Deletion Strain | FD score | P-value | Gene | Gene Description |
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YCR066W | 13.80 | 8.04E-44 | RAD18 | E3 ubiquitin ligase; forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair; SUMO-targeted ubiquitin ligase (STUbl) that contains a SUMO-interacting motif (SIM) which stimulates its ubiquitin ligase activity towards the sumoylated form of PCNA |
YIL154C | 5.95 | 1.35E-9 | IMP2' | Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat |
YDR126W | 5.85 | 2.53E-9 | SWF1 | Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion |
YDR444W_p | 5.74 | 4.64E-9 | YDR444W_p | Putative hydrolase acting on ester bonds |
YPL097W | 5.43 | 2.75E-8 | MSY1 | Mitochondrial tyrosyl-tRNA synthetase |
YDR085C | 5.11 | 1.57E-7 | AFR1 | Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p; AFR1 has a paralog, YER158C, that arose from the whole genome duplication |
YCL036W | 5.06 | 2.08E-7 | GFD2 | Protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; GFD2 has a paralog, YDR514C, that arose from the whole genome duplication |
YLR373C | 5.06 | 2.15E-7 | VID22 | Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles |
YPL072W | 5.04 | 2.28E-7 | UBP16 | Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria |
YHR141C | 4.68 | 1.43E-6 | RPL42B | Ribosomal 60S subunit protein L42B; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus; homologous to mammalian ribosomal protein L36A, no bacterial homolog; RPL42B has a paralog, RPL42A, that arose from the whole genome duplication |
YJR095W | 4.57 | 2.41E-6 | SFC1 | Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization |
YLR241W_p | 4.32 | 7.86E-6 | YLR241W_p | Putative protein of unknown function, may be involved in detoxification |
YNR058W | 4.15 | 1.68E-5 | BIO3 | 7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis |
YAR028W_p | 4.08 | 2.30E-5 | YAR028W_p | Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS |
YOL012C | 3.96 | 3.82E-5 | HTZ1 | Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin |