Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YOR102W_d | 5.88 | 1.99E-9 | 1.82 | YOR102W_d | Dubious open reading frame, unlikely to encode a functional protein; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex |
YJL031C | 4.06 | 2.40E-5 | 0.16 | BET4 | Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p |
YOR077W | 3.90 | 4.79E-5 | 0.11 | RTS2 | Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication |
YNL088W | 3.79 | 7.54E-5 | 0.02 | TOP2 | Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation |
YEL032W | 3.76 | 8.33E-5 | 0.14 | MCM3 | Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex |
YLR103C | 3.63 | 1.43E-4 | 0.02 | CDC45 | DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes |
YDR373W | 3.61 | 1.52E-4 | 0.04 | FRQ1 | N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily |
YBR190W_d | 3.57 | 1.78E-4 | 0.05 | YBR190W_d | Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W |
YIL004C | 3.52 | 2.17E-4 | 0.17 | BET1 | Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins |
YNL317W | 3.35 | 4.03E-4 | 0.08 | PFS2 | Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex |
YJL111W | 3.27 | 5.31E-4 | 0.12 | CCT7 | Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance |
YDL166C | 3.15 | 8.16E-4 | 0.06 | FAP7 | Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D |
YGR073C_d | 3.09 | 9.98E-4 | 0.03 | YGR073C_d | Dubious open reading frame unlikely to encode a functional protein, extensively overlaps essential SMD1 gene encoding a U6 snRNP protein |
YAL041W | 3.06 | 0.00110 | 0.06 | CDC24 | Guanine nucleotide exchange factor for Cdc42p; also known as a GEF or GDP-release factor; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; relocalizes from nucleus to cytoplasm upon DNA replication stress |
YKR037C | 3.00 | 0.00134 | 0.11 | SPC34 | Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body |