| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YDL068W_d | 8.13 | 2.21E-16 | YDL068W_d | Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data |
| YPR115W | 6.01 | 9.35E-10 | RGC1 | Pleckstrin homology domain containing protein; proposed to function as a glycerol channel activator; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; RGC1 has a paralog, ASK10, that arose from the whole genome duplication |
| YML079W_p | 5.86 | 2.28E-9 | YML079W_p | Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm |
| YOR205C | 5.31 | 5.48E-8 | GEP3 | Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (phb1) |
| YHR152W | 5.29 | 6.05E-8 | SPO12 | Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis |
| YBR293W | 5.26 | 7.10E-8 | VBA2 | Permease of basic amino acids in the vacuolar membrane |
| YIL014W | 5.14 | 1.36E-7 | MNT3 | Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation |
| YML014W | 4.79 | 8.39E-7 | TRM9 | tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses |
| YDL125C | 4.76 | 9.58E-7 | HNT1 | Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint; protein abundance increases in response to DNA replication stress |
| YNR019W | 4.68 | 1.46E-6 | ARE2 | Acyl-CoA:sterol acyltransferase; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen; ARE2 has a paralog, ARE1, that arose from the whole genome duplication |
| YIL067C_p | 4.65 | 1.68E-6 | YIL067C_p | Uncharacterized protein of unknown function |
| YKL002W | 4.63 | 1.82E-6 | DID4 | Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis |
| YLR426W_p | 4.62 | 1.92E-6 | TDA5_p | Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele |
| YCR004C | 4.25 | 1.06E-5 | YCP4 | Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies |
| YHR092C | 4.21 | 1.28E-5 | HXT4 | High-affinity glucose transporter; member of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose; HXT4 has a paralog, HXT7, that arose from the whole genome duplication |
