| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YIR023W | 8.56 | 5.61E-18 | DAL81 | Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism |
| YKL126W | 6.62 | 1.79E-11 | YPK1 | Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication |
| YGR056W | 4.66 | 1.56E-6 | RSC1 | Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook |
| YGR165W | 4.31 | 8.27E-6 | MRPS35 | Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets |
| YNL338W_d | 4.28 | 9.31E-6 | YNL338W_d | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV |
| YCR092C | 3.82 | 6.77E-5 | MSH3 | Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability |
| YNL010W_p | 3.81 | 6.88E-5 | YNL010W_p | Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation |
| YOR248W_d | 3.75 | 8.85E-5 | YOR248W_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| YMR287C | 3.41 | 3.24E-4 | DSS1 | 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs |
| YKL198C | 3.40 | 3.35E-4 | PTK1 | Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein |
| YBR291C | 3.40 | 3.39E-4 | CTP1 | Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family |
| YDL172C_d | 3.37 | 3.80E-4 | YDL172C_d | Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data |
| YCL011C | 3.35 | 4.02E-4 | GBP2 | Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication |
| YOR067C | 3.24 | 5.95E-4 | ALG8 | Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p |
| YGL211W | 3.23 | 6.15E-4 | NCS6 | Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae |
