9106582

N-(3-chlorophenyl)-4-methoxy-3-methylbenzamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3176
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 17018027
SMILES CC1=C(C=CC(=C1)C(=O)NC2=CC(=CC=C2)Cl)OC
Standardized SMILES COc1ccc(cc1C)C(=O)Nc2cccc(Cl)c2
Molecular weight 275.7302
ALogP 3.75
H-bond donor count 1
H-bond acceptor count 2
Response signature

Pool Growth Kinetics
% growth inhibition (Het. pool) 19
% growth inhibition (Hom. pool) 11.15


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 17018027
Download HIP data (tab-delimited text)  (excel)
Gene:CCT7(YJL111W)|FD-Score:3.78|P-value:7.70E-5|Clearance:0.65||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance Gene:MRD1(YPR112C)|FD-Score:4.09|P-value:2.18E-5|Clearance:0.65||SGD DESC:Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region Gene:PUP3(YER094C)|FD-Score:-3.34|P-value:4.19E-4|Clearance:0||SGD DESC:Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10 Gene:SEC23(YPR181C)|FD-Score:3.14|P-value:8.56E-4|Clearance:0.34||SGD DESC:GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p Gene:UBC1(YDR177W)|FD-Score:-3.21|P-value:6.71E-4|Clearance:0||SGD DESC:Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress Gene:CCT7(YJL111W)|FD-Score:3.78|P-value:7.70E-5|Clearance:0.65||SGD DESC:Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance Gene:MRD1(YPR112C)|FD-Score:4.09|P-value:2.18E-5|Clearance:0.65||SGD DESC:Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region Gene:PUP3(YER094C)|FD-Score:-3.34|P-value:4.19E-4|Clearance:0||SGD DESC:Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10 Gene:SEC23(YPR181C)|FD-Score:3.14|P-value:8.56E-4|Clearance:0.34||SGD DESC:GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p Gene:UBC1(YDR177W)|FD-Score:-3.21|P-value:6.71E-4|Clearance:0||SGD DESC:Ubiquitin-conjugating enzyme; mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response; protein abundance increases in response to DNA replication stress

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 17018027
Download HOP data (tab-delimited text)  (excel)
Gene:ALD3(YMR169C)|FD-Score:4|P-value:3.10E-5||SGD DESC:Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose Gene:ICP55(YER078C)|FD-Score:3.23|P-value:6.08E-4||SGD DESC:Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family Gene:PKR1(YMR123W)|FD-Score:-4.07|P-value:2.39E-5||SGD DESC:V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress Gene:SEC66(YBR171W)|FD-Score:4.56|P-value:2.53E-6||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SLX8(YER116C)|FD-Score:-3.11|P-value:9.36E-4||SGD DESC:Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress Gene:TRP3(YKL211C)|FD-Score:-3.86|P-value:5.75E-5||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:VPH1(YOR270C)|FD-Score:-3.18|P-value:7.38E-4||SGD DESC:Subunit a of vacuolar-ATPase V0 domain; one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes; relative distribution to the vacuolar membrane decreases upon DNA replication stress Gene:YBL065W(YBL065W_d)|FD-Score:-3.1|P-value:9.70E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene Gene:YOL029C(YOL029C_p)|FD-Score:3.45|P-value:2.82E-4||SGD DESC:Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens Gene:YPR063C(YPR063C_p)|FD-Score:-3.23|P-value:6.19E-4||SGD DESC:ER-localized protein of unknown function Gene:ALD3(YMR169C)|FD-Score:4|P-value:3.10E-5||SGD DESC:Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose Gene:ICP55(YER078C)|FD-Score:3.23|P-value:6.08E-4||SGD DESC:Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family Gene:PKR1(YMR123W)|FD-Score:-4.07|P-value:2.39E-5||SGD DESC:V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress Gene:SEC66(YBR171W)|FD-Score:4.56|P-value:2.53E-6||SGD DESC:Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER Gene:SLX8(YER116C)|FD-Score:-3.11|P-value:9.36E-4||SGD DESC:Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain; forms nuclear foci upon DNA replication stress Gene:TRP3(YKL211C)|FD-Score:-3.86|P-value:5.75E-5||SGD DESC:Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p Gene:VPH1(YOR270C)|FD-Score:-3.18|P-value:7.38E-4||SGD DESC:Subunit a of vacuolar-ATPase V0 domain; one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes; relative distribution to the vacuolar membrane decreases upon DNA replication stress Gene:YBL065W(YBL065W_d)|FD-Score:-3.1|P-value:9.70E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene Gene:YOL029C(YOL029C_p)|FD-Score:3.45|P-value:2.82E-4||SGD DESC:Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens Gene:YPR063C(YPR063C_p)|FD-Score:-3.23|P-value:6.19E-4||SGD DESC:ER-localized protein of unknown function

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YPR112C4.092.18E-50.65MRD1Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region
YJL111W3.787.70E-50.65CCT7Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance
YPR181C3.148.56E-40.34SEC23GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome-mediated degradation of Sec23p is regulated by Cdc48p
YOL069W2.790.002600.05NUF2Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering
YDR526C_d2.750.002990.07YDR526C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBL023C2.680.003700.12MCM2Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress
YJL041W2.550.005320.09NSP1FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; found in stable complex with Nup82p, Gle2p and two other FG-nucleoporins (Nup159p and Nup116p); also found in stable complex with Nic96p and two other FG-nucleoproteins (Nup49p and Nup57p); forms foci at the nuclear periphery upon DNA replication stress
YIL062C2.470.006780.02ARC15Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; has mRNA binding activity
YOR319W2.450.007180.04HSH49U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)
YDL108W2.400.008100.20KIN28Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters
YJR041C2.200.013800.01URB2Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis
YER159C2.190.014100.03BUR6Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
YGR030C2.160.015400.00POP6Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YGL074C_d2.160.015600.03YGL074C_dDubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor
YJR065C2.130.016600.06ARP3Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YBR171W4.562.53E-6SEC66Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
YMR169C4.003.10E-5ALD3Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose
YOL029C_p3.452.82E-4YOL029C_pPutative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens
YER078C3.236.08E-4ICP55Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family
YMR063W3.060.00111RIM9Plasma membrane protein of unknown function; involved in the proteolytic activation of Rim101p in response to alkaline pH; interacts with Rim21p and Dfg16p to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; has similarity to A. nidulans PalI;
YJL153C3.060.00111INO1Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
YMR278W3.060.00112PGM3Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential
YLR370C2.950.00161ARC18Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
YOR301W2.890.00191RAX1Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily
YBR036C2.850.00217CSG2Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress
YDL180W_p2.830.00230YDL180W_pPutative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YDR392W2.820.00243SPT3Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
YER181C_d2.820.00243YER181C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies
YCL035C2.700.00350GRX1Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
YIL095W2.690.00355PRK1Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex; PRK1 has a paralog, ARK1, that arose from the whole genome duplication

GO enrichment analysis for SGTC_3176
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1102.98E-17SGTC_28639028737 58.4 μMChembridge (Drug-like library)64609170.296875
0.1001.63E-14SGTC_31689103419 49.5 μMChembridge (Drug-like library)166492560.32258160S ribosome export
0.0913.02E-12SGTC_31669102297 49.5 μMChembridge (Drug-like library)252370720.21875Golgi
0.0881.50E-11SGTC_20895281248 129.7 μMChembridge (Fragment library)27378780.0649351superoxide
0.0872.70E-11SGTC_31659101544 49.5 μMChembridge (Drug-like library)50021840.25
0.0841.13E-10SGTC_29829019404 26.0 μMChembridge (Drug-like library)223332320.144928
0.0764.57E-9SGTC_28107959871 45.5 μMChembridge (Drug-like library)29745350.246377copper-dependent oxidative stress
0.0765.37E-9SGTC_21575649910 96.4 μMChembridge (Fragment library)28580910.0634921
0.0732.00E-8SGTC_29819013952 39.0 μMChembridge (Drug-like library)29963440.21875
0.0732.05E-8SGTC_1116jasmonic acid  1.6 μMTimTec (Natural product library)52811660.0746269
0.0723.31E-8SGTC_33309141424 71.4 μMChembridge (Drug-like library)272610200.105263amide catabolism
0.0723.48E-8SGTC_32719137798 49.5 μMChembridge (Drug-like library)64983260.183099
0.0714.00E-8SGTC_11770983-0204 23.6 μMChemDiv (Drug-like library)7668180.315789
0.0682.03E-7SGTC_31079121808 49.5 μMChembridge (Drug-like library)6626810.136986
0.0672.11E-7SGTC_29839022671 13.0 μMChembridge (Drug-like library)64051610.094117660S ribosome export

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_2787528454071.43 μM0.804878736958Chembridge (Drug-like library)291.729563.24613
SGTC_3205911348349.47 μM0.74418617018033Chembridge (Drug-like library)271.311083.06813
SGTC_3203911354349.47 μM0.73170717018012Chembridge (Drug-like library)241.28513.08412
SGTC_3186911046449.47 μM0.67441917018021Chembridge (Drug-like library)269.338264.05612RPP1 & pyrimidine depletion
SGTC_2900532852885.29 μM0.622222795359Chembridge (Drug-like library)261.703583.26212Golgi
SGTC_3200911438549.47 μM0.60869617018030Chembridge (Drug-like library)277.2660263.49514
SGTC_8261683-5028118 μM0.553191722377ChemDiv (Drug-like library)261.703583.26212
SGTC_3195911308249.47 μM0.55319117018038Chembridge (Drug-like library)301.337063.05114
SGTC_12550566-0045221 μM0.5208332788469ChemDiv (Drug-like library)304.728323.04223excess fatty acid
SGTC_7161683-5115658 μM0.52723597ChemDiv (Drug-like library)303.740263.48313