Deletion Strain | FD score | P-value | Clearance | Gene | Gene Description |
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YER012W | 5.37 | 4.01E-8 | 1.56 | PRE1 | Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle |
YNL178W | 3.81 | 6.99E-5 | 0.38 | RPS3 | Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3 |
YMR028W | 3.43 | 2.99E-4 | 0.45 | TAP42 | Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits |
YDL102W | 2.98 | 0.00143 | 0.04 | POL3 | Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER) |
YBR049C | 2.94 | 0.00164 | 0.02 | REB1 | RNA polymerase I enhancer binding protein; DNA binding protein that binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription; REB1 has a paralog, NSI1, that arose from the whole genome duplication |
YKL052C | 2.92 | 0.00173 | 0.13 | ASK1 | Essential subunit of the Dam1 complex (aka DASH complex); couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases; protein abundance increases in response to DNA replication stress |
YCR057C | 2.79 | 0.00263 | 0.02 | PWP2 | Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis |
YPR176C | 2.77 | 0.00280 | 0.05 | BET2 | Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p |
YGR156W | 2.72 | 0.00327 | 0.04 | PTI1 | Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64 |
YDR327W_d | 2.68 | 0.00371 | 0.00 | YDR327W_d | Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SKP1 |
YNL272C | 2.67 | 0.00376 | 0.01 | SEC2 | Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles |
YAL025C | 2.66 | 0.00390 | 0.07 | MAK16 | Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus |
YLR088W | 2.59 | 0.00473 | 0.04 | GAA1 | Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER |
YEL058W | 2.56 | 0.00529 | 0.03 | PCM1 | Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors |
YDL152W_d | 2.53 | 0.00570 | 0.06 | YDL152W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome |