Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YDL195W | 6.50 | 3.89E-11 | 1.38 | SEC31 | Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance |
YBL023C | 5.13 | 1.46E-7 | 0.93 | MCM2 | Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress |
YFR031C | 4.20 | 1.36E-5 | 0.08 | SMC2 | Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus |
YDR473C | 4.12 | 1.89E-5 | 0.68 | PRP3 | Splicing factor, component of the U4/U6-U5 snRNP complex |
YBL004W | 3.44 | 2.93E-4 | 0.15 | UTP20 | Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA |
YER168C | 3.29 | 5.04E-4 | 0.16 | CCA1 | ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites |
YDR356W | 3.13 | 8.83E-4 | 0.03 | SPC110 | Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner |
YOR361C | 3.10 | 9.79E-4 | 0.04 | PRT1 | eIF3b subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes |
YOR174W | 3.05 | 0.00114 | 0.01 | MED4 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation |
YBR152W | 3.04 | 0.00117 | 0.03 | SPP381 | mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p |
YDR489W | 3.01 | 0.00131 | 0.10 | SLD5 | Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery |
YAL038W | 2.91 | 0.00179 | 0.02 | CDC19 | Pyruvate kinase; functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration; regulated via allosteric activation by fructose bisphosphate; CDC19 has a paralog, PYK2, that arose from the whole genome duplication |
YMR061W | 2.89 | 0.00191 | 0.03 | RNA14 | Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping |
YPR187W | 2.86 | 0.00211 | 0.06 | RPO26 | RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit |
YHR062C | 2.80 | 0.00257 | 0.00 | RPP1 | Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs |