9103034

N-(2-phenylmethoxyphenyl)furan-2-carboxamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3167
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 5127859
SMILES C1=CC=C(C=C1)COC2=CC=CC=C2NC(=O)C3=CC=CO3
Standardized SMILES O=C(Nc1ccccc1OCc2ccccc2)c3occc3
Molecular weight 293.3166
ALogP 3.58
H-bond donor count 1
H-bond acceptor count 3
Response signature RPP1 & pyrimidine depletion

Pool Growth Kinetics
% growth inhibition (Het. pool) 11.81
% growth inhibition (Hom. pool) 8.05


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 5127859
Download HIP data (tab-delimited text)  (excel)
Gene:BOS1(YLR078C)|FD-Score:3.49|P-value:2.44E-4|Clearance:0.19||SGD DESC:v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi Gene:DCP1(YOL149W)|FD-Score:3.13|P-value:8.67E-4|Clearance:0.11||SGD DESC:Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress Gene:LSM2(YBL026W)|FD-Score:3.29|P-value:4.93E-4|Clearance:0.16||SGD DESC:Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:MSL5(YLR116W)|FD-Score:-3.22|P-value:6.33E-4|Clearance:0||SGD DESC:Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA Gene:PAP1(YKR002W)|FD-Score:3.9|P-value:4.85E-5|Clearance:0.41||SGD DESC:Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping Gene:POL3(YDL102W)|FD-Score:4|P-value:3.12E-5|Clearance:0.11||SGD DESC:Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER) Gene:RPL15A(YLR029C)|FD-Score:6.37|P-value:9.20E-11|Clearance:1.27||SGD DESC:Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication Gene:RPP1(YHR062C)|FD-Score:5.41|P-value:3.13E-8|Clearance:1.27||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:TAF12(YDR145W)|FD-Score:4.14|P-value:1.73E-5|Clearance:0.14||SGD DESC:Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A Gene:BOS1(YLR078C)|FD-Score:3.49|P-value:2.44E-4|Clearance:0.19||SGD DESC:v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi Gene:DCP1(YOL149W)|FD-Score:3.13|P-value:8.67E-4|Clearance:0.11||SGD DESC:Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress Gene:LSM2(YBL026W)|FD-Score:3.29|P-value:4.93E-4|Clearance:0.16||SGD DESC:Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress Gene:MSL5(YLR116W)|FD-Score:-3.22|P-value:6.33E-4|Clearance:0||SGD DESC:Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA Gene:PAP1(YKR002W)|FD-Score:3.9|P-value:4.85E-5|Clearance:0.41||SGD DESC:Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping Gene:POL3(YDL102W)|FD-Score:4|P-value:3.12E-5|Clearance:0.11||SGD DESC:Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER) Gene:RPL15A(YLR029C)|FD-Score:6.37|P-value:9.20E-11|Clearance:1.27||SGD DESC:Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication Gene:RPP1(YHR062C)|FD-Score:5.41|P-value:3.13E-8|Clearance:1.27||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:TAF12(YDR145W)|FD-Score:4.14|P-value:1.73E-5|Clearance:0.14||SGD DESC:Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 5127859
Download HOP data (tab-delimited text)  (excel)
Gene:ALG8(YOR067C)|FD-Score:3.24|P-value:5.95E-4||SGD DESC:Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p Gene:CTP1(YBR291C)|FD-Score:3.4|P-value:3.39E-4||SGD DESC:Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family Gene:DAL81(YIR023W)|FD-Score:8.56|P-value:5.61E-18||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:DSS1(YMR287C)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs Gene:GBP2(YCL011C)|FD-Score:3.35|P-value:4.02E-4||SGD DESC:Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication Gene:GUF1(YLR289W)|FD-Score:-3.57|P-value:1.75E-4||SGD DESC:Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor Gene:MRPS35(YGR165W)|FD-Score:4.31|P-value:8.27E-6||SGD DESC:Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets Gene:MSH3(YCR092C)|FD-Score:3.82|P-value:6.77E-5||SGD DESC:Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability Gene:NCS6(YGL211W)|FD-Score:3.23|P-value:6.15E-4||SGD DESC:Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae Gene:PGC1(YPL206C)|FD-Score:3.15|P-value:8.29E-4||SGD DESC:Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs Gene:PIG2(YIL045W)|FD-Score:-4.22|P-value:1.25E-5||SGD DESC:Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase Gene:PTK1(YKL198C)|FD-Score:3.4|P-value:3.35E-4||SGD DESC:Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein Gene:RSC1(YGR056W)|FD-Score:4.66|P-value:1.56E-6||SGD DESC:Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook Gene:STP2(YHR006W)|FD-Score:3.21|P-value:6.71E-4||SGD DESC:Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication Gene:VTC1(YER072W)|FD-Score:-3.33|P-value:4.28E-4||SGD DESC:Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress Gene:YDL172C(YDL172C_d)|FD-Score:3.37|P-value:3.80E-4||SGD DESC:Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YGR250C(YGR250C)|FD-Score:-3.48|P-value:2.54E-4||SGD DESC:Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress Gene:YLR400W(YLR400W_d)|FD-Score:3.09|P-value:9.95E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNL010W(YNL010W_p)|FD-Score:3.81|P-value:6.88E-5||SGD DESC:Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation Gene:YNL338W(YNL338W_d)|FD-Score:4.28|P-value:9.31E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV Gene:YOR248W(YOR248W_d)|FD-Score:3.75|P-value:8.85E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPK1(YKL126W)|FD-Score:6.62|P-value:1.79E-11||SGD DESC:Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication Gene:ALG8(YOR067C)|FD-Score:3.24|P-value:5.95E-4||SGD DESC:Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p Gene:CTP1(YBR291C)|FD-Score:3.4|P-value:3.39E-4||SGD DESC:Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family Gene:DAL81(YIR023W)|FD-Score:8.56|P-value:5.61E-18||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:DSS1(YMR287C)|FD-Score:3.41|P-value:3.24E-4||SGD DESC:3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs Gene:GBP2(YCL011C)|FD-Score:3.35|P-value:4.02E-4||SGD DESC:Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication Gene:GUF1(YLR289W)|FD-Score:-3.57|P-value:1.75E-4||SGD DESC:Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor Gene:MRPS35(YGR165W)|FD-Score:4.31|P-value:8.27E-6||SGD DESC:Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets Gene:MSH3(YCR092C)|FD-Score:3.82|P-value:6.77E-5||SGD DESC:Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability Gene:NCS6(YGL211W)|FD-Score:3.23|P-value:6.15E-4||SGD DESC:Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae Gene:PGC1(YPL206C)|FD-Score:3.15|P-value:8.29E-4||SGD DESC:Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs Gene:PIG2(YIL045W)|FD-Score:-4.22|P-value:1.25E-5||SGD DESC:Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase Gene:PTK1(YKL198C)|FD-Score:3.4|P-value:3.35E-4||SGD DESC:Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein Gene:RSC1(YGR056W)|FD-Score:4.66|P-value:1.56E-6||SGD DESC:Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook Gene:STP2(YHR006W)|FD-Score:3.21|P-value:6.71E-4||SGD DESC:Transcription factor; activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes; STP2 has a paralog, STP1, that arose from the whole genome duplication Gene:VTC1(YER072W)|FD-Score:-3.33|P-value:4.28E-4||SGD DESC:Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress Gene:YDL172C(YDL172C_d)|FD-Score:3.37|P-value:3.80E-4||SGD DESC:Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YGR250C(YGR250C)|FD-Score:-3.48|P-value:2.54E-4||SGD DESC:Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress Gene:YLR400W(YLR400W_d)|FD-Score:3.09|P-value:9.95E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNL010W(YNL010W_p)|FD-Score:3.81|P-value:6.88E-5||SGD DESC:Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation Gene:YNL338W(YNL338W_d)|FD-Score:4.28|P-value:9.31E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV Gene:YOR248W(YOR248W_d)|FD-Score:3.75|P-value:8.85E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YPK1(YKL126W)|FD-Score:6.62|P-value:1.79E-11||SGD DESC:Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YLR029C6.379.20E-111.27RPL15ARibosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication
YHR062C5.413.13E-81.27RPP1Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YDR145W4.141.73E-50.14TAF12Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A
YDL102W4.003.12E-50.11POL3Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)
YKR002W3.904.85E-50.41PAP1Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping
YLR078C3.492.44E-40.19BOS1v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi
YBL026W3.294.93E-40.16LSM2Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
YOL149W3.138.67E-40.11DCP1Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress
YLR340W3.020.001270.05RPP0Conserved ribosomal protein P0 of the ribosomal stalk; involved in interaction between translational elongation factors and the ribosome; phosphorylated on serine 302; homologous to mammalian ribosomal protein LP0 and bacterial L10
YDR301W2.970.001490.00CFT1RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF
YOL097C2.970.001510.01WRS1Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA
YLR409C2.950.001580.02UTP21Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma
YER094C2.930.001710.11PUP3Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
YLR291C2.820.002430.04GCD7Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
YLR010C2.770.002760.12TEN1Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YIR023W8.565.61E-18DAL81Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
YKL126W6.621.79E-11YPK1Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication
YGR056W4.661.56E-6RSC1Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook
YGR165W4.318.27E-6MRPS35Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets
YNL338W_d4.289.31E-6YNL338W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV
YCR092C3.826.77E-5MSH3Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability
YNL010W_p3.816.88E-5YNL010W_pPutative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation
YOR248W_d3.758.85E-5YOR248W_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YMR287C3.413.24E-4DSS13'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
YKL198C3.403.35E-4PTK1Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein
YBR291C3.403.39E-4CTP1Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family
YDL172C_d3.373.80E-4YDL172C_dDubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
YCL011C3.354.02E-4GBP2Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication
YOR067C3.245.95E-4ALG8Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p
YGL211W3.236.15E-4NCS6Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae

GO enrichment analysis for SGTC_3167
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.2756.68E-103SGTC_486niguldipine 82.0 μMMiscellaneous12360.11828amide catabolism
0.2634.08E-94SGTC_28459003024 43.0 μMChembridge (Drug-like library)29901730.222222amide catabolism
0.2535.81E-87SGTC_32379133362 49.5 μMChembridge (Drug-like library)438451370.125
0.2198.16E-65SGTC_3371315-0038 354.0 μMChemDiv (Drug-like library)16264370.0352941amide catabolism
0.2182.25E-64SGTC_24605552655 174.2 μMMiscellaneous54019890.15625amide catabolism
0.1977.17E-53SGTC_9903985-0011 41.3 μMChemDiv (Drug-like library)53995650.0857143amide catabolism
0.1971.14E-52SGTC_32289131799 49.5 μMChembridge (Drug-like library)170158180.205882amide catabolism
0.1951.58E-51SGTC_7003453-2283 142.0 μMChemDiv (Drug-like library)5656640.15873amide catabolism
0.1931.46E-50SGTC_31699102970 49.5 μMChembridge (Drug-like library)170278390.0882353RPP1 & pyrimidine depletion
0.1899.22E-49SGTC_20935331342 194.4 μMChembridge (Fragment library)338390.109375
0.1865.11E-47SGTC_5694130-2812 160.0 μMChemDiv (Drug-like library)7435520.114754amide catabolism
0.1819.81E-45SGTC_10563448-1962 115.0 μMChemDiv (Drug-like library)7155070.16129amide catabolism
0.1771.46E-42SGTC_1973st070275 50.2 μMTimTec (Natural product derivative library)171183340.115942
0.1681.92E-38SGTC_1464k208-0027 110.0 μMChemDiv (Drug-like library)X14640.146341
0.1672.56E-38SGTC_14113909-8223 150.0 μMChemDiv (Drug-like library)X14110.123457

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_20635246145200 μM0.545455711240Chembridge (Fragment library)221.639722.67412
SGTC_22817943571200 μM0.4423081244024Chembridge (Fragment library)231.247222.47913
SGTC_2034519701553.07 μM0.423077780676Chembridge (Fragment library)262.28442.91934SWF1 & branched chain AA biosynthesis
SGTC_20625245942200 μM0.4081631376160Chembridge (Fragment library)215.247822.22202
SGTC_3250913558349.47 μM0.3962267699353Chembridge (Drug-like library)299.321182.80214
SGTC_20255147754141 μM0.384615315777Chembridge (Fragment library)229.231341.74913
SGTC_21255246583200 μM0.384615835267Chembridge (Fragment library)202.20931.88413tubulin folding & SWR complex
SGTC_21745790901200 μM0.377358786020Chembridge (Fragment library)208.237021.28914tubulin folding & SWR complex
SGTC_22637948595193.29 μM0.3773582971371Chembridge (Fragment library)236.247120.79824
SGTC_2998906676271.43 μM0.3620694945196Chembridge (Drug-like library)297.348363.54713RPP1 & pyrimidine depletion