9100705

N-(4-methoxy-2-methylphenyl)-2,3-dihydro-1,4-benzodioxine-6-carboxamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3164
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 17174235
SMILES CC1=C(C=CC(=C1)OC)NC(=O)C2=CC3=C(C=C2)OCCO3
Standardized SMILES COc1ccc(NC(=O)c2ccc3OCCOc3c2)c(C)c1
Molecular weight 299.3212
ALogP 2.87
H-bond donor count 1
H-bond acceptor count 4
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 3.9
% growth inhibition (Hom. pool) -1.18


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 17174235
Download HIP data (tab-delimited text)  (excel)
Gene:ARC35(YNR035C)|FD-Score:3.77|P-value:8.14E-5|Clearance:0.71||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin Gene:GCD1(YOR260W)|FD-Score:-3.21|P-value:6.67E-4|Clearance:0||SGD DESC:Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression Gene:TAF12(YDR145W)|FD-Score:-3.51|P-value:2.23E-4|Clearance:0||SGD DESC:Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A Gene:UBC1(YDR177W)|FD-Score:-3.54|P-value:2.01E-4|Clearance:0||SGD DESC:Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress Gene:YPL142C(YPL142C_d)|FD-Score:4.11|P-value:1.97E-5|Clearance:0.71||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit Gene:ARC35(YNR035C)|FD-Score:3.77|P-value:8.14E-5|Clearance:0.71||SGD DESC:Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin Gene:GCD1(YOR260W)|FD-Score:-3.21|P-value:6.67E-4|Clearance:0||SGD DESC:Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression Gene:TAF12(YDR145W)|FD-Score:-3.51|P-value:2.23E-4|Clearance:0||SGD DESC:Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A Gene:UBC1(YDR177W)|FD-Score:-3.54|P-value:2.01E-4|Clearance:0||SGD DESC:Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress Gene:YPL142C(YPL142C_d)|FD-Score:4.11|P-value:1.97E-5|Clearance:0.71||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 17174235
Download HOP data (tab-delimited text)  (excel)
Gene:APS3(YJL024C)|FD-Score:-3.13|P-value:8.62E-4||SGD DESC:Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress Gene:ARG82(YDR173C)|FD-Score:3.12|P-value:9.05E-4||SGD DESC:Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes Gene:ART5(YGR068C)|FD-Score:3.18|P-value:7.31E-4||SGD DESC:Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane Gene:AVT6(YER119C)|FD-Score:3.87|P-value:5.38E-5||SGD DESC:Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication Gene:BSC4(YNL269W)|FD-Score:3.39|P-value:3.43E-4||SGD DESC:Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p Gene:BUD26(YDR241W_d)|FD-Score:3.29|P-value:5.02E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:COX17(YLL009C)|FD-Score:-4.91|P-value:4.63E-7||SGD DESC:Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs Gene:EST1(YLR233C)|FD-Score:-4.25|P-value:1.06E-5||SGD DESC:TLC1 RNA-associated factor involved in telomere length regulation as recruitment subunit of telomerase; has G-quadruplex promoting activity that is required for telomere elongation; possible role in activating telomere-bound Est2p-TLC1-RNA Gene:FMP23(YBR047W_p)|FD-Score:-3.21|P-value:6.60E-4||SGD DESC:Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:FMP41(YNL168C_p)|FD-Score:3.88|P-value:5.16E-5||SGD DESC:Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:HBN1(YCL026C-B_p)|FD-Score:3.77|P-value:8.04E-5||SGD DESC:Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress Gene:IXR1(YKL032C)|FD-Score:3.45|P-value:2.78E-4||SGD DESC:Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b Gene:LSM1(YJL124C)|FD-Score:-3.8|P-value:7.12E-5||SGD DESC:Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress Gene:MBB1(YJL199C_d)|FD-Score:3.27|P-value:5.42E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies Gene:NHP10(YDL002C)|FD-Score:3.55|P-value:1.95E-4||SGD DESC:Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair Gene:PDH1(YPR002W)|FD-Score:-3.31|P-value:4.58E-4||SGD DESC:Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate Gene:PSH1(YOL054W)|FD-Score:5.52|P-value:1.73E-8||SGD DESC:E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p Gene:RPL24B(YGR148C)|FD-Score:3.69|P-value:1.14E-4||SGD DESC:Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication Gene:SPT7(YBR081C)|FD-Score:3.24|P-value:6.00E-4||SGD DESC:Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex Gene:SRX1(YKL086W)|FD-Score:3.27|P-value:5.46E-4||SGD DESC:Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress Gene:SSF1(YHR066W)|FD-Score:3.47|P-value:2.64E-4||SGD DESC:Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication Gene:STP2(YHR006W)|FD-Score:-3.74|P-value:9.20E-5||SGD DESC:Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication Gene:TRM11(YOL124C)|FD-Score:3.6|P-value:1.56E-4||SGD DESC:Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain Gene:TSR3(YOR006C)|FD-Score:3.18|P-value:7.33E-4||SGD DESC:Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress Gene:YAR028W(YAR028W_p)|FD-Score:3.36|P-value:3.96E-4||SGD DESC:Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS Gene:YBL012C(YBL012C_d)|FD-Score:4.7|P-value:1.33E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR008C(YDR008C_d)|FD-Score:3.22|P-value:6.43E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR179W-A(YDR179W-A_p)|FD-Score:-3.39|P-value:3.52E-4||SGD DESC:Putative protein of unknown function Gene:YNR048W(YNR048W)|FD-Score:4.41|P-value:5.13E-6||SGD DESC:Protein that interacts with phospholipid translocase (flippase) Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication Gene:YPR063C(YPR063C_p)|FD-Score:3.52|P-value:2.14E-4||SGD DESC:ER-localized protein of unknown function Gene:ZAP1(YJL056C)|FD-Score:-5.07|P-value:1.97E-7||SGD DESC:Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains Gene:APS3(YJL024C)|FD-Score:-3.13|P-value:8.62E-4||SGD DESC:Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress Gene:ARG82(YDR173C)|FD-Score:3.12|P-value:9.05E-4||SGD DESC:Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes Gene:ART5(YGR068C)|FD-Score:3.18|P-value:7.31E-4||SGD DESC:Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane Gene:AVT6(YER119C)|FD-Score:3.87|P-value:5.38E-5||SGD DESC:Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication Gene:BSC4(YNL269W)|FD-Score:3.39|P-value:3.43E-4||SGD DESC:Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p Gene:BUD26(YDR241W_d)|FD-Score:3.29|P-value:5.02E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay Gene:COX17(YLL009C)|FD-Score:-4.91|P-value:4.63E-7||SGD DESC:Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs Gene:EST1(YLR233C)|FD-Score:-4.25|P-value:1.06E-5||SGD DESC:TLC1 RNA-associated factor involved in telomere length regulation as recruitment subunit of telomerase; has G-quadruplex promoting activity that is required for telomere elongation; possible role in activating telomere-bound Est2p-TLC1-RNA Gene:FMP23(YBR047W_p)|FD-Score:-3.21|P-value:6.60E-4||SGD DESC:Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:FMP41(YNL168C_p)|FD-Score:3.88|P-value:5.16E-5||SGD DESC:Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:HBN1(YCL026C-B_p)|FD-Score:3.77|P-value:8.04E-5||SGD DESC:Protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress Gene:IXR1(YKL032C)|FD-Score:3.45|P-value:2.78E-4||SGD DESC:Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b Gene:LSM1(YJL124C)|FD-Score:-3.8|P-value:7.12E-5||SGD DESC:Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress Gene:MBB1(YJL199C_d)|FD-Score:3.27|P-value:5.42E-4||SGD DESC:Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies Gene:NHP10(YDL002C)|FD-Score:3.55|P-value:1.95E-4||SGD DESC:Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair Gene:PDH1(YPR002W)|FD-Score:-3.31|P-value:4.58E-4||SGD DESC:Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate Gene:PSH1(YOL054W)|FD-Score:5.52|P-value:1.73E-8||SGD DESC:E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p Gene:RPL24B(YGR148C)|FD-Score:3.69|P-value:1.14E-4||SGD DESC:Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication Gene:SPT7(YBR081C)|FD-Score:3.24|P-value:6.00E-4||SGD DESC:Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex Gene:SRX1(YKL086W)|FD-Score:3.27|P-value:5.46E-4||SGD DESC:Sulfiredoxin; contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes; protein abundance increases in response to DNA replication stress Gene:SSF1(YHR066W)|FD-Score:3.47|P-value:2.64E-4||SGD DESC:Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication Gene:STP2(YHR006W)|FD-Score:-3.74|P-value:9.20E-5||SGD DESC:Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication Gene:TRM11(YOL124C)|FD-Score:3.6|P-value:1.56E-4||SGD DESC:Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain Gene:TSR3(YOR006C)|FD-Score:3.18|P-value:7.33E-4||SGD DESC:Protein required for 20S pre-rRNA processing; involved in processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress Gene:YAR028W(YAR028W_p)|FD-Score:3.36|P-value:3.96E-4||SGD DESC:Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS Gene:YBL012C(YBL012C_d)|FD-Score:4.7|P-value:1.33E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR008C(YDR008C_d)|FD-Score:3.22|P-value:6.43E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR179W-A(YDR179W-A_p)|FD-Score:-3.39|P-value:3.52E-4||SGD DESC:Putative protein of unknown function Gene:YNR048W(YNR048W)|FD-Score:4.41|P-value:5.13E-6||SGD DESC:Protein that interacts with phospholipid translocase (flippase) Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication Gene:YPR063C(YPR063C_p)|FD-Score:3.52|P-value:2.14E-4||SGD DESC:ER-localized protein of unknown function Gene:ZAP1(YJL056C)|FD-Score:-5.07|P-value:1.97E-7||SGD DESC:Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YPL142C_d4.111.97E-50.71YPL142C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit
YNR035C3.778.14E-50.71ARC35Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin
YNL172W3.060.001100.26APC1Largest subunit of the Anaphase-Promoting Complex/Cyclosome; APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; localizes to nuclear foci that become diffuse upon DNA replication stress
YDL097C2.800.002550.00RPN6Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress
YML092C2.800.002590.02PRE8Alpha 2 subunit of the 20S proteasome
YNL189W2.770.002770.08SRP1Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation
YML114C2.700.003490.06TAF8TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
YIL061C2.640.004170.00SNP1Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein; protein abundance increases in response to DNA replication stress
YNL251C2.630.004230.08NRD1RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), preferentially at phosphorylated Ser5, to direct transcription termination of non-polyadenylated transcripts; H3K4 trimethylation of transcribed regions by Set1p enhances recruitment of Nrd1p to those sites
YDR361C2.550.005390.02BCP1Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport
YMR314W2.530.005720.03PRE5Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
YAL025C2.500.006270.03MAK16Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus
YPR025C2.470.006760.01CCL1Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters
YOR143C2.460.006970.02THI80Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)
YOR077W2.440.007340.07RTS2Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YOL054W5.521.73E-8PSH1E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p
YBL012C_d4.701.33E-6YBL012C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YNR048W4.415.13E-6YNR048WProtein that interacts with phospholipid translocase (flippase) Dnf3p; YNR048W has a paralog, CDC50, that arose from the whole genome duplication
YNL168C_p3.885.16E-5FMP41_pPutative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YER119C3.875.38E-5AVT6Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation; AVT6 has a paralog, AVT5, that arose from the whole genome duplication
YCL026C-B_p3.778.04E-5HBN1_pProtein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion; protein abundance increases in response to DNA replication stress
YGR148C3.691.14E-4RPL24BRibosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication
YOL124C3.601.56E-4TRM11Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YDL002C3.551.95E-4NHP10Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair
YPR063C_p3.522.14E-4YPR063C_pER-localized protein of unknown function
YHR066W3.472.64E-4SSF1Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication
YKL032C3.452.78E-4IXR1Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b
YNL269W3.393.43E-4BSC4Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p
YAR028W_p3.363.96E-4YAR028W_pPutative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YDR241W_d3.295.02E-4BUD26_dDubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay

GO enrichment analysis for SGTC_3164
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0741.29E-8SGTC_9881497-1057 103.0 μMChemDiv (Drug-like library)35330440.0540541
0.0691.10E-7SGTC_1117retinoic acid 1.1 μMTimTec (Natural product library)4447950.0933333
0.0655.22E-7SGTC_7924534-1957 155.0 μMChemDiv (Drug-like library)17179040.173913
0.0631.43E-6SGTC_1090132-0036 33.7 μMChemDiv (Drug-like library)672740.262295
0.0631.53E-6SGTC_7791360-0071 233.0 μMChemDiv (Drug-like library)75660.0655738fatty acid desaturase (OLE1)
0.0596.56E-6SGTC_2650prasterone 100.0 μMMicrosource (Natural product library)167592470.0675676
0.0588.28E-6SGTC_748act1.228 77.9 μMChemDiv (Drug-like library)44215050.0491803redox potentiating
0.0579.94E-6SGTC_2851486-1325 46.0 μMChemDiv (Drug-like library)223102300.138889
0.0571.40E-5SGTC_21976588183 93.1 μMChembridge (Fragment library)8841360.205882
0.0561.77E-5SGTC_2717st081029 62.3 μMTimTec (Natural product derivative library)52928460.144737
0.0552.76E-5SGTC_2678equilin 100.0 μMMicrosource (Natural product library)32470.0909091
0.0543.20E-5SGTC_1883229-0966 278.5 μMChemDiv (Drug-like library)57223700.0666667
0.0543.58E-5SGTC_7844579-0127 173.0 μMChemDiv (Drug-like library)19485470.2
0.0534.10E-5SGTC_13451488-0192 31.4 μMChemDiv (Drug-like library)6583480.0405405
0.0534.57E-5SGTC_260302-0163 425.2 μMChemDiv (Drug-like library)31009150.121212heme biosynthesis & mitochondrial translocase

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_22817943571200 μM0.5294121244024Chembridge (Fragment library)231.247222.47913
SGTC_3195911308249.47 μM0.5217018038Chembridge (Drug-like library)301.337063.05114
SGTC_3009908081971.43 μM0.46428617027216Chembridge (Drug-like library)342.388982.43115
SGTC_3148909789349.47 μM0.45762717174100Chembridge (Drug-like library)322.357823.63114
SGTC_1960st01136651.8 μM0.4354843972846TimTec (Natural product derivative library)386.403324.22815
SGTC_3013908013371.43 μM0.41935517050193Chembridge (Drug-like library)354.442743.64214
SGTC_3039909027049.47 μM0.41818217173750Chembridge (Drug-like library)303.740263.07113RPP1 & pyrimidine depletion
SGTC_3205911348349.47 μM0.41818217018033Chembridge (Drug-like library)271.311083.06813
SGTC_3166910229749.47 μM0.39655225237072Chembridge (Drug-like library)348.191263.15513Golgi
SGTC_1759st04305970 μM0.392857669426TimTec (Natural product derivative library)285.29462.45314amide catabolism