9108214

7,7-dimethyl-4-(2-morpholin-4-ylethylsulfanyl)-2-phenyl-5,8-dihydropyrano[4,3-d]pyrimidine

[PubChem] [DrugBank] [Wikipedia] [WikiGenes] [ChEMBL] [ChemSpider] 



Source SMILES: standardizedunstandardized
Compound:
Screen ID SGTC_3183
Screen concentration 49.5 μM
Source Chembridge (Drug-like library)
PubChem CID 4974831
SMILES CC1(CC2=C(CO1)C(=NC(=N2)C3=CC=CC=C3)SCCN4CCOCC4)C
Standardized SMILES CC1(C)Cc2nc(nc(SCCN3CCOCC3)c2CO1)c4ccccc4
Molecular weight 385.523
ALogP 3.18
H-bond donor count 0
H-bond acceptor count 6
Response signature RPP1 & pyrimidine depletion

Pool Growth Kinetics
% growth inhibition (Het. pool) 9.54
% growth inhibition (Hom. pool) 6.49


HIP profile

Heterozygous deletion strains
Scale: fixedexpanded
Heterozygous profile for 4974831
Download HIP data (tab-delimited text)  (excel)

HOP profile

Homozygous deletion strains
Scale: fixedexpanded
Homozygous profile for 4974831
Download HOP data (tab-delimited text)  (excel)
Gene:HIS6(YIL020C)|FD-Score:3.75|P-value:9.00E-5||SGD DESC:Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts Gene:HMG2(YLR450W)|FD-Score:3.51|P-value:2.24E-4||SGD DESC:HMG-CoA reductase; converts HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; forms foci at the nuclear periphery upon DNA replication stress Gene:IES3(YLR052W)|FD-Score:3.3|P-value:4.79E-4||SGD DESC:Subunit of the INO80 chromatin remodeling complex Gene:KGD1(YIL125W)|FD-Score:-3.81|P-value:6.82E-5||SGD DESC:Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA Gene:MET13(YGL125W)|FD-Score:-3.21|P-value:6.63E-4||SGD DESC:Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway Gene:RAD33(YML011C)|FD-Score:-3.16|P-value:7.99E-4||SGD DESC:Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus Gene:SKG3(YLR187W_p)|FD-Score:-4.53|P-value:2.96E-6||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication Gene:SOD1(YJR104C)|FD-Score:3.41|P-value:3.21E-4||SGD DESC:Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid Gene:TDP1(YBR223C)|FD-Score:4.07|P-value:2.38E-5||SGD DESC:Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI Gene:YBL070C(YBL070C_d)|FD-Score:-3.37|P-value:3.81E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDL032W(YDL032W_d)|FD-Score:3.13|P-value:8.81E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene Gene:YGL176C(YGL176C_p)|FD-Score:-3.58|P-value:1.73E-4||SGD DESC:Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype Gene:YLL059C(YLL059C_d)|FD-Score:3.82|P-value:6.55E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YMR230W-A(YMR230W-A_p)|FD-Score:3.62|P-value:1.48E-4||SGD DESC:Putative protein of unknown function Gene:YNL024C(YNL024C_p)|FD-Score:-3.25|P-value:5.86E-4||SGD DESC:Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern Gene:YPR063C(YPR063C_p)|FD-Score:-3.17|P-value:7.55E-4||SGD DESC:ER-localized protein of unknown function Gene:HIS6(YIL020C)|FD-Score:3.75|P-value:9.00E-5||SGD DESC:Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts Gene:HMG2(YLR450W)|FD-Score:3.51|P-value:2.24E-4||SGD DESC:HMG-CoA reductase; converts HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; forms foci at the nuclear periphery upon DNA replication stress Gene:IES3(YLR052W)|FD-Score:3.3|P-value:4.79E-4||SGD DESC:Subunit of the INO80 chromatin remodeling complex Gene:KGD1(YIL125W)|FD-Score:-3.81|P-value:6.82E-5||SGD DESC:Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA Gene:MET13(YGL125W)|FD-Score:-3.21|P-value:6.63E-4||SGD DESC:Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway Gene:RAD33(YML011C)|FD-Score:-3.16|P-value:7.99E-4||SGD DESC:Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus Gene:SKG3(YLR187W_p)|FD-Score:-4.53|P-value:2.96E-6||SGD DESC:Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Skg4p; relocalizes from bud neck to cytoplasm upon DNA replication stress; SKG3 has a paralog, CAF120, that arose from the whole genome duplication Gene:SOD1(YJR104C)|FD-Score:3.41|P-value:3.21E-4||SGD DESC:Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid Gene:TDP1(YBR223C)|FD-Score:4.07|P-value:2.38E-5||SGD DESC:Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI Gene:YBL070C(YBL070C_d)|FD-Score:-3.37|P-value:3.81E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YDL032W(YDL032W_d)|FD-Score:3.13|P-value:8.81E-4||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene Gene:YGL176C(YGL176C_p)|FD-Score:-3.58|P-value:1.73E-4||SGD DESC:Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype Gene:YLL059C(YLL059C_d)|FD-Score:3.82|P-value:6.55E-5||SGD DESC:Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data Gene:YMR230W-A(YMR230W-A_p)|FD-Score:3.62|P-value:1.48E-4||SGD DESC:Putative protein of unknown function Gene:YNL024C(YNL024C_p)|FD-Score:-3.25|P-value:5.86E-4||SGD DESC:Putative methyltransferase; has seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; despite similarity to methyltransferases, null mutant does not display alterations in lysine methylation pattern Gene:YPR063C(YPR063C_p)|FD-Score:-3.17|P-value:7.55E-4||SGD DESC:ER-localized protein of unknown function

Click on Significant Values for Strain Details

Top 15 HET fitness defect scores (HIP)

Download all HIP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Clearance Gene Gene Description
YHR170W3.641.34E-40.70NMD3Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex
YDR381W2.940.001630.06YRA1RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
YOL038W2.890.001950.62PRE6Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress
YGR090W2.270.011600.06UTP22Component of the small-subunit processome; required for nuclear export of tRNAs; may facilitate binding of Utp8p to aminoacylated tRNAs and their delivery to Los1p for export; conserved from yeast to mammals
YPR168W2.210.013500.12NUT2Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription; protein abundance increases in response to DNA replication stress
YHR062C2.090.018300.00RPP1Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
YNL207W2.090.018500.03RIO2Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p
YER104W2.050.020000.00RTT105Protein with a role in regulation of Ty1 transposition
YGL055W2.050.020200.02OLE1Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YLL050C2.020.021500.04COF1Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes
YGL048C1.990.023500.02RPT6ATPase of the 19S regulatory particle of the 26S proteasome; one of six ATPases of the regulatory particle; involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle; protein abundance increases in response to DNA replication stress
YBR192W1.960.024800.02RIM2Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family
YOR004W1.940.026000.01UTP23Component of the small subunit processome, involved in 40S ribosomal subunit biogenesis; interacts with snR30 and is required for dissociation of snR30 from large pre-ribosomal particles; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function; essential protein
YJR064W1.940.026500.02CCT5Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
YPL237W1.920.027700.00SUI3Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding

Top 15 HOM fitness defect scores (HOP)

Download all HOP Data (tab-delimited text)  (excel)
Deletion Strain FD score P-value Gene Gene Description
YBR223C4.072.38E-5TDP1Tyrosyl-DNA phosphodiesterase I; hydrolyzes 3' and 5'-phosphotyrosyl bonds; involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI
YLL059C_d3.826.55E-5YLL059C_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YIL020C3.759.00E-5HIS6Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts
YMR230W-A_p3.621.48E-4YMR230W-A_pPutative protein of unknown function
YLR450W3.512.24E-4HMG2HMG-CoA reductase; converts HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; forms foci at the nuclear periphery upon DNA replication stress
YJR104C3.413.21E-4SOD1Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans; protein abundance increases in response to DNA replication stress and in response to prolonged exposure to boric acid
YLR052W3.304.79E-4IES3Subunit of the INO80 chromatin remodeling complex
YDL032W_d3.138.81E-4YDL032W_dDubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene
YBR015C3.030.00122MNN2Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment
YBR175W2.910.00181SWD3Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5
YLR300W2.870.00206EXG1Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes
YOL095C2.860.00211HMI1Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
YER086W2.850.00221ILV1Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
YNL070W2.750.00301TOM7Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
YHR076W2.750.00301PTC7Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope

GO enrichment analysis for SGTC_3183
No biological processes are significantly enriched (FDR < 0.1).

No protein complexes are significantly enriched (FDR < 0.1).

Coinhibitory screens
Download Coinhibition data (tab-delimited text)  (excel)

Correlation pval Screen ID Condition Source PubChem
CID
Tanimoto
Score
Response
Signature
0.1041.17E-15SGTC_31689103419 49.5 μMChembridge (Drug-like library)166492560.09195460S ribosome export
0.1001.27E-14SGTC_1913914-0123 66.5 μMChemDiv (Drug-like library)31444120.13580260S ribosome export
0.0806.98E-10SGTC_2505galangin 7.9 μMMicrosource (Natural product library)52816160.12RPP1 & pyrimidine depletion
0.0807.08E-10SGTC_15924',5'-dihydroxyflavone 8.8 μMTimTec (Pure natural product library)6886690.087560S ribosome export
0.0808.15E-10SGTC_31859108267 49.5 μMChembridge (Drug-like library)49104860.7966160S ribosome export
0.0782.32E-9SGTC_7651319-0117 244.0 μMChemDiv (Drug-like library)34877460.0960S ribosome export
0.0772.69E-9SGTC_6450845-0943 5.4 μMChemDiv (Drug-like library)18851060.065217460S ribosome export
0.0773.92E-9SGTC_1972st070201 17.4 μMTimTec (Natural product derivative library)28290990.0795455
0.0741.41E-8SGTC_2504purpurogallin 52.3 μMMicrosource (Natural product library)52815710.0263158RPP1 & pyrimidine depletion
0.0732.01E-8SGTC_1674st016616 23.6 μMTimTec (Natural product derivative library)6258300.0813954
0.0707.47E-8SGTC_32769139060 49.5 μMChembridge (Drug-like library)48706190.096774260S ribosome export
0.0699.34E-8SGTC_8660495-0101 262.0 μMChemDiv (Drug-like library)6356940.10465160S ribosome export
0.0691.07E-7SGTC_13611608-0041 5.6 μMChemDiv (Drug-like library)X13610.0759494RPP1 & pyrimidine depletion
0.0691.10E-7SGTC_29839022671 13.0 μMChembridge (Drug-like library)64051610.29268360S ribosome export
0.0681.70E-7SGTC_1833914-0051 30.6 μMChemDiv (Drug-like library)15962320.090909160S ribosome export

Screens with compounds having similar structures
Screen ID Chemical Concentration Tanimoto Score PubChem ID Source Molecular Weight AlogP H-bond
donor
count
H-bond
acceptor
count
Response
Signature
SGTC_3185910826749.47 μM0.796614910486Chembridge (Drug-like library)415.548963.1650760S ribosome export
SGTC_1824st05372368.6 μM0.328125675225TimTec (Natural product derivative library)291.347083.39704
SGTC_3249913518349.47 μM0.34902779Chembridge (Drug-like library)365.471983.0271560S ribosome export
SGTC_3319913845016.76 μM0.2962962029690Chembridge (Drug-like library)379.498563.4915
SGTC_2983902267112.99 μM0.2926836405161Chembridge (Drug-like library)373.472523.1320760S ribosome export
SGTC_2801790780081.82 μM0.2837846620925Chembridge (Drug-like library)343.421643.40203
SGTC_14801070-004441.2 μM0.2769233124987ChemDiv (Drug-like library)294.390783.41702
SGTC_3258913847749.47 μM0.2470594970355Chembridge (Drug-like library)367.44482.06116
SGTC_12021988-006829.6 μM0.2469142850480ChemDiv (Drug-like library)426.555.45913RNA processing & uracil transport
SGTC_10543429-0080167 μM0.243591162877ChemDiv (Drug-like library)399.281063.20113