9123671

2,3,4,5-tetrafluoro-N-(1-phenylethyl)benzamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3115
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 3286988
SMILES CC(C1=CC=CC=C1)NC(=O)C2=CC(=C(C(=C2F)F)F)F
Standardized SMILES CC(NC(=O)c1cc(F)c(F)c(F)c1F)c2ccccc2
Molecular weight 297.2476
ALogP 3.82
H-bond donor count 1
H-bond acceptor count 5
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 1.98
% growth inhibition (Hom. pool) 1.22


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 3286988
Download HIP data (tab-delimited text)  (excel)
Gene:CAK1(YFL029C)|FD-Score:-3.66|P-value:1.28E-4|Clearance:0||SGD DESC:Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases Gene:MCM7(YBR202W)|FD-Score:3.67|P-value:1.23E-4|Clearance:0.24||SGD DESC:Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex Gene:PHS1(YJL097W)|FD-Score:-4.04|P-value:2.70E-5|Clearance:0||SGD DESC:Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking Gene:PRE10(YOR362C)|FD-Score:3.43|P-value:3.03E-4|Clearance:0.01||SGD DESC:Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress Gene:RPA43(YOR340C)|FD-Score:3.17|P-value:7.67E-4|Clearance:0.05||SGD DESC:RNA polymerase I subunit A43 Gene:RPP1(YHR062C)|FD-Score:3.12|P-value:9.15E-4|Clearance:0.1||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:SEC31(YDL195W)|FD-Score:4.69|P-value:1.39E-6|Clearance:1.02||SGD DESC:Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance Gene:SEC7(YDR170C)|FD-Score:3.42|P-value:3.10E-4|Clearance:0.23||SGD DESC:Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles Gene:SNU23(YDL098C)|FD-Score:3.2|P-value:6.99E-4|Clearance:0.03||SGD DESC:Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome Gene:CAK1(YFL029C)|FD-Score:-3.66|P-value:1.28E-4|Clearance:0||SGD DESC:Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases Gene:MCM7(YBR202W)|FD-Score:3.67|P-value:1.23E-4|Clearance:0.24||SGD DESC:Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex Gene:PHS1(YJL097W)|FD-Score:-4.04|P-value:2.70E-5|Clearance:0||SGD DESC:Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking Gene:PRE10(YOR362C)|FD-Score:3.43|P-value:3.03E-4|Clearance:0.01||SGD DESC:Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress Gene:RPA43(YOR340C)|FD-Score:3.17|P-value:7.67E-4|Clearance:0.05||SGD DESC:RNA polymerase I subunit A43 Gene:RPP1(YHR062C)|FD-Score:3.12|P-value:9.15E-4|Clearance:0.1||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:SEC31(YDL195W)|FD-Score:4.69|P-value:1.39E-6|Clearance:1.02||SGD DESC:Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance Gene:SEC7(YDR170C)|FD-Score:3.42|P-value:3.10E-4|Clearance:0.23||SGD DESC:Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles Gene:SNU23(YDL098C)|FD-Score:3.2|P-value:6.99E-4|Clearance:0.03||SGD DESC:Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 3286988
Download HOP data (tab-delimited text)  (excel)
Gene:AKR1(YDR264C)|FD-Score:3.52|P-value:2.20E-4||SGD DESC:Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication Gene:ATP14(YLR295C)|FD-Score:4.5|P-value:3.40E-6||SGD DESC:Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress Gene:DSE2(YHR143W)|FD-Score:3.37|P-value:3.76E-4||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP Gene:GAC1(YOR178C)|FD-Score:3.28|P-value:5.23E-4||SGD DESC:Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock Gene:GEP3(YOR205C)|FD-Score:3.9|P-value:4.84E-5||SGD DESC:Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (phb1) Gene:GSP2(YOR185C)|FD-Score:3.17|P-value:7.72E-4||SGD DESC:GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability; protein abundance increases in response to DNA replication stress Gene:IKI3(YLR384C)|FD-Score:3.36|P-value:3.83E-4||SGD DESC:Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD) Gene:MPM1(YJL066C)|FD-Score:3.43|P-value:3.02E-4||SGD DESC:Mitochondrial intermembrane space protein of unknown function Gene:NDT80(YHR124W)|FD-Score:-3.37|P-value:3.76E-4||SGD DESC:Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) Gene:PEX27(YOR193W)|FD-Score:3.3|P-value:4.82E-4||SGD DESC:Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p Gene:PHO89(YBR296C)|FD-Score:-3.7|P-value:1.08E-4||SGD DESC:Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification Gene:PPT2(YPL148C)|FD-Score:3.62|P-value:1.47E-4||SGD DESC:Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation Gene:SAM37(YMR060C)|FD-Score:3.24|P-value:6.03E-4||SGD DESC:Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability Gene:SIT4(YDL047W)|FD-Score:3.57|P-value:1.81E-4||SGD DESC:Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization Gene:STE13(YOR219C)|FD-Score:3.68|P-value:1.19E-4||SGD DESC:Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor Gene:TRP2(YER090W)|FD-Score:5.08|P-value:1.90E-7||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:YDL073W(YDL073W_p)|FD-Score:3.35|P-value:4.07E-4||SGD DESC:Putative protein of unknown function; YDL073W is not an essential gene Gene:YDR194W-A(YDR194W-A_p)|FD-Score:3.25|P-value:5.70E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YIR018C-A(YIR018C-A_p)|FD-Score:3.27|P-value:5.44E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YLR253W(YLR253W_p)|FD-Score:3.19|P-value:7.13E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene Gene:YLR342W-A(YLR342W-A_p)|FD-Score:-3.59|P-value:1.63E-4||SGD DESC:Putative protein of unknown function Gene:YME2(YMR302C)|FD-Score:3.21|P-value:6.62E-4||SGD DESC:Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases Gene:YMR144W(YMR144W_p)|FD-Score:3.46|P-value:2.67E-4||SGD DESC:Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene Gene:YPL247C(YPL247C_p)|FD-Score:4.31|P-value:8.18E-6||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest Gene:AKR1(YDR264C)|FD-Score:3.52|P-value:2.20E-4||SGD DESC:Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication Gene:ATP14(YLR295C)|FD-Score:4.5|P-value:3.40E-6||SGD DESC:Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress Gene:DSE2(YHR143W)|FD-Score:3.37|P-value:3.76E-4||SGD DESC:Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP Gene:GAC1(YOR178C)|FD-Score:3.28|P-value:5.23E-4||SGD DESC:Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock Gene:GEP3(YOR205C)|FD-Score:3.9|P-value:4.84E-5||SGD DESC:Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (phb1) Gene:GSP2(YOR185C)|FD-Score:3.17|P-value:7.72E-4||SGD DESC:GTP binding protein (mammalian Ranp homolog); involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability; protein abundance increases in response to DNA replication stress Gene:IKI3(YLR384C)|FD-Score:3.36|P-value:3.83E-4||SGD DESC:Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD) Gene:MPM1(YJL066C)|FD-Score:3.43|P-value:3.02E-4||SGD DESC:Mitochondrial intermembrane space protein of unknown function Gene:NDT80(YHR124W)|FD-Score:-3.37|P-value:3.76E-4||SGD DESC:Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) Gene:PEX27(YOR193W)|FD-Score:3.3|P-value:4.82E-4||SGD DESC:Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p Gene:PHO89(YBR296C)|FD-Score:-3.7|P-value:1.08E-4||SGD DESC:Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p; mutations in related human transporter genes hPit1 and hPit2 are associated with hyperphosphatemia-induced calcification of vascular tissue and familial idiopathic basal ganglia calcification Gene:PPT2(YPL148C)|FD-Score:3.62|P-value:1.47E-4||SGD DESC:Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation Gene:SAM37(YMR060C)|FD-Score:3.24|P-value:6.03E-4||SGD DESC:Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability Gene:SIT4(YDL047W)|FD-Score:3.57|P-value:1.81E-4||SGD DESC:Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization Gene:STE13(YOR219C)|FD-Score:3.68|P-value:1.19E-4||SGD DESC:Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor Gene:TRP2(YER090W)|FD-Score:5.08|P-value:1.90E-7||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:YDL073W(YDL073W_p)|FD-Score:3.35|P-value:4.07E-4||SGD DESC:Putative protein of unknown function; YDL073W is not an essential gene Gene:YDR194W-A(YDR194W-A_p)|FD-Score:3.25|P-value:5.70E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YIR018C-A(YIR018C-A_p)|FD-Score:3.27|P-value:5.44E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YLR253W(YLR253W_p)|FD-Score:3.19|P-value:7.13E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene Gene:YLR342W-A(YLR342W-A_p)|FD-Score:-3.59|P-value:1.63E-4||SGD DESC:Putative protein of unknown function Gene:YME2(YMR302C)|FD-Score:3.21|P-value:6.62E-4||SGD DESC:Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases Gene:YMR144W(YMR144W_p)|FD-Score:3.46|P-value:2.67E-4||SGD DESC:Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene Gene:YPL247C(YPL247C_p)|FD-Score:4.31|P-value:8.18E-6||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YDL195W4.691.39E-61.02SEC31Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance
YBR202W3.671.23E-40.24MCM7Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex
YOR362C3.433.03E-40.01PRE10Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
YDR170C3.423.10E-40.23SEC7Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
YDL098C3.206.99E-40.03SNU23Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome
YOR340C3.177.67E-40.05RPA43RNA polymerase I subunit A43
YHR062C3.129.15E-40.10RPP1Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YCR035C3.020.001280.03RRP43Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8); protein abundance increases in response to DNA replication stress
YBR196C2.990.001410.01PGI1Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation
YDR053W_d2.980.001450.01YDR053W_dPutative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex
YGL225W2.970.001500.14VRG4Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi
YBR247C2.830.002360.17ENP1Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus
YDL102W2.650.004010.03POL3Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)
YCL054W2.620.004390.03SPB1AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants
YDR489W2.590.004740.06SLD5Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YER090W5.081.90E-7TRP2Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
YLR295C4.503.40E-6ATP14Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; protein abundance increases in response to DNA replication stress
YPL247C_p4.318.18E-6YPL247C_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest
YOR205C3.904.84E-5GEP3Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (phb1)
YOR219C3.681.19E-4STE13Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor
YPL148C3.621.47E-4PPT2Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation
YDL047W3.571.81E-4SIT4Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YDR264C3.522.20E-4AKR1Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats; AKR1 has a paralog, AKR2, that arose from the whole genome duplication
YMR144W_p3.462.67E-4YMR144W_pPutative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene
YJL066C3.433.02E-4MPM1Mitochondrial intermembrane space protein of unknown function
YHR143W3.373.76E-4DSE2Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP
YLR384C3.363.83E-4IKI3Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD)
YDL073W_p3.354.07E-4YDL073W_pPutative protein of unknown function; YDL073W is not an essential gene
YOR193W3.304.82E-4PEX27Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p
YOR178C3.285.23E-4GAC1Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock

GO enrichment analysis for SGTC_3115
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1791.37E-43SGTC_8940960-0238 55.9 μMChemDiv (Drug-like library)67419070.136986
0.1475.08E-30SGTC_1994st072947 40.9 μMTimTec (Natural product derivative library)52865650.08
0.1411.74E-27SGTC_1724st037281 8.3 μMTimTec (Natural product derivative library)5741240.138462
0.1381.85E-26SGTC_1772st048439 82.2 μMTimTec (Natural product derivative library)29270680.078125
0.1187.27E-20SGTC_22246650123 117.6 μMChembridge (Fragment library)29083700.136364
0.1187.86E-20SGTC_1457k015-0032 57.3 μMChemDiv (Drug-like library)43026600.128571
0.1164.81E-19SGTC_1104tacrolimus 29.8 μMNIH Clinical Collection235817960.0416667
0.1133.55E-18SGTC_999SEC7.066 22.7 μMChemDiv (Drug-like library)7405110.0923077Golgi
0.1081.12E-16SGTC_22967971656 126.5 μMChembridge (Fragment library)6665700.084507
0.1071.92E-16SGTC_18815652484 16.0 μMMiscellaneous22551290.106667TRP & mitochondrial translation
0.1062.53E-16SGTC_16014'-hydroxyflavanone 55.5 μMTimTec (Pure natural product library)1655060.1RPP1 & pyrimidine depletion
0.1056.04E-16SGTC_13271436-0082 2.2 μMChemDiv (Drug-like library)159922050.133333
0.1041.25E-15SGTC_10995-nonyloxytryptamine 2.9 μMNIH Clinical Collection235818250.0724638
0.1041.50E-15SGTC_1320417-1715 25.8 μMChemDiv (Drug-like library)67690980.0821918RPP1 & pyrimidine depletion
0.1025.05E-15SGTC_21896047310 154.4 μMChembridge (Fragment library)7115350.111111RPP1 & pyrimidine depletion

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3090911769649.47 μM0.4893627923821Chembridge (Drug-like library)297.2475534.37915
SGTC_2889905965651.95 μM0.4666673949838Chembridge (Drug-like library)287.1848563.64216
SGTC_274sirtinol40.1 μM0.3965526836442Miscellaneous394.465084.31923
SGTC_23639053361176 μM0.3469396469797Chembridge (Fragment library)260.718822.51212Golgi
SGTC_3155909926549.47 μM0.325236499Chembridge (Drug-like library)330.83184.15213
SGTC_7431275-0778158 μM0.2941182849257ChemDiv (Drug-like library)317.445724.10213excess fatty acid
SGTC_3278913960549.47 μM0.2884627958859Chembridge (Drug-like library)267.6585263.6913
SGTC_21245246320200 μM0.285714579342Chembridge (Fragment library)216.2110631.66913heme biosynthesis & mitochondrial translocase
SGTC_3042909157849.47 μM0.27692325236497Chembridge (Drug-like library)314.445083.89313ERG2
SGTC_2856902292519.48 μM0.2758624944862Chembridge (Drug-like library)287.3287234.11213