Deletion Strain | FD score | P-value | Gene | Gene Description |
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YER090W | 5.08 | 1.90E-7 | TRP2 | Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p |
YLR295C | 4.50 | 3.40E-6 | ATP14 | Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress |
YPL247C_p | 4.31 | 8.18E-6 | YPL247C_p | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest |
YOR205C | 3.90 | 4.84E-5 | GEP3 | Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (phb1) |
YOR219C | 3.68 | 1.19E-4 | STE13 | Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor |
YPL148C | 3.62 | 1.47E-4 | PPT2 | Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation |
YDL047W | 3.57 | 1.81E-4 | SIT4 | Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization |
YDR264C | 3.52 | 2.20E-4 | AKR1 | Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication |
YMR144W_p | 3.46 | 2.67E-4 | YMR144W_p | Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene |
YJL066C | 3.43 | 3.02E-4 | MPM1 | Mitochondrial intermembrane space protein of unknown function |
YHR143W | 3.37 | 3.76E-4 | DSE2 | Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP |
YLR384C | 3.36 | 3.83E-4 | IKI3 | Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD) |
YDL073W_p | 3.35 | 4.07E-4 | YDL073W_p | Putative protein of unknown function; YDL073W is not an essential gene |
YOR193W | 3.30 | 4.82E-4 | PEX27 | Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p |
YOR178C | 3.28 | 5.23E-4 | GAC1 | Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock |