9099914

methyl 3-[(5-methyl-1,2-oxazole-3-carbonyl)amino]benzoate

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3163
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 16268368
SMILES CC1=CC(=NO1)C(=O)NC2=CC=CC(=C2)C(=O)OC
Standardized SMILES COC(=O)c1cccc(NC(=O)c2cc(C)on2)c1
Molecular weight 260.2454
ALogP 1.5
H-bond donor count 1
H-bond acceptor count 5
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 3.63
% growth inhibition (Hom. pool) -0.01


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 16268368
Download HIP data (tab-delimited text)  (excel)

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 16268368
Download HOP data (tab-delimited text)  (excel)
Gene:GGA1(YDR358W)|FD-Score:-3.26|P-value:5.64E-4||SGD DESC:Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi Gene:ISY1(YJR050W)|FD-Score:3.74|P-value:9.39E-5||SGD DESC:Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles Gene:MRPS35(YGR165W)|FD-Score:4.03|P-value:2.75E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets Gene:TRP3(YKL211C)|FD-Score:3.57|P-value:1.76E-4||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:YER010C(YER010C)|FD-Score:3.29|P-value:5.06E-4||SGD DESC:Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction Gene:YNL179C(YNL179C_d)|FD-Score:3.17|P-value:7.72E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance Gene:YPL199C(YPL199C_p)|FD-Score:3.41|P-value:3.26E-4||SGD DESC:Putative protein of unknown function, predicted to be palmitoylated Gene:GGA1(YDR358W)|FD-Score:-3.26|P-value:5.64E-4||SGD DESC:Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi Gene:ISY1(YJR050W)|FD-Score:3.74|P-value:9.39E-5||SGD DESC:Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles Gene:MRPS35(YGR165W)|FD-Score:4.03|P-value:2.75E-5||SGD DESC:Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets Gene:TRP3(YKL211C)|FD-Score:3.57|P-value:1.76E-4||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:YER010C(YER010C)|FD-Score:3.29|P-value:5.06E-4||SGD DESC:Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction Gene:YNL179C(YNL179C_d)|FD-Score:3.17|P-value:7.72E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance Gene:YPL199C(YPL199C_p)|FD-Score:3.41|P-value:3.26E-4||SGD DESC:Putative protein of unknown function, predicted to be palmitoylated

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YKL154W2.980.001460.12SRP102Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane
YOL021C2.860.002130.12DIS3Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress
YGL150C2.790.002650.12INO80ATPase and nucleosome spacing factor, subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; has a role in modulating stress gene transcription
YHR019C2.670.003850.10DED81Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
YKL210W2.560.005170.02UBA1Ubiquitin activating enzyme (E1); involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress
YIR015W2.550.005450.03RPR2Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits; protein abundance increases in response to DNA replication stress
YOR210W2.520.005870.07RPB10RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III
YLR078C2.450.007060.03BOS1v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi
YKR062W2.420.007780.01TFA2TFIIE small subunit, involved in RNA polymerase II transcription initiation
YMR005W2.410.007970.02TAF4TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate
YGL238W2.390.008500.01CSE1Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation
YFR042W2.380.008620.01KEG1Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability
YIL048W2.370.008880.04NEO1Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
YDR189W2.330.009820.10SLY1Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex
YJR093C2.230.012800.02FIP1Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YGR165W4.032.75E-5MRPS35Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets
YJR050W3.749.39E-5ISY1Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles
YKL211C3.571.76E-4TRP3Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
YPL199C_p3.413.26E-4YPL199C_pPutative protein of unknown function, predicted to be palmitoylated
YER010C3.295.06E-4YER010CProtein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction
YNL179C_d3.177.72E-4YNL179C_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
YDR524C-B_p3.030.00121YDR524C-B_pPutative protein of unknown function; YDR524C-B has a paralog, YCL048W-A, that arose from the whole genome duplication
YDR440W3.020.00127DOT1Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response
YLR014C3.010.00132PPR1Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of URA1, URA3, URA4, and URA10, which are involved in de novo pyrimidine biosynthesis, in response to pyrimidine starvation; activity may be modulated by interaction with Tup1p
YMR257C3.000.00134PET111Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane
YOR164C2.940.00162GET4Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20
YDL238C2.920.00174GUD1Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures
YNL097C-B_p2.910.00178YNL097C-B_pPutative protein of unknown function
YLR405W2.870.00207DUS4Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
YDR536W2.800.00253STL1Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock

GO enrichment analysis for SGTC_3163
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.2131.21E-61SGTC_1617st002906 78.0 μMTimTec (Natural product derivative library)51508590.0689655
0.2091.47E-59SGTC_2409alverine citrate 64.0 μMMiscellaneous217180.0862069
0.2071.99E-58SGTC_11931488-0126 41.5 μMChemDiv (Drug-like library)13847100.0675676
0.1844.13E-46SGTC_11941488-0194 225.0 μMChemDiv (Drug-like library)13914520.0833333
0.1757.54E-42SGTC_15465-methoxyflavanone 78.7 μMTimTec (Pure natural product library)1477950.151515
0.1721.57E-40SGTC_21976588183 93.1 μMChembridge (Fragment library)8841360.208955
0.1717.17E-40SGTC_15412',3',6-trimethoxyflavone 64.0 μMTimTec (Pure natural product library)6888010.15942
0.1652.12E-37SGTC_22246650123 117.6 μMChembridge (Fragment library)29083700.125
0.1604.67E-35SGTC_1603st002045 67.8 μMTimTec (Natural product derivative library)58879850.123077TSC3-RPN4
0.1606.20E-35SGTC_22547938975 95.2 μMChembridge (Fragment library)29692770.136364
0.1511.52E-31SGTC_1909st060837 51.5 μMTimTec (Natural product derivative library)6789370.130435
0.1491.15E-30SGTC_14964469-0713 57.4 μMChemDiv (Drug-like library)7466910.105263
0.1382.29E-26SGTC_30189082602 49.5 μMChembridge (Drug-like library)173320890.0869565
0.1382.29E-26SGTC_1975st070967 30.8 μMTimTec (Natural product derivative library)2613910.09375
0.1372.99E-26SGTC_2669eugenol 100.0 μMMicrosource (Natural product library)33140.114754

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3047909212249.47 μM0.76595717173831Chembridge (Drug-like library)274.271961.84715
SGTC_5544483-2211187 μM0.5625747107ChemDiv (Drug-like library)285.29462.45314
SGTC_3232913287449.47 μM0.5434783784940Chembridge (Drug-like library)255.268622.4713RPP1 & pyrimidine depletion
SGTC_23157733312200 μM0.531915726316Chembridge (Fragment library)210.25291.93523
SGTC_2897904859812.99 μM0.4905666467404Chembridge (Drug-like library)283.321782.99113
SGTC_23137726885200 μM0.454545726423Chembridge (Fragment library)293.384562.8614RPP1 & pyrimidine depletion
SGTC_1710st03175861.5 μM0.426235394341TimTec (Natural product derivative library)325.31542.70515
SGTC_7161683-5115658 μM0.418182723597ChemDiv (Drug-like library)303.740263.48313
SGTC_12550566-0045221 μM0.4150942788469ChemDiv (Drug-like library)304.728323.04223excess fatty acid
SGTC_6704204-0025119 μM0.403509719039ChemDiv (Drug-like library)341.745183.07115copper-dependent oxidative stress