9108277

N-[3-(3-methylbutoxy)phenyl]pyridine-4-carboxamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3181
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 17097298
SMILES CC(C)CCOC1=CC=CC(=C1)NC(=O)C2=CC=NC=C2
Standardized SMILES CC(C)CCOc1cccc(NC(=O)c2ccncc2)c1
Molecular weight 284.3529
ALogP 3.03
H-bond donor count 1
H-bond acceptor count 3
Response signature iron homeostasis

Pool Growth Kinetics
% growth inhibition (Het. pool) 33.18
% growth inhibition (Hom. pool) 12.92


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 17097298
Download HIP data (tab-delimited text)  (excel)
Gene:ACT1(YFL039C)|FD-Score:-4.1|P-value:2.04E-5|Clearance:0||SGD DESC:Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions Gene:BET3(YKR068C)|FD-Score:3.13|P-value:8.74E-4|Clearance:0.03||SGD DESC:Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex Gene:CLP1(YOR250C)|FD-Score:3.1|P-value:9.56E-4|Clearance:0.01||SGD DESC:Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation Gene:CTF13(YMR094W)|FD-Score:3.23|P-value:6.17E-4|Clearance:0.08||SGD DESC:Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis Gene:DBP2(YNL112W)|FD-Score:4.52|P-value:3.05E-6|Clearance:0.05||SGD DESC:ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites Gene:DML1(YMR211W)|FD-Score:5.38|P-value:3.63E-8|Clearance:0||SGD DESC:Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family Gene:DPS1(YLL018C)|FD-Score:4.09|P-value:2.11E-5|Clearance:0.04||SGD DESC:Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation Gene:ECM16(YMR128W)|FD-Score:-3.61|P-value:1.55E-4|Clearance:0||SGD DESC:Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis Gene:ENP1(YBR247C)|FD-Score:3.63|P-value:1.42E-4|Clearance:0.02||SGD DESC:Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus Gene:ESP1(YGR098C)|FD-Score:3.09|P-value:9.99E-4|Clearance:0.07||SGD DESC:Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress Gene:FOL1(YNL256W)|FD-Score:3.71|P-value:1.04E-4|Clearance:0.08||SGD DESC:Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities Gene:NAR1(YNL240C)|FD-Score:3.15|P-value:8.07E-4|Clearance:0||SGD DESC:Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf Gene:NAT2(YGR147C)|FD-Score:3.5|P-value:2.34E-4|Clearance:0.01||SGD DESC:Protein with an apparent role in acetylation of N-terminal methionine residues Gene:NOP8(YOL144W)|FD-Score:4.43|P-value:4.62E-6|Clearance:0.34||SGD DESC:Nucleolar protein required for 60S ribosomal subunit biogenesis Gene:NUS1(YDL193W)|FD-Score:-3.25|P-value:5.74E-4|Clearance:0||SGD DESC:Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY Gene:PTI1(YGR156W)|FD-Score:5.25|P-value:7.43E-8|Clearance:0.12||SGD DESC:Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64 Gene:RBA50(YDR527W)|FD-Score:4.47|P-value:3.93E-6|Clearance:0.03||SGD DESC:Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1 Gene:RIM2(YBR192W)|FD-Score:10.1|P-value:2.19E-24|Clearance:4.1||SGD DESC:Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family Gene:RPA190(YOR341W)|FD-Score:3.15|P-value:8.13E-4|Clearance:0.02||SGD DESC:RNA polymerase I largest subunit A190 Gene:RPB8(YOR224C)|FD-Score:3.61|P-value:1.56E-4|Clearance:0.11||SGD DESC:RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III Gene:RPT5(YOR117W)|FD-Score:4.05|P-value:2.56E-5|Clearance:0.25||SGD DESC:One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1 Gene:SSS1(YDR086C)|FD-Score:3.8|P-value:7.24E-5|Clearance:0.09||SGD DESC:Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p Gene:TIM22(YDL217C)|FD-Score:5.38|P-value:3.72E-8|Clearance:0.13||SGD DESC:Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported Gene:TOM40(YMR203W)|FD-Score:9.49|P-value:1.19E-21|Clearance:4.1||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore Gene:YDL196W(YDL196W_d)|FD-Score:5.08|P-value:1.91E-7|Clearance:0.55||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 Gene:YDR413C(YDR413C_d)|FD-Score:-3.59|P-value:1.66E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing Gene:YDR526C(YDR526C_d)|FD-Score:3.13|P-value:8.66E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR076C(YLR076C_d)|FD-Score:-4.2|P-value:1.31E-5|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10 Gene:YLR140W(YLR140W_d)|FD-Score:3.48|P-value:2.46E-4|Clearance:0.25||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I Gene:YPT1(YFL038C)|FD-Score:5.14|P-value:1.40E-7|Clearance:0.06||SGD DESC:Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p) Gene:ACT1(YFL039C)|FD-Score:-4.1|P-value:2.04E-5|Clearance:0||SGD DESC:Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions Gene:BET3(YKR068C)|FD-Score:3.13|P-value:8.74E-4|Clearance:0.03||SGD DESC:Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex Gene:CLP1(YOR250C)|FD-Score:3.1|P-value:9.56E-4|Clearance:0.01||SGD DESC:Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation Gene:CTF13(YMR094W)|FD-Score:3.23|P-value:6.17E-4|Clearance:0.08||SGD DESC:Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis Gene:DBP2(YNL112W)|FD-Score:4.52|P-value:3.05E-6|Clearance:0.05||SGD DESC:ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites Gene:DML1(YMR211W)|FD-Score:5.38|P-value:3.63E-8|Clearance:0||SGD DESC:Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family Gene:DPS1(YLL018C)|FD-Score:4.09|P-value:2.11E-5|Clearance:0.04||SGD DESC:Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation Gene:ECM16(YMR128W)|FD-Score:-3.61|P-value:1.55E-4|Clearance:0||SGD DESC:Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis Gene:ENP1(YBR247C)|FD-Score:3.63|P-value:1.42E-4|Clearance:0.02||SGD DESC:Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus Gene:ESP1(YGR098C)|FD-Score:3.09|P-value:9.99E-4|Clearance:0.07||SGD DESC:Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress Gene:FOL1(YNL256W)|FD-Score:3.71|P-value:1.04E-4|Clearance:0.08||SGD DESC:Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities Gene:NAR1(YNL240C)|FD-Score:3.15|P-value:8.07E-4|Clearance:0||SGD DESC:Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf Gene:NAT2(YGR147C)|FD-Score:3.5|P-value:2.34E-4|Clearance:0.01||SGD DESC:Protein with an apparent role in acetylation of N-terminal methionine residues Gene:NOP8(YOL144W)|FD-Score:4.43|P-value:4.62E-6|Clearance:0.34||SGD DESC:Nucleolar protein required for 60S ribosomal subunit biogenesis Gene:NUS1(YDL193W)|FD-Score:-3.25|P-value:5.74E-4|Clearance:0||SGD DESC:Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY Gene:PTI1(YGR156W)|FD-Score:5.25|P-value:7.43E-8|Clearance:0.12||SGD DESC:Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64 Gene:RBA50(YDR527W)|FD-Score:4.47|P-value:3.93E-6|Clearance:0.03||SGD DESC:Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1 Gene:RIM2(YBR192W)|FD-Score:10.1|P-value:2.19E-24|Clearance:4.1||SGD DESC:Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family Gene:RPA190(YOR341W)|FD-Score:3.15|P-value:8.13E-4|Clearance:0.02||SGD DESC:RNA polymerase I largest subunit A190 Gene:RPB8(YOR224C)|FD-Score:3.61|P-value:1.56E-4|Clearance:0.11||SGD DESC:RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III Gene:RPT5(YOR117W)|FD-Score:4.05|P-value:2.56E-5|Clearance:0.25||SGD DESC:One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1 Gene:SSS1(YDR086C)|FD-Score:3.8|P-value:7.24E-5|Clearance:0.09||SGD DESC:Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p Gene:TIM22(YDL217C)|FD-Score:5.38|P-value:3.72E-8|Clearance:0.13||SGD DESC:Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported Gene:TOM40(YMR203W)|FD-Score:9.49|P-value:1.19E-21|Clearance:4.1||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore Gene:YDL196W(YDL196W_d)|FD-Score:5.08|P-value:1.91E-7|Clearance:0.55||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 Gene:YDR413C(YDR413C_d)|FD-Score:-3.59|P-value:1.66E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing Gene:YDR526C(YDR526C_d)|FD-Score:3.13|P-value:8.66E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YLR076C(YLR076C_d)|FD-Score:-4.2|P-value:1.31E-5|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10 Gene:YLR140W(YLR140W_d)|FD-Score:3.48|P-value:2.46E-4|Clearance:0.25||SGD DESC:Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I Gene:YPT1(YFL038C)|FD-Score:5.14|P-value:1.40E-7|Clearance:0.06||SGD DESC:Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 17097298
Download HOP data (tab-delimited text)  (excel)
Gene:ADE4(YMR300C)|FD-Score:3.62|P-value:1.50E-4||SGD DESC:Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway Gene:AIM14(YGL160W)|FD-Score:4.33|P-value:7.31E-6||SGD DESC:NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p Gene:ANB1(YJR047C)|FD-Score:6.09|P-value:5.68E-10||SGD DESC:Translation elongation factor eIF-5A; previously thought to function in translation initiation; undergoes an essential hypusination modification; expressed under anaerobic conditions; ANB1 has a paralog, HYP2, that arose from the whole genome duplication Gene:APM1(YPL259C)|FD-Score:4.33|P-value:7.54E-6||SGD DESC:Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting Gene:ARO1(YDR127W)|FD-Score:-5.11|P-value:1.64E-7||SGD DESC:Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids Gene:ATF1(YOR377W)|FD-Score:3.87|P-value:5.39E-5||SGD DESC:Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism Gene:ATP3(YBR039W)|FD-Score:3.86|P-value:5.71E-5||SGD DESC:Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis Gene:CEM1(YER061C)|FD-Score:-4.32|P-value:7.93E-6||SGD DESC:Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration Gene:COX17(YLL009C)|FD-Score:-4.5|P-value:3.34E-6||SGD DESC:Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs Gene:DBF2(YGR092W)|FD-Score:3.24|P-value:5.98E-4||SGD DESC:Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis Gene:DBP7(YKR024C)|FD-Score:3.67|P-value:1.19E-4||SGD DESC:Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions Gene:ECI1(YLR284C)|FD-Score:3.98|P-value:3.40E-5||SGD DESC:Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced Gene:ECM33(YBR078W)|FD-Score:-5.01|P-value:2.69E-7||SGD DESC:GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p Gene:ELP3(YPL086C)|FD-Score:4.57|P-value:2.45E-6||SGD DESC:Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin Gene:FRA1(YLL029W)|FD-Score:-3.63|P-value:1.42E-4||SGD DESC:Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation Gene:GCS1(YDL226C)|FD-Score:3.36|P-value:3.87E-4||SGD DESC:ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p Gene:GET3(YDL100C)|FD-Score:3.51|P-value:2.24E-4||SGD DESC:Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress Gene:GSY2(YLR258W)|FD-Score:-3.36|P-value:3.91E-4||SGD DESC:Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase; GSY2 has a paralog, GSY1, that arose from the whole genome duplication; relocalizes from cytoplasm to plasma membrane upon DNA replication stress Gene:HFA1(YMR207C)|FD-Score:-5.72|P-value:5.46E-9||SGD DESC:Mitochondrial acetyl-coenzyme A carboxylase; catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress Gene:HFI1(YPL254W)|FD-Score:-3.82|P-value:6.63E-5||SGD DESC:Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions Gene:HIS6(YIL020C)|FD-Score:-4.97|P-value:3.32E-7||SGD DESC:Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts Gene:HOS1(YPR068C)|FD-Score:3.12|P-value:9.15E-4||SGD DESC:Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex Gene:INP1(YMR204C)|FD-Score:3.6|P-value:1.62E-4||SGD DESC:Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane Gene:LYP1(YNL268W)|FD-Score:3.55|P-value:1.90E-4||SGD DESC:Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids Gene:MAG1(YER142C)|FD-Score:4.01|P-value:3.03E-5||SGD DESC:3-methyl-adenine DNA glycosylase; involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; protein abundance increases in response to DNA replication stress Gene:MDM20(YOL076W)|FD-Score:3.51|P-value:2.23E-4||SGD DESC:Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly Gene:MDS3(YGL197W)|FD-Score:-3.57|P-value:1.80E-4||SGD DESC:Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain Gene:NCE101(YJL205C)|FD-Score:3.62|P-value:1.48E-4||SGD DESC:Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences Gene:NPR1(YNL183C)|FD-Score:3.26|P-value:5.63E-4||SGD DESC:Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex Gene:PBP2(YBR233W)|FD-Score:3.85|P-value:6.02E-5||SGD DESC:RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress Gene:PDC1(YLR044C)|FD-Score:-4.25|P-value:1.09E-5||SGD DESC:Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism Gene:PRO2(YOR323C)|FD-Score:3.84|P-value:6.03E-5||SGD DESC:Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis Gene:PTK2(YJR059W)|FD-Score:3.27|P-value:5.38E-4||SGD DESC:Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake Gene:PUS2(YGL063W)|FD-Score:3.81|P-value:6.91E-5||SGD DESC:Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification Gene:RPL15B(YMR121C)|FD-Score:-3.16|P-value:8.00E-4||SGD DESC:Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress Gene:RPL24B(YGR148C)|FD-Score:4.14|P-value:1.72E-5||SGD DESC:Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication Gene:RPN4(YDL020C)|FD-Score:-3.71|P-value:1.02E-4||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:RTF1(YGL244W)|FD-Score:-4.1|P-value:2.10E-5||SGD DESC:Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay Gene:SHR5(YOL110W)|FD-Score:3.93|P-value:4.16E-5||SGD DESC:Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization Gene:SVS1(YPL163C)|FD-Score:3.17|P-value:7.59E-4||SGD DESC:Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication Gene:SWR1(YDR334W)|FD-Score:4.63|P-value:1.82E-6||SGD DESC:Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A Gene:TEX1(YNL253W)|FD-Score:3.2|P-value:6.79E-4||SGD DESC:Protein involved in mRNA export, component of the transcription export (TREX) complex Gene:TOS1(YBR162C)|FD-Score:5.12|P-value:1.51E-7||SGD DESC:Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C Gene:VAM10(YOR068C)|FD-Score:3.52|P-value:2.12E-4||SGD DESC:Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering Gene:VHS2(YIL135C)|FD-Score:-3.9|P-value:4.78E-5||SGD DESC:Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p Gene:VMA11(YPL234C)|FD-Score:-3.16|P-value:7.89E-4||SGD DESC:Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen Gene:VMA22(YHR060W)|FD-Score:4.14|P-value:1.70E-5||SGD DESC:Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER) Gene:VPS24(YKL041W)|FD-Score:4|P-value:3.12E-5||SGD DESC:One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway Gene:VPS68(YOL129W)|FD-Score:3.65|P-value:1.32E-4||SGD DESC:Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria Gene:YBR074W(YBR074W_p)|FD-Score:4.22|P-value:1.20E-5||SGD DESC:Putative metalloprotease Gene:YBR219C(YBR219C_p)|FD-Score:3.54|P-value:2.04E-4||SGD DESC:Putative protein of unknown function; YBR219C is not an essential gene Gene:YDR003W-A(YDR003W-A_p)|FD-Score:3.22|P-value:6.42E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YDR271C(YDR271C_d)|FD-Score:3.53|P-value:2.05E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W Gene:YER034W(YER034W_p)|FD-Score:3.54|P-value:2.03E-4||SGD DESC:Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress Gene:YER181C(YER181C_d)|FD-Score:3.2|P-value:6.84E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies Gene:YGR273C(YGR273C_p)|FD-Score:5.06|P-value:2.14E-7||SGD DESC:Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene Gene:YKR078W(YKR078W)|FD-Score:3.15|P-value:8.16E-4||SGD DESC:Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) Gene:YLL059C(YLL059C_d)|FD-Score:3.51|P-value:2.25E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YMR052C-A(YMR052C-A_d)|FD-Score:3.29|P-value:5.09E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNR062C(YNR062C_p)|FD-Score:4.49|P-value:3.51E-6||SGD DESC:Putative membrane protein of unknown function Gene:YOR053W(YOR053W_d)|FD-Score:3.23|P-value:6.26E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C Gene:YPL109C(YPL109C_p)|FD-Score:3.2|P-value:6.92E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YPL205C(YPL205C_d)|FD-Score:3.33|P-value:4.27E-4||SGD DESC:Hypothetical protein; deletion of locus affects telomere length Gene:YPR014C(YPR014C_d)|FD-Score:3.7|P-value:1.09E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene Gene:YPR123C(YPR123C_d)|FD-Score:5.1|P-value:1.73E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR Gene:ADE4(YMR300C)|FD-Score:3.62|P-value:1.50E-4||SGD DESC:Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway Gene:AIM14(YGL160W)|FD-Score:4.33|P-value:7.31E-6||SGD DESC:NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p Gene:ANB1(YJR047C)|FD-Score:6.09|P-value:5.68E-10||SGD DESC:Translation elongation factor eIF-5A; previously thought to function in translation initiation; undergoes an essential hypusination modification; expressed under anaerobic conditions; ANB1 has a paralog, HYP2, that arose from the whole genome duplication Gene:APM1(YPL259C)|FD-Score:4.33|P-value:7.54E-6||SGD DESC:Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting Gene:ARO1(YDR127W)|FD-Score:-5.11|P-value:1.64E-7||SGD DESC:Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids Gene:ATF1(YOR377W)|FD-Score:3.87|P-value:5.39E-5||SGD DESC:Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism Gene:ATP3(YBR039W)|FD-Score:3.86|P-value:5.71E-5||SGD DESC:Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis Gene:CEM1(YER061C)|FD-Score:-4.32|P-value:7.93E-6||SGD DESC:Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration Gene:COX17(YLL009C)|FD-Score:-4.5|P-value:3.34E-6||SGD DESC:Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs Gene:DBF2(YGR092W)|FD-Score:3.24|P-value:5.98E-4||SGD DESC:Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis Gene:DBP7(YKR024C)|FD-Score:3.67|P-value:1.19E-4||SGD DESC:Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions Gene:ECI1(YLR284C)|FD-Score:3.98|P-value:3.40E-5||SGD DESC:Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced Gene:ECM33(YBR078W)|FD-Score:-5.01|P-value:2.69E-7||SGD DESC:GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p Gene:ELP3(YPL086C)|FD-Score:4.57|P-value:2.45E-6||SGD DESC:Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin Gene:FRA1(YLL029W)|FD-Score:-3.63|P-value:1.42E-4||SGD DESC:Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation Gene:GCS1(YDL226C)|FD-Score:3.36|P-value:3.87E-4||SGD DESC:ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p Gene:GET3(YDL100C)|FD-Score:3.51|P-value:2.24E-4||SGD DESC:Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress Gene:GSY2(YLR258W)|FD-Score:-3.36|P-value:3.91E-4||SGD DESC:Glycogen synthase; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase; GSY2 has a paralog, GSY1, that arose from the whole genome duplication; relocalizes from cytoplasm to plasma membrane upon DNA replication stress Gene:HFA1(YMR207C)|FD-Score:-5.72|P-value:5.46E-9||SGD DESC:Mitochondrial acetyl-coenzyme A carboxylase; catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress Gene:HFI1(YPL254W)|FD-Score:-3.82|P-value:6.63E-5||SGD DESC:Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions Gene:HIS6(YIL020C)|FD-Score:-4.97|P-value:3.32E-7||SGD DESC:Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts Gene:HOS1(YPR068C)|FD-Score:3.12|P-value:9.15E-4||SGD DESC:Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex Gene:INP1(YMR204C)|FD-Score:3.6|P-value:1.62E-4||SGD DESC:Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane Gene:LYP1(YNL268W)|FD-Score:3.55|P-value:1.90E-4||SGD DESC:Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids Gene:MAG1(YER142C)|FD-Score:4.01|P-value:3.03E-5||SGD DESC:3-methyl-adenine DNA glycosylase; involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; protein abundance increases in response to DNA replication stress Gene:MDM20(YOL076W)|FD-Score:3.51|P-value:2.23E-4||SGD DESC:Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly Gene:MDS3(YGL197W)|FD-Score:-3.57|P-value:1.80E-4||SGD DESC:Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain Gene:NCE101(YJL205C)|FD-Score:3.62|P-value:1.48E-4||SGD DESC:Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences Gene:NPR1(YNL183C)|FD-Score:3.26|P-value:5.63E-4||SGD DESC:Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex Gene:PBP2(YBR233W)|FD-Score:3.85|P-value:6.02E-5||SGD DESC:RNA binding protein; has similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length; relative distribution to the nucleus increases upon DNA replication stress Gene:PDC1(YLR044C)|FD-Score:-4.25|P-value:1.09E-5||SGD DESC:Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism Gene:PRO2(YOR323C)|FD-Score:3.84|P-value:6.03E-5||SGD DESC:Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis Gene:PTK2(YJR059W)|FD-Score:3.27|P-value:5.38E-4||SGD DESC:Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake Gene:PUS2(YGL063W)|FD-Score:3.81|P-value:6.91E-5||SGD DESC:Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification Gene:RPL15B(YMR121C)|FD-Score:-3.16|P-value:8.00E-4||SGD DESC:Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress Gene:RPL24B(YGR148C)|FD-Score:4.14|P-value:1.72E-5||SGD DESC:Ribosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication Gene:RPN4(YDL020C)|FD-Score:-3.71|P-value:1.02E-4||SGD DESC:Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress Gene:RTF1(YGL244W)|FD-Score:-4.1|P-value:2.10E-5||SGD DESC:Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay Gene:SHR5(YOL110W)|FD-Score:3.93|P-value:4.16E-5||SGD DESC:Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization Gene:SVS1(YPL163C)|FD-Score:3.17|P-value:7.59E-4||SGD DESC:Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication Gene:SWR1(YDR334W)|FD-Score:4.63|P-value:1.82E-6||SGD DESC:Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A Gene:TEX1(YNL253W)|FD-Score:3.2|P-value:6.79E-4||SGD DESC:Protein involved in mRNA export, component of the transcription export (TREX) complex Gene:TOS1(YBR162C)|FD-Score:5.12|P-value:1.51E-7||SGD DESC:Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C Gene:VAM10(YOR068C)|FD-Score:3.52|P-value:2.12E-4||SGD DESC:Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering Gene:VHS2(YIL135C)|FD-Score:-3.9|P-value:4.78E-5||SGD DESC:Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p Gene:VMA11(YPL234C)|FD-Score:-3.16|P-value:7.89E-4||SGD DESC:Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen Gene:VMA22(YHR060W)|FD-Score:4.14|P-value:1.70E-5||SGD DESC:Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER) Gene:VPS24(YKL041W)|FD-Score:4|P-value:3.12E-5||SGD DESC:One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway Gene:VPS68(YOL129W)|FD-Score:3.65|P-value:1.32E-4||SGD DESC:Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria Gene:YBR074W(YBR074W_p)|FD-Score:4.22|P-value:1.20E-5||SGD DESC:Putative metalloprotease Gene:YBR219C(YBR219C_p)|FD-Score:3.54|P-value:2.04E-4||SGD DESC:Putative protein of unknown function; YBR219C is not an essential gene Gene:YDR003W-A(YDR003W-A_p)|FD-Score:3.22|P-value:6.42E-4||SGD DESC:Putative protein of unknown function; identified by expression profiling and mass spectrometry Gene:YDR271C(YDR271C_d)|FD-Score:3.53|P-value:2.05E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W Gene:YER034W(YER034W_p)|FD-Score:3.54|P-value:2.03E-4||SGD DESC:Protein of unknown function; non-essential gene; expression induced upon calcium shortage; protein abundance increases in response to DNA replication stress Gene:YER181C(YER181C_d)|FD-Score:3.2|P-value:6.84E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies Gene:YGR273C(YGR273C_p)|FD-Score:5.06|P-value:2.14E-7||SGD DESC:Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene Gene:YKR078W(YKR078W)|FD-Score:3.15|P-value:8.16E-4||SGD DESC:Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) Gene:YLL059C(YLL059C_d)|FD-Score:3.51|P-value:2.25E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YMR052C-A(YMR052C-A_d)|FD-Score:3.29|P-value:5.09E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNR062C(YNR062C_p)|FD-Score:4.49|P-value:3.51E-6||SGD DESC:Putative membrane protein of unknown function Gene:YOR053W(YOR053W_d)|FD-Score:3.23|P-value:6.26E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C Gene:YPL109C(YPL109C_p)|FD-Score:3.2|P-value:6.92E-4||SGD DESC:Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies Gene:YPL205C(YPL205C_d)|FD-Score:3.33|P-value:4.27E-4||SGD DESC:Hypothetical protein; deletion of locus affects telomere length Gene:YPR014C(YPR014C_d)|FD-Score:3.7|P-value:1.09E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene Gene:YPR123C(YPR123C_d)|FD-Score:5.1|P-value:1.73E-7||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR

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Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YBR192W10.102.19E-244.10RIM2Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
YMR203W9.491.19E-214.10TOM40Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
YMR211W5.383.63E-80.00DML1Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
YDL217C5.383.72E-80.13TIM22Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported
YGR156W5.257.43E-80.12PTI1Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64
YFL038C5.141.40E-70.06YPT1Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
YDL196W_d5.081.91E-70.56YDL196W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
YNL112W4.523.05E-60.05DBP2ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites
YDR527W4.473.93E-60.03RBA50Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
YOL144W4.434.62E-60.34NOP8Nucleolar protein required for 60S ribosomal subunit biogenesis
YLL018C4.092.11E-50.04DPS1Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation
YOR117W4.052.56E-50.25RPT5One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1
YDR086C3.807.24E-50.09SSS1Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p
YNL256W3.711.04E-40.08FOL1Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities
YBR247C3.631.42E-40.02ENP1Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YJR047C6.095.68E-10ANB1Translation elongation factor eIF-5A; previously thought to function in translation initiation; undergoes an essential hypusination modification; expressed under anaerobic conditions; ANB1 has a paralog, HYP2, that arose from the whole genome duplication
YBR162C5.121.51E-7TOS1Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C
YPR123C_d5.101.73E-7YPR123C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR
YGR273C_p5.062.14E-7YGR273C_pPutative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene
YDR334W4.631.82E-6SWR1Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A
YPL086C4.572.45E-6ELP3Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin
YNR062C_p4.493.51E-6YNR062C_pPutative membrane protein of unknown function
YGL160W4.337.31E-6AIM14NADPH oxidase localized to the perinuclear ER; produces superoxide from NADPH; overexpression causes MCA1 dependent apoptosis; likely involved in superoxide-mediated regulation of the actin cytoskeleton; member of a conserved superfamily of NADPH oxidases (NOX enzymes); has similarity to iron/copper reductases (FRE1-8), particularly Fre8p
YPL259C4.337.54E-6APM1Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting
YBR074W_p4.221.20E-5YBR074W_pPutative metalloprotease
YHR060W4.141.70E-5VMA22Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER)
YGR148C4.141.72E-5RPL24BRibosomal 60S subunit protein L24B; not essential for translation but may be required for normal translation rate; homologous to mammalian ribosomal protein L24, no bacterial homolog; RPL24B has a paralog, RPL24A, that arose from the whole genome duplication
YER142C4.013.03E-5MAG13-methyl-adenine DNA glycosylase; involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired; protein abundance increases in response to DNA replication stress
YKL041W4.003.12E-5VPS24One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway
YLR284C3.983.40E-5ECI1Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced

GO enrichment analysis for SGTC_3181
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.2611.07E-92SGTC_31619100388 49.5 μMChembridge (Drug-like library)252363680.231884iron homeostasis
0.2231.20E-67SGTC_14224031-0024 15.5 μMChemDiv (Drug-like library)7824270.230769iron homeostasis
0.2142.03E-62SGTC_31759106517 49.5 μMChembridge (Drug-like library)414680730.246154iron homeostasis
0.1761.94E-42SGTC_1962st076595 64.5 μMTimTec (Natural product derivative library)2796190.1redox potentiating
0.1633.28E-36SGTC_31419094609 49.5 μMChembridge (Drug-like library)252363090.214286iron homeostasis
0.1449.52E-29SGTC_7301436-0052 41.2 μMChemDiv (Drug-like library)7687640.179104mitochondrial processes
0.1441.08E-28SGTC_29309013230 14.9 μMChembridge (Drug-like library)29958570.15942heme biosynthesis & mitochondrial translocase
0.1411.83E-27SGTC_21245246320 200.0 μMChembridge (Fragment library)5793420.314815heme biosynthesis & mitochondrial translocase
0.1382.41E-26SGTC_20665222451 176.0 μMChembridge (Fragment library)22811470.084507heme biosynthesis & mitochondrial translocase
0.1316.67E-24SGTC_2675theaflavin digallate 100.0 μMMicrosource (Natural product library)4673200.0860215iron homeostasis
0.1292.07E-23SGTC_29289011484 9.8 μMChembridge (Drug-like library)29947510.152778heme biosynthesis & mitochondrial translocase
0.1278.41E-23SGTC_1641st009299 47.1 μMTimTec (Natural product derivative library)40460540.109589mitochondrial processes
0.1257.19E-22SGTC_623k072-0108 16.9 μMChemDiv (Drug-like library)53828030.149254heme biosynthesis & mitochondrial translocase
0.1232.94E-21SGTC_2230bromochlorosalicylanilide 954.5 nMMiscellaneous772540.190476
0.1202.37E-20SGTC_2727riluzole 51.8 μMMiscellaneous50700.106061mitochondrial processes

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3091911637249.47 μM0.55769217169793Chembridge (Drug-like library)285.337662.95313
SGTC_3184910875849.47 μM0.55102902885Chembridge (Drug-like library)241.28512.94712
SGTC_3191911035249.47 μM0.50943417122424Chembridge (Drug-like library)267.322383.66112
SGTC_2999906976571.43 μM0.4905662097066Chembridge (Drug-like library)285.337663.30813amide catabolism
SGTC_3077911731949.47 μM0.49056617154678Chembridge (Drug-like library)285.337663.30813
SGTC_3098911903949.47 μM0.48214317161528Chembridge (Drug-like library)287.3287234.05313Golgi
SGTC_3188911078949.47 μM0.481481849217Chembridge (Drug-like library)275.730163.61112iron homeostasis
SGTC_3173910569349.47 μM0.46428617096658Chembridge (Drug-like library)289.756744.13512
SGTC_2986902244571.43 μM0.4629636459286Chembridge (Drug-like library)285.337663.30813
SGTC_2827799384771.43 μM0.456142985692Chembridge (Drug-like library)283.321783.19813