| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YML071C | 5.80 | 3.24E-9 | COG8 | Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments |
| YJR105W | 4.78 | 8.98E-7 | ADO1 | Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle |
| YGR069W_d | 4.58 | 2.38E-6 | YGR069W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
| YJL099W | 3.95 | 3.92E-5 | CHS6 | Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication |
| YGR225W | 3.72 | 9.83E-5 | AMA1 | Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis |
| YFL011W | 3.64 | 1.39E-4 | HXT10 | Putative hexose transporter, expressed at low levels and expression is repressed by glucose |
| YGL159W_p | 3.61 | 1.56E-4 | YGL159W_p | Putative protein of unknown function; deletion mutant has no detectable phenotype |
| YMR021C | 3.42 | 3.10E-4 | MAC1 | Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport |
| YHR063C | 3.38 | 3.66E-4 | PAN5 | 2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE |
| YLL052C | 3.37 | 3.70E-4 | AQY2 | Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains |
| YIL030C | 3.34 | 4.16E-4 | SSM4 | Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation |
| YDL188C | 3.33 | 4.39E-4 | PPH22 | Catalytic subunit of protein phosphatase 2A (PP2A); functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis; protein abundance increases in response to DNA replication stress; PPH22 has a paralog, PPH21, that arose from the whole genome duplication |
| YDL006W | 3.21 | 6.66E-4 | PTC1 | Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation |
| YDR138W | 3.20 | 6.97E-4 | HPR1 | Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p |
| YKR001C | 3.14 | 8.42E-4 | VPS1 | Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis |
