Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YGR158C | 5.70 | 6.15E-9 | 2.11 | MTR3 | Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6) |
YPR144C | 3.59 | 1.68E-4 | 0.52 | NOC4 | Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits |
YNL263C | 3.06 | 0.00110 | 0.10 | YIF1 | Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3 |
YDR365C | 2.96 | 0.00152 | 0.25 | ESF1 | Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels |
YKL095W | 2.72 | 0.00330 | 0.02 | YJU2 | Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC (nineteen complex) and acts after Prp2p to promote the first catalytic reaction of splicing |
YBL076C | 2.69 | 0.00355 | 0.08 | ILS1 | Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A |
YDR301W | 2.61 | 0.00447 | 0.04 | CFT1 | RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF |
YJL005W | 2.58 | 0.00496 | 0.07 | CYR1 | Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation |
YNL261W | 2.51 | 0.00601 | 0.11 | ORC5 | Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing |
YKL089W | 2.40 | 0.00819 | 0.01 | MIF2 | Protein required for structural integrity of elongating spindles; localizes to the kinetochore; interacts with histones H2A, H2B, and H4; phosphorylated by Ipl1p; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-C and fission yeast cnp3 |
YDR331W | 2.39 | 0.00840 | 0.04 | GPI8 | ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog |
YHR058C | 2.35 | 0.00948 | 0.02 | MED6 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress |
YDR167W | 2.33 | 0.00991 | 0.01 | TAF10 | Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification |
YKL082C | 2.32 | 0.01030 | 0.00 | RRP14 | Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family |
YNL306W | 2.31 | 0.01040 | 0.01 | MRPS18 | Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins |