.00122PPE1Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein

GO enrichment analysis for SGTC_3051
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.1219.01E-21SGTC_30539095903 49.5 μMChembridge (Drug-like library)171740180.178082Golgi
0.0953.05E-13SGTC_30509093513 49.5 μMChembridge (Drug-like library)252366640.256757
0.0953.30E-13SGTC_14984478-3555 97.6 μMChemDiv (Drug-like library)34379190.103896
0.0759.54E-9SGTC_30579095946 49.5 μMChembridge (Drug-like library)245400430.162162Golgi
0.0707.30E-8SGTC_1109tnp00067 928.3 nMTimTec (Natural product library)6762950.115942
0.0681.70E-7SGTC_1166k206-0078 225.0 μMChemDiv (Drug-like library)54045950.1
0.0664.98E-7SGTC_448monastrol 171.0 μMICCB bioactive library29879270.171053
0.0664.23E-7SGTC_30239089636 49.5 μMChembridge (Drug-like library)172492410.25
0.0641.00E-6SGTC_30469092212 49.5 μMChembridge (Drug-like library)252366370.25
0.0604.29E-6SGTC_13481493-0373 93.8 μMChemDiv (Drug-like library)30101290.109375
0.0604.55E-6SGTC_3364111-0029 111.0 μMChemDiv (Drug-like library)31311750.1
0.0587.01E-6SGTC_1080509-0257 621.1 μMChemDiv (Drug-like library)5366240.121212
0.0588.93E-6SGTC_12480469-0687 58.6 μMChemDiv (Drug-like library)40174820.125
0.0571.15E-5SGTC_28137971799 71.4 μMChembridge (Drug-like library)22340540.131579
0.0561.40E-5SGTC_15372',6'-dihydroxyflavanone 78.0 μMTimTec (Pure natural product library)51067870.111111

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_11574092-039427.6 μM0.4833333659885ChemDiv (Drug-like library)358.861823.7703
SGTC_3159910009649.47 μM0.47272725236875Chembridge (Drug-like library)304.427123.06303
SGTC_3049909222349.47 μM0.4655178623917Chembridge (Drug-like library)328.835843.93502
SGTC_13752910-0797186 μM0.448276742508ChemDiv (Drug-like library)340.416162.75204
SGTC_6164092-0450108 μM0.436364787165ChemDiv (Drug-like library)322.443943.76202
SGTC_7294092-058594.1 μM0.4354842169061ChemDiv (Drug-like library)390.4500234.5504
SGTC_3056909490049.47 μM0.43333325236784Chembridge (Drug-like library)342.4072233.88404
SGTC_2841900476138.96 μM0.4310342991039Chembridge (Drug-like library)289.756744.08412amide catabolism
SGTC_3054909439749.47 μM0.4285712598354Chembridge (Drug-like library)330.422883.69302fatty acid desaturase (OLE1)
SGTC_3150909757449.47 μM0.42857117217476Chembridge (Drug-like library)339.43143.52304