9100388

4-bromo-3-chloro-N-(pyridin-4-ylmethyl)-1-benzothiophene-2-carboxamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3161
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 25236368
SMILES C1=CC2=C(C(=C1)Br)C(=C(S2)C(=O)NCC3=CC=NC=C3)Cl
Standardized SMILES Clc1c(sc2cccc(Br)c12)C(=O)NCc3ccncc3
Molecular weight 381.6747
ALogP 4.04
H-bond donor count 1
H-bond acceptor count 3
Response signature iron homeostasis

Pool Growth Kinetics
% growth inhibition (Het. pool) 26.82
% growth inhibition (Hom. pool) 14.05


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 25236368
Download HIP data (tab-delimited text)  (excel)
Gene:BOS1(YLR078C)|FD-Score:3.43|P-value:3.01E-4|Clearance:0.03||SGD DESC:v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi Gene:DBP2(YNL112W)|FD-Score:6.16|P-value:3.69E-10|Clearance:1.76||SGD DESC:ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites Gene:LSM2(YBL026W)|FD-Score:3.4|P-value:3.36E-4|Clearance:0.01||SGD DESC:Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:NMD3(YHR170W)|FD-Score:-3.7|P-value:1.07E-4|Clearance:0||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:RIM2(YBR192W)|FD-Score:4.3|P-value:8.72E-6|Clearance:0.03||SGD DESC:Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family Gene:TFC3(YAL001C)|FD-Score:3.39|P-value:3.47E-4|Clearance:0.32||SGD DESC:Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding Gene:TIF11(YMR260C)|FD-Score:4.4|P-value:5.42E-6|Clearance:0.1||SGD DESC:Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3 Gene:TOM22(YNL131W)|FD-Score:3.8|P-value:7.10E-5|Clearance:0.37||SGD DESC:Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes Gene:TOM40(YMR203W)|FD-Score:11.3|P-value:1.02E-29|Clearance:3.71||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore Gene:TRE2(YOR256C)|FD-Score:4.26|P-value:1.01E-5|Clearance:0.46||SGD DESC:Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication Gene:YDL196W(YDL196W_d)|FD-Score:7.55|P-value:2.15E-14|Clearance:1.12||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 Gene:YDR526C(YDR526C_d)|FD-Score:6.43|P-value:6.35E-11|Clearance:0.27||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:BOS1(YLR078C)|FD-Score:3.43|P-value:3.01E-4|Clearance:0.03||SGD DESC:v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi Gene:DBP2(YNL112W)|FD-Score:6.16|P-value:3.69E-10|Clearance:1.76||SGD DESC:ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites Gene:LSM2(YBL026W)|FD-Score:3.4|P-value:3.36E-4|Clearance:0.01||SGD DESC:Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:NMD3(YHR170W)|FD-Score:-3.7|P-value:1.07E-4|Clearance:0||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:RIM2(YBR192W)|FD-Score:4.3|P-value:8.72E-6|Clearance:0.03||SGD DESC:Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family Gene:TFC3(YAL001C)|FD-Score:3.39|P-value:3.47E-4|Clearance:0.32||SGD DESC:Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding Gene:TIF11(YMR260C)|FD-Score:4.4|P-value:5.42E-6|Clearance:0.1||SGD DESC:Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3 Gene:TOM22(YNL131W)|FD-Score:3.8|P-value:7.10E-5|Clearance:0.37||SGD DESC:Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes Gene:TOM40(YMR203W)|FD-Score:11.3|P-value:1.02E-29|Clearance:3.71||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore Gene:TRE2(YOR256C)|FD-Score:4.26|P-value:1.01E-5|Clearance:0.46||SGD DESC:Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication Gene:YDL196W(YDL196W_d)|FD-Score:7.55|P-value:2.15E-14|Clearance:1.12||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 Gene:YDR526C(YDR526C_d)|FD-Score:6.43|P-value:6.35E-11|Clearance:0.27||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 25236368
Download HOP data (tab-delimited text)  (excel)
Gene:ATH1(YPR026W)|FD-Score:3.6|P-value:1.61E-4||SGD DESC:Acid trehalase required for utilization of extracellular trehalose Gene:CSF1(YLR087C)|FD-Score:3.21|P-value:6.67E-4||SGD DESC:Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:DAL81(YIR023W)|FD-Score:-3.36|P-value:3.85E-4||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:EDS1(YBR033W_p)|FD-Score:-3.17|P-value:7.75E-4||SGD DESC:Putative zinc cluster protein, predicted to be a transcription factor; not an essential gene; EDS1 has a paralog, RGT1, that arose from the whole genome duplication Gene:ERP1(YAR002C-A)|FD-Score:3.39|P-value:3.53E-4||SGD DESC:Member of the p24 family involved in ER to Golgi transport; forms heterotrimeric complex with Erp2p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP1 has a paralog, ERP6, that arose from the whole genome duplication Gene:ERT1(YBR239C_p)|FD-Score:3.75|P-value:8.80E-5||SGD DESC:Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition Gene:EST1(YLR233C)|FD-Score:-4.07|P-value:2.36E-5||SGD DESC:TLC1 RNA-associated factor involved in telomere length regulation as recruitment subunit of telomerase; has G-quadruplex promoting activity that is required for telomere elongation; possible role in activating telomere-bound Est2p-TLC1-RNA Gene:GCS1(YDL226C)|FD-Score:8.49|P-value:1.07E-17||SGD DESC:ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p Gene:GET1(YGL020C)|FD-Score:3.16|P-value:8.00E-4||SGD DESC:Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance Gene:INM1(YHR046C)|FD-Score:-3.64|P-value:1.36E-4||SGD DESC:Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate Gene:MAK3(YPR051W)|FD-Score:3.15|P-value:8.29E-4||SGD DESC:Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus Gene:MST1(YKL194C)|FD-Score:-3.33|P-value:4.37E-4||SGD DESC:Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro Gene:PPZ1(YML016C)|FD-Score:3.16|P-value:7.86E-4||SGD DESC:Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance Gene:PRO2(YOR323C)|FD-Score:4.64|P-value:1.77E-6||SGD DESC:Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis Gene:PSR2(YLR019W)|FD-Score:3.62|P-value:1.46E-4||SGD DESC:Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p Gene:PTP2(YOR208W)|FD-Score:3.33|P-value:4.34E-4||SGD DESC:Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus Gene:RGT1(YKL038W)|FD-Score:4.1|P-value:2.09E-5||SGD DESC:Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication Gene:RPL35A(YDL191W)|FD-Score:-3.13|P-value:8.61E-4||SGD DESC:Ribosomal 60S subunit protein L35A; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35A has a paralog, RPL35B, that arose from the whole genome duplication Gene:RRT12(YCR045C)|FD-Score:3.51|P-value:2.24E-4||SGD DESC:Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores Gene:RTF1(YGL244W)|FD-Score:-3.93|P-value:4.27E-5||SGD DESC:Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay Gene:SEC22(YLR268W)|FD-Score:4.63|P-value:1.83E-6||SGD DESC:R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog Gene:SNF7(YLR025W)|FD-Score:3.21|P-value:6.69E-4||SGD DESC:One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes Gene:TDA10(YGR205W)|FD-Score:4.29|P-value:8.95E-6||SGD DESC:ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele Gene:VAC14(YLR386W)|FD-Score:4.8|P-value:7.93E-7||SGD DESC:Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p Gene:YGR228W(YGR228W_d)|FD-Score:3.49|P-value:2.43E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C Gene:YML094C-A(YML094C-A_d)|FD-Score:3.17|P-value:7.61E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO Gene:YML122C(YML122C_d)|FD-Score:-3.19|P-value:7.21E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YMR001C-A(YMR001C-A_p)|FD-Score:3.84|P-value:6.26E-5||SGD DESC:Putative protein of unknown function Gene:YMR209C(YMR209C_p)|FD-Score:4.34|P-value:7.00E-6||SGD DESC:Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene Gene:YPR063C(YPR063C_p)|FD-Score:5.06|P-value:2.06E-7||SGD DESC:ER-localized protein of unknown function Gene:YPR123C(YPR123C_d)|FD-Score:3.49|P-value:2.43E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR Gene:ATH1(YPR026W)|FD-Score:3.6|P-value:1.61E-4||SGD DESC:Acid trehalase required for utilization of extracellular trehalose Gene:CSF1(YLR087C)|FD-Score:3.21|P-value:6.67E-4||SGD DESC:Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:DAL81(YIR023W)|FD-Score:-3.36|P-value:3.85E-4||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:EDS1(YBR033W_p)|FD-Score:-3.17|P-value:7.75E-4||SGD DESC:Putative zinc cluster protein, predicted to be a transcription factor; not an essential gene; EDS1 has a paralog, RGT1, that arose from the whole genome duplication Gene:ERP1(YAR002C-A)|FD-Score:3.39|P-value:3.53E-4||SGD DESC:Member of the p24 family involved in ER to Golgi transport; forms heterotrimeric complex with Erp2p, Emp24p, and Erv25p; localized to COPII-coated vesicles; ERP1 has a paralog, ERP6, that arose from the whole genome duplication Gene:ERT1(YBR239C_p)|FD-Score:3.75|P-value:8.80E-5||SGD DESC:Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition Gene:EST1(YLR233C)|FD-Score:-4.07|P-value:2.36E-5||SGD DESC:TLC1 RNA-associated factor involved in telomere length regulation as recruitment subunit of telomerase; has G-quadruplex promoting activity that is required for telomere elongation; possible role in activating telomere-bound Est2p-TLC1-RNA Gene:GCS1(YDL226C)|FD-Score:8.49|P-value:1.07E-17||SGD DESC:ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p Gene:GET1(YGL020C)|FD-Score:3.16|P-value:8.00E-4||SGD DESC:Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance Gene:INM1(YHR046C)|FD-Score:-3.64|P-value:1.36E-4||SGD DESC:Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate Gene:MAK3(YPR051W)|FD-Score:3.15|P-value:8.29E-4||SGD DESC:Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus Gene:MST1(YKL194C)|FD-Score:-3.33|P-value:4.37E-4||SGD DESC:Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro Gene:PPZ1(YML016C)|FD-Score:3.16|P-value:7.86E-4||SGD DESC:Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance Gene:PRO2(YOR323C)|FD-Score:4.64|P-value:1.77E-6||SGD DESC:Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis Gene:PSR2(YLR019W)|FD-Score:3.62|P-value:1.46E-4||SGD DESC:Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p Gene:PTP2(YOR208W)|FD-Score:3.33|P-value:4.34E-4||SGD DESC:Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus Gene:RGT1(YKL038W)|FD-Score:4.1|P-value:2.09E-5||SGD DESC:Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication Gene:RPL35A(YDL191W)|FD-Score:-3.13|P-value:8.61E-4||SGD DESC:Ribosomal 60S subunit protein L35A; homologous to mammalian ribosomal protein L35 and bacterial L29; RPL35A has a paralog, RPL35B, that arose from the whole genome duplication Gene:RRT12(YCR045C)|FD-Score:3.51|P-value:2.24E-4||SGD DESC:Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores Gene:RTF1(YGL244W)|FD-Score:-3.93|P-value:4.27E-5||SGD DESC:Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay Gene:SEC22(YLR268W)|FD-Score:4.63|P-value:1.83E-6||SGD DESC:R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog Gene:SNF7(YLR025W)|FD-Score:3.21|P-value:6.69E-4||SGD DESC:One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes Gene:TDA10(YGR205W)|FD-Score:4.29|P-value:8.95E-6||SGD DESC:ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele Gene:VAC14(YLR386W)|FD-Score:4.8|P-value:7.93E-7||SGD DESC:Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p Gene:YGR228W(YGR228W_d)|FD-Score:3.49|P-value:2.43E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C Gene:YML094C-A(YML094C-A_d)|FD-Score:3.17|P-value:7.61E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO Gene:YML122C(YML122C_d)|FD-Score:-3.19|P-value:7.21E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YMR001C-A(YMR001C-A_p)|FD-Score:3.84|P-value:6.26E-5||SGD DESC:Putative protein of unknown function Gene:YMR209C(YMR209C_p)|FD-Score:4.34|P-value:7.00E-6||SGD DESC:Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene Gene:YPR063C(YPR063C_p)|FD-Score:5.06|P-value:2.06E-7||SGD DESC:ER-localized protein of unknown function Gene:YPR123C(YPR123C_d)|FD-Score:3.49|P-value:2.43E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YMR203W11.301.02E-293.71TOM40Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
YDL196W_d7.552.15E-141.12YDL196W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
YDR526C_d6.436.35E-110.27YDR526C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL112W6.163.69E-101.76DBP2ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites
YMR260C4.405.42E-60.10TIF11Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3
YBR192W4.308.72E-60.03RIM2Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
YOR256C4.261.01E-50.46TRE2Transferrin receptor-like protein; functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; inviability of null mutant in systematic studies is due to proximity to CDC31; TRE2 has a paralog, TRE1, that arose from the whole genome duplication
YNL131W3.807.10E-50.37TOM22Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes
YLR078C3.433.01E-40.03BOS1v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi
YBL026W3.403.36E-40.01LSM2Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
YAL001C3.393.47E-40.32TFC3Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding
YJL195C_d3.080.001050.06YJL195C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6
YJR093C3.020.001270.00FIP1Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p
YOR117W3.010.001290.01RPT5One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1
YDR238C3.010.001320.00SEC26Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YDL226C8.491.07E-17GCS1ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
YPR063C_p5.062.06E-7YPR063C_pER-localized protein of unknown function
YLR386W4.807.93E-7VAC14Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p
YOR323C4.641.77E-6PRO2Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis
YLR268W4.631.83E-6SEC22R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog
YMR209C_p4.347.00E-6YMR209C_pPutative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene
YGR205W4.298.95E-6TDA10ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele
YKL038W4.102.09E-5RGT1Glucose-responsive transcription factor; regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor; RGT1 has a paralog, EDS1, that arose from the whole genome duplication
YMR001C-A_p3.846.26E-5YMR001C-A_pPutative protein of unknown function
YBR239C_p3.758.80E-5ERT1_pTranscriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition
YLR019W3.621.46E-4PSR2Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p
YPR026W3.601.61E-4ATH1Acid trehalase required for utilization of extracellular trehalose
YCR045C3.512.24E-4RRT12Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores
YGR228W_d3.492.43E-4YGR228W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C
YPR123C_d3.492.43E-4YPR123C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR

GO enrichment analysis for SGTC_3161
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.3841.20E-206SGTC_31759106517 49.5 μMChembridge (Drug-like library)414680730.188406iron homeostasis
0.3421.27E-161SGTC_14224031-0024 15.5 μMChemDiv (Drug-like library)7824270.140845iron homeostasis
0.2611.07E-92SGTC_31819108277 49.5 μMChembridge (Drug-like library)170972980.231884iron homeostasis
0.2518.61E-86SGTC_31419094609 49.5 μMChembridge (Drug-like library)252363090.622642iron homeostasis
0.2392.13E-77SGTC_29309013230 14.9 μMChembridge (Drug-like library)29958570.140845heme biosynthesis & mitochondrial translocase
0.2382.43E-76SGTC_218alverine citrate 93.8 μMMiscellaneous217180.1fatty acid desaturase (OLE1)
0.2226.11E-67SGTC_1962st076595 64.5 μMTimTec (Natural product derivative library)2796190.0985916redox potentiating
0.2197.91E-65SGTC_31889110789 49.5 μMChembridge (Drug-like library)8492170.191176iron homeostasis
0.2181.24E-64SGTC_2675theaflavin digallate 100.0 μMMicrosource (Natural product library)4673200.0515464iron homeostasis
0.2182.73E-64SGTC_2666tannic acid 100.0 μMMicrosource (Natural product library)161342670.0722892iron homeostasis
0.2171.01E-63SGTC_262fenpropimorph 62.5 μMMiscellaneous916950.0675676ergosterol depletion effects on membrane
0.2128.55E-61SGTC_2733amorolfine 100.0 μMMiscellaneous542600.0649351plasma membrane duress
0.1963.44E-52SGTC_8750709-0210 25.7 μMChemDiv (Drug-like library)62513640.0821918fatty acid desaturase (OLE1)
0.1951.12E-51SGTC_258haloperidol 50.8 μMMiscellaneous35590.115385fatty acid desaturase (OLE1)
0.1942.77E-51SGTC_31269127922 49.5 μMChembridge (Drug-like library)455956820.0769231fatty acid desaturase (OLE1)

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3141909460949.47 μM0.62264225236309Chembridge (Drug-like library)381.67474.03713iron homeostasis
SGTC_3037909102649.47 μM0.49152525236398Chembridge (Drug-like library)387.722343.71413NEO1-PIK1
SGTC_23899091542195.52 μM0.4901963626624Chembridge (Fragment library)252.719961.88313iron homeostasis
SGTC_21535569715200 μM0.4339622054701Chembridge (Fragment library)281.13732.79912iron homeostasis
SGTC_23649055074200 μM0.3965526470630Chembridge (Fragment library)275.733462.52922
SGTC_3142908649849.47 μM0.34328425236367Chembridge (Drug-like library)300.41853.51513iron homeostasis
SGTC_3155909926549.47 μM0.33846225236499Chembridge (Drug-like library)330.83184.15213
SGTC_22917917025104.35 μM0.3333332964612Chembridge (Fragment library)280.321143.03813iron homeostasis
SGTC_3015908084549.47 μM0.3283585296973Chembridge (Drug-like library)345.35472.14415
SGTC_22787948257134.34 μM0.3166671247028Chembridge (Fragment library)297.170962.20713