9122088

1-morpholin-4-yl-2-(4,6,8-trimethylquinolin-2-yl)sulfanylpropan-1-one

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3111
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 16876704
SMILES CC1=CC(=C2C(=C1)C(=CC(=N2)SC(C)C(=O)N3CCOCC3)C)C
Standardized SMILES CC(Sc1cc(C)c2cc(C)cc(C)c2n1)C(=O)N3CCOCC3
Molecular weight 344.4711
ALogP 3.99
H-bond donor count 0
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 12.72
% growth inhibition (Hom. pool) -2.4


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 16876704
Download HIP data (tab-delimited text)  (excel)
Gene:CSE1(YGL238W)|FD-Score:-3.46|P-value:2.66E-4|Clearance:0||SGD DESC:Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation Gene:DBP2(YNL112W)|FD-Score:3.39|P-value:3.51E-4|Clearance:0.36||SGD DESC:ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites Gene:DRE2(YKR071C)|FD-Score:-3.36|P-value:3.94E-4|Clearance:0||SGD DESC:Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress Gene:HIP1(YGR191W)|FD-Score:-3.37|P-value:3.81E-4|Clearance:0||SGD DESC:High-affinity histidine permease, also involved in the transport of manganese ions Gene:PRP24(YMR268C)|FD-Score:4.18|P-value:1.44E-5|Clearance:0.79||SGD DESC:Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling Gene:RMP1(YLR145W)|FD-Score:-3.41|P-value:3.23E-4|Clearance:0||SGD DESC:Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P Gene:RNA14(YMR061W)|FD-Score:-3.88|P-value:5.16E-5|Clearance:0||SGD DESC:Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping Gene:YML6(YML025C)|FD-Score:-3.4|P-value:3.32E-4|Clearance:0||SGD DESC:Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins Gene:YPL238C(YPL238C_d)|FD-Score:4.72|P-value:1.19E-6|Clearance:0.79||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W Gene:CSE1(YGL238W)|FD-Score:-3.46|P-value:2.66E-4|Clearance:0||SGD DESC:Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation Gene:DBP2(YNL112W)|FD-Score:3.39|P-value:3.51E-4|Clearance:0.36||SGD DESC:ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites Gene:DRE2(YKR071C)|FD-Score:-3.36|P-value:3.94E-4|Clearance:0||SGD DESC:Component of the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18pin an early step in the CIA pathway; ortholog of human Ciapin1; protein abundance increases in response to DNA replication stress Gene:HIP1(YGR191W)|FD-Score:-3.37|P-value:3.81E-4|Clearance:0||SGD DESC:High-affinity histidine permease, also involved in the transport of manganese ions Gene:PRP24(YMR268C)|FD-Score:4.18|P-value:1.44E-5|Clearance:0.79||SGD DESC:Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling Gene:RMP1(YLR145W)|FD-Score:-3.41|P-value:3.23E-4|Clearance:0||SGD DESC:Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P Gene:RNA14(YMR061W)|FD-Score:-3.88|P-value:5.16E-5|Clearance:0||SGD DESC:Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping Gene:YML6(YML025C)|FD-Score:-3.4|P-value:3.32E-4|Clearance:0||SGD DESC:Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins Gene:YPL238C(YPL238C_d)|FD-Score:4.72|P-value:1.19E-6|Clearance:0.79||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 16876704
Download HOP data (tab-delimited text)  (excel)
Gene:AIM18(YHR198C)|FD-Score:3.32|P-value:4.48E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss Gene:AUA1(YFL010W-A)|FD-Score:3.16|P-value:7.81E-4||SGD DESC:Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease Gene:BUB2(YMR055C)|FD-Score:4.18|P-value:1.47E-5||SGD DESC:Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage Gene:CTI6(YPL181W)|FD-Score:3.65|P-value:1.30E-4||SGD DESC:Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain Gene:ELM1(YKL048C)|FD-Score:4.57|P-value:2.44E-6||SGD DESC:Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring Gene:ENT5(YDR153C)|FD-Score:-3.54|P-value:1.98E-4||SGD DESC:Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin Gene:GCV3(YAL044C)|FD-Score:-3.97|P-value:3.54E-5||SGD DESC:H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF Gene:HSE1(YHL002W)|FD-Score:-3.19|P-value:7.07E-4||SGD DESC:Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes Gene:IMO32(YGR031W)|FD-Score:3.24|P-value:5.96E-4||SGD DESC:Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1 Gene:MEH1(YKR007W)|FD-Score:-3.2|P-value:6.78E-4||SGD DESC:Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification Gene:MET16(YPR167C)|FD-Score:-3.61|P-value:1.52E-4||SGD DESC:3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism Gene:MOT2(YER068W)|FD-Score:-3.32|P-value:4.54E-4||SGD DESC:Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications Gene:MSW1(YDR268W)|FD-Score:-3.37|P-value:3.77E-4||SGD DESC:Mitochondrial tryptophanyl-tRNA synthetase Gene:NDT80(YHR124W)|FD-Score:4.07|P-value:2.34E-5||SGD DESC:Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) Gene:NUP133(YKR082W)|FD-Score:-3.44|P-value:2.93E-4||SGD DESC:Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP133 Gene:OXA1(YER154W)|FD-Score:-3.36|P-value:3.86E-4||SGD DESC:Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals Gene:PAU7(YAR020C)|FD-Score:-3.14|P-value:8.54E-4||SGD DESC:Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme Gene:PEX28(YHR150W)|FD-Score:3.25|P-value:5.69E-4||SGD DESC:Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p Gene:POP2(YNR052C)|FD-Score:3.24|P-value:5.89E-4||SGD DESC:RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation Gene:PRO2(YOR323C)|FD-Score:3.82|P-value:6.60E-5||SGD DESC:Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis Gene:RPS17A(YML024W)|FD-Score:-4.09|P-value:2.16E-5||SGD DESC:Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17A has a paralog, RPS17B, that arose from the whole genome duplication Gene:RTG1(YOL067C)|FD-Score:-3.66|P-value:1.27E-4||SGD DESC:Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus Gene:SNT309(YPR101W)|FD-Score:3.2|P-value:6.97E-4||SGD DESC:Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p Gene:SPR6(YER115C)|FD-Score:3.18|P-value:7.32E-4||SGD DESC:Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation Gene:SWS2(YNL081C)|FD-Score:-3.48|P-value:2.54E-4||SGD DESC:Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency Gene:TAT1(YBR069C)|FD-Score:4.2|P-value:1.32E-5||SGD DESC:Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress Gene:TRP4(YDR354W)|FD-Score:3.44|P-value:2.87E-4||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:TUF1(YOR187W)|FD-Score:-4.33|P-value:7.29E-6||SGD DESC:Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans Gene:YNR071C(YNR071C_p)|FD-Score:3.36|P-value:3.95E-4||SGD DESC:Putative aldose 1-epimerase Gene:YPL039W(YPL039W_p)|FD-Score:3.48|P-value:2.52E-4||SGD DESC:Putative protein of unknown function; YPL039W is not an essential gene Gene:AIM18(YHR198C)|FD-Score:3.32|P-value:4.48E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss Gene:AUA1(YFL010W-A)|FD-Score:3.16|P-value:7.81E-4||SGD DESC:Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease Gene:BUB2(YMR055C)|FD-Score:4.18|P-value:1.47E-5||SGD DESC:Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage Gene:CTI6(YPL181W)|FD-Score:3.65|P-value:1.30E-4||SGD DESC:Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain Gene:ELM1(YKL048C)|FD-Score:4.57|P-value:2.44E-6||SGD DESC:Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring Gene:ENT5(YDR153C)|FD-Score:-3.54|P-value:1.98E-4||SGD DESC:Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin Gene:GCV3(YAL044C)|FD-Score:-3.97|P-value:3.54E-5||SGD DESC:H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF Gene:HSE1(YHL002W)|FD-Score:-3.19|P-value:7.07E-4||SGD DESC:Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes Gene:IMO32(YGR031W)|FD-Score:3.24|P-value:5.96E-4||SGD DESC:Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1 Gene:MEH1(YKR007W)|FD-Score:-3.2|P-value:6.78E-4||SGD DESC:Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification Gene:MET16(YPR167C)|FD-Score:-3.61|P-value:1.52E-4||SGD DESC:3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism Gene:MOT2(YER068W)|FD-Score:-3.32|P-value:4.54E-4||SGD DESC:Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications Gene:MSW1(YDR268W)|FD-Score:-3.37|P-value:3.77E-4||SGD DESC:Mitochondrial tryptophanyl-tRNA synthetase Gene:NDT80(YHR124W)|FD-Score:4.07|P-value:2.34E-5||SGD DESC:Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) Gene:NUP133(YKR082W)|FD-Score:-3.44|P-value:2.93E-4||SGD DESC:Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport and NPC biogenesis and is involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; also plays roles in several processes that may require localization of genes or chromosomes at the nuclear periphery, including double-strand break repair, transcription and chromatin silencing; homologous to human NUP133 Gene:OXA1(YER154W)|FD-Score:-3.36|P-value:3.86E-4||SGD DESC:Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals Gene:PAU7(YAR020C)|FD-Score:-3.14|P-value:8.54E-4||SGD DESC:Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme Gene:PEX28(YHR150W)|FD-Score:3.25|P-value:5.69E-4||SGD DESC:Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p Gene:POP2(YNR052C)|FD-Score:3.24|P-value:5.89E-4||SGD DESC:RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation Gene:PRO2(YOR323C)|FD-Score:3.82|P-value:6.60E-5||SGD DESC:Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis Gene:RPS17A(YML024W)|FD-Score:-4.09|P-value:2.16E-5||SGD DESC:Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17A has a paralog, RPS17B, that arose from the whole genome duplication Gene:RTG1(YOL067C)|FD-Score:-3.66|P-value:1.27E-4||SGD DESC:Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus Gene:SNT309(YPR101W)|FD-Score:3.2|P-value:6.97E-4||SGD DESC:Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p Gene:SPR6(YER115C)|FD-Score:3.18|P-value:7.32E-4||SGD DESC:Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation Gene:SWS2(YNL081C)|FD-Score:-3.48|P-value:2.54E-4||SGD DESC:Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency Gene:TAT1(YBR069C)|FD-Score:4.2|P-value:1.32E-5||SGD DESC:Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress Gene:TRP4(YDR354W)|FD-Score:3.44|P-value:2.87E-4||SGD DESC:Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis Gene:TUF1(YOR187W)|FD-Score:-4.33|P-value:7.29E-6||SGD DESC:Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans Gene:YNR071C(YNR071C_p)|FD-Score:3.36|P-value:3.95E-4||SGD DESC:Putative aldose 1-epimerase Gene:YPL039W(YPL039W_p)|FD-Score:3.48|P-value:2.52E-4||SGD DESC:Putative protein of unknown function; YPL039W is not an essential gene

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YPL238C_d4.721.19E-60.79YPL238C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W
YMR268C4.181.44E-50.79PRP24Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling
YNL112W3.393.51E-40.36DBP2ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites
YPR034W3.030.001220.01ARP7Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
YMR093W3.020.001270.09UTP15Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YJL081C2.930.001680.05ARP4Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
YPR107C2.880.001990.08YTH1Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation
YOR217W2.800.002570.01RFC1Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
YPL233W2.790.002610.08NSL1Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation
YJR064W2.720.003290.04CCT5Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YBR136W2.680.003670.03MEC1Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; regulates P-body formation induced by replication stress; monitors and participates in meiotic recombination; associates with shortened, dysfunctional telomeres
YDR054C2.650.004020.09CDC34Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress
YBL105C2.560.005170.03PKC1Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
YIL021W2.540.005600.02RPB3RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit
YER165W2.510.005980.04PAB1Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YKL048C4.572.44E-6ELM1Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring
YBR069C4.201.32E-5TAT1Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress
YMR055C4.181.47E-5BUB2Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage
YHR124W4.072.34E-5NDT80Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE)
YOR323C3.826.60E-5PRO2Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis
YPL181W3.651.30E-4CTI6Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain
YPL039W_p3.482.52E-4YPL039W_pPutative protein of unknown function; YPL039W is not an essential gene
YDR354W3.442.87E-4TRP4Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis
YNR071C_p3.363.95E-4YNR071C_pPutative aldose 1-epimerase
YHR198C3.324.48E-4AIM18Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
YHR150W3.255.69E-4PEX28Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p
YNR052C3.245.89E-4POP2RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation
YGR031W3.245.96E-4IMO32Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1
YPR101W3.206.97E-4SNT309Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p
YER115C3.187.32E-4SPR6Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation

GO enrichment analysis for SGTC_3111
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0938.00E-13SGTC_31149122766 49.5 μMChembridge (Drug-like library)171769850.125
0.0904.68E-12SGTC_9332914-0560 114.0 μMChemDiv (Drug-like library)4638870.056338
0.0896.95E-12SGTC_2501sodium tetradecyl sulfate 13.4 μMMicrosource (Natural product library)236657720.0540541
0.0862.86E-11SGTC_468gf-109203x 121.0 μMICCB bioactive library23960.0561798amide catabolism
0.0864.21E-11SGTC_1025k007-0731 70.0 μMChemDiv (Drug-like library)62561180.084507
0.0822.29E-10SGTC_24665983409 37.1 μMMiscellaneous28796570.1
0.0814.11E-10SGTC_10114112-3381 17.4 μMChemDiv (Drug-like library)28771390.0705882
0.0791.56E-9SGTC_15081080-0625 72.9 μMChemDiv (Drug-like library)7671110.0958904
0.0791.54E-9SGTC_1613st002381 52.1 μMTimTec (Natural product derivative library)5511670.160494
0.0781.79E-9SGTC_507nimesulide 162.0 μMMiscellaneous44950.0641026
0.0732.03E-8SGTC_32309131665 49.5 μMChembridge (Drug-like library)159437200.0985916
0.0722.61E-8SGTC_2636apigenin dimethyl ether 100.0 μMMicrosource (Natural product library)52816010.0789474
0.0722.79E-8SGTC_28639028737 58.4 μMChembridge (Drug-like library)64609170.139241
0.0722.89E-8SGTC_23327982454 138.9 μMChembridge (Fragment library)29817480.105263
0.0722.93E-8SGTC_31199125183 49.5 μMChembridge (Drug-like library)226953340.0821918

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3243913414749.47 μM0.31147524282180Chembridge (Drug-like library)245.343.65103
SGTC_2970909093841.86 μM0.27777817217104Chembridge (Drug-like library)339.43143.55304RNA processing & uracil transport
SGTC_2170morpholine200 μM0.274194121171Chembridge (Fragment library)234.294221.09303
SGTC_6800417-1641114 μM0.260872835990ChemDiv (Drug-like library)339.471163.54702RPP1 & pyrimidine depletion
SGTC_2992907459171.43 μM0.2517741321Chembridge (Drug-like library)374.453981.91215
SGTC_3136909567249.47 μM0.24324317217380Chembridge (Drug-like library)373.876464.21804
SGTC_2147554593289.72 μM0.237288797404Chembridge (Fragment library)232.32142.33802ergosterol biosynthesis
SGTC_3160910021649.47 μM0.23684217191039Chembridge (Drug-like library)359.849883.73204
SGTC_3051909377849.47 μM0.23611117217378Chembridge (Drug-like library)338.443343.5903
SGTC_1963st07656550.3 μM0.2345684914280TimTec (Natural product derivative library)397.464183.60305