Deletion Strain | FD score | P-value | Gene | Gene Description |
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YPL080C_d | 9.41 | 2.37E-21 | YPL080C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YGL084C | 7.07 | 7.98E-13 | GUP1 | Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport |
YNL298W | 6.41 | 7.26E-11 | CLA4 | Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p |
YHR015W | 6.08 | 6.16E-10 | MIP6 | Putative RNA-binding protein; interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export; MIP6 has a paralog, PES4, that arose from the whole genome duplication |
YIL002C | 5.88 | 2.02E-9 | INP51 | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth |
YNR066C_p | 5.86 | 2.28E-9 | YNR066C_p | Putative membrane-localized protein of unknown function |
YMR032W | 5.18 | 1.11E-7 | HOF1 | Bud neck-localized, SH3 domain-containing protein required for cytokinesis; is phosphorylated by Dbf2p; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p |
YGL148W | 4.91 | 4.45E-7 | ARO2 | Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress |
YIR002C | 4.54 | 2.81E-6 | MPH1 | 3'-5' DNA helicase involved in error-free bypass of DNA lesions; binds to flap DNA in an error-free bypass pathway and stimulates the activity of Rad27p and Dna2p; also involved in interstrand cross-link repair mutations confer a mutator phenotype; similarity to FANCM, a human Fanconi anemia complementation group protein that along with the MHF complex is involved in stabilizing and remodeling blocked replication forks; member of the SF2 DExD/H superfamily of helicases |
YJL213W | 4.49 | 3.51E-6 | YJL213W | Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p |
YGR291C_d | 4.12 | 1.91E-5 | YGR291C_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YPL091W | 4.11 | 1.97E-5 | GLR1 | Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress |
YKL118W_d | 4.05 | 2.55E-5 | YKL118W_d | Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2 |
YER016W | 4.05 | 2.57E-5 | BIM1 | Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally |
YMR202W | 4.02 | 2.95E-5 | ERG2 | C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis |