| Deletion Strain | FD score | P-value | Gene | Gene Description |
|---|
| YDL020C | 5.37 | 4.03E-8 | RPN4 | Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress |
| YOR312C | 3.96 | 3.74E-5 | RPL20B | Ribosomal 60S subunit protein L20B; homologous to mammalian ribosomal protein L18A, no bacterial homolog; RPL20B has a paralog, RPL20A, that arose from the whole genome duplication |
| YNR005C_d | 3.88 | 5.12E-5 | YNR005C_d | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| YNL190W_p | 3.83 | 6.48E-5 | YNL190W_p | Hydrophilin essential in dessication-rehydration process; cell wall protein; contains a putative GPI-attachment site |
| YCL011C | 3.83 | 6.52E-5 | GBP2 | Poly(A+) RNA-binding protein; involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Npl3p; also binds single-stranded telomeric repeat sequence in vitro; GBP2 has a paralog, HRB1, that arose from the whole genome duplication |
| YOL051W | 3.73 | 9.43E-5 | GAL11 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator |
| YLR104W_p | 3.63 | 1.42E-4 | LCL2_p | Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD) |
| YGL013C | 3.63 | 1.44E-4 | PDR1 | Transcription factor that regulates the pleiotropic drug response; zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes; PDR1 has a paralog, PDR3, that arose from the whole genome duplication |
| YKL149C | 3.59 | 1.66E-4 | DBR1 | RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition |
| YHR139C | 3.47 | 2.64E-4 | SPS100 | Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin |
| YGR056W | 3.33 | 4.33E-4 | RSC1 | Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook |
| YBL093C | 3.28 | 5.17E-4 | ROX3 | Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme |
| YPL098C | 3.19 | 7.11E-4 | MGR2 | Subunit of the TIM23 translocase complex; acts to couple Tim21p with the core Tim23 translocase; absolutely required for mitochondrial import of presequence-containing proteins at elevated temperature; required for viability of cells lacking the mitochondrial genome (petite-negative phenotype) |
| YER028C | 3.15 | 8.23E-4 | MIG3 | Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication |
| YPL198W | 3.14 | 8.49E-4 | RPL7B | Ribosomal 60S subunit protein L7B; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication |
