9102970

2-[1-[(2,6-dichlorophenyl)methyl]benzimidazol-2-yl]ethanol

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3169
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 17027839
SMILES C1=CC=C2C(=C1)N=C(N2CC3=C(C=CC=C3Cl)Cl)CCO
Standardized SMILES OCCc1nc2ccccc2n1Cc3c(Cl)cccc3Cl
Molecular weight 321.2012
ALogP 4.3
H-bond donor count 1
H-bond acceptor count 2
Response signature RPP1 & pyrimidine depletion

Pool Growth Kinetics
% growth inhibition (Het. pool) 7.46
% growth inhibition (Hom. pool) 5.15


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 17027839
Download HIP data (tab-delimited text)  (excel)
Gene:BOS1(YLR078C)|FD-Score:3.19|P-value:7.11E-4|Clearance:0.05||SGD DESC:v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi Gene:MCM2(YBL023C)|FD-Score:3.49|P-value:2.41E-4|Clearance:0.03||SGD DESC:Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress Gene:RPP1(YHR062C)|FD-Score:5.93|P-value:1.52E-9|Clearance:2.44||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:SRP102(YKL154W)|FD-Score:3.14|P-value:8.48E-4|Clearance:0.12||SGD DESC:Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane Gene:TIF6(YPR016C)|FD-Score:3.46|P-value:2.72E-4|Clearance:0.27||SGD DESC:Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits Gene:BOS1(YLR078C)|FD-Score:3.19|P-value:7.11E-4|Clearance:0.05||SGD DESC:v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi Gene:MCM2(YBL023C)|FD-Score:3.49|P-value:2.41E-4|Clearance:0.03||SGD DESC:Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress Gene:RPP1(YHR062C)|FD-Score:5.93|P-value:1.52E-9|Clearance:2.44||SGD DESC:Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs Gene:SRP102(YKL154W)|FD-Score:3.14|P-value:8.48E-4|Clearance:0.12||SGD DESC:Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane Gene:TIF6(YPR016C)|FD-Score:3.46|P-value:2.72E-4|Clearance:0.27||SGD DESC:Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 17027839
Download HOP data (tab-delimited text)  (excel)
Gene:BAP3(YDR046C)|FD-Score:-3.38|P-value:3.61E-4||SGD DESC:Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication Gene:DBR1(YKL149C)|FD-Score:3.59|P-value:1.66E-4||SGD DESC:RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition Gene:GAL11(YOL051W)|FD-Score:3.73|P-value:9.43E-5||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator Gene:GBP2(YCL011C)|FD-Score:3.83|P-value:6.52E-5||SGD DESC:Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication Gene:IMA5(YJL216C)|FD-Score:-3.26|P-value:5.58E-4||SGD DESC:Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose Gene:LCL2(YLR104W_p)|FD-Score:3.63|P-value:1.42E-4||SGD DESC:Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD) Gene:MGR2(YPL098C)|FD-Score:3.19|P-value:7.11E-4||SGD DESC:Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome (petite-negative phenotype) Gene:MIG3(YER028C)|FD-Score:3.15|P-value:8.23E-4||SGD DESC:Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication Gene:MRPL37(YBR268W)|FD-Score:3.13|P-value:8.66E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:PDR1(YGL013C)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication Gene:PIG2(YIL045W)|FD-Score:-3.14|P-value:8.33E-4||SGD DESC:Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase Gene:ROX3(YBL093C)|FD-Score:3.28|P-value:5.17E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme Gene:RPL20B(YOR312C)|FD-Score:3.96|P-value:3.74E-5||SGD DESC:Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication Gene:RPL7B(YPL198W)|FD-Score:3.14|P-value:8.49E-4||SGD DESC:Ribosomal 60S subunit protein L7B; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication Gene:RPN4(YDL020C)|FD-Score:5.37|P-value:4.03E-8||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:RSC1(YGR056W)|FD-Score:3.33|P-value:4.33E-4||SGD DESC:Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook Gene:SPS100(YHR139C)|FD-Score:3.47|P-value:2.64E-4||SGD DESC:Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin Gene:TRP2(YER090W)|FD-Score:3.13|P-value:8.80E-4||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:YNL190W(YNL190W_p)|FD-Score:3.83|P-value:6.48E-5||SGD DESC:Hydrophilin essential in dessication-rehydration process; cell wall protein; contains a putative GPI-attachment site Gene:YNR005C(YNR005C_d)|FD-Score:3.88|P-value:5.12E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNR029C(YNR029C_p)|FD-Score:-3.67|P-value:1.23E-4||SGD DESC:Putative protein of unknown function, deletion confers reduced fitness in saline Gene:BAP3(YDR046C)|FD-Score:-3.38|P-value:3.61E-4||SGD DESC:Amino acid permease; involved in uptake of cysteine, leucine, isoleucine and valine; BAP3 has a paralog, BAP2, that arose from the whole genome duplication Gene:DBR1(YKL149C)|FD-Score:3.59|P-value:1.66E-4||SGD DESC:RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition Gene:GAL11(YOL051W)|FD-Score:3.73|P-value:9.43E-5||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator Gene:GBP2(YCL011C)|FD-Score:3.83|P-value:6.52E-5||SGD DESC:Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication Gene:IMA5(YJL216C)|FD-Score:-3.26|P-value:5.58E-4||SGD DESC:Alpha-glucosidase; specificity for isomaltose, maltose, and palatinose, but not alpha-methylglucoside; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose Gene:LCL2(YLR104W_p)|FD-Score:3.63|P-value:1.42E-4||SGD DESC:Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD) Gene:MGR2(YPL098C)|FD-Score:3.19|P-value:7.11E-4||SGD DESC:Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome (petite-negative phenotype) Gene:MIG3(YER028C)|FD-Score:3.15|P-value:8.23E-4||SGD DESC:Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication Gene:MRPL37(YBR268W)|FD-Score:3.13|P-value:8.66E-4||SGD DESC:Mitochondrial ribosomal protein of the large subunit Gene:PDR1(YGL013C)|FD-Score:3.63|P-value:1.44E-4||SGD DESC:Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication Gene:PIG2(YIL045W)|FD-Score:-3.14|P-value:8.33E-4||SGD DESC:Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase Gene:ROX3(YBL093C)|FD-Score:3.28|P-value:5.17E-4||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme Gene:RPL20B(YOR312C)|FD-Score:3.96|P-value:3.74E-5||SGD DESC:Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication Gene:RPL7B(YPL198W)|FD-Score:3.14|P-value:8.49E-4||SGD DESC:Ribosomal 60S subunit protein L7B; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication Gene:RPN4(YDL020C)|FD-Score:5.37|P-value:4.03E-8||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:RSC1(YGR056W)|FD-Score:3.33|P-value:4.33E-4||SGD DESC:Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook Gene:SPS100(YHR139C)|FD-Score:3.47|P-value:2.64E-4||SGD DESC:Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin Gene:TRP2(YER090W)|FD-Score:3.13|P-value:8.80E-4||SGD DESC:Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p Gene:YNL190W(YNL190W_p)|FD-Score:3.83|P-value:6.48E-5||SGD DESC:Hydrophilin essential in dessication-rehydration process; cell wall protein; contains a putative GPI-attachment site Gene:YNR005C(YNR005C_d)|FD-Score:3.88|P-value:5.12E-5||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNR029C(YNR029C_p)|FD-Score:-3.67|P-value:1.23E-4||SGD DESC:Putative protein of unknown function, deletion confers reduced fitness in saline

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YHR062C5.931.52E-92.44RPP1Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YBL023C3.492.41E-40.03MCM2Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress
YPR016C3.462.72E-40.27TIF6Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits
YLR078C3.197.11E-40.05BOS1v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi
YKL154W3.148.48E-40.12SRP102Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane
YPR103W3.020.001280.24PRE2Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome
YPR187W2.770.002760.04RPO26RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit
YBR256C2.730.003140.02RIB5Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway
YLR316C2.710.003330.09TAD3Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs
YKR022C2.620.004380.02NTR2Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly
YDL105W2.610.004580.05NSE4Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair
YOR117W2.550.005310.01RPT5One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1
YPL210C2.550.005390.15SRP72Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
YDR052C2.400.008240.02DBF4Regulatory subunit of Cdc7p-Dbf4p kinase complex; required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated; relative distribution to the nucleus increases upon DNA replication stress
YOR340C2.380.008700.04RPA43RNA polymerase I subunit A43

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YDL020C5.374.03E-8RPN4Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress
YOR312C3.963.74E-5RPL20BRibosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication
YNR005C_d3.885.12E-5YNR005C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YNL190W_p3.836.48E-5YNL190W_pHydrophilin essential in dessication-rehydration process; cell wall protein; contains a putative GPI-attachment site
YCL011C3.836.52E-5GBP2Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication
YOL051W3.739.43E-5GAL11Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator
YLR104W_p3.631.42E-4LCL2_pPutative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD)
YGL013C3.631.44E-4PDR1Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication
YKL149C3.591.66E-4DBR1RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition
YHR139C3.472.64E-4SPS100Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin
YGR056W3.334.33E-4RSC1Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook
YBL093C3.285.17E-4ROX3Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme
YPL098C3.197.11E-4MGR2Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome (petite-negative phenotype)
YER028C3.158.23E-4MIG3Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication
YPL198W3.148.49E-4RPL7BRibosomal 60S subunit protein L7B; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication

GO enrichment analysis for SGTC_3169
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.2341.75E-74SGTC_2508celastrol 40.5 μMMicrosource (Natural product library)1227240.0344828PDR1
0.2313.11E-72SGTC_26602',4'-dihydroxychalcone 17.1 μMTimTec (Pure natural product library)53572180.101695
0.2111.23E-60SGTC_26682',4'-dihydroxychalcone 15.1 μMTimTec (Pure natural product library)53572180.101695
0.1956.31E-52SGTC_1700st030840 7.9 μMTimTec (Natural product derivative library)54993070.0449438PDR1
0.1931.46E-50SGTC_31679103034 49.5 μMChembridge (Drug-like library)51278590.0882353RPP1 & pyrimidine depletion
0.1923.17E-50SGTC_2752diclazuril 33.1 μMMiscellaneous4563890.0958904
0.1819.18E-45SGTC_2701st077767 14.7 μMTimTec (Natural product derivative library)57211880.0757576
0.1742.44E-41SGTC_2023594-0513 34.8 μMChemDiv (Drug-like library)7084290.103448PDR1
0.1672.98E-38SGTC_30259087895 49.5 μMChembridge (Drug-like library)171736410.0625PDR1
0.1633.48E-36SGTC_1139k015-0024 46.9 μMChemDiv (Drug-like library)27666520.106061PDR1
0.1582.05E-34SGTC_1604st002052 72.4 μMTimTec (Natural product derivative library)62548340.0952381TSC3-RPN4
0.1554.13E-33SGTC_12430416-0003 5.7 μMChemDiv (Drug-like library)21419770.109091PDR1
0.1557.79E-33SGTC_21945927483 104.5 μMChembridge (Fragment library)7609790.0833333
0.1541.40E-32SGTC_32619137475 49.5 μMChembridge (Drug-like library)170276900.08RPP1 & pyrimidine depletion
0.1511.18E-31SGTC_1661st013063 9.7 μMTimTec (Natural product derivative library)7213950.056338

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_2987901833871.43 μM0.3559325055682Chembridge (Drug-like library)330.808663.98313RPP1 & pyrimidine depletion
SGTC_3019908197149.47 μM0.3516451803Chembridge (Drug-like library)357.448223.99703
SGTC_3017908068149.47 μM0.34482816451914Chembridge (Drug-like library)307.389543.14702
SGTC_1974544-004341.56 μM0.327586896523ChemDiv (Drug-like library)322.189224.30713endomembrane recycling
SGTC_7243910-0327137 μM0.3220342885483ChemDiv (Drug-like library)316.782083.59813ERG2
SGTC_2862902763471.43 μM0.317465012562Chembridge (Drug-like library)324.416764.45213ERG2
SGTC_5623772-2733112 μM0.3114752876874ChemDiv (Drug-like library)422.260134.17813ERG2
SGTC_14133910-053534.4 μM0.3076922876951ChemDiv (Drug-like library)358.861825.21313
SGTC_21495554786194.83 μM0.296296745063Chembridge (Fragment library)230.308821.94613cell wall signaling
SGTC_9943910-0338138 μM0.2835823479481ChemDiv (Drug-like library)425.318345.25713calcium & mitochondrial duress