9117005

N-(4-fluorophenyl)-3-propan-2-yloxybenzamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3070
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 8779016
SMILES CC(C)OC1=CC=CC(=C1)C(=O)NC2=CC=C(C=C2)F
Standardized SMILES CC(C)Oc1cccc(c1)C(=O)Nc2ccc(F)cc2
Molecular weight 273.3021
ALogP 3.53
H-bond donor count 1
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 12.96
% growth inhibition (Hom. pool) 8.23


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 8779016
Download HIP data (tab-delimited text)  (excel)
Gene:CDC39(YCR093W)|FD-Score:5.27|P-value:6.87E-8|Clearance:0.98||SGD DESC:Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor Gene:ILV5(YLR355C)|FD-Score:3.3|P-value:4.80E-4|Clearance:0.48||SGD DESC:Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids Gene:PGA1(YNL158W)|FD-Score:4.1|P-value:2.04E-5|Clearance:0.56||SGD DESC:Essential component of GPI-mannosyltransferase II, responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interations with secretory pathway genes Gene:SPP381(YBR152W)|FD-Score:3.51|P-value:2.20E-4|Clearance:0.21||SGD DESC:mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p Gene:TSR1(YDL060W)|FD-Score:4.29|P-value:9.04E-6|Clearance:0.19||SGD DESC:Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:WRS1(YOL097C)|FD-Score:3.54|P-value:2.01E-4|Clearance:0.02||SGD DESC:Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA Gene:CDC39(YCR093W)|FD-Score:5.27|P-value:6.87E-8|Clearance:0.98||SGD DESC:Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor Gene:ILV5(YLR355C)|FD-Score:3.3|P-value:4.80E-4|Clearance:0.48||SGD DESC:Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids Gene:PGA1(YNL158W)|FD-Score:4.1|P-value:2.04E-5|Clearance:0.56||SGD DESC:Essential component of GPI-mannosyltransferase II, responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interations with secretory pathway genes Gene:SPP381(YBR152W)|FD-Score:3.51|P-value:2.20E-4|Clearance:0.21||SGD DESC:mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p Gene:TSR1(YDL060W)|FD-Score:4.29|P-value:9.04E-6|Clearance:0.19||SGD DESC:Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress Gene:WRS1(YOL097C)|FD-Score:3.54|P-value:2.01E-4|Clearance:0.02||SGD DESC:Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 8779016
Download HOP data (tab-delimited text)  (excel)
Gene:ADH6(YMR318C)|FD-Score:-3.62|P-value:1.50E-4||SGD DESC:NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress Gene:AHA1(YDR214W)|FD-Score:3.56|P-value:1.88E-4||SGD DESC:Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress Gene:AYT1(YLL063C)|FD-Score:-4.18|P-value:1.45E-5||SGD DESC:Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis Gene:BTN2(YGR142W)|FD-Score:-4.28|P-value:9.25E-6||SGD DESC:v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; BTN2 has a paralog, CUR1, that arose from the whole genome duplication Gene:DFG16(YOR030W)|FD-Score:3.26|P-value:5.53E-4||SGD DESC:Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p Gene:DLD2(YDL178W)|FD-Score:3.91|P-value:4.69E-5||SGD DESC:D-lactate dehydrogenase, located in the mitochondrial matrix Gene:FAP1(YNL023C)|FD-Score:-3.8|P-value:7.10E-5||SGD DESC:Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1 Gene:GCN2(YDR283C)|FD-Score:-3.77|P-value:8.18E-5||SGD DESC:Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control Gene:GTO1(YGR154C)|FD-Score:-3.74|P-value:9.37E-5||SGD DESC:Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization Gene:HCR1(YLR192C)|FD-Score:4.54|P-value:2.84E-6||SGD DESC:Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA Gene:MAL13(YGR288W)|FD-Score:5.57|P-value:1.28E-8||SGD DESC:MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C Gene:MIC17(YMR002W)|FD-Score:3.9|P-value:4.89E-5||SGD DESC:Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress Gene:MNL1(YHR204W)|FD-Score:3.21|P-value:6.75E-4||SGD DESC:Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation Gene:NMA2(YGR010W)|FD-Score:3.31|P-value:4.61E-4||SGD DESC:Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication Gene:OPI8(YKR035C_d)|FD-Score:3.44|P-value:2.94E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A Gene:PEP8(YJL053W)|FD-Score:3.31|P-value:4.71E-4||SGD DESC:Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress Gene:PES4(YFR023W)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication Gene:PUF2(YPR042C)|FD-Score:3.26|P-value:5.56E-4||SGD DESC:Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins Gene:RHR2(YIL053W)|FD-Score:3.14|P-value:8.31E-4||SGD DESC:Constitutively expressed glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; RHR2 has a paralog, HOR2, that arose from the whole genome duplication Gene:SAC3(YDR159W)|FD-Score:3.11|P-value:9.24E-4||SGD DESC:Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP) Gene:SET3(YKR029C)|FD-Score:3.43|P-value:3.00E-4||SGD DESC:Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication Gene:SOD2(YHR008C)|FD-Score:3.28|P-value:5.18E-4||SGD DESC:Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated Gene:TRM11(YOL124C)|FD-Score:3.16|P-value:7.85E-4||SGD DESC:Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain Gene:VAB2(YEL005C)|FD-Score:4.12|P-value:1.91E-5||SGD DESC:Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter Gene:YCL022C(YCL022C_d)|FD-Score:-3.93|P-value:4.27E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W Gene:YCR006C(YCR006C_d)|FD-Score:3.18|P-value:7.37E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YMR119W-A(YMR119W-A_d)|FD-Score:3.18|P-value:7.43E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNL146C-A(YNL146C-A_p)|FD-Score:-3.73|P-value:9.44E-5||SGD DESC:Putative protein of unknown function Gene:YOR050C(YOR050C_d)|FD-Score:-4.9|P-value:4.73E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable Gene:YOR121C(YOR121C_d)|FD-Score:3.44|P-value:2.96E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W Gene:ADH6(YMR318C)|FD-Score:-3.62|P-value:1.50E-4||SGD DESC:NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress Gene:AHA1(YDR214W)|FD-Score:3.56|P-value:1.88E-4||SGD DESC:Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress Gene:AYT1(YLL063C)|FD-Score:-4.18|P-value:1.45E-5||SGD DESC:Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis Gene:BTN2(YGR142W)|FD-Score:-4.28|P-value:9.25E-6||SGD DESC:v-SNARE binding protein; facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase; BTN2 has a paralog, CUR1, that arose from the whole genome duplication Gene:DFG16(YOR030W)|FD-Score:3.26|P-value:5.53E-4||SGD DESC:Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p Gene:DLD2(YDL178W)|FD-Score:3.91|P-value:4.69E-5||SGD DESC:D-lactate dehydrogenase, located in the mitochondrial matrix Gene:FAP1(YNL023C)|FD-Score:-3.8|P-value:7.10E-5||SGD DESC:Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1 Gene:GCN2(YDR283C)|FD-Score:-3.77|P-value:8.18E-5||SGD DESC:Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control Gene:GTO1(YGR154C)|FD-Score:-3.74|P-value:9.37E-5||SGD DESC:Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization Gene:HCR1(YLR192C)|FD-Score:4.54|P-value:2.84E-6||SGD DESC:Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA Gene:MAL13(YGR288W)|FD-Score:5.57|P-value:1.28E-8||SGD DESC:MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C Gene:MIC17(YMR002W)|FD-Score:3.9|P-value:4.89E-5||SGD DESC:Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress Gene:MNL1(YHR204W)|FD-Score:3.21|P-value:6.75E-4||SGD DESC:Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation Gene:NMA2(YGR010W)|FD-Score:3.31|P-value:4.61E-4||SGD DESC:Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication Gene:OPI8(YKR035C_d)|FD-Score:3.44|P-value:2.94E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A Gene:PEP8(YJL053W)|FD-Score:3.31|P-value:4.71E-4||SGD DESC:Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress Gene:PES4(YFR023W)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication Gene:PUF2(YPR042C)|FD-Score:3.26|P-value:5.56E-4||SGD DESC:Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins Gene:RHR2(YIL053W)|FD-Score:3.14|P-value:8.31E-4||SGD DESC:Constitutively expressed glycerol-1-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and osmotic stress; RHR2 has a paralog, HOR2, that arose from the whole genome duplication Gene:SAC3(YDR159W)|FD-Score:3.11|P-value:9.24E-4||SGD DESC:Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP) Gene:SET3(YKR029C)|FD-Score:3.43|P-value:3.00E-4||SGD DESC:Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication Gene:SOD2(YHR008C)|FD-Score:3.28|P-value:5.18E-4||SGD DESC:Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated Gene:TRM11(YOL124C)|FD-Score:3.16|P-value:7.85E-4||SGD DESC:Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain Gene:VAB2(YEL005C)|FD-Score:4.12|P-value:1.91E-5||SGD DESC:Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter Gene:YCL022C(YCL022C_d)|FD-Score:-3.93|P-value:4.27E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W Gene:YCR006C(YCR006C_d)|FD-Score:3.18|P-value:7.37E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YMR119W-A(YMR119W-A_d)|FD-Score:3.18|P-value:7.43E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNL146C-A(YNL146C-A_p)|FD-Score:-3.73|P-value:9.44E-5||SGD DESC:Putative protein of unknown function Gene:YOR050C(YOR050C_d)|FD-Score:-4.9|P-value:4.73E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable Gene:YOR121C(YOR121C_d)|FD-Score:3.44|P-value:2.96E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YCR093W5.276.87E-80.98CDC39Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
YDL060W4.299.04E-60.18TSR1Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
YNL158W4.102.04E-50.56PGA1Essential component of GPI-mannosyltransferase II, responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interations with secretory pathway genes
YOL097C3.542.01E-40.02WRS1Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA
YBR152W3.512.20E-40.21SPP381mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p
YLR355C3.304.80E-40.48ILV5Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids
YOR168W2.830.002360.02GLN4Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions
YGR073C_d2.810.002490.03YGR073C_dDubious open reading frame unlikely to encode a functional protein, extensively overlaps essential SMD1 gene encoding a U6 snRNP protein
YOL146W2.780.002750.05PSF3Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
YMR211W2.720.003220.10DML1Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
YJL050W2.620.004340.16MTR4ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing
YMR236W2.470.006790.00TAF9Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3
YAR008W2.470.006820.05SEN34Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
YDL195W2.420.007840.15SEC31Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance
YDR473C2.260.011800.12PRP3Splicing factor, component of the U4/U6-U5 snRNP complex

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YGR288W5.571.28E-8MAL13MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C
YLR192C4.542.84E-6HCR1Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA
YEL005C4.121.91E-5VAB2Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter
YDL178W3.914.69E-5DLD2D-lactate dehydrogenase, located in the mitochondrial matrix
YMR002W3.904.89E-5MIC17Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
YDR214W3.561.88E-4AHA1Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress
YKR035C_d3.442.94E-4OPI8_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A
YOR121C_d3.442.96E-4YOR121C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W
YKR029C3.433.00E-4SET3Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains; SET3 has a paralog, SET4, that arose from the whole genome duplication
YFR023W3.413.24E-4PES4Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation; PES4 has a paralog, MIP6, that arose from the whole genome duplication
YGR010W3.314.61E-4NMA2Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication
YJL053W3.314.71E-4PEP8Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
YHR008C3.285.18E-4SOD2Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated
YOR030W3.265.53E-4DFG16Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p
YPR042C3.265.56E-4PUF2Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins

GO enrichment analysis for SGTC_3070
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1478.39E-30SGTC_30779117319 49.5 μMChembridge (Drug-like library)171546780.574468
0.0781.89E-9SGTC_12300170-0365 3.8 μMChemDiv (Drug-like library)40189320.101449endomembrane recycling
0.0672.73E-7SGTC_9011112-0062 60.1 μMChemDiv (Drug-like library)19084570.0597015
0.0663.42E-7SGTC_227fluconazole 33.5 μMMiscellaneous33650.125azole & statin
0.0655.04E-7SGTC_8770771-0151 33.1 μMChemDiv (Drug-like library)61665230.0704225
0.0648.63E-7SGTC_1904st060225 78.0 μMTimTec (Natural product derivative library)665950.129032
0.0621.80E-6SGTC_30729116419 49.5 μMChembridge (Drug-like library)171701620.185714ERG2
0.0596.40E-6SGTC_29237992654 58.1 μMChembridge (Drug-like library)29851260.229508Golgi
0.0588.30E-6SGTC_30679117431 49.5 μMChembridge (Drug-like library)171508850.377358
0.0571.03E-5SGTC_31029121669 49.5 μMChembridge (Drug-like library)419050720.102941
0.0552.31E-5SGTC_32329132874 49.5 μMChembridge (Drug-like library)37849400.446809RPP1 & pyrimidine depletion
0.0534.51E-5SGTC_28429000675 19.5 μMChembridge (Drug-like library)29890720.209677
0.0518.00E-5SGTC_1747st037496 66.6 μMTimTec (Natural product derivative library)7233050.0952381
0.0519.65E-5SGTC_31129123419 49.5 μMChembridge (Drug-like library)170158540.123077RPP1 & pyrimidine depletion
0.0501.07E-4SGTC_28007887935 81.8 μMChembridge (Drug-like library)29610020.2RPP1 & pyrimidine depletion

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_2877904072471.43 μM0.7619056463895Chembridge (Drug-like library)285.337663.30813
SGTC_2986902244571.43 μM0.6818186459286Chembridge (Drug-like library)285.337663.30813
SGTC_3098911903949.47 μM0.59183717161528Chembridge (Drug-like library)287.3287234.05313Golgi
SGTC_3094911774249.47 μM0.5817149698Chembridge (Drug-like library)312.3632.8523
SGTC_3077911731949.47 μM0.57446817154678Chembridge (Drug-like library)285.337663.30813
SGTC_2999906976571.43 μM0.5416672097066Chembridge (Drug-like library)285.337663.30813amide catabolism
SGTC_2851901592271.43 μM0.5098042996893Chembridge (Drug-like library)299.364243.31513
SGTC_3182910884949.47 μM0.47058817133045Chembridge (Drug-like library)267.322383.66112RPP1 & pyrimidine depletion
SGTC_5544483-2211187 μM0.469388747107ChemDiv (Drug-like library)285.29462.45314
SGTC_2865903031351.95 μM0.46296342562754Chembridge (Drug-like library)295.332483.91913