Deletion Strain | FD score | P-value | Gene | Gene Description |
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YPR060C | 9.36 | 3.88E-21 | ARO7 | Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis |
YIR023W | 7.58 | 1.70E-14 | DAL81 | Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism |
YBR069C | 6.41 | 7.45E-11 | TAT1 | Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress |
YKR019C | 6.25 | 1.99E-10 | IRS4 | EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication |
YGL186C | 5.88 | 2.11E-9 | TPN1 | Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p |
YER090W | 5.83 | 2.85E-9 | TRP2 | Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p |
YLR255C_d | 5.47 | 2.29E-8 | YLR255C_d | Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YNR057C | 5.45 | 2.55E-8 | BIO4 | Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels |
YJR105W | 5.39 | 3.43E-8 | ADO1 | Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle |
YKR042W | 5.37 | 3.95E-8 | UTH1 | Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication |
YCR043C_p | 5.25 | 7.55E-8 | YCR043C_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene |
YLR236C_d | 5.25 | 7.67E-8 | YLR236C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
YPR172W_p | 5.19 | 1.07E-7 | YPR172W_p | Putative pyridoxal 5'-phosphate synthase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; YPR172W has a paralog, YLR456W, that arose from the whole genome duplication |
YDR320C | 4.88 | 5.37E-7 | SWA2 | Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles |
YNL323W | 4.86 | 5.89E-7 | LEM3 | Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane |