9099931

2-(2-chlorophenoxy)-1-[4-(2-methylphenyl)piperazin-1-yl]ethanone

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3156
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 18111053
SMILES CC1=CC=CC=C1N2CCN(CC2)C(=O)COC3=CC=CC=C3Cl
Standardized SMILES Cc1ccccc1N2CCN(CC2)C(=O)COc3ccccc3Cl
Molecular weight 344.8352
ALogP 3.86
H-bond donor count 0
H-bond acceptor count 3
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 3.51
% growth inhibition (Hom. pool) 1.24


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 18111053
Download HIP data (tab-delimited text)  (excel)
Gene:ACS2(YLR153C)|FD-Score:3.13|P-value:8.77E-4|Clearance:0.02||SGD DESC:Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions Gene:CCT7(YJL111W)|FD-Score:-3.26|P-value:5.49E-4|Clearance:0||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance Gene:CDC21(YOR074C)|FD-Score:3.63|P-value:1.39E-4|Clearance:0.15||SGD DESC:Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S Gene:JAC1(YGL018C)|FD-Score:3.44|P-value:2.95E-4|Clearance:0.07||SGD DESC:Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix Gene:MNP1(YGL068W)|FD-Score:3.25|P-value:5.68E-4|Clearance:0.07||SGD DESC:Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth Gene:MTR4(YJL050W)|FD-Score:3.75|P-value:8.69E-5|Clearance:0.12||SGD DESC:ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing Gene:PDS5(YMR076C)|FD-Score:5.02|P-value:2.60E-7|Clearance:1.26||SGD DESC:Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis Gene:RPC37(YKR025W)|FD-Score:3.18|P-value:7.28E-4|Clearance:0.05||SGD DESC:RNA polymerase III subunit C37 Gene:RSC8(YFR037C)|FD-Score:3.1|P-value:9.55E-4|Clearance:0.29||SGD DESC:Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters Gene:SFH1(YLR321C)|FD-Score:3.49|P-value:2.43E-4|Clearance:0.05||SGD DESC:Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog Gene:URB1(YKL014C)|FD-Score:-3.23|P-value:6.28E-4|Clearance:0||SGD DESC:Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit Gene:YOR102W(YOR102W_d)|FD-Score:3.37|P-value:3.75E-4|Clearance:0.12||SGD DESC:Dubious open reading frame, unlikely to encode a functional protein; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex Gene:ACS2(YLR153C)|FD-Score:3.13|P-value:8.77E-4|Clearance:0.02||SGD DESC:Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions Gene:CCT7(YJL111W)|FD-Score:-3.26|P-value:5.49E-4|Clearance:0||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance Gene:CDC21(YOR074C)|FD-Score:3.63|P-value:1.39E-4|Clearance:0.15||SGD DESC:Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S Gene:JAC1(YGL018C)|FD-Score:3.44|P-value:2.95E-4|Clearance:0.07||SGD DESC:Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix Gene:MNP1(YGL068W)|FD-Score:3.25|P-value:5.68E-4|Clearance:0.07||SGD DESC:Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth Gene:MTR4(YJL050W)|FD-Score:3.75|P-value:8.69E-5|Clearance:0.12||SGD DESC:ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing Gene:PDS5(YMR076C)|FD-Score:5.02|P-value:2.60E-7|Clearance:1.26||SGD DESC:Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis Gene:RPC37(YKR025W)|FD-Score:3.18|P-value:7.28E-4|Clearance:0.05||SGD DESC:RNA polymerase III subunit C37 Gene:RSC8(YFR037C)|FD-Score:3.1|P-value:9.55E-4|Clearance:0.29||SGD DESC:Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters Gene:SFH1(YLR321C)|FD-Score:3.49|P-value:2.43E-4|Clearance:0.05||SGD DESC:Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog Gene:URB1(YKL014C)|FD-Score:-3.23|P-value:6.28E-4|Clearance:0||SGD DESC:Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit Gene:YOR102W(YOR102W_d)|FD-Score:3.37|P-value:3.75E-4|Clearance:0.12||SGD DESC:Dubious open reading frame, unlikely to encode a functional protein; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 18111053
Download HOP data (tab-delimited text)  (excel)
Gene:ALE1(YOR175C)|FD-Score:3.56|P-value:1.88E-4||SGD DESC:Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids Gene:APL4(YPR029C)|FD-Score:3.28|P-value:5.15E-4||SGD DESC:Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport Gene:ARA2(YMR041C)|FD-Score:3.32|P-value:4.53E-4||SGD DESC:NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase Gene:ARF2(YDL137W)|FD-Score:4.15|P-value:1.69E-5||SGD DESC:ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication Gene:CHA4(YLR098C)|FD-Score:3.15|P-value:8.21E-4||SGD DESC:DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain Gene:CHD1(YER164W)|FD-Score:-3.13|P-value:8.67E-4||SGD DESC:Chromatin remodeler that regulates various aspects of transcription; acts in in conjunction with Isw1b to regulate chromatin structure and maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes Gene:COX12(YLR038C)|FD-Score:3.17|P-value:7.56E-4||SGD DESC:Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV Gene:ECM34(YHL043W)|FD-Score:-5.61|P-value:9.83E-9||SGD DESC:Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins Gene:ERP3(YDL018C)|FD-Score:3.14|P-value:8.59E-4||SGD DESC:Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport Gene:ISC10(YER180C)|FD-Score:3.48|P-value:2.53E-4||SGD DESC:Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells Gene:KNH1(YDL049C)|FD-Score:6.87|P-value:3.32E-12||SGD DESC:Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance Gene:LOS1(YKL205W)|FD-Score:3.29|P-value:4.93E-4||SGD DESC:Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm Gene:MDH3(YDL078C)|FD-Score:3.83|P-value:6.38E-5||SGD DESC:Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle Gene:MMR1(YLR190W)|FD-Score:-3.4|P-value:3.39E-4||SGD DESC:Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p Gene:MPA43(YNL249C)|FD-Score:3.43|P-value:3.01E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:MRPL37(YBR268W)|FD-Score:3.13|P-value:8.78E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:NPP2(YEL016C)|FD-Score:4.59|P-value:2.18E-6||SGD DESC:Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication Gene:NRM1(YNR009W)|FD-Score:3.76|P-value:8.42E-5||SGD DESC:Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase Gene:NUM1(YDR150W)|FD-Score:3.96|P-value:3.75E-5||SGD DESC:Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex Gene:OXP1(YKL215C)|FD-Score:3.48|P-value:2.46E-4||SGD DESC:5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress Gene:PAN6(YIL145C)|FD-Score:-3.34|P-value:4.21E-4||SGD DESC:Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC Gene:PHO84(YML123C)|FD-Score:3.16|P-value:7.96E-4||SGD DESC:High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity Gene:PMT5(YDL093W)|FD-Score:3.72|P-value:9.87E-5||SGD DESC:Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals Gene:PTP3(YER075C)|FD-Score:3.75|P-value:8.75E-5||SGD DESC:Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm Gene:RGI1(YER067W)|FD-Score:-5.59|P-value:1.12E-8||SGD DESC:Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress Gene:RPN14(YGL004C)|FD-Score:3.99|P-value:3.25E-5||SGD DESC:Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p Gene:SAN1(YDR143C)|FD-Score:3.25|P-value:5.69E-4||SGD DESC:Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition Gene:SHE9(YDR393W)|FD-Score:3.63|P-value:1.43E-4||SGD DESC:Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex Gene:SIN4(YNL236W)|FD-Score:3.55|P-value:1.95E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription Gene:SPL2(YHR136C)|FD-Score:-3.33|P-value:4.32E-4||SGD DESC:Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm Gene:SPO12(YHR152W)|FD-Score:-3.3|P-value:4.90E-4||SGD DESC:Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis Gene:THP3(YPR045C)|FD-Score:4.45|P-value:4.21E-6||SGD DESC:Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes Gene:TRP2(YER090W)|FD-Score:3.79|P-value:7.66E-5||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:VAB2(YEL005C)|FD-Score:4.45|P-value:4.27E-6||SGD DESC:Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter Gene:VMA1(YDL185W)|FD-Score:3.53|P-value:2.11E-4||SGD DESC:Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease Gene:YAL004W(YAL004W_d)|FD-Score:-3.84|P-value:6.12E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C Gene:YBL086C(YBL086C_p)|FD-Score:3.33|P-value:4.33E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery Gene:YBR285W(YBR285W_p)|FD-Score:4.05|P-value:2.57E-5||SGD DESC:Putative protein of unknown function; YBR285W is not an essential gene Gene:YDR239C(YDR239C)|FD-Score:-3.1|P-value:9.62E-4||SGD DESC:Protein of unknown function that may interact with ribosomes, based on co-purification experiments Gene:YER038W-A(YER038W-A_d)|FD-Score:3.13|P-value:8.85E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria Gene:YLR149C(YLR149C_p)|FD-Score:-4.14|P-value:1.76E-5||SGD DESC:Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress Gene:YMR001C-A(YMR001C-A_p)|FD-Score:-6.2|P-value:2.76E-10||SGD DESC:Putative protein of unknown function Gene:YMR031W-A(YMR031W-A_d)|FD-Score:3.49|P-value:2.42E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C Gene:ALE1(YOR175C)|FD-Score:3.56|P-value:1.88E-4||SGD DESC:Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids Gene:APL4(YPR029C)|FD-Score:3.28|P-value:5.15E-4||SGD DESC:Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport Gene:ARA2(YMR041C)|FD-Score:3.32|P-value:4.53E-4||SGD DESC:NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase Gene:ARF2(YDL137W)|FD-Score:4.15|P-value:1.69E-5||SGD DESC:ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication Gene:CHA4(YLR098C)|FD-Score:3.15|P-value:8.21E-4||SGD DESC:DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain Gene:CHD1(YER164W)|FD-Score:-3.13|P-value:8.67E-4||SGD DESC:Chromatin remodeler that regulates various aspects of transcription; acts in in conjunction with Isw1b to regulate chromatin structure and maintain chromatin integrity during transcription elongation by RNAP II by preventing trans-histone exchange over coding regions; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes Gene:COX12(YLR038C)|FD-Score:3.17|P-value:7.56E-4||SGD DESC:Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV Gene:ECM34(YHL043W)|FD-Score:-5.61|P-value:9.83E-9||SGD DESC:Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins Gene:ERP3(YDL018C)|FD-Score:3.14|P-value:8.59E-4||SGD DESC:Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport Gene:ISC10(YER180C)|FD-Score:3.48|P-value:2.53E-4||SGD DESC:Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells Gene:KNH1(YDL049C)|FD-Score:6.87|P-value:3.32E-12||SGD DESC:Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance Gene:LOS1(YKL205W)|FD-Score:3.29|P-value:4.93E-4||SGD DESC:Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm Gene:MDH3(YDL078C)|FD-Score:3.83|P-value:6.38E-5||SGD DESC:Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle Gene:MMR1(YLR190W)|FD-Score:-3.4|P-value:3.39E-4||SGD DESC:Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p Gene:MPA43(YNL249C)|FD-Score:3.43|P-value:3.01E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:MRPL37(YBR268W)|FD-Score:3.13|P-value:8.78E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:NPP2(YEL016C)|FD-Score:4.59|P-value:2.18E-6||SGD DESC:Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication Gene:NRM1(YNR009W)|FD-Score:3.76|P-value:8.42E-5||SGD DESC:Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase Gene:NUM1(YDR150W)|FD-Score:3.96|P-value:3.75E-5||SGD DESC:Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex Gene:OXP1(YKL215C)|FD-Score:3.48|P-value:2.46E-4||SGD DESC:5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress Gene:PAN6(YIL145C)|FD-Score:-3.34|P-value:4.21E-4||SGD DESC:Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC Gene:PHO84(YML123C)|FD-Score:3.16|P-value:7.96E-4||SGD DESC:High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity Gene:PMT5(YDL093W)|FD-Score:3.72|P-value:9.87E-5||SGD DESC:Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals Gene:PTP3(YER075C)|FD-Score:3.75|P-value:8.75E-5||SGD DESC:Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm Gene:RGI1(YER067W)|FD-Score:-5.59|P-value:1.12E-8||SGD DESC:Protein of unknown function; involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion; protein abundance increases in response to DNA replication stress Gene:RPN14(YGL004C)|FD-Score:3.99|P-value:3.25E-5||SGD DESC:Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p Gene:SAN1(YDR143C)|FD-Score:3.25|P-value:5.69E-4||SGD DESC:Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordered regions that contribute to substrate recognition Gene:SHE9(YDR393W)|FD-Score:3.63|P-value:1.43E-4||SGD DESC:Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex Gene:SIN4(YNL236W)|FD-Score:3.55|P-value:1.95E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription Gene:SPL2(YHR136C)|FD-Score:-3.33|P-value:4.32E-4||SGD DESC:Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm Gene:SPO12(YHR152W)|FD-Score:-3.3|P-value:4.90E-4||SGD DESC:Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis Gene:THP3(YPR045C)|FD-Score:4.45|P-value:4.21E-6||SGD DESC:Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes Gene:TRP2(YER090W)|FD-Score:3.79|P-value:7.66E-5||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:VAB2(YEL005C)|FD-Score:4.45|P-value:4.27E-6||SGD DESC:Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter Gene:VMA1(YDL185W)|FD-Score:3.53|P-value:2.11E-4||SGD DESC:Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease Gene:YAL004W(YAL004W_d)|FD-Score:-3.84|P-value:6.12E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C Gene:YBL086C(YBL086C_p)|FD-Score:3.33|P-value:4.33E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery Gene:YBR285W(YBR285W_p)|FD-Score:4.05|P-value:2.57E-5||SGD DESC:Putative protein of unknown function; YBR285W is not an essential gene Gene:YDR239C(YDR239C)|FD-Score:-3.1|P-value:9.62E-4||SGD DESC:Protein of unknown function that may interact with ribosomes, based on co-purification experiments Gene:YER038W-A(YER038W-A_d)|FD-Score:3.13|P-value:8.85E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria Gene:YLR149C(YLR149C_p)|FD-Score:-4.14|P-value:1.76E-5||SGD DESC:Protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene; protein abundance increases in response to DNA replication stress Gene:YMR001C-A(YMR001C-A_p)|FD-Score:-6.2|P-value:2.76E-10||SGD DESC:Putative protein of unknown function Gene:YMR031W-A(YMR031W-A_d)|FD-Score:3.49|P-value:2.42E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YMR076C5.022.60E-71.26PDS5Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis
YJL050W3.758.69E-50.12MTR4ATP-dependent 3'-5' RNA helicase of the DExD/H family; involved in nuclear RNA processing and degradation both as a component of TRAMP complex and in TRAMP-independent processes; TRAMP unwinds RNA duplexes, with Mtr4p unwinding activity stimulated by Pap2p/Air2p but not dependent on ongoing polyadenylation; contains an arch domain, with two coiled-coil arms/stalks and a globular fist/KOW domain, which has RNA binding activity and is required for 5.8S rRNA processing
YOR074C3.631.39E-40.15CDC21Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
YLR321C3.492.43E-40.05SFH1Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
YGL018C3.442.95E-40.07JAC1Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix
YOR102W_d3.373.75E-40.12YOR102W_dDubious open reading frame, unlikely to encode a functional protein; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex
YGL068W3.255.68E-40.07MNP1Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth
YKR025W3.187.28E-40.05RPC37RNA polymerase III subunit C37
YLR153C3.138.77E-40.03ACS2Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions
YFR037C3.109.55E-40.28RSC8Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters
YIL068C2.820.002410.09SEC6Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p
YDR145W2.720.003220.06TAF12Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A
YGR048W2.660.003850.05UFD1Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP)
YGL171W2.610.004490.01ROK1RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation
YLR229C2.610.004570.04CDC42Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YDL049C6.873.32E-12KNH1Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance
YEL016C4.592.18E-6NPP2Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP2 has a paralog, NPP1, that arose from the whole genome duplication
YPR045C4.454.21E-6THP3Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes
YEL005C4.454.27E-6VAB2Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter
YDL137W4.151.69E-5ARF2ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; ARF2 has a paralog, ARF1, that arose from the whole genome duplication
YBR285W_p4.052.57E-5YBR285W_pPutative protein of unknown function; YBR285W is not an essential gene
YGL004C3.993.25E-5RPN14Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
YDR150W3.963.75E-5NUM1Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex
YDL078C3.836.38E-5MDH3Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle
YER090W3.797.66E-5TRP2Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p
YNR009W3.768.42E-5NRM1Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase
YER075C3.758.75E-5PTP3Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm
YDL093W3.729.87E-5PMT5Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals
YDR393W3.631.43E-4SHE9Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex
YOR175C3.561.88E-4ALE1Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids

GO enrichment analysis for SGTC_3156
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1086.79E-17SGTC_60844-0013 19.8 μMChemDiv (Drug-like library)15849000.084507
0.0992.10E-14SGTC_31479097027 49.5 μMChembridge (Drug-like library)252368410.230769
0.0912.56E-12SGTC_249418-aminoabieta-8,11,13-triene sulfate 3.7 μMMicrosource (Natural product library)167250760.0779221
0.0872.55E-11SGTC_31549100113 49.5 μMChembridge (Drug-like library)252375250.191781
0.0773.57E-9SGTC_9292805-0021 398.0 μMChemDiv (Drug-like library)30980240.117647
0.0764.09E-9SGTC_23047443016 91.4 μMChembridge (Fragment library)9398540.084507
0.0722.55E-8SGTC_1548st061468 90.8 μMTimTec (Pure natural product library)3907990.107692
0.0713.97E-8SGTC_14123909-8563 178.0 μMChemDiv (Drug-like library)237675300.131868
0.0714.87E-8SGTC_27867743617 45.5 μMChembridge (Drug-like library)5836740.104478
0.0681.90E-7SGTC_1102cgs 12066b 26.1 μMNIH Clinical Collection64383520.135135endomembrane recycling
0.0648.14E-7SGTC_21375261020 140.0 μMChembridge (Fragment library)7636550.115942
0.0621.88E-6SGTC_1766st045414 44.8 μMTimTec (Natural product derivative library)2539600.0945946RPP1 & pyrimidine depletion
0.0612.73E-6SGTC_1600coumarin 106 71.1 μMTimTec (Pure natural product library)1003360.0985916
0.0594.80E-6SGTC_31849108758 49.5 μMChembridge (Drug-like library)9028850.190476
0.0587.22E-6SGTC_1756st041558 35.5 μMTimTec (Natural product derivative library)39557920.147368

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3046909221249.47 μM0.74468125236637Chembridge (Drug-like library)328.3806433.404
SGTC_3020908914049.47 μM0.53571417217859Chembridge (Drug-like library)366.241783.42604
SGTC_3029908868349.47 μM0.50943425236615Chembridge (Drug-like library)300.41853.34703
SGTC_3214534-389065.3 μM0.508475699746ChemDiv (Drug-like library)345.82333.24704RPP1 & pyrimidine depletion
SGTC_3157909927449.47 μM0.45762717217662Chembridge (Drug-like library)339.43143.29104
SGTC_3143908665849.47 μM0.4528325236626Chembridge (Drug-like library)300.41853.45803
SGTC_3036909018149.47 μM0.43636425236586Chembridge (Drug-like library)314.445083.65303
SGTC_3149909785549.47 μM0.43636425236625Chembridge (Drug-like library)365.287983.88103Golgi
SGTC_3056909490049.47 μM0.43103425236784Chembridge (Drug-like library)342.4072233.88404
SGTC_22016605497169.86 μM0.42670741Chembridge (Fragment library)232.32142.18102ergosterol biosynthesis