Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YLR009W | 4.38 | 5.91E-6 | 0.36 | RLP24 | Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp |
YFL002C | 4.25 | 1.05E-5 | 0.36 | SPB4 | Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients |
YGR074W | 3.90 | 4.91E-5 | 0.21 | SMD1 | Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1; protein abundance increases in response to DNA replication stress |
YLR029C | 3.68 | 1.16E-4 | 0.02 | RPL15A | Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication |
YPR190C | 3.66 | 1.27E-4 | 0.17 | RPC82 | RNA polymerase III subunit C82 |
YJL015C_d | 3.49 | 2.44E-4 | 0.05 | YJL015C_d | Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W |
YPR186C | 3.44 | 2.96E-4 | 0.03 | PZF1 | Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA |
YCR057C | 3.41 | 3.30E-4 | 0.02 | PWP2 | Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis |
YGR119C | 3.38 | 3.57E-4 | 0.01 | NUP57 | FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nic96p and two other FG-nucleoproteins (Nsp1p and Nup49p) |
YLL008W | 3.38 | 3.66E-4 | 0.22 | DRS1 | Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles |
YDL196W_d | 3.16 | 7.87E-4 | 0.03 | YDL196W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 |
YDR232W | 3.13 | 8.79E-4 | 0.21 | HEM1 | 5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p |
YLR005W | 2.92 | 0.00176 | 0.03 | SSL1 | Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p |
YPL169C | 2.89 | 0.00191 | 0.01 | MEX67 | Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP |
YCR093W | 2.88 | 0.00197 | 0.05 | CDC39 | Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor |