9120822

4-methoxy-N-[3-(oxolan-2-ylmethoxy)phenyl]benzamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3103
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 17141819
SMILES COC1=CC=C(C=C1)C(=O)NC2=CC(=CC=C2)OCC3CCCO3
Standardized SMILES COc1ccc(cc1)C(=O)Nc2cccc(OCC3CCCO3)c2
Molecular weight 327.3743
ALogP 2.94
H-bond donor count 1
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 3.64
% growth inhibition (Hom. pool) 4.05


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 17141819
Download HIP data (tab-delimited text)  (excel)
Gene:CIA2(YHR122W)|FD-Score:3.81|P-value:6.85E-5|Clearance:0.05||SGD DESC:Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B Gene:COG4(YPR105C)|FD-Score:3.45|P-value:2.80E-4|Clearance:0.01||SGD DESC:Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:DAD2(YKR083C)|FD-Score:-3.6|P-value:1.61E-4|Clearance:0||SGD DESC:Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis Gene:DBP2(YNL112W)|FD-Score:3.14|P-value:8.52E-4|Clearance:0.01||SGD DESC:ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites Gene:DED1(YOR204W)|FD-Score:3.13|P-value:8.88E-4|Clearance:0.04||SGD DESC:ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility Gene:ERG29(YMR134W_p)|FD-Score:-4.06|P-value:2.47E-5|Clearance:0||SGD DESC:Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes Gene:EXO84(YBR102C)|FD-Score:3.33|P-value:4.40E-4|Clearance:0.05||SGD DESC:Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate Gene:LSG1(YGL099W)|FD-Score:-4.41|P-value:5.26E-6|Clearance:0||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:MED6(YHR058C)|FD-Score:3.25|P-value:5.77E-4|Clearance:0.11||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress Gene:NET1(YJL076W)|FD-Score:-3.84|P-value:6.21E-5|Clearance:0||SGD DESC:Core subunit of the RENT complex; involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure; NET1 has a paralog, TOF2, that arose from the whole genome duplication Gene:NIP1(YMR309C)|FD-Score:4.19|P-value:1.39E-5|Clearance:0.38||SGD DESC:eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection Gene:PGS1(YCL004W)|FD-Score:4.51|P-value:3.20E-6|Clearance:0.38||SGD DESC:Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis Gene:PRE4(YFR050C)|FD-Score:3.41|P-value:3.24E-4|Clearance:0.04||SGD DESC:Beta 7 subunit of the 20S proteasome Gene:PSF3(YOL146W)|FD-Score:3.75|P-value:8.77E-5|Clearance:0.3||SGD DESC:Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery Gene:QRI1(YDL103C)|FD-Score:3.77|P-value:8.31E-5|Clearance:0.01||SGD DESC:UDP-N-acetylglucosamine pyrophosphorylase; catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis; protein abundance increases in response to DNA replication stress Gene:ROK1(YGL171W)|FD-Score:-3.66|P-value:1.27E-4|Clearance:0||SGD DESC:RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation Gene:RPC82(YPR190C)|FD-Score:4.92|P-value:4.23E-7|Clearance:0.38||SGD DESC:RNA polymerase III subunit C82 Gene:RPO31(YOR116C)|FD-Score:5.08|P-value:1.88E-7|Clearance:0.38||SGD DESC:RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 Gene:RPS15(YOL040C)|FD-Score:-3.49|P-value:2.45E-4|Clearance:0||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19 Gene:RRN7(YJL025W)|FD-Score:-3.21|P-value:6.75E-4|Clearance:0||SGD DESC:Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p Gene:SEC21(YNL287W)|FD-Score:4.62|P-value:1.90E-6|Clearance:0.38||SGD DESC:Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo Gene:SEC23(YPR181C)|FD-Score:3.27|P-value:5.31E-4|Clearance:0.02||SGD DESC:GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p Gene:SNU23(YDL098C)|FD-Score:3.44|P-value:2.92E-4|Clearance:0||SGD DESC:Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome Gene:SRP21(YKL122C)|FD-Score:3.37|P-value:3.82E-4|Clearance:0.04||SGD DESC:Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm Gene:TAM41(YGR046W)|FD-Score:-3.22|P-value:6.43E-4|Clearance:0||SGD DESC:Mitochondrial protein required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition Gene:TIF35(YDR429C)|FD-Score:5.4|P-value:3.30E-8|Clearance:0.38||SGD DESC:eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation Gene:TSR4(YOL022C)|FD-Score:4.71|P-value:1.25E-6|Clearance:0.38||SGD DESC:Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2 Gene:UTP4(YDR324C)|FD-Score:-5.37|P-value:3.96E-8|Clearance:0||SGD DESC:Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript Gene:VRG4(YGL225W)|FD-Score:3.44|P-value:2.92E-4|Clearance:0.03||SGD DESC:Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi Gene:CIA2(YHR122W)|FD-Score:3.81|P-value:6.85E-5|Clearance:0.05||SGD DESC:Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B Gene:COG4(YPR105C)|FD-Score:3.45|P-value:2.80E-4|Clearance:0.01||SGD DESC:Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments Gene:DAD2(YKR083C)|FD-Score:-3.6|P-value:1.61E-4|Clearance:0||SGD DESC:Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis Gene:DBP2(YNL112W)|FD-Score:3.14|P-value:8.52E-4|Clearance:0.01||SGD DESC:ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites Gene:DED1(YOR204W)|FD-Score:3.13|P-value:8.88E-4|Clearance:0.04||SGD DESC:ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility Gene:ERG29(YMR134W_p)|FD-Score:-4.06|P-value:2.47E-5|Clearance:0||SGD DESC:Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes Gene:EXO84(YBR102C)|FD-Score:3.33|P-value:4.40E-4|Clearance:0.05||SGD DESC:Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate Gene:LSG1(YGL099W)|FD-Score:-4.41|P-value:5.26E-6|Clearance:0||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:MED6(YHR058C)|FD-Score:3.25|P-value:5.77E-4|Clearance:0.11||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; protein abundance increases in response to DNA replication stress Gene:NET1(YJL076W)|FD-Score:-3.84|P-value:6.21E-5|Clearance:0||SGD DESC:Core subunit of the RENT complex; involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure; NET1 has a paralog, TOF2, that arose from the whole genome duplication Gene:NIP1(YMR309C)|FD-Score:4.19|P-value:1.39E-5|Clearance:0.38||SGD DESC:eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection Gene:PGS1(YCL004W)|FD-Score:4.51|P-value:3.20E-6|Clearance:0.38||SGD DESC:Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis Gene:PRE4(YFR050C)|FD-Score:3.41|P-value:3.24E-4|Clearance:0.04||SGD DESC:Beta 7 subunit of the 20S proteasome Gene:PSF3(YOL146W)|FD-Score:3.75|P-value:8.77E-5|Clearance:0.3||SGD DESC:Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery Gene:QRI1(YDL103C)|FD-Score:3.77|P-value:8.31E-5|Clearance:0.01||SGD DESC:UDP-N-acetylglucosamine pyrophosphorylase; catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis; protein abundance increases in response to DNA replication stress Gene:ROK1(YGL171W)|FD-Score:-3.66|P-value:1.27E-4|Clearance:0||SGD DESC:RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation Gene:RPC82(YPR190C)|FD-Score:4.92|P-value:4.23E-7|Clearance:0.38||SGD DESC:RNA polymerase III subunit C82 Gene:RPO31(YOR116C)|FD-Score:5.08|P-value:1.88E-7|Clearance:0.38||SGD DESC:RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 Gene:RPS15(YOL040C)|FD-Score:-3.49|P-value:2.45E-4|Clearance:0||SGD DESC:Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19 Gene:RRN7(YJL025W)|FD-Score:-3.21|P-value:6.75E-4|Clearance:0||SGD DESC:Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p Gene:SEC21(YNL287W)|FD-Score:4.62|P-value:1.90E-6|Clearance:0.38||SGD DESC:Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo Gene:SEC23(YPR181C)|FD-Score:3.27|P-value:5.31E-4|Clearance:0.02||SGD DESC:GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p Gene:SNU23(YDL098C)|FD-Score:3.44|P-value:2.92E-4|Clearance:0||SGD DESC:Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome Gene:SRP21(YKL122C)|FD-Score:3.37|P-value:3.82E-4|Clearance:0.04||SGD DESC:Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm Gene:TAM41(YGR046W)|FD-Score:-3.22|P-value:6.43E-4|Clearance:0||SGD DESC:Mitochondrial protein required for cardiolipin biosynthesis; viability of null mutant is strain-dependent; mRNA is targeted to the bud; mutant displays defect in mitochondrial protein import, likely due to altered membrane lipid composition Gene:TIF35(YDR429C)|FD-Score:5.4|P-value:3.30E-8|Clearance:0.38||SGD DESC:eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation Gene:TSR4(YOL022C)|FD-Score:4.71|P-value:1.25E-6|Clearance:0.38||SGD DESC:Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2 Gene:UTP4(YDR324C)|FD-Score:-5.37|P-value:3.96E-8|Clearance:0||SGD DESC:Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript Gene:VRG4(YGL225W)|FD-Score:3.44|P-value:2.92E-4|Clearance:0.03||SGD DESC:Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 17141819
Download HOP data (tab-delimited text)  (excel)
Gene:ADO1(YJR105W)|FD-Score:5.58|P-value:1.20E-8||SGD DESC:Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle Gene:ALR2(YFL050C)|FD-Score:-3.43|P-value:3.00E-4||SGD DESC:Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition Gene:APA1(YCL050C)|FD-Score:-3.17|P-value:7.67E-4||SGD DESC:AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication Gene:ARL3(YPL051W)|FD-Score:3.17|P-value:7.62E-4||SGD DESC:GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor Gene:ARO2(YGL148W)|FD-Score:-3.16|P-value:7.80E-4||SGD DESC:Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress Gene:ASF1(YJL115W)|FD-Score:-3.14|P-value:8.48E-4||SGD DESC:Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition Gene:BNA3(YJL060W)|FD-Score:4.04|P-value:2.72E-5||SGD DESC:Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate Gene:CBP1(YJL209W)|FD-Score:5.07|P-value:1.96E-7||SGD DESC:Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress Gene:CLC1(YGR167W)|FD-Score:3.12|P-value:9.17E-4||SGD DESC:Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W Gene:COS111(YBR203W)|FD-Score:3.39|P-value:3.53E-4||SGD DESC:Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:COX14(YML129C)|FD-Score:-3.57|P-value:1.82E-4||SGD DESC:Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes Gene:ENT5(YDR153C)|FD-Score:4.67|P-value:1.48E-6||SGD DESC:Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin Gene:FMP27(YLR454W_p)|FD-Score:3.94|P-value:4.11E-5||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:GLE2(YER107C)|FD-Score:-3.14|P-value:8.32E-4||SGD DESC:RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1 Gene:GLR1(YPL091W)|FD-Score:3.56|P-value:1.85E-4||SGD DESC:Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress Gene:KAR5(YMR065W)|FD-Score:-4.17|P-value:1.55E-5||SGD DESC:Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone Gene:MND2(YIR025W)|FD-Score:-3.46|P-value:2.74E-4||SGD DESC:Subunit of the anaphase-promoting complex (APC); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase Gene:MNT3(YIL014W)|FD-Score:3.65|P-value:1.31E-4||SGD DESC:Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation Gene:MPM1(YJL066C)|FD-Score:4.06|P-value:2.50E-5||SGD DESC:Mitochondrial intermembrane space protein of unknown function Gene:MSH5(YDL154W)|FD-Score:3.4|P-value:3.40E-4||SGD DESC:Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans Gene:MSN2(YMR037C)|FD-Score:3.47|P-value:2.57E-4||SGD DESC:Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN2 has a paralog, MSN4, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:OAR1(YKL055C)|FD-Score:-3.82|P-value:6.74E-5||SGD DESC:Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p Gene:OYE2(YHR179W)|FD-Score:3.12|P-value:9.11E-4||SGD DESC:Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress Gene:PAD1(YDR538W)|FD-Score:4.29|P-value:8.94E-6||SGD DESC:Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX Gene:PEX2(YJL210W)|FD-Score:4.19|P-value:1.41E-5||SGD DESC:RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import Gene:PHM6(YDR281C)|FD-Score:-3.73|P-value:9.56E-5||SGD DESC:Protein of unknown function, expression is regulated by phosphate levels Gene:PHO88(YBR106W)|FD-Score:6.09|P-value:5.81E-10||SGD DESC:Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations Gene:PTR2(YKR093W)|FD-Score:-3.1|P-value:9.65E-4||SGD DESC:Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p Gene:PUG1(YER185W)|FD-Score:-4.64|P-value:1.71E-6||SGD DESC:Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins Gene:RAD26(YJR035W)|FD-Score:3.84|P-value:6.09E-5||SGD DESC:Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein Gene:RUD3(YOR216C)|FD-Score:3.59|P-value:1.65E-4||SGD DESC:Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1 Gene:RVS161(YCR009C)|FD-Score:5.08|P-value:1.94E-7||SGD DESC:Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress Gene:SAM4(YPL273W)|FD-Score:3.24|P-value:5.92E-4||SGD DESC:S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio Gene:SEC22(YLR268W)|FD-Score:-3.34|P-value:4.13E-4||SGD DESC:R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog Gene:SEC72(YLR292C)|FD-Score:3.88|P-value:5.32E-5||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SLA2(YNL243W)|FD-Score:-3.37|P-value:3.73E-4||SGD DESC:Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo Gene:SOL2(YCR073W-A)|FD-Score:4.2|P-value:1.33E-5||SGD DESC:Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication Gene:SPL2(YHR136C)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm Gene:SPS2(YDR522C)|FD-Score:3.28|P-value:5.12E-4||SGD DESC:Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component Gene:SPT3(YDR392W)|FD-Score:3.32|P-value:4.50E-4||SGD DESC:Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters Gene:SYO1(YDL063C)|FD-Score:4.1|P-value:2.06E-5||SGD DESC:Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus Gene:VPS25(YJR102C)|FD-Score:3.55|P-value:1.91E-4||SGD DESC:Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome Gene:VPS29(YHR012W)|FD-Score:-5.48|P-value:2.13E-8||SGD DESC:Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval Gene:YBL012C(YBL012C_d)|FD-Score:3.59|P-value:1.64E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YBR184W(YBR184W_p)|FD-Score:3.36|P-value:3.86E-4||SGD DESC:Putative protein of unknown function; YBR184W is not an essential gene Gene:YCR095W-A(YCR095W-A_p)|FD-Score:6.02|P-value:8.50E-10||SGD DESC:Putative protein of unknown function Gene:YCR102W-A(YCR102W-A_d)|FD-Score:4.84|P-value:6.37E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR114C(YDR114C_p)|FD-Score:3.57|P-value:1.76E-4||SGD DESC:Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium Gene:YDR535C(YDR535C_d)|FD-Score:3.38|P-value:3.61E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene. Gene:YFL013W-A(YFL013W-A_d)|FD-Score:3.19|P-value:7.08E-4||SGD DESC:Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching Gene:YGL262W(YGL262W_p)|FD-Score:3.51|P-value:2.23E-4||SGD DESC:Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene Gene:YGR164W(YGR164W_d)|FD-Score:3.13|P-value:8.64E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGR176W(YGR176W_d)|FD-Score:3.83|P-value:6.33E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YHL015W-A(YHL015W-A_p)|FD-Score:3.27|P-value:5.44E-4||SGD DESC:Putative protein of unknown function Gene:YJR115W(YJR115W_p)|FD-Score:3.93|P-value:4.26E-5||SGD DESC:Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication Gene:YLR225C(YLR225C_p)|FD-Score:-4.09|P-value:2.20E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene Gene:YOR248W(YOR248W_d)|FD-Score:3.4|P-value:3.39E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPL185W(YPL185W_d)|FD-Score:3.5|P-value:2.32E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C Gene:ZRC1(YMR243C)|FD-Score:3.47|P-value:2.63E-4||SGD DESC:Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication Gene:ADO1(YJR105W)|FD-Score:5.58|P-value:1.20E-8||SGD DESC:Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle Gene:ALR2(YFL050C)|FD-Score:-3.43|P-value:3.00E-4||SGD DESC:Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition Gene:APA1(YCL050C)|FD-Score:-3.17|P-value:7.67E-4||SGD DESC:AP4A phosphorylase; bifunctional diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase and ADP sulfurylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; catalyzes phosphorolysis of dinucleoside oligophosphates, cleaving substrates' alpha/beta-anhydride bond and introducing Pi into the beta-position of the corresponding NDP formed; protein abundance increases under DNA replication stress; APA1 has a paralog, APA2, that arose from the whole genome duplication Gene:ARL3(YPL051W)|FD-Score:3.17|P-value:7.62E-4||SGD DESC:GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor Gene:ARO2(YGL148W)|FD-Score:-3.16|P-value:7.80E-4||SGD DESC:Bifunctional chorismate synthase and flavin reductase; catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids; protein abundance increases in response to DNA replication stress Gene:ASF1(YJL115W)|FD-Score:-3.14|P-value:8.48E-4||SGD DESC:Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition Gene:BNA3(YJL060W)|FD-Score:4.04|P-value:2.72E-5||SGD DESC:Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate Gene:CBP1(YJL209W)|FD-Score:5.07|P-value:1.96E-7||SGD DESC:Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress Gene:CLC1(YGR167W)|FD-Score:3.12|P-value:9.17E-4||SGD DESC:Clathrin light chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component; YGR167W Gene:COS111(YBR203W)|FD-Score:3.39|P-value:3.53E-4||SGD DESC:Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:COX14(YML129C)|FD-Score:-3.57|P-value:1.82E-4||SGD DESC:Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes Gene:ENT5(YDR153C)|FD-Score:4.67|P-value:1.48E-6||SGD DESC:Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin Gene:FMP27(YLR454W_p)|FD-Score:3.94|P-value:4.11E-5||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:GLE2(YER107C)|FD-Score:-3.14|P-value:8.32E-4||SGD DESC:RNA export factor associated with the nuclear pore complex (NPC); associates with NUP116p; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p and human RAE1 Gene:GLR1(YPL091W)|FD-Score:3.56|P-value:1.85E-4||SGD DESC:Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia; protein abundance increases in response to DNA replication stress Gene:KAR5(YMR065W)|FD-Score:-4.17|P-value:1.55E-5||SGD DESC:Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone Gene:MND2(YIR025W)|FD-Score:-3.46|P-value:2.74E-4||SGD DESC:Subunit of the anaphase-promoting complex (APC); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase Gene:MNT3(YIL014W)|FD-Score:3.65|P-value:1.31E-4||SGD DESC:Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation Gene:MPM1(YJL066C)|FD-Score:4.06|P-value:2.50E-5||SGD DESC:Mitochondrial intermembrane space protein of unknown function Gene:MSH5(YDL154W)|FD-Score:3.4|P-value:3.40E-4||SGD DESC:Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans Gene:MSN2(YMR037C)|FD-Score:3.47|P-value:2.57E-4||SGD DESC:Transcriptional activator; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression; MSN2 has a paralog, MSN4, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress Gene:OAR1(YKL055C)|FD-Score:-3.82|P-value:6.74E-5||SGD DESC:Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p Gene:OYE2(YHR179W)|FD-Score:3.12|P-value:9.11E-4||SGD DESC:Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress Gene:PAD1(YDR538W)|FD-Score:4.29|P-value:8.94E-6||SGD DESC:Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX Gene:PEX2(YJL210W)|FD-Score:4.19|P-value:1.41E-5||SGD DESC:RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import Gene:PHM6(YDR281C)|FD-Score:-3.73|P-value:9.56E-5||SGD DESC:Protein of unknown function, expression is regulated by phosphate levels Gene:PHO88(YBR106W)|FD-Score:6.09|P-value:5.81E-10||SGD DESC:Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations Gene:PTR2(YKR093W)|FD-Score:-3.1|P-value:9.65E-4||SGD DESC:Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p Gene:PUG1(YER185W)|FD-Score:-4.64|P-value:1.71E-6||SGD DESC:Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins Gene:RAD26(YJR035W)|FD-Score:3.84|P-value:6.09E-5||SGD DESC:Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein Gene:RUD3(YOR216C)|FD-Score:3.59|P-value:1.65E-4||SGD DESC:Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1 Gene:RVS161(YCR009C)|FD-Score:5.08|P-value:1.94E-7||SGD DESC:Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress Gene:SAM4(YPL273W)|FD-Score:3.24|P-value:5.92E-4||SGD DESC:S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio Gene:SEC22(YLR268W)|FD-Score:-3.34|P-value:4.13E-4||SGD DESC:R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog Gene:SEC72(YLR292C)|FD-Score:3.88|P-value:5.32E-5||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SLA2(YNL243W)|FD-Score:-3.37|P-value:3.73E-4||SGD DESC:Adaptor protein that links actin to clathrin and endocytosis; involved in membrane cytoskeleton assembly and cell polarization; present in the actin cortical patch of the emerging bud tip; dimer in vivo Gene:SOL2(YCR073W-A)|FD-Score:4.2|P-value:1.33E-5||SGD DESC:Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication Gene:SPL2(YHR136C)|FD-Score:3.66|P-value:1.27E-4||SGD DESC:Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm Gene:SPS2(YDR522C)|FD-Score:3.28|P-value:5.12E-4||SGD DESC:Protein expressed during sporulation; SPS2 has a paralog, SPS22, that arose from the whole genome duplication; redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component Gene:SPT3(YDR392W)|FD-Score:3.32|P-value:4.50E-4||SGD DESC:Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters Gene:SYO1(YDL063C)|FD-Score:4.1|P-value:2.06E-5||SGD DESC:Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus Gene:VPS25(YJR102C)|FD-Score:3.55|P-value:1.91E-4||SGD DESC:Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome Gene:VPS29(YHR012W)|FD-Score:-5.48|P-value:2.13E-8||SGD DESC:Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval Gene:YBL012C(YBL012C_d)|FD-Score:3.59|P-value:1.64E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YBR184W(YBR184W_p)|FD-Score:3.36|P-value:3.86E-4||SGD DESC:Putative protein of unknown function; YBR184W is not an essential gene Gene:YCR095W-A(YCR095W-A_p)|FD-Score:6.02|P-value:8.50E-10||SGD DESC:Putative protein of unknown function Gene:YCR102W-A(YCR102W-A_d)|FD-Score:4.84|P-value:6.37E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR114C(YDR114C_p)|FD-Score:3.57|P-value:1.76E-4||SGD DESC:Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium Gene:YDR535C(YDR535C_d)|FD-Score:3.38|P-value:3.61E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene. Gene:YFL013W-A(YFL013W-A_d)|FD-Score:3.19|P-value:7.08E-4||SGD DESC:Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching Gene:YGL262W(YGL262W_p)|FD-Score:3.51|P-value:2.23E-4||SGD DESC:Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene Gene:YGR164W(YGR164W_d)|FD-Score:3.13|P-value:8.64E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YGR176W(YGR176W_d)|FD-Score:3.83|P-value:6.33E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YHL015W-A(YHL015W-A_p)|FD-Score:3.27|P-value:5.44E-4||SGD DESC:Putative protein of unknown function Gene:YJR115W(YJR115W_p)|FD-Score:3.93|P-value:4.26E-5||SGD DESC:Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication Gene:YLR225C(YLR225C_p)|FD-Score:-4.09|P-value:2.20E-5||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene Gene:YOR248W(YOR248W_d)|FD-Score:3.4|P-value:3.39E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPL185W(YPL185W_d)|FD-Score:3.5|P-value:2.32E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C Gene:ZRC1(YMR243C)|FD-Score:3.47|P-value:2.63E-4||SGD DESC:Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication

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Top 15 HET fitness defect scores (HIP)

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Deletion Strain FD score P-value Clearance Gene Gene Description
YDR429C5.403.30E-80.38TIF35eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation
YOR116C5.081.88E-70.38RPO31RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
YPR190C4.924.23E-70.38RPC82RNA polymerase III subunit C82
YOL022C4.711.25E-60.38TSR4Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2
YNL287W4.621.90E-60.38SEC21Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
YCL004W4.513.20E-60.38PGS1Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis
YMR309C4.191.39E-50.38NIP1eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection
YHR122W3.816.85E-50.05CIA2Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia1p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; ortholog of human FAM96B
YDL103C3.778.31E-50.01QRI1UDP-N-acetylglucosamine pyrophosphorylase; catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis; protein abundance increases in response to DNA replication stress
YOL146W3.758.77E-50.30PSF3Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
YPR105C3.452.80E-40.01COG4Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
YDL098C3.442.92E-41.26E-4SNU23Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome
YGL225W3.442.92E-40.03VRG4Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
YFR050C3.413.24E-40.04PRE4Beta 7 subunit of the 20S proteasome
YKL122C3.373.82E-40.04SRP21Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm

Top 15 HOM fitness defect scores (HOP)

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Deletion Strain FD score P-value Gene Gene Description
YBR106W6.095.81E-10PHO88Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
YCR095W-A_p6.028.50E-10YCR095W-A_pPutative protein of unknown function
YJR105W5.581.20E-8ADO1Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YCR009C5.081.94E-7RVS161Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress
YJL209W5.071.96E-7CBP1Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress
YCR102W-A_d4.846.37E-7YCR102W-A_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR153C4.671.48E-6ENT5Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin
YDR538W4.298.94E-6PAD1Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX
YCR073W-A4.201.33E-5SOL2Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication
YJL210W4.191.41E-5PEX2RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import
YDL063C4.102.06E-5SYO1Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YJL066C4.062.50E-5MPM1Mitochondrial intermembrane space protein of unknown function
YJL060W4.042.72E-5BNA3Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate
YLR454W_p3.944.11E-5FMP27_pPutative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJR115W_p3.934.26E-5YJR115W_pPutative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication

GO enrichment analysis for SGTC_3103
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID		 Tanimoto
Score		 Response
Signature
0.0863.02E-11SGTC_31099122853 49.5 μMChembridge (Drug-like library)12347090.353846
0.0841.05E-10SGTC_2544sphondin 68.5 μMMicrosource (Natural product library)1081040.135135RNA pol III & RNase P/MRP
0.0757.24E-9SGTC_29329016711 44.5 μMChembridge (Drug-like library)71173280.166667
0.0741.51E-8SGTC_1930st074634 34.3 μMTimTec (Natural product derivative library)6842530.0933333RNA pol III & RNase P/MRP
0.0731.93E-8SGTC_2522biochanin a 4.9 μMMicrosource (Natural product library)52803730.191781RNA pol III & RNase P/MRP
0.0714.29E-8SGTC_2411st077133 39.9 μMTimTec (Natural product derivative library)14031420.210526RNA pol III & RNase P/MRP
0.0708.96E-8SGTC_12360330-0013 258.0 μMChemDiv (Drug-like library)46170660.106667
0.0672.40E-7SGTC_1923455-0609 60.9 μMChemDiv (Drug-like library)37696390.0571429
0.0631.17E-6SGTC_2738aclarubicin 5.5 μMMiscellaneous4514150.138211RNA pol III & RNase P/MRP
0.0595.10E-6SGTC_910417-1751 58.4 μMChemDiv (Drug-like library)67956240.0666667Golgi
0.0589.31E-6SGTC_31429086498 49.5 μMChembridge (Drug-like library)252363670.170732iron homeostasis
0.0589.81E-6SGTC_6781218-2179 85.9 μMChemDiv (Drug-like library)68200810.126582RNA pol III & RNase P/MRP
0.0561.70E-5SGTC_2685mycophenolic acid 18.9 μMMiscellaneous4465410.127907RNA pol III & RNase P/MRP
0.0525.89E-5SGTC_57miconazole 162.5 nMChemDiv (Drug-like library)41890.0705882ergosterol depletion effects on membrane
0.0526.16E-5SGTC_21385575593 77.7 μMChembridge (Fragment library)7622130.115942

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count		 H-bond
acceptor
count		 Response
Signature
SGTC_3226913125649.47 μM0.63934417178073Chembridge (Drug-like library)333.3292863.36815
SGTC_3092911724849.47 μM0.63793117141857Chembridge (Drug-like library)346.808063.52923cell wall signaling
SGTC_3077911731949.47 μM0.53571417154678Chembridge (Drug-like library)285.337663.30813
SGTC_2871903851012.99 μM0.5254244945164Chembridge (Drug-like library)283.321783.19813
SGTC_2881905895351.95 μM0.52542417122249Chembridge (Drug-like library)281.30593.77413
SGTC_2999906976571.43 μM0.5087722097066Chembridge (Drug-like library)285.337663.30813amide catabolism
SGTC_3072911641949.47 μM0.50793717170162Chembridge (Drug-like library)331.793423.62113ERG2
SGTC_3091911637249.47 μM0.49152517169793Chembridge (Drug-like library)285.337662.95313
SGTC_3184910875849.47 μM0.482143902885Chembridge (Drug-like library)241.28512.94712
SGTC_2827799384771.43 μM0.475412985692Chembridge (Drug-like library)283.321783.19813