9103419

1-(3-methoxyphenyl)-5-methyl-N-phenyltriazole-4-carboxamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3168
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 16649256
SMILES CC1=C(N=NN1C2=CC(=CC=C2)OC)C(=O)NC3=CC=CC=C3
Standardized SMILES COc1cccc(c1)n2nnc(C(=O)Nc3ccccc3)c2C
Molecular weight 308.3345
ALogP 2.93
H-bond donor count 1
H-bond acceptor count 4
Response signature 60S ribosome export

Pool Growth Kinetics
% growth inhibition (Het. pool) 14.49
% growth inhibition (Hom. pool) 7.04


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 16649256
Download HIP data (tab-delimited text)  (excel)
Gene:HYM1(YKL189W)|FD-Score:4.52|P-value:3.15E-6|Clearance:0.07||SGD DESC:Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response Gene:LSG1(YGL099W)|FD-Score:4.13|P-value:1.80E-5|Clearance:0.52||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:MMS21(YEL019C)|FD-Score:4.45|P-value:4.28E-6|Clearance:0.32||SGD DESC:SUMO ligase and component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination Gene:NMD3(YHR170W)|FD-Score:6.84|P-value:4.06E-12|Clearance:2.32||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:PRO3(YER023W)|FD-Score:3.62|P-value:1.50E-4|Clearance:0.82||SGD DESC:Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis Gene:HYM1(YKL189W)|FD-Score:4.52|P-value:3.15E-6|Clearance:0.07||SGD DESC:Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response Gene:LSG1(YGL099W)|FD-Score:4.13|P-value:1.80E-5|Clearance:0.52||SGD DESC:Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm Gene:MMS21(YEL019C)|FD-Score:4.45|P-value:4.28E-6|Clearance:0.32||SGD DESC:SUMO ligase and component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination Gene:NMD3(YHR170W)|FD-Score:6.84|P-value:4.06E-12|Clearance:2.32||SGD DESC:Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex Gene:PRO3(YER023W)|FD-Score:3.62|P-value:1.50E-4|Clearance:0.82||SGD DESC:Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 16649256
Download HOP data (tab-delimited text)  (excel)
Gene:BUD25(YER014C-A)|FD-Score:-3.21|P-value:6.59E-4||SGD DESC:Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern Gene:DAL81(YIR023W)|FD-Score:6.72|P-value:9.28E-12||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:ECM33(YBR078W)|FD-Score:-3.89|P-value:4.99E-5||SGD DESC:GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p Gene:GTT2(YLL060C)|FD-Score:3.56|P-value:1.84E-4||SGD DESC:Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress Gene:INO1(YJL153C)|FD-Score:3.39|P-value:3.45E-4||SGD DESC:Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element Gene:IRS4(YKR019C)|FD-Score:3.49|P-value:2.42E-4||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:KDX1(YKL161C)|FD-Score:-3.19|P-value:7.17E-4||SGD DESC:Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p Gene:LCB4(YOR171C)|FD-Score:3.71|P-value:1.05E-4||SGD DESC:Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes Gene:MKK1(YOR231W)|FD-Score:-3.39|P-value:3.51E-4||SGD DESC:MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication Gene:MRP8(YKL142W)|FD-Score:-3.24|P-value:5.90E-4||SGD DESC:Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis Gene:NPR3(YHL023C)|FD-Score:3.12|P-value:8.89E-4||SGD DESC:Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; required for Npr2p phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed meiotic DNA replication and double-strand break repair Gene:NTH1(YDR001C)|FD-Score:-3.14|P-value:8.49E-4||SGD DESC:Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication Gene:PEX14(YGL153W)|FD-Score:3.16|P-value:7.84E-4||SGD DESC:Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p Gene:RBG2(YGR173W)|FD-Score:-3.13|P-value:8.74E-4||SGD DESC:Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein Gene:REV3(YPL167C)|FD-Score:-3.31|P-value:4.71E-4||SGD DESC:Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair Gene:SAC6(YDR129C)|FD-Score:3.64|P-value:1.35E-4||SGD DESC:Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:SAS2(YMR127C)|FD-Score:3.2|P-value:6.89E-4||SGD DESC:Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family Gene:SEC66(YBR171W)|FD-Score:7.08|P-value:7.47E-13||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SGF11(YPL047W)|FD-Score:-4.13|P-value:1.78E-5||SGD DESC:Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation Gene:SOD1(YJR104C)|FD-Score:3.16|P-value:7.82E-4||SGD DESC:Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid Gene:TPM1(YNL079C)|FD-Score:-3.42|P-value:3.08E-4||SGD DESC:Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication Gene:XRS2(YDR369C)|FD-Score:3.18|P-value:7.27E-4||SGD DESC:Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling Gene:YBL062W(YBL062W_d)|FD-Score:3.48|P-value:2.51E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR306C(YDR306C_p)|FD-Score:4.38|P-value:5.90E-6||SGD DESC:F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain Gene:YJR056C(YJR056C_p)|FD-Score:3.14|P-value:8.45E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress Gene:YML122C(YML122C_d)|FD-Score:4.97|P-value:3.38E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YOR376W-A(YOR376W-A_p)|FD-Score:5.02|P-value:2.58E-7||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:ZAP1(YJL056C)|FD-Score:-3.31|P-value:4.71E-4||SGD DESC:Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains Gene:BUD25(YER014C-A)|FD-Score:-3.21|P-value:6.59E-4||SGD DESC:Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern Gene:DAL81(YIR023W)|FD-Score:6.72|P-value:9.28E-12||SGD DESC:Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism Gene:ECM33(YBR078W)|FD-Score:-3.89|P-value:4.99E-5||SGD DESC:GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p Gene:GTT2(YLL060C)|FD-Score:3.56|P-value:1.84E-4||SGD DESC:Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress Gene:INO1(YJL153C)|FD-Score:3.39|P-value:3.45E-4||SGD DESC:Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element Gene:IRS4(YKR019C)|FD-Score:3.49|P-value:2.42E-4||SGD DESC:EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication Gene:KDX1(YKL161C)|FD-Score:-3.19|P-value:7.17E-4||SGD DESC:Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p Gene:LCB4(YOR171C)|FD-Score:3.71|P-value:1.05E-4||SGD DESC:Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes Gene:MKK1(YOR231W)|FD-Score:-3.39|P-value:3.51E-4||SGD DESC:MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication Gene:MRP8(YKL142W)|FD-Score:-3.24|P-value:5.90E-4||SGD DESC:Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; protein abundance increases in response to DNA replication stress; originally thought to be a mitochondrial ribosomal protein based on sequence analysis Gene:NPR3(YHL023C)|FD-Score:3.12|P-value:8.89E-4||SGD DESC:Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; required for Npr2p phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed meiotic DNA replication and double-strand break repair Gene:NTH1(YDR001C)|FD-Score:-3.14|P-value:8.49E-4||SGD DESC:Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication Gene:PEX14(YGL153W)|FD-Score:3.16|P-value:7.84E-4||SGD DESC:Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p Gene:RBG2(YGR173W)|FD-Score:-3.13|P-value:8.74E-4||SGD DESC:Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein Gene:REV3(YPL167C)|FD-Score:-3.31|P-value:4.71E-4||SGD DESC:Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair Gene:SAC6(YDR129C)|FD-Score:3.64|P-value:1.35E-4||SGD DESC:Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress Gene:SAS2(YMR127C)|FD-Score:3.2|P-value:6.89E-4||SGD DESC:Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family Gene:SEC66(YBR171W)|FD-Score:7.08|P-value:7.47E-13||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SGF11(YPL047W)|FD-Score:-4.13|P-value:1.78E-5||SGD DESC:Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation Gene:SOD1(YJR104C)|FD-Score:3.16|P-value:7.82E-4||SGD DESC:Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid Gene:TPM1(YNL079C)|FD-Score:-3.42|P-value:3.08E-4||SGD DESC:Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently; TPM1 has a paralog, TPM2, that arose from the whole genome duplication Gene:XRS2(YDR369C)|FD-Score:3.18|P-value:7.27E-4||SGD DESC:Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling Gene:YBL062W(YBL062W_d)|FD-Score:3.48|P-value:2.51E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDR306C(YDR306C_p)|FD-Score:4.38|P-value:5.90E-6||SGD DESC:F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain Gene:YJR056C(YJR056C_p)|FD-Score:3.14|P-value:8.45E-4||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress Gene:YML122C(YML122C_d)|FD-Score:4.97|P-value:3.38E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YOR376W-A(YOR376W-A_p)|FD-Score:5.02|P-value:2.58E-7||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:ZAP1(YJL056C)|FD-Score:-3.31|P-value:4.71E-4||SGD DESC:Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YHR170W6.844.06E-122.32NMD3Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
YKL189W4.523.15E-60.07HYM1Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
YEL019C4.454.28E-60.32MMS21SUMO ligase and component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination
YGL099W4.131.80E-50.52LSG1Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm
YER023W3.621.50E-40.82PRO3Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis
YMR094W2.800.002570.16CTF13Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis
YOR020C2.640.004180.02HSP10Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES
YCR013C_d2.610.004490.07YCR013C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant
YGR195W2.540.005470.04SKI6Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4)
YGR185C2.510.006057.06E-4TYS1Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress
YKL022C2.510.006060.01CDC16Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation
YDL008W2.490.006310.18APC11Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity
YLR305C2.320.010200.06STT4Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization
YJR023C_d2.260.012000.01YJR023C_dPutative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing
YDL030W2.240.012400.03PRP9Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YBR171W7.087.47E-13SEC66Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YIR023W6.729.28E-12DAL81Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism
YOR376W-A_p5.022.58E-7YOR376W-A_pPutative protein of unknown function; identified by fungal homology and RT-PCR
YML122C_d4.973.38E-7YML122C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YDR306C_p4.385.90E-6YDR306C_pF-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain
YOR171C3.711.05E-4LCB4Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes
YDR129C3.641.35E-4SAC6Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton; relocalizes from plasma membrane to cytoplasm upon DNA replication stress
YLL060C3.561.84E-4GTT2Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p; protein abundance increases in response to DNA replication stress
YKR019C3.492.42E-4IRS4EH domain-containing protein; involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS; IRS4 has a paralog, TAX4, that arose from the whole genome duplication
YBL062W_d3.482.51E-4YBL062W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL153C3.393.45E-4INO1Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
YMR127C3.206.89E-4SAS2Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
YDR369C3.187.27E-4XRS2Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling
YJR104C3.167.82E-4SOD1Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid
YGL153W3.167.84E-4PEX14Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p

GO enrichment analysis for SGTC_3168
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.2351.07E-74SGTC_9903985-0011 41.3 μMChemDiv (Drug-like library)53995650.188406amide catabolism
0.2107.24E-60SGTC_24605552655 174.2 μMMiscellaneous54019890.15942amide catabolism
0.2086.46E-59SGTC_486niguldipine 82.0 μMMiscellaneous12360.157895amide catabolism
0.2042.82E-56SGTC_32259130819 49.5 μMChembridge (Drug-like library)45471210.592593amide catabolism
0.1886.88E-48SGTC_10583448-5425 97.3 μMChemDiv (Drug-like library)72797050.151515
0.1839.30E-46SGTC_850868-0259 160.1 μMChemDiv (Drug-like library)831730.20634960S ribosome export
0.1775.99E-43SGTC_1913914-0123 66.5 μMChemDiv (Drug-like library)31444120.11842160S ribosome export
0.1777.11E-43SGTC_28459003024 43.0 μMChembridge (Drug-like library)29901730.220588amide catabolism
0.1779.41E-43SGTC_1958st076513 41.9 μMTimTec (Natural product derivative library)7321220.095890460S ribosome export
0.1714.33E-40SGTC_2680butyl paraben 22.2 μMMicrosource (Natural product library)71840.125amide catabolism
0.1702.89E-39SGTC_30349090421 49.5 μMChembridge (Drug-like library)171737610.20270360S ribosome export
0.1687.76E-39SGTC_3371315-0038 354.0 μMChemDiv (Drug-like library)16264370.0804598amide catabolism
0.1591.37E-34SGTC_31859108267 49.5 μMChembridge (Drug-like library)49104860.1123660S ribosome export
0.1581.76E-34SGTC_618k072-0232 33.2 μMChemDiv (Drug-like library)58727560.093333360S ribosome export
0.1583.76E-34SGTC_7003453-2283 142.0 μMChemDiv (Drug-like library)5656640.179104amide catabolism

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3065911388849.47 μM0.8723416648368Chembridge (Drug-like library)338.360522.91515
SGTC_3209911361649.47 μM0.80392216649353Chembridge (Drug-like library)342.77963.59514
SGTC_3192911036249.47 μM0.72222216649480Chembridge (Drug-like library)358.393223.83914mitochondrial processes
SGTC_3079911751249.47 μM0.6603777185044Chembridge (Drug-like library)338.360522.91515
SGTC_3225913081949.47 μM0.5925934547121Chembridge (Drug-like library)293.32322.66624amide catabolism
SGTC_3263913701849.47 μM0.55932243844957Chembridge (Drug-like library)336.38773.20624
SGTC_3325913876055.18 μM0.54098443844959Chembridge (Drug-like library)356.806183.38524Golgi
SGTC_3201911399949.47 μM0.516649224Chembridge (Drug-like library)336.38773.90314
SGTC_3237913336249.47 μM0.543845137Chembridge (Drug-like library)370.832763.87124
SGTC_3290912103171.43 μM0.48387117014854Chembridge (Drug-like library)354.3781634.00915