9105863

1-(2,3-dihydroindol-1-yl)-2-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]ethanone

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3172
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 2348785
SMILES C1CN(C2=CC=CC=C21)C(=O)CN3CCN(CC3)C4=CC=CC(=C4)C(F)(F)F
Standardized SMILES FC(F)(F)c1cccc(c1)N2CCN(CC(=O)N3CCc4ccccc34)CC2
Molecular weight 389.4141
ALogP 3.81
H-bond donor count 0
H-bond acceptor count 6
Response signature ERG2

Pool Growth Kinetics
% growth inhibition (Het. pool) 9.15
% growth inhibition (Hom. pool) 9.53


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 2348785
Download HIP data (tab-delimited text)  (excel)

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 2348785
Download HOP data (tab-delimited text)  (excel)
Gene:ARG7(YMR062C)|FD-Score:4.62|P-value:1.89E-6||SGD DESC:Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine Gene:ATP5(YDR298C)|FD-Score:-3.34|P-value:4.26E-4||SGD DESC:Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated Gene:DUS4(YLR405W)|FD-Score:3.59|P-value:1.68E-4||SGD DESC:Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p Gene:ERG2(YMR202W)|FD-Score:6.23|P-value:2.31E-10||SGD DESC:C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis Gene:ERP6(YGL002W)|FD-Score:3.33|P-value:4.33E-4||SGD DESC:Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication Gene:GSF2(YML048W)|FD-Score:5.68|P-value:6.77E-9||SGD DESC:ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression Gene:LYS20(YDL182W)|FD-Score:-3.35|P-value:4.05E-4||SGD DESC:Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication Gene:MKK1(YOR231W)|FD-Score:4.47|P-value:3.88E-6||SGD DESC:MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication Gene:PGD1(YGL025C)|FD-Score:3.83|P-value:6.54E-5||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor Gene:PKH3(YDR466W)|FD-Score:3.1|P-value:9.69E-4||SGD DESC:Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant Gene:RAD5(YLR032W)|FD-Score:3.61|P-value:1.52E-4||SGD DESC:DNA helicase; proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress Gene:REG1(YDR028C)|FD-Score:4.36|P-value:6.49E-6||SGD DESC:Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p Gene:SRC1(YML034W)|FD-Score:3.65|P-value:1.30E-4||SGD DESC:Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance Gene:YBR219C(YBR219C_p)|FD-Score:3.21|P-value:6.66E-4||SGD DESC:Putative protein of unknown function; YBR219C is not an essential gene Gene:ARG7(YMR062C)|FD-Score:4.62|P-value:1.89E-6||SGD DESC:Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine Gene:ATP5(YDR298C)|FD-Score:-3.34|P-value:4.26E-4||SGD DESC:Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated Gene:DUS4(YLR405W)|FD-Score:3.59|P-value:1.68E-4||SGD DESC:Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p Gene:ERG2(YMR202W)|FD-Score:6.23|P-value:2.31E-10||SGD DESC:C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis Gene:ERP6(YGL002W)|FD-Score:3.33|P-value:4.33E-4||SGD DESC:Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication Gene:GSF2(YML048W)|FD-Score:5.68|P-value:6.77E-9||SGD DESC:ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression Gene:LYS20(YDL182W)|FD-Score:-3.35|P-value:4.05E-4||SGD DESC:Homocitrate synthase isozyme; catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; LYS20 has a paralog, LYS21, that arose from the whole genome duplication Gene:MKK1(YOR231W)|FD-Score:4.47|P-value:3.88E-6||SGD DESC:MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication Gene:PGD1(YGL025C)|FD-Score:3.83|P-value:6.54E-5||SGD DESC:Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor Gene:PKH3(YDR466W)|FD-Score:3.1|P-value:9.69E-4||SGD DESC:Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant Gene:RAD5(YLR032W)|FD-Score:3.61|P-value:1.52E-4||SGD DESC:DNA helicase; proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress Gene:REG1(YDR028C)|FD-Score:4.36|P-value:6.49E-6||SGD DESC:Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p Gene:SRC1(YML034W)|FD-Score:3.65|P-value:1.30E-4||SGD DESC:Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance Gene:YBR219C(YBR219C_p)|FD-Score:3.21|P-value:6.66E-4||SGD DESC:Putative protein of unknown function; YBR219C is not an essential gene

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YLR078C3.265.58E-40.31BOS1v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi
YNL207W2.950.001580.09RIO2Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p
YGL112C2.860.002110.11TAF6Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
YDR062W2.760.002930.13LCB2Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine
YKR062W2.630.004330.06TFA2TFIIE small subunit, involved in RNA polymerase II transcription initiation
YGR074W2.560.005200.06SMD1Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1; protein abundance increases in response to DNA replication stress
YGR065C2.500.006230.06VHT1High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YOL130W2.440.007270.02ALR1Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions
YAL001C2.420.007750.04TFC3Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding
YPL210C2.380.008680.04SRP72Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane
YNL062C2.340.009680.01GCD10Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression
YOR119C2.320.010100.04RIO1Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA
YML093W2.280.011200.06UTP14Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
YNL152W2.230.013000.04INN1Essential protein that associates with contractile actomyosin ring; required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function; activates chitin synthase activity of Chs2p during cytokinesis
YJL195C_d2.190.014400.05YJL195C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YMR202W6.232.31E-10ERG2C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis
YML048W5.686.77E-9GSF2ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression
YMR062C4.621.89E-6ARG7Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine
YOR231W4.473.88E-6MKK1MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
YDR028C4.366.49E-6REG1Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p
YGL025C3.836.54E-5PGD1Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor
YML034W3.651.30E-4SRC1Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
YLR032W3.611.52E-4RAD5DNA helicase; proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; required for error-prone translesion synthesis; forms nuclear foci upon DNA replication stress
YLR405W3.591.68E-4DUS4Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
YGL002W3.334.33E-4ERP6Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
YBR219C_p3.216.66E-4YBR219C_pPutative protein of unknown function; YBR219C is not an essential gene
YDR466W3.109.69E-4PKH3Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant
YOR246C3.030.00122ENV9Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
YDR515W2.940.00165SLF1RNA binding protein that associates with polysomes; may be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts; SLF1 has a paralog, SRO9, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
YPR031W2.910.00180NTO1Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3

GO enrichment analysis for SGTC_3172
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.2521.98E-86SGTC_21445628481 200.0 μMChembridge (Fragment library)28183990.0821918ERG2
0.2406.67E-78SGTC_12440416-0015 52.5 μMChemDiv (Drug-like library)962010.0645161ERG2
0.2261.64E-69SGTC_20555235184 200.0 μMChembridge (Fragment library)28360340.15873ERG2
0.2201.12E-65SGTC_234nsc-17383 10.7 μMMiscellaneous4089740.0823529ERG2
0.2111.10E-60SGTC_28207989630 71.4 μMChembridge (Drug-like library)29840980.107143ERG2
0.2086.48E-59SGTC_6341611-4317 11.2 μMChemDiv (Drug-like library)28435220.102564ERG2
0.2036.01E-56SGTC_5983937-0236 20.2 μMChemDiv (Drug-like library)13793130.0625ERG2
0.1983.89E-53SGTC_13601598-0022 39.8 μMChemDiv (Drug-like library)7615250.0821918ERG2
0.1931.88E-50SGTC_12063978-0017 132.0 μMChemDiv (Drug-like library)38736770.195122ERG2
0.1871.94E-47SGTC_9741326-0144 138.0 μMChemDiv (Drug-like library)54118560.119403ERG2
0.1851.00E-46SGTC_1694st024011 44.9 μMTimTec (Natural product derivative library)27875330.0989011ERG2
0.1831.15E-45SGTC_7243910-0327 137.0 μMChemDiv (Drug-like library)28854830.0722892ERG2
0.1798.58E-44SGTC_2734clemastine 41.6 μMMiscellaneous269870.155844ERG2
0.1714.31E-40SGTC_12470448-0043 5.8 μMChemDiv (Drug-like library)30890130.0512821ERG2
0.1714.88E-40SGTC_31669102297 49.5 μMChembridge (Drug-like library)252370720.144737Golgi

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3199911131849.47 μM0.5333338548020Chembridge (Drug-like library)381.3672733.73317
SGTC_1605st00008249.1 μM0.4242421114022TimTec (Natural product derivative library)407.452513.9270760S ribosome export
SGTC_23117694451200 μM0.4210532163142Chembridge (Fragment library)205.2531.31602
SGTC_10204335-096193.3 μM0.393443669075ChemDiv (Drug-like library)267.322382.91302
SGTC_13963511-000798.6 μM0.375X1396ChemDiv (Drug-like library)421.843265.08441mitochondrial processes
SGTC_2045510665278.05 μM0.355932673349Chembridge (Fragment library)213.231942.2902
SGTC_22837944793200 μM0.3492062970533Chembridge (Fragment library)228.246581.92303
SGTC_2476580691610.51 μM0.3150682870194Miscellaneous395.352393.63918
SGTC_1139k015-002446.9 μM0.31252766652ChemDiv (Drug-like library)305.251313.40205PDR1
SGTC_2902043-672248.1 μM0.30303773758ChemDiv (Drug-like library)281.3241434.02402