Deletion Strain | FD score | P-value | Gene | Gene Description |
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YBR106W | 6.09 | 5.81E-10 | PHO88 | Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations |
YCR095W-A_p | 6.02 | 8.50E-10 | YCR095W-A_p | Putative protein of unknown function |
YJR105W | 5.58 | 1.20E-8 | ADO1 | Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle |
YCR009C | 5.08 | 1.94E-7 | RVS161 | Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress |
YJL209W | 5.07 | 1.96E-7 | CBP1 | Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress |
YCR102W-A_d | 4.84 | 6.37E-7 | YCR102W-A_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data |
YDR153C | 4.67 | 1.48E-6 | ENT5 | Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin |
YDR538W | 4.29 | 8.94E-6 | PAD1 | Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX |
YCR073W-A | 4.20 | 1.33E-5 | SOL2 | Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol3p and Sol4p; SOL2 has a paralog, SOL1, that arose from the whole genome duplication |
YJL210W | 4.19 | 1.41E-5 | PEX2 | RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import |
YDL063C | 4.10 | 2.06E-5 | SYO1 | Transport adaptor or symportin; facilitates synchronized nuclear coimport of the two 5S-rRNA binding proteins Rpl5p and Rpl11p; required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus |
YJL066C | 4.06 | 2.50E-5 | MPM1 | Mitochondrial intermembrane space protein of unknown function |
YJL060W | 4.04 | 2.72E-5 | BNA3 | Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate |
YLR454W_p | 3.94 | 4.11E-5 | FMP27_p | Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
YJR115W_p | 3.93 | 4.26E-5 | YJR115W_p | Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication |