9117468

(3-aminothieno[2,3-b]pyridin-2-yl)-pyrrolidin-1-ylmethanone

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3096
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 41316311
SMILES C1CCN(C1)C(=O)C2=C(C3=C(S2)N=CC=C3)N
Standardized SMILES Nc1c(sc2ncccc12)C(=O)N3CCCC3
Molecular weight 247.3161
ALogP 1.16
H-bond donor count 1
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 3.44
% growth inhibition (Hom. pool) 4.3


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 41316311
Download HIP data (tab-delimited text)  (excel)
Gene:DBF4(YDR052C)|FD-Score:-3.36|P-value:3.84E-4|Clearance:0||SGD DESC:Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress Gene:DIB1(YPR082C)|FD-Score:-3.48|P-value:2.51E-4|Clearance:0||SGD DESC:17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein Gene:DRE2(YKR071C)|FD-Score:-3.97|P-value:3.66E-5|Clearance:0||SGD DESC:Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress Gene:MPE1(YKL059C)|FD-Score:3.15|P-value:8.22E-4|Clearance:0.15||SGD DESC:Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif Gene:PRP11(YDL043C)|FD-Score:-3.16|P-value:7.77E-4|Clearance:0||SGD DESC:Subunit of the SF3a splicing factor complex, required for spliceosome assembly Gene:PUP1(YOR157C)|FD-Score:4.47|P-value:3.99E-6|Clearance:1.32||SGD DESC:Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z Gene:DBF4(YDR052C)|FD-Score:-3.36|P-value:3.84E-4|Clearance:0||SGD DESC:Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress Gene:DIB1(YPR082C)|FD-Score:-3.48|P-value:2.51E-4|Clearance:0||SGD DESC:17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein Gene:DRE2(YKR071C)|FD-Score:-3.97|P-value:3.66E-5|Clearance:0||SGD DESC:Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress Gene:MPE1(YKL059C)|FD-Score:3.15|P-value:8.22E-4|Clearance:0.15||SGD DESC:Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif Gene:PRP11(YDL043C)|FD-Score:-3.16|P-value:7.77E-4|Clearance:0||SGD DESC:Subunit of the SF3a splicing factor complex, required for spliceosome assembly Gene:PUP1(YOR157C)|FD-Score:4.47|P-value:3.99E-6|Clearance:1.32||SGD DESC:Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 41316311
Download HOP data (tab-delimited text)  (excel)
Gene:ACF2(YLR144C)|FD-Score:-3.54|P-value:1.97E-4||SGD DESC:Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress Gene:AIM18(YHR198C)|FD-Score:3.09|P-value:9.84E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss Gene:AIM33(YML087C)|FD-Score:-3.69|P-value:1.11E-4||SGD DESC:Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication Gene:ATP23(YNR020C)|FD-Score:-3.13|P-value:8.65E-4||SGD DESC:Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p Gene:BTS1(YPL069C)|FD-Score:-3.71|P-value:1.05E-4||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:CHS5(YLR330W)|FD-Score:-3.18|P-value:7.25E-4||SGD DESC:Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane Gene:CPR7(YJR032W)|FD-Score:3.81|P-value:7.01E-5||SGD DESC:Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity Gene:EFG1(YGR271C-A)|FD-Score:3.1|P-value:9.55E-4||SGD DESC:Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus Gene:FAR11(YNL127W)|FD-Score:3.12|P-value:8.91E-4||SGD DESC:Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2 Gene:FCY1(YPR062W)|FD-Score:3.27|P-value:5.33E-4||SGD DESC:Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) Gene:FMP27(YLR454W_p)|FD-Score:3.36|P-value:3.85E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:HAL1(YPR005C)|FD-Score:3.17|P-value:7.64E-4||SGD DESC:Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p Gene:LOT6(YLR011W)|FD-Score:3.91|P-value:4.52E-5||SGD DESC:FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions Gene:LYS4(YDR234W)|FD-Score:-3.16|P-value:7.83E-4||SGD DESC:Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway Gene:MDV1(YJL112W)|FD-Score:3.57|P-value:1.77E-4||SGD DESC:Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication Gene:MRPL28(YDR462W)|FD-Score:3.4|P-value:3.40E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress Gene:MRPS17(YMR188C)|FD-Score:3.34|P-value:4.19E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MSE1(YOL033W)|FD-Score:3.36|P-value:3.85E-4||SGD DESC:Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated Gene:MSN4(YKL062W)|FD-Score:3.84|P-value:6.22E-5||SGD DESC:Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication Gene:PAR32(YDL173W)|FD-Score:3.72|P-value:9.78E-5||SGD DESC:Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene Gene:PEX5(YDR244W)|FD-Score:-4.16|P-value:1.61E-5||SGD DESC:Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions Gene:PPG1(YNR032W)|FD-Score:-3.57|P-value:1.79E-4||SGD DESC:Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases Gene:RPS12(YOR369C)|FD-Score:3.21|P-value:6.54E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S12, no bacterial homolog Gene:RTS1(YOR014W)|FD-Score:3.3|P-value:4.92E-4||SGD DESC:B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A Gene:SFM1(YOR021C)|FD-Score:3.58|P-value:1.72E-4||SGD DESC:SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism Gene:SUR1(YPL057C)|FD-Score:4.3|P-value:8.37E-6||SGD DESC:Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication Gene:TGL3(YMR313C)|FD-Score:3.26|P-value:5.52E-4||SGD DESC:Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation Gene:TOM7(YNL070W)|FD-Score:3.65|P-value:1.32E-4||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex Gene:TPN1(YGL186C)|FD-Score:4.9|P-value:4.80E-7||SGD DESC:Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p Gene:TSC3(YBR058C-A)|FD-Score:-4.06|P-value:2.47E-5||SGD DESC:Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis Gene:VPS52(YDR484W)|FD-Score:-3.86|P-value:5.58E-5||SGD DESC:Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin Gene:YBP1(YBR216C)|FD-Score:3.22|P-value:6.52E-4||SGD DESC:Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication Gene:YCR006C(YCR006C_d)|FD-Score:-3.19|P-value:7.05E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YGR050C(YGR050C_p)|FD-Score:-3.38|P-value:3.63E-4||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data Gene:YKR012C(YKR012C_d)|FD-Score:4.06|P-value:2.45E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2 Gene:YLR122C(YLR122C_d)|FD-Score:-3.2|P-value:6.84E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C Gene:ACF2(YLR144C)|FD-Score:-3.54|P-value:1.97E-4||SGD DESC:Intracellular beta-1,3-endoglucanase; expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly; protein abundance increases in response to DNA replication stress Gene:AIM18(YHR198C)|FD-Score:3.09|P-value:9.84E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss Gene:AIM33(YML087C)|FD-Score:-3.69|P-value:1.11E-4||SGD DESC:Putative protein of unknown function, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication Gene:ATP23(YNR020C)|FD-Score:-3.13|P-value:8.65E-4||SGD DESC:Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p Gene:BTS1(YPL069C)|FD-Score:-3.71|P-value:1.05E-4||SGD DESC:Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic Gene:CHS5(YLR330W)|FD-Score:-3.18|P-value:7.25E-4||SGD DESC:Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane Gene:CPR7(YJR032W)|FD-Score:3.81|P-value:7.01E-5||SGD DESC:Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity Gene:EFG1(YGR271C-A)|FD-Score:3.1|P-value:9.55E-4||SGD DESC:Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus Gene:FAR11(YNL127W)|FD-Score:3.12|P-value:8.91E-4||SGD DESC:Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2 Gene:FCY1(YPR062W)|FD-Score:3.27|P-value:5.33E-4||SGD DESC:Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) Gene:FMP27(YLR454W_p)|FD-Score:3.36|P-value:3.85E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:HAL1(YPR005C)|FD-Score:3.17|P-value:7.64E-4||SGD DESC:Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p Gene:LOT6(YLR011W)|FD-Score:3.91|P-value:4.52E-5||SGD DESC:FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions Gene:LYS4(YDR234W)|FD-Score:-3.16|P-value:7.83E-4||SGD DESC:Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway Gene:MDV1(YJL112W)|FD-Score:3.57|P-value:1.77E-4||SGD DESC:Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication Gene:MRPL28(YDR462W)|FD-Score:3.4|P-value:3.40E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress Gene:MRPS17(YMR188C)|FD-Score:3.34|P-value:4.19E-4||SGD DESC:Mitochondrial ribosomal protein of the small subunit Gene:MSE1(YOL033W)|FD-Score:3.36|P-value:3.85E-4||SGD DESC:Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated Gene:MSN4(YKL062W)|FD-Score:3.84|P-value:6.22E-5||SGD DESC:Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication Gene:PAR32(YDL173W)|FD-Score:3.72|P-value:9.78E-5||SGD DESC:Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene Gene:PEX5(YDR244W)|FD-Score:-4.16|P-value:1.61E-5||SGD DESC:Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions Gene:PPG1(YNR032W)|FD-Score:-3.57|P-value:1.79E-4||SGD DESC:Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases Gene:RPS12(YOR369C)|FD-Score:3.21|P-value:6.54E-4||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S12, no bacterial homolog Gene:RTS1(YOR014W)|FD-Score:3.3|P-value:4.92E-4||SGD DESC:B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A Gene:SFM1(YOR021C)|FD-Score:3.58|P-value:1.72E-4||SGD DESC:SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism Gene:SUR1(YPL057C)|FD-Score:4.3|P-value:8.37E-6||SGD DESC:Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication Gene:TGL3(YMR313C)|FD-Score:3.26|P-value:5.52E-4||SGD DESC:Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation Gene:TOM7(YNL070W)|FD-Score:3.65|P-value:1.32E-4||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex Gene:TPN1(YGL186C)|FD-Score:4.9|P-value:4.80E-7||SGD DESC:Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p Gene:TSC3(YBR058C-A)|FD-Score:-4.06|P-value:2.47E-5||SGD DESC:Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis Gene:VPS52(YDR484W)|FD-Score:-3.86|P-value:5.58E-5||SGD DESC:Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin Gene:YBP1(YBR216C)|FD-Score:3.22|P-value:6.52E-4||SGD DESC:Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication Gene:YCR006C(YCR006C_d)|FD-Score:-3.19|P-value:7.05E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YGR050C(YGR050C_p)|FD-Score:-3.38|P-value:3.63E-4||SGD DESC:Protein of unknown function; mRNA identified as translated by ribosome profiling data Gene:YKR012C(YKR012C_d)|FD-Score:4.06|P-value:2.45E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2 Gene:YLR122C(YLR122C_d)|FD-Score:-3.2|P-value:6.84E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YOR157C4.473.99E-61.32PUP1Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z
YKL059C3.158.22E-40.15MPE1Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif
YDR526C_d3.000.001360.03YDR526C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL247W2.960.001520.23BRR6Essential nuclear envelope integral membrane protein required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism
YKR079C2.730.003170.00TRZ1tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2
YCR012W2.730.003190.01PGK13-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis
YAL003W2.720.003280.02EFB1Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
YOR336W2.700.003450.01KRE5Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects
YGL030W2.690.003520.03RPL30Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog
YDL207W2.660.003870.03GLE1Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export
YPL063W2.630.004270.01TIM50Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel
YMR227C2.620.004390.11TAF7TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation
YLR208W2.510.005970.11SEC13Structural component of 3 distinct complexes; subunit of Nup84 nuclear pore sub-complex (NPC), COPII vesicle coat, and Seh1-associated (SEA) complex; COPII vesicle coat is required for ER to Golgi transport; the Nup84 subcomplex contributes to nucleocytoplasmic transport, NPC biogenesis and processes that may require localization of chromosomes at the nuclear periphery, including transcription; homologous to human SEC13; abundance increases under DNA replication stress
YIR011C2.410.008040.06STS1Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation
YBR091C2.350.009460.01TIM12Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YGL186C4.904.80E-7TPN1Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p
YPL057C4.308.37E-6SUR1Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
YKR012C_d4.062.45E-5YKR012C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2
YLR011W3.914.52E-5LOT6FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions
YKL062W3.846.22E-5MSN4Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN4 has a paralog, MSN2, that arose from the whole genome duplication
YJR032W3.817.01E-5CPR7Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity
YDL173W3.729.78E-5PAR32Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene
YNL070W3.651.32E-4TOM7Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
YOR021C3.581.72E-4SFM1SPOUT methyltransferase; catalyzes omega-monomethylation of Rps3p on Arg-146; not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism
YJL112W3.571.77E-4MDV1Peripheral protein of cytosolic face of mitochondrial outer membrane; required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats; MDV1 has a paralog, CAF4, that arose from the whole genome duplication
YDR462W3.403.40E-4MRPL28Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
YLR454W_p3.363.85E-4FMP27_pPutative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YOL033W3.363.85E-4MSE1Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated
YMR188C3.344.19E-4MRPS17Mitochondrial ribosomal protein of the small subunit
YOR014W3.304.92E-4RTS1B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A

GO enrichment analysis for SGTC_3096
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1232.69E-21SGTC_32309131665 49.5 μMChembridge (Drug-like library)159437200.0606061
0.0991.86E-14SGTC_32269131256 49.5 μMChembridge (Drug-like library)171780730.113924
0.0911.91E-12SGTC_30899117425 49.5 μMChembridge (Drug-like library)94016570.101449
0.0913.09E-12SGTC_30869117350 49.5 μMChembridge (Drug-like library)26792650.140845
0.0881.41E-11SGTC_9373122-0005 46.7 μMChemDiv (Drug-like library)7595350.0746269
0.0863.79E-11SGTC_30699117009 49.5 μMChembridge (Drug-like library)419049810.160S ribosome export
0.0841.30E-10SGTC_30909117696 49.5 μMChembridge (Drug-like library)79238210.106061
0.0791.05E-9SGTC_31629099653 49.5 μMChembridge (Drug-like library)252375110.196721
0.0782.39E-9SGTC_7181130-0073 349.0 μMChemDiv (Drug-like library)67400200.119403
0.0772.73E-9SGTC_9342950-0684 338.0 μMChemDiv (Drug-like library)11212530.131579
0.0757.69E-9SGTC_28869058944 52.0 μMChembridge (Drug-like library)49499290.0895522
0.0722.87E-8SGTC_1825st052143 62.6 μMTimTec (Natural product derivative library)6741730.140625
0.0706.85E-8SGTC_1100850-0284 111.6 μMChemDiv (Drug-like library)39062650.0632911
0.0707.54E-8SGTC_1861st057647 17.4 μMTimTec (Natural product derivative library)6886680.0714286
0.0708.94E-8SGTC_23629071156 126.0 μMChembridge (Fragment library)6531330.0793651

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3128912769149.47 μM0.7391341316314Chembridge (Drug-like library)338.426722.32815
SGTC_22267298446200 μM0.3508773283010Chembridge (Fragment library)287.379982.70104
SGTC_20965468907200 μM0.333333759785Chembridge (Fragment library)236.293480.44925
SGTC_22867945697125 μM0.31245733Chembridge (Fragment library)287.379982.06904
SGTC_21645685496200 μM0.298246759046Chembridge (Fragment library)257.28781.65704
SGTC_2706st07823982.5 μM0.29090915434492TimTec (Natural product derivative library)242.273161.08712
SGTC_22887946289167.31 μM0.2881361246052Chembridge (Fragment library)271.314381.80204
SGTC_6790422-009141.4 μM0.285714627384ChemDiv (Drug-like library)301.965342.76612Golgi
SGTC_1962st07659564.5 μM0.285714279619TimTec (Natural product derivative library)242.316222.76513redox potentiating
SGTC_3043909230349.47 μM0.28070225236084Chembridge (Drug-like library)299.430443.97302