9117512

N-(3,4-dimethoxyphenyl)-5-methyl-1-phenyltriazole-4-carboxamide

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3079
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 7185044
SMILES CC1=C(N=NN1C2=CC=CC=C2)C(=O)NC3=CC(=C(C=C3)OC)OC
Standardized SMILES COc1ccc(NC(=O)c2nnn(c2C)c3ccccc3)cc1OC
Molecular weight 338.3605
ALogP 2.92
H-bond donor count 1
H-bond acceptor count 5
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 12.25
% growth inhibition (Hom. pool) 7.82


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 7185044
Download HIP data (tab-delimited text)  (excel)
Gene:DIB1(YPR082C)|FD-Score:3.36|P-value:3.91E-4|Clearance:0.29||SGD DESC:17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein Gene:ISD11(YER048W-A)|FD-Score:3.72|P-value:9.97E-5|Clearance:0.29||SGD DESC:Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis Gene:NIC96(YFR002W)|FD-Score:3.24|P-value:5.89E-4|Clearance:0.29||SGD DESC:Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p) Gene:PUP3(YER094C)|FD-Score:3.58|P-value:1.75E-4|Clearance:0.29||SGD DESC:Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10 Gene:DIB1(YPR082C)|FD-Score:3.36|P-value:3.91E-4|Clearance:0.29||SGD DESC:17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein Gene:ISD11(YER048W-A)|FD-Score:3.72|P-value:9.97E-5|Clearance:0.29||SGD DESC:Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis Gene:NIC96(YFR002W)|FD-Score:3.24|P-value:5.89E-4|Clearance:0.29||SGD DESC:Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p) Gene:PUP3(YER094C)|FD-Score:3.58|P-value:1.75E-4|Clearance:0.29||SGD DESC:Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 7185044
Download HOP data (tab-delimited text)  (excel)
Gene:ACE2(YLR131C)|FD-Score:3.48|P-value:2.52E-4||SGD DESC:Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication Gene:CHA4(YLR098C)|FD-Score:3.17|P-value:7.59E-4||SGD DESC:DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain Gene:CNM67(YNL225C)|FD-Score:3.19|P-value:7.16E-4||SGD DESC:Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication Gene:CTT1(YGR088W)|FD-Score:-3.64|P-value:1.34E-4||SGD DESC:Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide Gene:FYV5(YCL058C)|FD-Score:-3.27|P-value:5.33E-4||SGD DESC:Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis Gene:GET3(YDL100C)|FD-Score:-3.36|P-value:3.89E-4||SGD DESC:Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress Gene:LDB7(YBL006C)|FD-Score:3.44|P-value:2.93E-4||SGD DESC:Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions Gene:MOD5(YOR274W)|FD-Score:-3.32|P-value:4.52E-4||SGD DESC:Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis Gene:MSB3(YNL293W)|FD-Score:3.35|P-value:4.08E-4||SGD DESC:Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:PRY2(YKR013W)|FD-Score:3.47|P-value:2.63E-4||SGD DESC:Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication Gene:SDH4(YDR178W)|FD-Score:3.76|P-value:8.48E-5||SGD DESC:Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain Gene:SEH1(YGL100W)|FD-Score:-3.12|P-value:9.17E-4||SGD DESC:Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1 Gene:TUM1(YOR251C)|FD-Score:3.32|P-value:4.46E-4||SGD DESC:Rhodanese domain sulfur transferase, accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized Gene:YPR108W-A(YPR108W-A_p)|FD-Score:-4.83|P-value:6.96E-7||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YPT11(YNL304W)|FD-Score:3.43|P-value:2.97E-4||SGD DESC:Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells Gene:ACE2(YLR131C)|FD-Score:3.48|P-value:2.52E-4||SGD DESC:Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication Gene:CHA4(YLR098C)|FD-Score:3.17|P-value:7.59E-4||SGD DESC:DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain Gene:CNM67(YNL225C)|FD-Score:3.19|P-value:7.16E-4||SGD DESC:Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication Gene:CTT1(YGR088W)|FD-Score:-3.64|P-value:1.34E-4||SGD DESC:Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide Gene:FYV5(YCL058C)|FD-Score:-3.27|P-value:5.33E-4||SGD DESC:Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis Gene:GET3(YDL100C)|FD-Score:-3.36|P-value:3.89E-4||SGD DESC:Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress Gene:LDB7(YBL006C)|FD-Score:3.44|P-value:2.93E-4||SGD DESC:Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions Gene:MOD5(YOR274W)|FD-Score:-3.32|P-value:4.52E-4||SGD DESC:Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms; converts to a prion form, and prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis Gene:MSB3(YNL293W)|FD-Score:3.35|P-value:4.08E-4||SGD DESC:Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress Gene:PRY2(YKR013W)|FD-Score:3.47|P-value:2.63E-4||SGD DESC:Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication Gene:SDH4(YDR178W)|FD-Score:3.76|P-value:8.48E-5||SGD DESC:Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain Gene:SEH1(YGL100W)|FD-Score:-3.12|P-value:9.17E-4||SGD DESC:Component of two distinct complexes; subunit of the Nup84 nuclear pore sub-complex (NPC) and the Seh1-associated (SEA) complex; the the NUP84 subcomplex contributes to nucleocytoplasmic transport and NPC biogenesis; the SEA complex is a coatamer-related complex that associates dynamically with the vacuole; homologous to human SEH1 Gene:TUM1(YOR251C)|FD-Score:3.32|P-value:4.46E-4||SGD DESC:Rhodanese domain sulfur transferase, accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized Gene:YPR108W-A(YPR108W-A_p)|FD-Score:-4.83|P-value:6.96E-7||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YPT11(YNL304W)|FD-Score:3.43|P-value:2.97E-4||SGD DESC:Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YER048W-A3.729.97E-50.29ISD11Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis
YER094C3.581.75E-40.29PUP3Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
YPR082C3.363.91E-40.29DIB117-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein
YFR002W3.245.89E-40.29NIC96Linker nucleoporin component of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes to nucleocytoplasmic transport and NPC biogenesis; forms stable associations with three FG-nucleoporins (Nsp1p, Nup57p, and Nup49p)
YDR478W2.950.001590.10SNM1Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
YGL123W2.850.002190.01RPS2Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
YGR073C_d2.840.002240.01YGR073C_dDubious open reading frame unlikely to encode a functional protein, extensively overlaps essential SMD1 gene encoding a U6 snRNP protein
YKL182W2.830.002340.16FAS1Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YGL150C2.670.003830.06INO80ATPase and nucleosome spacing factor, subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; has a role in modulating stress gene transcription
YDL105W2.610.004560.01NSE4Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair
YHR069C2.600.004690.03RRP4Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)
YKR022C2.560.005190.01NTR2Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly
YHR019C2.550.005390.06DED81Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
YDR052C2.490.006330.01DBF4Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress
YGL245W2.490.006440.06GUS1Glutamyl-tRNA synthetase (GluRS); forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm; protein abundance increases in response to DNA replication stress

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YDR178W3.768.48E-5SDH4Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain
YLR131C3.482.52E-4ACE2Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit during M/G1 transition, causing localization to daughter cell nuclei, and also increases Ace2p activity; phosphorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of RAM network that regulates cellular polarity and morphogenesis; ACE2 has a paralog, SWI5, that arose from the whole genome duplication
YKR013W3.472.63E-4PRY2Sterol binding protein involved in the export of acetylated sterols; secreted glycoprotein and member of the CAP protein superfamily (cysteine-rich secretory proteins (CRISP), antigen 5, and pathogenesis related 1 proteins); sterol export function is redundant with that of PRY1; may be involved in detoxification of hydrophobic compounds; PRY2 has a paralog, PRY1, that arose from the whole genome duplication
YBL006C3.442.93E-4LDB7Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
YNL304W3.432.97E-4YPT11Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells
YNL293W3.354.08E-4MSB3Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress
YOR251C3.324.46E-4TUM1Rhodanese domain sulfur transferase, accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized
YNL225C3.197.16E-4CNM67Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration; CNM67 has a paralog, ADY3, that arose from the whole genome duplication
YLR098C3.177.59E-4CHA4DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain
YKL102C_d3.020.00127YKL102C_dDubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site
YPL267W2.990.00141ACM1Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein
YLR261C_d2.950.00158VPS63_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect
YIL028W_d2.920.00175YIL028W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YHR038W2.890.00191RRF1Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria
YJL055W_p2.870.00207YJL055W_pPutative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU

GO enrichment analysis for SGTC_3079
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1089.61E-17SGTC_31349127454 49.5 μMChembridge (Drug-like library)242628200.21875
0.1063.98E-16SGTC_830170-0301 39.0 μMChemDiv (Drug-like library)30897160.0615385endomembrane recycling
0.0978.18E-14SGTC_1603453-0671 289.7 μMChemDiv (Drug-like library)53222680.0869565
0.0961.32E-13SGTC_29799012552 45.5 μMChembridge (Drug-like library)171009050.19403
0.0921.51E-12SGTC_2674ligustilide 100.0 μMMicrosource (Natural product library)53190220.0540541
0.0881.16E-11SGTC_8630466-0191 129.0 μMChemDiv (Drug-like library)7651600.179104cell wall
0.0864.03E-11SGTC_9721319-0219 195.0 μMChemDiv (Drug-like library)239037020.157303
0.0814.90E-10SGTC_2629bisabolol 100.0 μMMicrosource (Natural product library)60976210.0666667
0.0791.25E-9SGTC_33569151811 4.5 μMChembridge (Drug-like library)18592540.142857cell wall
0.0741.43E-8SGTC_32859112818 20.9 μMChembridge (Drug-like library)170179470.256757cell wall
0.0732.25E-8SGTC_29909074105 71.4 μMChembridge (Drug-like library)65020010.1
0.0681.52E-7SGTC_32669136860 49.5 μMChembridge (Drug-like library)48712710.135802cell wall
0.0682.08E-7SGTC_33169136639 10.5 μMChembridge (Drug-like library)49036650.120482
0.0655.92E-7SGTC_30889117578 49.5 μMChembridge (Drug-like library)6783410.119403amide catabolism
0.0631.24E-6SGTC_22157188065 200.0 μMChembridge (Fragment library)9402170.112903

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3168910341949.47 μM0.66037716649256Chembridge (Drug-like library)308.334542.9311460S ribosome export
SGTC_3065911388849.47 μM0.6296316648368Chembridge (Drug-like library)338.360522.91515
SGTC_3209911361649.47 μM0.58620716649353Chembridge (Drug-like library)342.77963.59514
SGTC_3201911399949.47 μM0.52631616649224Chembridge (Drug-like library)336.38773.90314
SGTC_3192911036249.47 μM0.5245916649480Chembridge (Drug-like library)358.393223.83914mitochondrial processes
SGTC_3263913701849.47 μM0.50819743844957Chembridge (Drug-like library)336.38773.20624
SGTC_3325913876055.18 μM0.49206343844959Chembridge (Drug-like library)356.806183.38524Golgi
SGTC_3290912103171.43 μM0.48387117014854Chembridge (Drug-like library)354.3781634.00915
SGTC_3225913081949.47 μM0.4827594547121Chembridge (Drug-like library)293.32322.66624amide catabolism
SGTC_3095911720749.47 μM0.4754117015229Chembridge (Drug-like library)344.366644.49314