| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YKL181W | 4.58 | 2.30E-6 | PRS1 | 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes |
| YDR007W | 4.51 | 3.20E-6 | TRP1 | Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) |
| YIR001C | 4.42 | 4.99E-6 | SGN1 | Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation |
| YGL104C | 4.39 | 5.61E-6 | VPS73 | Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family |
| YHR026W | 4.13 | 1.81E-5 | VMA16 | Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain |
| YER024W | 4.13 | 1.81E-5 | YAT2 | Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane |
| YGL241W | 4.09 | 2.17E-5 | KAP114 | Karyopherin, responsible for nuclear import of specific proteins; cargoes include Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear; function is regulated by sumoylation; protein abundance increases in response to DNA replication stress |
| YMR156C | 3.94 | 4.12E-5 | TPP1 | DNA 3'-phosphatase; functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; similar to the l-2-haloacid dehalogenase superfamily; homolog of human polynucleotide kinase/3′-phosphatase |
| YPL149W | 3.91 | 4.55E-5 | ATG5 | Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation |
| YFR031C-A | 3.90 | 4.76E-5 | RPL2A | Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication |
| YHR143W | 3.90 | 4.82E-5 | DSE2 | Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP |
| YDR205W | 3.88 | 5.15E-5 | MSC2 | Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids |
| YPL008W | 3.84 | 6.27E-5 | CHL1 | Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity and interstrand cross-link repair; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome |
| YOR201C | 3.83 | 6.30E-5 | MRM1 | Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA |
| YNL211C_p | 3.78 | 7.82E-5 | YNL211C_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene |
