9108849

3-(2-methylprop-2-enoxy)-N-phenylbenzamide

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Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3182
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 17133045
SMILES CC(=C)COC1=CC=CC(=C1)C(=O)NC2=CC=CC=C2
Standardized SMILES CC(=C)COc1cccc(c1)C(=O)Nc2ccccc2
Molecular weight 267.3224
ALogP 3.66
H-bond donor count 1
H-bond acceptor count 2
Response signature RPP1 & pyrimidine depletion

Pool Growth Kinetics
% growth inhibition (Het. pool) 15.56
% growth inhibition (Hom. pool) 10.43


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 17133045
Download HIP data (tab-delimited text)  (excel)
Gene:ERG11(YHR007C)|FD-Score:3.89|P-value:4.99E-5|Clearance:0.07||SGD DESC:Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p Gene:GLC7(YER133W)|FD-Score:5.48|P-value:2.13E-8|Clearance:1.09||SGD DESC:Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest Gene:NOC4(YPR144C)|FD-Score:3.38|P-value:3.63E-4|Clearance:0.23||SGD DESC:Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits Gene:ROK1(YGL171W)|FD-Score:3.15|P-value:8.13E-4|Clearance:0.08||SGD DESC:RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation Gene:RPL15A(YLR029C)|FD-Score:3.92|P-value:4.42E-5|Clearance:0.03||SGD DESC:Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication Gene:SEC4(YFL005W)|FD-Score:3.41|P-value:3.28E-4|Clearance:0.03||SGD DESC:Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane Gene:SEC53(YFL045C)|FD-Score:-3.63|P-value:1.40E-4|Clearance:0||SGD DESC:Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen Gene:SPC42(YKL042W)|FD-Score:3.82|P-value:6.66E-5|Clearance:0.35||SGD DESC:Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane Gene:TAF11(YML015C)|FD-Score:3.47|P-value:2.64E-4|Clearance:0.06||SGD DESC:TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors Gene:TEN1(YLR010C)|FD-Score:3.93|P-value:4.25E-5|Clearance:0.01||SGD DESC:Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p Gene:TIF35(YDR429C)|FD-Score:3.47|P-value:2.63E-4|Clearance:0||SGD DESC:eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation Gene:TOM40(YMR203W)|FD-Score:-3.65|P-value:1.31E-4|Clearance:0||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore Gene:VHT1(YGR065C)|FD-Score:4.39|P-value:5.79E-6|Clearance:0.46||SGD DESC:High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin Gene:YGR115C(YGR115C_d)|FD-Score:-3.16|P-value:7.78E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C Gene:ERG11(YHR007C)|FD-Score:3.89|P-value:4.99E-5|Clearance:0.07||SGD DESC:Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p Gene:GLC7(YER133W)|FD-Score:5.48|P-value:2.13E-8|Clearance:1.09||SGD DESC:Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest Gene:NOC4(YPR144C)|FD-Score:3.38|P-value:3.63E-4|Clearance:0.23||SGD DESC:Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits Gene:ROK1(YGL171W)|FD-Score:3.15|P-value:8.13E-4|Clearance:0.08||SGD DESC:RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation Gene:RPL15A(YLR029C)|FD-Score:3.92|P-value:4.42E-5|Clearance:0.03||SGD DESC:Ribosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication Gene:SEC4(YFL005W)|FD-Score:3.41|P-value:3.28E-4|Clearance:0.03||SGD DESC:Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane Gene:SEC53(YFL045C)|FD-Score:-3.63|P-value:1.40E-4|Clearance:0||SGD DESC:Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen Gene:SPC42(YKL042W)|FD-Score:3.82|P-value:6.66E-5|Clearance:0.35||SGD DESC:Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane Gene:TAF11(YML015C)|FD-Score:3.47|P-value:2.64E-4|Clearance:0.06||SGD DESC:TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors Gene:TEN1(YLR010C)|FD-Score:3.93|P-value:4.25E-5|Clearance:0.01||SGD DESC:Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p Gene:TIF35(YDR429C)|FD-Score:3.47|P-value:2.63E-4|Clearance:0||SGD DESC:eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation Gene:TOM40(YMR203W)|FD-Score:-3.65|P-value:1.31E-4|Clearance:0||SGD DESC:Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore Gene:VHT1(YGR065C)|FD-Score:4.39|P-value:5.79E-6|Clearance:0.46||SGD DESC:High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin Gene:YGR115C(YGR115C_d)|FD-Score:-3.16|P-value:7.78E-4|Clearance:0||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 17133045
Download HOP data (tab-delimited text)  (excel)
Gene:AAD3(YCR107W)|FD-Score:3.6|P-value:1.60E-4||SGD DESC:Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role Gene:AIM41(YOR215C)|FD-Score:3.22|P-value:6.37E-4||SGD DESC:Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss Gene:ASF1(YJL115W)|FD-Score:-4.46|P-value:4.01E-6||SGD DESC:Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition Gene:ATS1(YAL020C)|FD-Score:4.46|P-value:4.06E-6||SGD DESC:Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle Gene:BEM3(YPL115C)|FD-Score:-3.12|P-value:9.00E-4||SGD DESC:Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly Gene:BIO3(YNR058W)|FD-Score:3.53|P-value:2.08E-4||SGD DESC:7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis Gene:BUD25(YER014C-A)|FD-Score:-3.24|P-value:6.04E-4||SGD DESC:Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern Gene:CCW12(YLR110C)|FD-Score:5.37|P-value:3.96E-8||SGD DESC:Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication Gene:CIS3(YJL158C)|FD-Score:3.19|P-value:7.12E-4||SGD DESC:Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family Gene:CLB6(YGR109C)|FD-Score:3.51|P-value:2.24E-4||SGD DESC:B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 Gene:CTF19(YPL018W)|FD-Score:3.11|P-value:9.30E-4||SGD DESC:Outer kinetochore protein, needed for accurate chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-P and fission yeast fta2 Gene:EKI1(YDR147W)|FD-Score:3.22|P-value:6.42E-4||SGD DESC:Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication Gene:GCN4(YEL009C)|FD-Score:-3.11|P-value:9.23E-4||SGD DESC:Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels Gene:GDE1(YPL110C)|FD-Score:-3.15|P-value:8.19E-4||SGD DESC:Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes Gene:GET3(YDL100C)|FD-Score:3.89|P-value:5.03E-5||SGD DESC:Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress Gene:GRX7(YBR014C)|FD-Score:5.17|P-value:1.17E-7||SGD DESC:Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication Gene:ICY2(YPL250C)|FD-Score:3.36|P-value:3.83E-4||SGD DESC:Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate Gene:IES2(YNL215W)|FD-Score:4.54|P-value:2.88E-6||SGD DESC:Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress Gene:IRC15(YPL017C)|FD-Score:3.28|P-value:5.27E-4||SGD DESC:Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci Gene:MDM35(YKL053C-A)|FD-Score:-3.2|P-value:6.96E-4||SGD DESC:Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress Gene:MNT4(YNR059W)|FD-Score:-3.39|P-value:3.54E-4||SGD DESC:Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation Gene:NAT5(YOR253W)|FD-Score:-4.27|P-value:9.91E-6||SGD DESC:Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing Gene:NCA3(YJL116C)|FD-Score:4.08|P-value:2.23E-5||SGD DESC:Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication Gene:NPT1(YOR209C)|FD-Score:3.15|P-value:8.26E-4||SGD DESC:Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus Gene:PCL8(YPL219W)|FD-Score:3.22|P-value:6.38E-4||SGD DESC:Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation Gene:PRE9(YGR135W)|FD-Score:-3.72|P-value:9.85E-5||SGD DESC:Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform Gene:RMD1(YDL001W)|FD-Score:-3.17|P-value:7.62E-4||SGD DESC:Cytoplasmic protein required for sporulation Gene:RPL16A(YIL133C)|FD-Score:3.11|P-value:9.28E-4||SGD DESC:Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:RPS7A(YOR096W)|FD-Score:5.28|P-value:6.52E-8||SGD DESC:Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication Gene:SBH2(YER019C-A)|FD-Score:6.13|P-value:4.34E-10||SGD DESC:Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p Gene:SIP3(YNL257C)|FD-Score:3.28|P-value:5.25E-4||SGD DESC:Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication Gene:SLM3(YDL033C)|FD-Score:3.53|P-value:2.05E-4||SGD DESC:tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF) Gene:SLS1(YLR139C)|FD-Score:3.69|P-value:1.10E-4||SGD DESC:Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery Gene:SLT2(YHR030C)|FD-Score:-3.47|P-value:2.58E-4||SGD DESC:Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway Gene:SOD1(YJR104C)|FD-Score:-3.46|P-value:2.66E-4||SGD DESC:Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid Gene:SPR3(YGR059W)|FD-Score:3.41|P-value:3.25E-4||SGD DESC:Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI Gene:SSK2(YNR031C)|FD-Score:3.27|P-value:5.45E-4||SGD DESC:MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress Gene:STB4(YMR019W)|FD-Score:3.55|P-value:1.92E-4||SGD DESC:Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay; Gene:TAT1(YBR069C)|FD-Score:-3.28|P-value:5.13E-4||SGD DESC:Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress Gene:THP2(YHR167W)|FD-Score:3.36|P-value:3.87E-4||SGD DESC:Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance Gene:TVP23(YDR084C)|FD-Score:4.25|P-value:1.08E-5||SGD DESC:Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:YCR023C(YCR023C)|FD-Score:-4.06|P-value:2.43E-5||SGD DESC:Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene Gene:YDR194W-A(YDR194W-A_p)|FD-Score:-3.37|P-value:3.70E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YGR151C(YGR151C_d)|FD-Score:3.79|P-value:7.56E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C; relative distribution to the nucleus increases upon DNA replication stress Gene:YGR228W(YGR228W_d)|FD-Score:-3.11|P-value:9.41E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C Gene:YGR291C(YGR291C_d)|FD-Score:4.11|P-value:1.94E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YIL012W(YIL012W_d)|FD-Score:-3.28|P-value:5.13E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YIR014W(YIR014W_p)|FD-Score:-3.65|P-value:1.33E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene Gene:YJR107W(YJR107W_p)|FD-Score:4.07|P-value:2.38E-5||SGD DESC:Putative lipase Gene:YKR051W(YKR051W_p)|FD-Score:4.61|P-value:1.98E-6||SGD DESC:Putative protein of unknown function Gene:YKR073C(YKR073C_d)|FD-Score:3.74|P-value:9.06E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YLR428C(YLR428C_d)|FD-Score:3.54|P-value:2.04E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1 Gene:YNL170W(YNL170W_d)|FD-Score:3.47|P-value:2.62E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNR066C(YNR066C_p)|FD-Score:-3.11|P-value:9.20E-4||SGD DESC:Putative membrane-localized protein of unknown function Gene:YOR019W(YOR019W)|FD-Score:-3.29|P-value:4.93E-4||SGD DESC:Protein of unknown function that may interact with ribosomes, based on co-purification experiments Gene:YPK1(YKL126W)|FD-Score:3.18|P-value:7.36E-4||SGD DESC:Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication Gene:YPR053C(YPR053C_d)|FD-Score:4.3|P-value:8.38E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C Gene:YPR197C(YPR197C_d)|FD-Score:3.47|P-value:2.60E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:ZAP1(YJL056C)|FD-Score:-3.35|P-value:4.06E-4||SGD DESC:Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains Gene:AAD3(YCR107W)|FD-Score:3.6|P-value:1.60E-4||SGD DESC:Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role Gene:AIM41(YOR215C)|FD-Score:3.22|P-value:6.37E-4||SGD DESC:Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss Gene:ASF1(YJL115W)|FD-Score:-4.46|P-value:4.01E-6||SGD DESC:Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition Gene:ATS1(YAL020C)|FD-Score:4.46|P-value:4.06E-6||SGD DESC:Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle Gene:BEM3(YPL115C)|FD-Score:-3.12|P-value:9.00E-4||SGD DESC:Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly Gene:BIO3(YNR058W)|FD-Score:3.53|P-value:2.08E-4||SGD DESC:7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis Gene:BUD25(YER014C-A)|FD-Score:-3.24|P-value:6.04E-4||SGD DESC:Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern Gene:CCW12(YLR110C)|FD-Score:5.37|P-value:3.96E-8||SGD DESC:Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication Gene:CIS3(YJL158C)|FD-Score:3.19|P-value:7.12E-4||SGD DESC:Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family Gene:CLB6(YGR109C)|FD-Score:3.51|P-value:2.24E-4||SGD DESC:B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 Gene:CTF19(YPL018W)|FD-Score:3.11|P-value:9.30E-4||SGD DESC:Outer kinetochore protein, needed for accurate chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-P and fission yeast fta2 Gene:EKI1(YDR147W)|FD-Score:3.22|P-value:6.42E-4||SGD DESC:Ethanolamine kinase; primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway; EKI1 has a paralog, CKI1, that arose from the whole genome duplication Gene:GCN4(YEL009C)|FD-Score:-3.11|P-value:9.23E-4||SGD DESC:Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels Gene:GDE1(YPL110C)|FD-Score:-3.15|P-value:8.19E-4||SGD DESC:Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes Gene:GET3(YDL100C)|FD-Score:3.89|P-value:5.03E-5||SGD DESC:Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress Gene:GRX7(YBR014C)|FD-Score:5.17|P-value:1.17E-7||SGD DESC:Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication Gene:ICY2(YPL250C)|FD-Score:3.36|P-value:3.83E-4||SGD DESC:Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate Gene:IES2(YNL215W)|FD-Score:4.54|P-value:2.88E-6||SGD DESC:Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress Gene:IRC15(YPL017C)|FD-Score:3.28|P-value:5.27E-4||SGD DESC:Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci Gene:MDM35(YKL053C-A)|FD-Score:-3.2|P-value:6.96E-4||SGD DESC:Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress Gene:MNT4(YNR059W)|FD-Score:-3.39|P-value:3.54E-4||SGD DESC:Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation Gene:NAT5(YOR253W)|FD-Score:-4.27|P-value:9.91E-6||SGD DESC:Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing Gene:NCA3(YJL116C)|FD-Score:4.08|P-value:2.23E-5||SGD DESC:Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication Gene:NPT1(YOR209C)|FD-Score:3.15|P-value:8.26E-4||SGD DESC:Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus Gene:PCL8(YPL219W)|FD-Score:3.22|P-value:6.38E-4||SGD DESC:Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation Gene:PRE9(YGR135W)|FD-Score:-3.72|P-value:9.85E-5||SGD DESC:Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform Gene:RMD1(YDL001W)|FD-Score:-3.17|P-value:7.62E-4||SGD DESC:Cytoplasmic protein required for sporulation Gene:RPL16A(YIL133C)|FD-Score:3.11|P-value:9.28E-4||SGD DESC:Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress Gene:RPS7A(YOR096W)|FD-Score:5.28|P-value:6.52E-8||SGD DESC:Protein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication Gene:SBH2(YER019C-A)|FD-Score:6.13|P-value:4.34E-10||SGD DESC:Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p Gene:SIP3(YNL257C)|FD-Score:3.28|P-value:5.25E-4||SGD DESC:Transcription cofactor; acts through interaction with DNA-bound Snf1p; C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate; SIP3 has a paralog, YSP1, that arose from the whole genome duplication Gene:SLM3(YDL033C)|FD-Score:3.53|P-value:2.05E-4||SGD DESC:tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF) Gene:SLS1(YLR139C)|FD-Score:3.69|P-value:1.10E-4||SGD DESC:Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery Gene:SLT2(YHR030C)|FD-Score:-3.47|P-value:2.58E-4||SGD DESC:Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway Gene:SOD1(YJR104C)|FD-Score:-3.46|P-value:2.66E-4||SGD DESC:Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid Gene:SPR3(YGR059W)|FD-Score:3.41|P-value:3.25E-4||SGD DESC:Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI Gene:SSK2(YNR031C)|FD-Score:3.27|P-value:5.45E-4||SGD DESC:MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress Gene:STB4(YMR019W)|FD-Score:3.55|P-value:1.92E-4||SGD DESC:Putative transcription factor; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters; binds Sin3p in a two-hybrid assay; Gene:TAT1(YBR069C)|FD-Score:-3.28|P-value:5.13E-4||SGD DESC:Amino acid transporter for valine, leucine, isoleucine, and tyrosine; low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance; protein abundance increases in response to DNA replication stress Gene:THP2(YHR167W)|FD-Score:3.36|P-value:3.87E-4||SGD DESC:Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance Gene:TVP23(YDR084C)|FD-Score:4.25|P-value:1.08E-5||SGD DESC:Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern Gene:YCR023C(YCR023C)|FD-Score:-4.06|P-value:2.43E-5||SGD DESC:Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene Gene:YDR194W-A(YDR194W-A_p)|FD-Score:-3.37|P-value:3.70E-4||SGD DESC:Putative protein of unknown function; identified by fungal homology and RT-PCR Gene:YGR151C(YGR151C_d)|FD-Score:3.79|P-value:7.56E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C; relative distribution to the nucleus increases upon DNA replication stress Gene:YGR228W(YGR228W_d)|FD-Score:-3.11|P-value:9.41E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C Gene:YGR291C(YGR291C_d)|FD-Score:4.11|P-value:1.94E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YIL012W(YIL012W_d)|FD-Score:-3.28|P-value:5.13E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YIR014W(YIR014W_p)|FD-Score:-3.65|P-value:1.33E-4||SGD DESC:Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene Gene:YJR107W(YJR107W_p)|FD-Score:4.07|P-value:2.38E-5||SGD DESC:Putative lipase Gene:YKR051W(YKR051W_p)|FD-Score:4.61|P-value:1.98E-6||SGD DESC:Putative protein of unknown function Gene:YKR073C(YKR073C_d)|FD-Score:3.74|P-value:9.06E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YLR428C(YLR428C_d)|FD-Score:3.54|P-value:2.04E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1 Gene:YNL170W(YNL170W_d)|FD-Score:3.47|P-value:2.62E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:YNR066C(YNR066C_p)|FD-Score:-3.11|P-value:9.20E-4||SGD DESC:Putative membrane-localized protein of unknown function Gene:YOR019W(YOR019W)|FD-Score:-3.29|P-value:4.93E-4||SGD DESC:Protein of unknown function that may interact with ribosomes, based on co-purification experiments Gene:YPK1(YKL126W)|FD-Score:3.18|P-value:7.36E-4||SGD DESC:Serine/threonine protein kinase; phosphorylates and downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p (inhibitors of serine:palmitoyl-coenzyme A transferase) by phosphorylation in response to compromised sphingolipid synthesis; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK; YPK1 has a paralog, YPK2, that arose from the whole genome duplication Gene:YPR053C(YPR053C_d)|FD-Score:4.3|P-value:8.38E-6||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C Gene:YPR197C(YPR197C_d)|FD-Score:3.47|P-value:2.60E-4||SGD DESC:Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data Gene:ZAP1(YJL056C)|FD-Score:-3.35|P-value:4.06E-4||SGD DESC:Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YER133W5.482.13E-81.09GLC7Type 1 serine/threonine protein phosphatase catalytic subunit; involved in various processes including glycogen metabolism, sporulation, mitosis; accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p; import into nucleus is inhibited during spindle assembly checkpoint arrest
YGR065C4.395.79E-60.46VHT1High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
YLR010C3.934.25E-50.01TEN1Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p
YLR029C3.924.42E-50.03RPL15ARibosomal 60S subunit protein L15A; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15A has a paralog, RPL15B, that arose from the whole genome duplication
YHR007C3.894.99E-50.07ERG11Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p
YKL042W3.826.66E-50.35SPC42Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane
YDR429C3.472.63E-40.00TIF35eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation
YML015C3.472.64E-40.06TAF11TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors
YFL005W3.413.28E-40.03SEC4Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane
YPR144C3.383.63E-40.23NOC4Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits
YGL171W3.158.13E-40.08ROK1RNA-dependent ATPase; involved in pre-rRNA processing at sites A0, A1, and A2, and in control of cell cycle progression; contains two upstream open reading frames (uORFs) in 5' untranslated region which regulate translation
YDL195W3.070.001060.09SEC31Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance
YOR260W2.980.001430.09GCD1Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
YGL111W2.890.001920.02NSA1Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis
YDR526C_d2.870.002050.15YDR526C_dDubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YER019C-A6.134.34E-10SBH2Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
YLR110C5.373.96E-8CCW12Cell wall mannoprotein; plays a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip; CCW12 has a paralog, YDR134C, that arose from the whole genome duplication
YOR096W5.286.52E-8RPS7AProtein component of the small (40S) ribosomal subunit; interacts with Kti11p; deletion causes hypersensitivity to zymocin; homologous to mammalian ribosomal protein S7, no bacterial homolog; RPS7A has a paralog, RPS7B, that arose from the whole genome duplication
YBR014C5.171.17E-7GRX7Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication
YKR051W_p4.611.98E-6YKR051W_pPutative protein of unknown function
YNL215W4.542.88E-6IES2Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress
YAL020C4.464.06E-6ATS1Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle
YPR053C_d4.308.38E-6YPR053C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C
YDR084C4.251.08E-5TVP23Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YGR291C_d4.111.94E-5YGR291C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YJL116C4.082.23E-5NCA3Protein involved in mitochondrion organization; functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin; NCA3 has a paralog, UTH1, that arose from the whole genome duplication
YJR107W_p4.072.38E-5YJR107W_pPutative lipase
YDL100C3.895.03E-5GET3Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress
YGR151C_d3.797.56E-5YGR151C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C; relative distribution to the nucleus increases upon DNA replication stress
YKR073C_d3.749.06E-5YKR073C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

GO enrichment analysis for SGTC_3182
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.0881.25E-11SGTC_12021988-0068 29.6 μMChemDiv (Drug-like library)28504800.113924RNA processing & uracil transport
0.0862.77E-11SGTC_390986-0283 58.3 μMChemDiv (Drug-like library)31106000.350877calcium & mitochondrial duress
0.0864.08E-11SGTC_1627st003713 25.6 μMTimTec (Natural product derivative library)161950700.151163calcium & mitochondrial duress
0.0807.28E-10SGTC_1731st035964 63.0 μMTimTec (Natural product derivative library)67395750.144928
0.0791.30E-9SGTC_1625st003711 30.1 μMTimTec (Natural product derivative library)242070340.137931calcium & mitochondrial duress
0.0772.75E-9SGTC_2515chrysin 20.8 μMMicrosource (Natural product library)52816070.126984RPP1 & pyrimidine depletion
0.0773.98E-9SGTC_13853091-4834 14.1 μMChemDiv (Drug-like library)40728140.138462RPP1 & pyrimidine depletion
0.0763.98E-9SGTC_32329132874 49.5 μMChembridge (Drug-like library)37849400.533333RPP1 & pyrimidine depletion
0.0764.85E-9SGTC_31259127534 49.5 μMChembridge (Drug-like library)16392350.275862
0.0706.34E-8SGTC_659k018-0002 107.0 μMChemDiv (Drug-like library)67978790.0941176
0.0681.65E-7SGTC_1974544-0043 41.6 μMChemDiv (Drug-like library)8965230.128571endomembrane recycling
0.0681.85E-7SGTC_22747947094 46.1 μMChembridge (Fragment library)29710280.277778
0.0672.16E-7SGTC_1850st056238 17.0 μMTimTec (Natural product derivative library)53931770.104478RPP1 & pyrimidine depletion
0.0672.42E-7SGTC_30399090270 49.5 μMChembridge (Drug-like library)171737500.190476RPP1 & pyrimidine depletion
0.0664.07E-7SGTC_384k007-0144 5.2 μMChemDiv (Drug-like library)68248860.227273ERAD & cell cycle

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3191911035249.47 μM0.85365917122424Chembridge (Drug-like library)267.322383.66112
SGTC_2926901072665.15 μM0.6666672994293Chembridge (Drug-like library)253.29583.21512
SGTC_3184910875849.47 μM0.6902885Chembridge (Drug-like library)241.28512.94712
SGTC_3189911068249.47 μM0.617122418Chembridge (Drug-like library)273.35013.61413
SGTC_2827799384771.43 μM0.549022985692Chembridge (Drug-like library)283.321783.19813
SGTC_3232913287449.47 μM0.5333333784940Chembridge (Drug-like library)255.268622.4713RPP1 & pyrimidine depletion
SGTC_3188911078949.47 μM0.52849217Chembridge (Drug-like library)275.730163.61112iron homeostasis
SGTC_3190911036649.47 μM0.50980417123768Chembridge (Drug-like library)283.321783.41923
SGTC_20034023581200 μM0.516641307Chembridge (Fragment library)199.677262.51222cell wall signaling
SGTC_2931901467455.67 μM0.52996810Chembridge (Drug-like library)326.174624.03323