9095903

N-[2-(3-chlorophenyl)ethyl]-2,3-dihydro-1,4-benzodioxine-6-carboxamide

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3053
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 17174018
SMILES C1COC2=C(O1)C=CC(=C2)C(=O)NCCC3=CC(=CC=C3)Cl
Standardized SMILES Clc1cccc(CCNC(=O)c2ccc3OCCOc3c2)c1
Molecular weight 317.7668
ALogP 3.39
H-bond donor count 1
H-bond acceptor count 3
Response signature Golgi

Pool Growth Kinetics
% growth inhibition (Het. pool) 9.02
% growth inhibition (Hom. pool) 8.92


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 17174018
Download HIP data (tab-delimited text)  (excel)
Gene:ASA1(YPR085C)|FD-Score:3.19|P-value:7.15E-4|Clearance:0.21||SGD DESC:Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1 Gene:CCT8(YJL008C)|FD-Score:3.37|P-value:3.76E-4|Clearance:0.21||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:FIP1(YJR093C)|FD-Score:3.57|P-value:1.79E-4|Clearance:0.21||SGD DESC:Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p Gene:PRP2(YNR011C)|FD-Score:-3.34|P-value:4.13E-4|Clearance:0||SGD DESC:RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16 Gene:RPC11(YDR045C)|FD-Score:3.19|P-value:7.21E-4|Clearance:0.21||SGD DESC:RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS Gene:SEC31(YDL195W)|FD-Score:3.15|P-value:8.17E-4|Clearance:0.21||SGD DESC:Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance Gene:TAM41(YGR046W)|FD-Score:3.62|P-value:1.48E-4|Clearance:0.21||SGD DESC:Mitochondrial protein required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition Gene:TFA2(YKR062W)|FD-Score:3.49|P-value:2.46E-4|Clearance:0.21||SGD DESC:TFIIE small subunit, involved in RNA polymerase II transcription initiation Gene:ASA1(YPR085C)|FD-Score:3.19|P-value:7.15E-4|Clearance:0.21||SGD DESC:Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1 Gene:CCT8(YJL008C)|FD-Score:3.37|P-value:3.76E-4|Clearance:0.21||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo Gene:FIP1(YJR093C)|FD-Score:3.57|P-value:1.79E-4|Clearance:0.21||SGD DESC:Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p Gene:PRP2(YNR011C)|FD-Score:-3.34|P-value:4.13E-4|Clearance:0||SGD DESC:RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16 Gene:RPC11(YDR045C)|FD-Score:3.19|P-value:7.21E-4|Clearance:0.21||SGD DESC:RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS Gene:SEC31(YDL195W)|FD-Score:3.15|P-value:8.17E-4|Clearance:0.21||SGD DESC:Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance Gene:TAM41(YGR046W)|FD-Score:3.62|P-value:1.48E-4|Clearance:0.21||SGD DESC:Mitochondrial protein required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition Gene:TFA2(YKR062W)|FD-Score:3.49|P-value:2.46E-4|Clearance:0.21||SGD DESC:TFIIE small subunit, involved in RNA polymerase II transcription initiation

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 17174018
Download HOP data (tab-delimited text)  (excel)
Gene:ADO1(YJR105W)|FD-Score:4.78|P-value:8.98E-7||SGD DESC:Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle Gene:AMA1(YGR225W)|FD-Score:3.72|P-value:9.83E-5||SGD DESC:Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis Gene:AQY2(YLL052C)|FD-Score:3.37|P-value:3.70E-4||SGD DESC:Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains Gene:CHS6(YJL099W)|FD-Score:3.95|P-value:3.92E-5||SGD DESC:Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication Gene:COG8(YML071C)|FD-Score:5.8|P-value:3.24E-9||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:HPR1(YDR138W)|FD-Score:3.2|P-value:6.97E-4||SGD DESC:Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p Gene:HXT10(YFL011W)|FD-Score:3.64|P-value:1.39E-4||SGD DESC:Putative hexose transporter, expressed at low levels and expression is repressed by glucose Gene:IRS4(YKR019C)|FD-Score:3.11|P-value:9.34E-4||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:MAC1(YMR021C)|FD-Score:3.42|P-value:3.10E-4||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MFM1(YPL060W)|FD-Score:3.11|P-value:9.46E-4||SGD DESC:Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p Gene:NMD2(YHR077C)|FD-Score:-3.74|P-value:9.22E-5||SGD DESC:Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance Gene:PAN5(YHR063C)|FD-Score:3.38|P-value:3.66E-4||SGD DESC:2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE Gene:PPH22(YDL188C)|FD-Score:3.33|P-value:4.39E-4||SGD DESC:Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication Gene:PTC1(YDL006W)|FD-Score:3.21|P-value:6.66E-4||SGD DESC:Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation Gene:RHR2(YIL053W)|FD-Score:3.13|P-value:8.70E-4||SGD DESC:Constitutively expressed glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; RHR2 has a paralog, HOR2, that arose from the whole genome duplication Gene:SSM4(YIL030C)|FD-Score:3.34|P-value:4.16E-4||SGD DESC:Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation Gene:TRP4(YDR354W)|FD-Score:-4.01|P-value:3.07E-5||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:VPS1(YKR001C)|FD-Score:3.14|P-value:8.42E-4||SGD DESC:Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis Gene:YFR016C(YFR016C)|FD-Score:-4.51|P-value:3.24E-6||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene Gene:YGL159W(YGL159W_p)|FD-Score:3.61|P-value:1.56E-4||SGD DESC:Putative protein of unknown function; deletion mutant has no detectable phenotype Gene:YGR069W(YGR069W_d)|FD-Score:4.58|P-value:2.38E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:ADO1(YJR105W)|FD-Score:4.78|P-value:8.98E-7||SGD DESC:Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle Gene:AMA1(YGR225W)|FD-Score:3.72|P-value:9.83E-5||SGD DESC:Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis Gene:AQY2(YLL052C)|FD-Score:3.37|P-value:3.70E-4||SGD DESC:Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains Gene:CHS6(YJL099W)|FD-Score:3.95|P-value:3.92E-5||SGD DESC:Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication Gene:COG8(YML071C)|FD-Score:5.8|P-value:3.24E-9||SGD DESC:Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:HPR1(YDR138W)|FD-Score:3.2|P-value:6.97E-4||SGD DESC:Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p Gene:HXT10(YFL011W)|FD-Score:3.64|P-value:1.39E-4||SGD DESC:Putative hexose transporter, expressed at low levels and expression is repressed by glucose Gene:IRS4(YKR019C)|FD-Score:3.11|P-value:9.34E-4||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:MAC1(YMR021C)|FD-Score:3.42|P-value:3.10E-4||SGD DESC:Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport Gene:MFM1(YPL060W)|FD-Score:3.11|P-value:9.46E-4||SGD DESC:Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p Gene:NMD2(YHR077C)|FD-Score:-3.74|P-value:9.22E-5||SGD DESC:Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance Gene:PAN5(YHR063C)|FD-Score:3.38|P-value:3.66E-4||SGD DESC:2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE Gene:PPH22(YDL188C)|FD-Score:3.33|P-value:4.39E-4||SGD DESC:Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication Gene:PTC1(YDL006W)|FD-Score:3.21|P-value:6.66E-4||SGD DESC:Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation Gene:RHR2(YIL053W)|FD-Score:3.13|P-value:8.70E-4||SGD DESC:Constitutively expressed glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; RHR2 has a paralog, HOR2, that arose from the whole genome duplication Gene:SSM4(YIL030C)|FD-Score:3.34|P-value:4.16E-4||SGD DESC:Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation Gene:TRP4(YDR354W)|FD-Score:-4.01|P-value:3.07E-5||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:VPS1(YKR001C)|FD-Score:3.14|P-value:8.42E-4||SGD DESC:Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis Gene:YFR016C(YFR016C)|FD-Score:-4.51|P-value:3.24E-6||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene Gene:YGL159W(YGL159W_p)|FD-Score:3.61|P-value:1.56E-4||SGD DESC:Putative protein of unknown function; deletion mutant has no detectable phenotype Gene:YGR069W(YGR069W_d)|FD-Score:4.58|P-value:2.38E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YGR046W3.621.48E-40.21TAM41Mitochondrial protein required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition
YJR093C3.571.79E-40.21FIP1Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p
YKR062W3.492.46E-40.21TFA2TFIIE small subunit, involved in RNA polymerase II transcription initiation
YJL008C3.373.76E-40.21CCT8Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YPR085C3.197.15E-40.21ASA1Subunit of the ASTRA complex, involved in chromatin remodeling; telomere length regulator involved in the stability or biogenesis of PIKKs such as TORC1
YDR045C3.197.21E-40.21RPC11RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS
YDL195W3.158.17E-40.21SEC31Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance
YGR114C_d2.940.001620.01YGR114C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6
YHR062C2.940.001660.01RPP1Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YDR238C2.930.001700.04SEC26Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)
YMR236W2.890.001910.03TAF9Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3
YFR002W2.860.002090.08NIC96Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p)
YPL217C2.780.002720.04BMS1GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p
YDR473C2.740.003050.05PRP3Splicing factor, component of the U4/U6-U5 snRNP complex
YHR007C2.690.003550.00ERG11Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YML071C5.803.24E-9COG8Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YJR105W4.788.98E-7ADO1Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YGR069W_d4.582.38E-6YGR069W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL099W3.953.92E-5CHS6Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
YGR225W3.729.83E-5AMA1Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis
YFL011W3.641.39E-4HXT10Putative hexose transporter, expressed at low levels and expression is repressed by glucose
YGL159W_p3.611.56E-4YGL159W_pPutative protein of unknown function; deletion mutant has no detectable phenotype
YMR021C3.423.10E-4MAC1Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport
YHR063C3.383.66E-4PAN52-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE
YLL052C3.373.70E-4AQY2Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
YIL030C3.344.16E-4SSM4Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
YDL188C3.334.39E-4PPH22Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication
YDL006W3.216.66E-4PTC1Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation
YDR138W3.206.97E-4HPR1Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p
YKR001C3.148.42E-4VPS1Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis

GO enrichment analysis for SGTC_3053
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1455.48E-29SGTC_4982,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 150.0 μMICCB bioactive library23740.0555556Golgi
0.1391.01E-26SGTC_1078idebenone 36.1 μMMiscellaneous36860.0597015Golgi
0.1369.03E-26SGTC_30579095946 49.5 μMChembridge (Drug-like library)245400430.135135Golgi
0.1352.14E-25SGTC_10603448-7350 82.0 μMChemDiv (Drug-like library)5701780.180328Golgi
0.1315.68E-24SGTC_3660181-0206 4.3 μMChemDiv (Drug-like library)2748740.0714286Golgi
0.1286.73E-23SGTC_9701315-0089 19.5 μMChemDiv (Drug-like library)68110830.135802RSC & ERG11
0.1279.04E-23SGTC_8550428-0020 25.0 μMChemDiv (Drug-like library)68124140.09375Golgi
0.1219.01E-21SGTC_30519093778 49.5 μMChembridge (Drug-like library)172173780.178082
0.1202.56E-20SGTC_1039k821-0043 94.0 μMChemDiv (Drug-like library)159927680.223684Golgi
0.1187.34E-20SGTC_2766oltipraz 83.9 μMMiscellaneous473180.0294118heme requiring
0.1181.03E-19SGTC_8940960-0238 55.9 μMChemDiv (Drug-like library)67419070.213333
0.1163.55E-19SGTC_1870st057514 26.5 μMTimTec (Natural product derivative library)53931610.128571RSC & ERG11
0.1164.59E-19SGTC_2234tolnaftate 200.0 μMMiscellaneous55100.0972222
0.1164.23E-19SGTC_1783st039459 87.5 μMTimTec (Natural product derivative library)7297610.106061Golgi
0.1165.44E-19SGTC_1994st072947 40.9 μMTimTec (Natural product derivative library)52865650.0722892

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3039909027049.47 μM0.61224517173750Chembridge (Drug-like library)303.740263.07113RPP1 & pyrimidine depletion
SGTC_3166910229749.47 μM0.57692325237072Chembridge (Drug-like library)348.191263.15513Golgi
SGTC_3310913022944.14 μM0.3965527761258Chembridge (Drug-like library)289.756743.8212Golgi
SGTC_3164910070549.47 μM0.38333317174235Chembridge (Drug-like library)299.321182.8714
SGTC_2902578700660.46 μM0.366667591003Chembridge (Drug-like library)309.240013.32516Golgi
SGTC_2888905854712.99 μM0.35593216476514Chembridge (Drug-like library)279.333084.11812
SGTC_6681682-049962.6 μM0.35682214ChemDiv (Drug-like library)324.20184.10612
SGTC_2929901334824.6 μM0.3448282995952Chembridge (Drug-like library)310.175223.99912
SGTC_2966908404148.03 μM0.34426217741380Chembridge (Drug-like library)374.239023.43915
SGTC_1960st01136651.8 μM0.3432843972846TimTec (Natural product derivative library)386.403324.22815